Abstract
In the last two decades, emerging viruses such as flaviviruses or coronaviruses have caused significant health andeconomic damage. Released upon infection in the host, methyltransferases are involved in the methylation of theviral messenger RNA cap. These methylations, on the N7 position of the guanosine and 2’ O position of the firstnucleotide transcribed in the cap, increase the stability of the viral messenger RNA in the cell while protecting itfrom the cellular receptors of the innate immune system. Their role is therefore essential and a deactivation of thesemethyltransferases could lead to the elimination of the virus by stimulation of the innate immune system. Followingthis objective, the work reported in this article concerns the design and evaluation of viral methyltransferaseinhibitors. The bisubstrate strategy was used to improve the specificity of these novel compounds