Inhaled Sedation in Acute Respiratory Distress Syndrome

Matthieu Jabaudon; Jean-Pierre Quenot; Julio Badie; Jules Audard; Benjamin Rieu; Caroline Varillon; Antoine Monsel; François Thouy; Julien Lorber; Joël Cousson; Stéphanie Bulyez; Jérémy Bourenne; Ghada Sboui; Claire Lhommet; Virginie Lemiale; Belaïd Bouhemad; Clément Brault; Sigismond Lasocki; François Legay; Thomas Lebouvier; Arthur Durand; Julien Pottecher; Alexandre Conia; Delphine Brégeaud; Lionel Velly; Arnaud Thille; Fabien Lambiotte; Erwan L’her; Mehran Monchi; Antoine Roquilly; Aziz Berrouba; Franck Verdonk; Russell Chabanne; Thomas Godet; Marc Garnier; Raiko Blondonnet; Jérémy Vernhes; Vincent Sapin; Lucile Borao; Emmanuel Futier; Bruno Pereira; Jean-Michel Constantin; Marc Gainnier; Béatrice Cresta; Aurélie Larosa; Pierre Simeone; Didier Sanchez; Imane Inal; Marine Challier; Valentine Verdier; Bénédicte Deluca-Bosc; Cyril Quemeneur; Sandrine Ndingamondze; Fanny Charbonnier; Souad Fellous; Christophe Quesnel; Anne Daguenel-Nguyen; Elie Azoulay; Igor Theodose; Michael Darmon; Isabelle Madeleine; Julien Le Roy; Christophe Vinsonneau; Sabine Janowski; Maryline Houdre; Sarah Tollot; Catherine Senis; Dominique Descamps; Pierre-Marie Bertrand; Marine Agullo; Arezki Agher; Eric Stoll; Maryse Camus; Bruno Mourvillier; Eric Marquis; Amandine Farget; Mélanie Gaillard; Sandy Aerts; Philippe Benoit; Catherine Bellot; Nathalie Kerneur; Valéry Bourbonneux; Laurent Pleven; Aude Davy; Amélie Le Gleut; Nathalie Mercier; Bénédicte Hue; Marie-Cécile Herve; Julien Maizel; Yoann Zerbib; Rayan Braik; Kahina Zid; Sophie Boddaert; Yves-Edouard Herpe; Maeva Campfort; Soizic Gergaud; Viviane Cassisa; Anne Sylvie Scholastique; Valérie Daniel; Erwan L'Her; Pierre Bailly; Isabelle Ledu; Hélène Fortin-Prunier; Amandine Tapon; Axelle Cornillet; Patricia Dias; Elsa Menanteau; Pascal Andreu; Audrey Massard; Solene Villot; Samantha Lima Pinheiro; Jean-Baptiste Roudaut; Nicolas Nowobilski; Vivien Berthoud; Hasni Si-Abdelkader; Samir Jaber; Gerald Chanques; Audrey de Jong; Boris Jung; Albert Prades; Fouad Belafia; Julie Carr; Moussa Cisse; Matthieu Conseil; Jean-Marc Delay; Julien Boudjemaa; Laurent Cachia; Jeanne Boyer; Karim Asehnoune; Clément Prouteau; Delphine Flattres Du Chaussoy; Cécilia Lebel; Amélie Trichot; Dominique Demeure Dit Latte; Yannick Hourmant; Pierre-Joachim Mahe; Laurence Flet; Carole Ichai; Jean-Christophe Orban; Christelle Boczek; Justine Bellegarde; Claire Roger; Laurent Muller; Jean-Yves Lefrant; Sophie Lloret; Audrey Ambert; Mathieu Expert; Caroline Maury; Virginie Viviez; Elodie Jullian; Céline Loiseau; Christian Maillard; Claire Dahyot-Fizelier; Nadia Imzi; Christelle Plumereau; Sabrina Seguin; Isabelle Princet; Jean-Pierre Frat; René Robert; Rémy Coudroy; Carole Guignon; Céline Delétage; Nacira Benhamouche; Delphine Chatellier; Damien Marie; Florence Boissier; Anne Veinstein; Philippe Seguin; Sophie Caradec; Eric Noll; Pierre Diemunsch; Thiennga Chamaraux-Tran; Habiba Moussa; Stéphane Hecketsweiler; Arnaud Romoli; Alain Meyer; Nadia Dhif; Magdalena Szczot; Alban Pellegrino; Alexandre Debaene; Anne Hutt; Sarah Lang; Roland Amathieu; Thierry Lazard; Gabriel Lejour; Emmanuelle Guillot; Caroline Blazejewski; Sébastien Beague; Maud Vasse; Pauline Boddaert; Maxime Samson; Raphael Krouchi; Cyril Fayolle; Thomas Queruau; François Beze; Solange Tombelle; Fréderique Danicourt; Basile Dectot; Carole Delattre; Valentin Vergriete; Fahima Zidat; Célia Komurkiewicz-Wellems; Virginie Paquez; Saad Nseir; Sylvie Brice; Claire Delcourte; Amélie Cerf; Laure Mariller; Thomas Costille; Thierry Gillart; Jean-Baptiste Joffredo; Audrey Johanny; Clémence Louis; Sébastien Perbet; Adrien Carla; Margaux Coudray; Loris Giordanetto; Marc Bégard; Camille Boissy; Thibaud Cammas; Bernard Cosserant; Romain Grobost; Katia Levrier; Pierre-Antoine Pioche; Bertille Paquette; Gauthier Arpajou; Lucie Aupetitgendre; Sophie Cayot; Renaud Guerin; Benoit Baietto; Laure-Anne Simand; Jean-Etienne Bazin; Nathalie Bourguignon; Sylvie Cosserant; Périne Vidal; Guillaume Chauvet; Dominique Morand; Camille Theilliere; Bertrand Souweine; Claire Dupuis; Mireille Adda-Pernot; Marine Bereiziat; Frederic Duee; Alexandre Lautrette; Nathanael Eisenmann; Ghislaine Niezgodzki; Rodolphe Hilaire; Régine Chevrier; Sonia Rucart; Maud Jonas; Céline Chevalier; Servane Vastral; Laurent Faivre; Elodie Bouvier; Charlotte Bourgoin; Isabelle Roussez; Pascale Dussert; Mohamed Ali Benbali; Hanane Fodil; Justine Lemtiri; Chaouki Bouras; Hedi Dhaouadi; Nabil El Beki; Delphine Bregeaud; Stéphanie Violette; Gwladys M’boungou; Eric Gerardin; Romain Blanchon; Elodie Protesti; Pierre Kalfon; Bénédicte Mauchien; Martine Ferrandière; Charlène Piat

doi:10.1001/jama.2025.3169

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Inhaled Sedation in Acute Respiratory Distress Syndrome

Journal article

Peer reviewed

Inhaled Sedation in Acute Respiratory Distress Syndrome

Matthieu Jabaudon, Jean-Pierre Quenot, Julio Badie, Jules Audard, Benjamin Rieu, Caroline Varillon, Antoine Monsel, François Thouy, Julien Lorber, Joël Cousson, …

JAMA Cardiology

18/03/2025

DOI: https://doi.org/10.1001/jama.2025.3169

Abstract

Importance Whether the use of inhaled or intravenous sedation affects outcomes differentially in mechanically ventilated adults with acute respiratory distress syndrome (ARDS) is unknown. Objective To determine the efficacy and safety of inhaled sevoflurane compared with intravenous propofol for sedation in patients with ARDS. Design, Setting, and Participants Phase 3 randomized, open-label, assessor-blinded clinical trial conducted from May 2020 to October 2023 with 90-day follow-up. Adults with early moderate to severe ARDS (defined by a ratio of Pao 2 to the fraction of inspired oxygen of <150 mm Hg with a positive end-expiratory pressure of ≥8 cm H 2 O) were enrolled in 37 French intensive care units. Interventions Patients were randomized to a strategy of inhaled sedation with sevoflurane (intervention group) or to a strategy of intravenous sedation with propofol (control group) for up to 7 days. Main Outcomes and Measures The primary end point was the number of ventilator-free days at 28 days; the key secondary end point was 90-day survival. Results Of 687 patients enrolled (mean [SD] age, 65 [12] years; 30% female), 346 were randomized to sevoflurane and 341 to propofol. The median total duration of sedation was 7 days (IQR, 4 to 7) in both groups. The number of ventilator-free days through day 28 was 0.0 days (IQR, 0.0 to 11.9) in the sevoflurane group and 0.0 days (IQR, 0.0 to 18.7) in the propofol group (median difference, −2.1 [95% CI, −3.6 to −0.7]; standardized hazard ratio, 0.76 [95% CI, 0.50 to 0.97]). The 90-day survival rates were 47.1% and 55.7% in the sevoflurane and propofol groups, respectively (hazard ratio, 1.31 [95% CI, 1.05 to 1.62]). Among 4 secondary outcomes, sevoflurane was associated with higher 7-day mortality (19.4% vs 13.5%, respectively; relative risk, 1.44 [95% CI, 1.02 to 2.03]) and fewer intensive care unit–free days through day 28 (median, 0.0 [IQR, 0.0 to 6.0] vs 0.0 [IQR, 0.0 to 15.0]; median difference, –2.5 [95% CI, –3.7 to –1.4]) compared with propofol. Conclusions and Relevance Among patients with moderate to severe ARDS, inhaled sedation with sevoflurane resulted in fewer ventilator-free days at day 28 and lower 90-day survival than sedation with propofol. Trial Registration ClinicalTrials.gov Identifier: NCT04235608

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Title: Inhaled Sedation in Acute Respiratory Distress Syndrome
Creators - without role: Matthieu Jabaudon - Centre Hospitalier Universitaire de Clermont-Ferrand
Jean-Pierre Quenot
Julio Badie - L'Hôpital Nord Franche-Comté
Jules Audard - Centre Hospitalier Universitaire de Clermont-Ferrand
Benjamin Rieu - Centre Hospitalier Universitaire de Clermont-Ferrand
Caroline Varillon - Clinical Trial Investigators
Antoine Monsel - Assistance Publique – Hôpitaux de Paris
François Thouy - Clinical Trial Investigators
Julien Lorber - Centre Hospitalier Saint-Nazaire
Joël Cousson - Université de Reims Champagne-Ardenne
Stéphanie Bulyez - Centre Hospitalier Universitaire de Nîmes
Jérémy Bourenne - Assistance Publique Hôpitaux de Marseille
Ghada Sboui - Centre Hospitalier de Béthune
Claire Lhommet - Groupe Hospitalier Diaconesses Croix Saint-Simon
Virginie Lemiale - Assistance Publique – Hôpitaux de Paris
Belaïd Bouhemad - Maison des Sciences de l’Homme de Dijon
Clément Brault - Centre Hospitalier Universitaire Amiens-Picardie
Sigismond Lasocki - Université d'Angers
François Legay - Centre Hospitalier de Saint-Brieuc
Thomas Lebouvier - Clinical Trial Investigators
Arthur Durand - Hôpital Roger Salengro
Julien Pottecher - Clinical Trial Investigators
Alexandre Conia - Les Hôpitaux de Chartres
Delphine Brégeaud - Clinical Trial Investigators
Lionel Velly - Institut de Neurosciences de la Timone
Arnaud Thille - Université de Poitiers
Fabien Lambiotte - Centre Hospitalier de Valenciennes
Erwan L’her - Université de Bretagne Occidentale
Mehran Monchi - Melun Hospital
Antoine Roquilly - Nantes Université
Aziz Berrouba - Université de Reims Champagne-Ardenne
Franck Verdonk - Groupe de recherche clinique en anesthésie réanimation médecine périopératoire
Russell Chabanne - Centre Hospitalier Universitaire de Clermont-Ferrand
Thomas Godet - Centre Hospitalier Universitaire de Clermont-Ferrand
Marc Garnier - Université Clermont Auvergne
Raiko Blondonnet - Université Clermont Auvergne
Jérémy Vernhes - Centre Hospitalier Universitaire de Clermont-Ferrand
Vincent Sapin - Université Clermont Auvergne
Lucile Borao - Centre Hospitalier Universitaire de Clermont-Ferrand
Emmanuel Futier - Centre Hospitalier Universitaire de Clermont-Ferrand
Bruno Pereira - Clinical Trial Investigators
Jean-Michel Constantin - Sorbonne Université
Marc Gainnier - Clinical Trial Investigators
Jérémy Bourenne - Assistance Publique Hôpitaux de Marseille
Béatrice Cresta - Clinical Trial Investigators
Aurélie Larosa - Clinical Trial Investigators
Lionel Velly - Institut de Neurosciences de la Timone
Pierre Simeone - Clinical Trial Investigators
Didier Sanchez - Clinical Trial Investigators
Imane Inal - Clinical Trial Investigators
Marine Challier - Clinical Trial Investigators
Valentine Verdier - Clinical Trial Investigators
Bénédicte Deluca-Bosc - Clinical Trial Investigators
Jean-Michel Constantin - Sorbonne Université
Antoine Monsel - Assistance Publique – Hôpitaux de Paris
Cyril Quemeneur - Clinical Trial Investigators
Sandrine Ndingamondze - Clinical Trial Investigators
Fanny Charbonnier - Clinical Trial Investigators
Franck Verdonk - Groupe de recherche clinique en anesthésie réanimation médecine périopératoire
Souad Fellous - Clinical Trial Investigators
Christophe Quesnel - Clinical Trial Investigators
Anne Daguenel-Nguyen - Clinical Trial Investigators
Virginie Lemiale - Assistance Publique – Hôpitaux de Paris
Elie Azoulay - Clinical Trial Investigators
Igor Theodose - Clinical Trial Investigators
Michael Darmon - Clinical Trial Investigators
Isabelle Madeleine - Clinical Trial Investigators
Julien Le Roy - Clinical Trial Investigators
Christophe Vinsonneau - Clinical Trial Investigators
Ghada Sboui - Centre Hospitalier de Béthune
Sabine Janowski - Clinical Trial Investigators
Maryline Houdre - Clinical Trial Investigators
Sarah Tollot - Clinical Trial Investigators
Catherine Senis - Clinical Trial Investigators
Dominique Descamps - Clinical Trial Investigators
Pierre-Marie Bertrand - Clinical Trial Investigators
Marine Agullo - Clinical Trial Investigators
Mehran Monchi - Melun Hospital
Arezki Agher - Clinical Trial Investigators
Eric Stoll - Clinical Trial Investigators
Maryse Camus - Clinical Trial Investigators
Joël Cousson - Université de Reims Champagne-Ardenne
Bruno Mourvillier - Clinical Trial Investigators
Eric Marquis - Clinical Trial Investigators
Amandine Farget - Clinical Trial Investigators
Mélanie Gaillard
Sandy Aerts - Clinical Trial Investigators
Philippe Benoit - Clinical Trial Investigators
François Legay - Centre Hospitalier de Saint-Brieuc
Catherine Bellot - Clinical Trial Investigators
Nathalie Kerneur - Clinical Trial Investigators
Valéry Bourbonneux - Clinical Trial Investigators
Laurent Pleven - Clinical Trial Investigators
Aude Davy - Clinical Trial Investigators
Amélie Le Gleut - Clinical Trial Investigators
Nathalie Mercier - Clinical Trial Investigators
Bénédicte Hue - Clinical Trial Investigators
Marie-Cécile Herve
Clément Brault - Centre Hospitalier Universitaire Amiens-Picardie
Julien Maizel - Clinical Trial Investigators
Yoann Zerbib - Clinical Trial Investigators
Rayan Braik - Clinical Trial Investigators
Kahina Zid - Clinical Trial Investigators
Sophie Boddaert - Clinical Trial Investigators
Yves-Edouard Herpe - Clinical Trial Investigators
Sigismond Lasocki - Université d'Angers
Maeva Campfort - Clinical Trial Investigators
Soizic Gergaud - Clinical Trial Investigators
Viviane Cassisa - Clinical Trial Investigators
Anne Sylvie Scholastique - Clinical Trial Investigators
Valérie Daniel - Clinical Trial Investigators
Erwan L'Her
Pierre Bailly - Clinical Trial Investigators
Isabelle Ledu - Clinical Trial Investigators
Hélène Fortin-Prunier - Clinical Trial Investigators
Amandine Tapon - Clinical Trial Investigators
Axelle Cornillet - Clinical Trial Investigators
Patricia Dias - Clinical Trial Investigators
Elsa Menanteau - Clinical Trial Investigators
Jean-Pierre Quenot
Pascal Andreu - Clinical Trial Investigators
Audrey Massard - Clinical Trial Investigators
Solene Villot - Clinical Trial Investigators
Samantha Lima Pinheiro
Jean-Baptiste Roudaut - Clinical Trial Investigators
Belaïd Bouhemad - Maison des Sciences de l’Homme de Dijon
Nicolas Nowobilski - Clinical Trial Investigators
Vivien Berthoud - Clinical Trial Investigators
Hasni Si-Abdelkader - Clinical Trial Investigators
Samir Jaber - Hôpital Saint Eloi
Gerald Chanques - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Audrey de Jong - Clinical Trial Investigators
Boris Jung - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Albert Prades - Clinical Trial Investigators
Fouad Belafia - Clinical Trial Investigators
Julie Carr - Clinical Trial Investigators
Moussa Cisse - Clinical Trial Investigators
Matthieu Conseil - Clinical Trial Investigators
Jean-Marc Delay - Clinical Trial Investigators
Julien Boudjemaa - Clinical Trial Investigators
Laurent Cachia - Clinical Trial Investigators
Jeanne Boyer - Clinical Trial Investigators
Antoine Roquilly - Nantes Université
Karim Asehnoune - Clinical Trial Investigators
Clément Prouteau - Clinical Trial Investigators
Delphine Flattres Du Chaussoy
Cécilia Lebel
Amélie Trichot - Clinical Trial Investigators
Dominique Demeure Dit Latte
Yannick Hourmant - Clinical Trial Investigators
Pierre-Joachim Mahe - Clinical Trial Investigators
Laurence Flet
Carole Ichai - Clinical Trial Investigators
Jean-Christophe Orban
Christelle Boczek - Clinical Trial Investigators
Justine Bellegarde - Clinical Trial Investigators
Stéphanie Bulyez - Centre Hospitalier Universitaire de Nîmes
Claire Roger - Clinical Trial Investigators
Laurent Muller - Clinical Trial Investigators
Jean-Yves Lefrant
Sophie Lloret - Clinical Trial Investigators
Audrey Ambert - Clinical Trial Investigators
Mathieu Expert - Clinical Trial Investigators
Caroline Maury - Clinical Trial Investigators
Virginie Viviez - Clinical Trial Investigators
Elodie Jullian - Clinical Trial Investigators
Céline Loiseau
Christian Maillard - Clinical Trial Investigators
Claire Dahyot-Fizelier - Clinical Trial Investigators
Nadia Imzi - Clinical Trial Investigators
Christelle Plumereau - Clinical Trial Investigators
Sabrina Seguin - Clinical Trial Investigators
Isabelle Princet - Clinical Trial Investigators
Arnaud Thille - Université de Poitiers
Jean-Pierre Frat - Clinical Trial Investigators
René Robert - Clinical Trial Investigators
Rémy Coudroy
Carole Guignon - Clinical Trial Investigators
Céline Delétage - Clinical Trial Investigators
Nacira Benhamouche - Clinical Trial Investigators
Delphine Chatellier - Clinical Trial Investigators
Damien Marie - Clinical Trial Investigators
Florence Boissier - Clinical Trial Investigators
Anne Veinstein - Clinical Trial Investigators
Thomas Lebouvier - Clinical Trial Investigators
Philippe Seguin - Clinical Trial Investigators
Sophie Caradec - Clinical Trial Investigators
Julien Pottecher - Clinical Trial Investigators
Eric Noll - Clinical Trial Investigators
Pierre Diemunsch - Clinical Trial Investigators
Thiennga Chamaraux-Tran
Habiba Moussa
Stéphane Hecketsweiler - Clinical Trial Investigators
Arnaud Romoli - Clinical Trial Investigators
Alain Meyer - Clinical Trial Investigators
Nadia Dhif - Clinical Trial Investigators
Magdalena Szczot - Clinical Trial Investigators
Alban Pellegrino - Clinical Trial Investigators
Alexandre Debaene - Clinical Trial Investigators
Anne Hutt - Clinical Trial Investigators
Sarah Lang - Clinical Trial Investigators
Claire Lhommet - Groupe Hospitalier Diaconesses Croix Saint-Simon
Roland Amathieu - Clinical Trial Investigators
Thierry Lazard - Clinical Trial Investigators
Gabriel Lejour - Clinical Trial Investigators
Emmanuelle Guillot - Clinical Trial Investigators
Caroline Varillon - Clinical Trial Investigators
Caroline Blazejewski - Clinical Trial Investigators
Sébastien Beague - Clinical Trial Investigators
Maud Vasse - Clinical Trial Investigators
Pauline Boddaert - Clinical Trial Investigators
Maxime Samson - Clinical Trial Investigators
Raphael Krouchi - Clinical Trial Investigators
Cyril Fayolle - Clinical Trial Investigators
Thomas Queruau - Clinical Trial Investigators
François Beze - Clinical Trial Investigators
Solange Tombelle - Clinical Trial Investigators
Fréderique Danicourt - Clinical Trial Investigators
Basile Dectot - Clinical Trial Investigators
Carole Delattre - Clinical Trial Investigators
Valentin Vergriete - Clinical Trial Investigators
Fahima Zidat - Clinical Trial Investigators
Célia Komurkiewicz-Wellems - Clinical Trial Investigators
Virginie Paquez - Clinical Trial Investigators
Arthur Durand - Hôpital Roger Salengro
Saad Nseir - Clinical Trial Investigators
Sylvie Brice - Clinical Trial Investigators
Claire Delcourte - Clinical Trial Investigators
Amélie Cerf - Clinical Trial Investigators
Laure Mariller - Clinical Trial Investigators
Benjamin Rieu - Centre Hospitalier Universitaire de Clermont-Ferrand
Raiko Blondonnet - Université Clermont Auvergne
Thomas Costille - Clinical Trial Investigators
Thierry Gillart - Clinical Trial Investigators
Jean-Baptiste Joffredo - Clinical Trial Investigators
Audrey Johanny - Clinical Trial Investigators
Clémence Louis - Clinical Trial Investigators
Sébastien Perbet - Clinical Trial Investigators
Adrien Carla - Clinical Trial Investigators
Margaux Coudray
Loris Giordanetto - Clinical Trial Investigators
Marc Bégard - Clinical Trial Investigators
Camille Boissy - Clinical Trial Investigators
Thibaud Cammas - Clinical Trial Investigators
Russell Chabanne - Centre Hospitalier Universitaire de Clermont-Ferrand
Bernard Cosserant - Clinical Trial Investigators
Romain Grobost - Clinical Trial Investigators
Katia Levrier - Clinical Trial Investigators
Pierre-Antoine Pioche - Clinical Trial Investigators
Bertille Paquette - Clinical Trial Investigators
Gauthier Arpajou - Clinical Trial Investigators
Jules Audard - Centre Hospitalier Universitaire de Clermont-Ferrand
Lucie Aupetitgendre - Clinical Trial Investigators
Sophie Cayot - Clinical Trial Investigators
Renaud Guerin
Benoit Baietto - Clinical Trial Investigators
Laure-Anne Simand - Clinical Trial Investigators
Emmanuel Futier - Centre Hospitalier Universitaire de Clermont-Ferrand
Jean-Etienne Bazin - Clinical Trial Investigators
Thomas Godet - Centre Hospitalier Universitaire de Clermont-Ferrand
Marc Garnier - Université Clermont Auvergne
Matthieu Jabaudon - Centre Hospitalier Universitaire de Clermont-Ferrand
Bruno Pereira - Clinical Trial Investigators
Nathalie Bourguignon - Clinical Trial Investigators
Sylvie Cosserant - Clinical Trial Investigators
Périne Vidal - Clinical Trial Investigators
Guillaume Chauvet - Clinical Trial Investigators
Jérémy Vernhes - Centre Hospitalier Universitaire de Clermont-Ferrand
Vincent Sapin - Université Clermont Auvergne
Dominique Morand - Clinical Trial Investigators
Camille Theilliere - Clinical Trial Investigators
François Thouy - Clinical Trial Investigators
Bertrand Souweine - Clinical Trial Investigators
Claire Dupuis - Clinical Trial Investigators
Mireille Adda-Pernot - Clinical Trial Investigators
Marine Bereiziat - Clinical Trial Investigators
Frederic Duee - Clinical Trial Investigators
Alexandre Lautrette - Clinical Trial Investigators
Nathanael Eisenmann - Clinical Trial Investigators
Ghislaine Niezgodzki - Clinical Trial Investigators
Rodolphe Hilaire - Clinical Trial Investigators
Régine Chevrier - Clinical Trial Investigators
Sonia Rucart - Clinical Trial Investigators
Julien Lorber - Centre Hospitalier Saint-Nazaire
Maud Jonas - Clinical Trial Investigators
Céline Chevalier
Servane Vastral - Clinical Trial Investigators
Julio Badie - L'Hôpital Nord Franche-Comté
Laurent Faivre - Clinical Trial Investigators
Elodie Bouvier - Clinical Trial Investigators
Charlotte Bourgoin - Clinical Trial Investigators
Isabelle Roussez - Clinical Trial Investigators
Pascale Dussert - Clinical Trial Investigators
Fabien Lambiotte - Centre Hospitalier de Valenciennes
Mohamed Ali Benbali
Hanane Fodil - Clinical Trial Investigators
Justine Lemtiri - Clinical Trial Investigators
Chaouki Bouras - Clinical Trial Investigators
Hedi Dhaouadi - Clinical Trial Investigators
Nabil El Beki - Clinical Trial Investigators
Delphine Bregeaud - Clinical Trial Investigators
Stéphanie Violette - Clinical Trial Investigators
Aziz Berrouba - Université de Reims Champagne-Ardenne
Gwladys M’boungou - Clinical Trial Investigators
Eric Gerardin
Romain Blanchon - Clinical Trial Investigators
Elodie Protesti - Clinical Trial Investigators
Alexandre Conia - Les Hôpitaux de Chartres
Pierre Kalfon - Clinical Trial Investigators
Bénédicte Mauchien - Clinical Trial Investigators
Martine Ferrandière - Clinical Trial Investigators
Charlène Piat - Clinical Trial Investigators
Publication Details: JAMA Cardiology
Identifiers: 9934132509311
Academic Unit: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Language: English
Resource Type: Journal article
Local Fields: hal-04995383