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Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins
Article de revue   Avec comité de lecture

Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins

László Jicsinszky, Kata Tuza, Giancarlo Cravotto, Andrea Porcheddu, Francesco Delogu et Evelina Colacino
Beilstein journal of organic chemistry, Vol.13(1), pp.1893-1899
07/09/2017
PMID: 29062408

Résumé

Chemistry Full Research Paper
The present work focuses on the mechanochemical preparation of industrially important β-cyclodextrin (CD) derivatives. Activated CDs have been reacted with nitrogen and sulfur nucleophiles using a planetary mill equipped with stainless steel, zirconia and glass milling tools of different sizes. It is shown that the milling frequency and the number as well as the size of the milling balls have an effect on the nucleophilic reaction.

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