Influence of geolocation and ethnicity on the phenotypic expression of primary Sjogren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjogren Project Consortium

Pilar Brito-Zeron; Nihan Acar-Denizli; Margit Zeher; Astrid Rasmussen; Raphaele Seror; Elke Theander; Xiaomei Li; Chiara Baldini; Jacques-Eric Gottenberg; Debashish Danda; Luca Quartuccio; Roberta Priori; Gabriela Hernandez-Molina; Aike A. Kruize; Valeria Valim; Marika Kvarnstrom; Damien Sene; Roberto Gerli; Sonja Praprotnik; David Isenberg; Roser Solans; Maureen Rischmueller; Seung-Ki Kwok; Gunnel Nordmark; Yasunori Suzuki; Roberto Giacomelli; Valerie Devauchelle-Pensec; Michele Bombardieri; Benedikt Hofauer; Hendrika Bootsma; Johan G. Brun; Guadalupe Fraile; Steven E. Carsons; Tamer A. Gheita; Jacques Morel; Cristina Vollenveider; Fabiola Atzeni; Soledad Retamozo; Ildiko Fanny Horvath; Kathy Sivils; Thomas Mandl; Pulukool Sandhya; Salvatore De Vita; Jorge Sanchez-Guerrero; Eefje van der Heijden; Virginia Fernandes Moca Trevisani; Marie Wahren-Herlenius; Xavier Mariette; Manuel Ramos-Casals; EULAR-SS Task Force Big Data Conso

doi:10.1136/annrheumdis-2016-209952

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Influence of geolocation and ethnicity on the phenotypic expression of primary Sjogren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjogren Project Consortium

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Influence of geolocation and ethnicity on the phenotypic expression of primary Sjogren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjogren Project Consortium

Pilar Brito-Zeron, Nihan Acar-Denizli, Margit Zeher, Astrid Rasmussen, Raphaele Seror, Elke Theander, Xiaomei Li, Chiara Baldini, Jacques-Eric Gottenberg, Debashish Danda, …

Annals of the rheumatic diseases, Vol.76(6), pp.1042-1050

01/06/2017

DOI: https://doi.org/10.1136/annrheumdis-2016-209952

PMID: 27899373

Résumé

Life Sciences & Biomedicine

Rheumatology

Science & Technology

Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjgren's syndrome (SjS) at diagnosis. Methods The Big Data Sjogren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. Results We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African-American and 147 patients (2%) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27: 1) and lowest in black/African-American patients (7: 1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69). Conclusions This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.

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Détails

Titre: Influence of geolocation and ethnicity on the phenotypic expression of primary Sjogren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjogren Project Consortium
Créateurs - sans rôle: Pilar Brito-Zeron - Hosp CIMA, Dept Med, Autoimmune Dis Unit, Barcelona, Spain
Nihan Acar-Denizli - Mimar Sinan Fine Arts Univ, Fac Sci & Letters, Dept Stat, Istanbul, Turkey
Margit Zeher - University of Debrecen
Astrid Rasmussen - College Station Medical Center
Raphaele Seror - Le Kremlin Bicetre Univ Paris Sud, Hop Univ Paris Sud, Assistance Publ Hop Paris,U1184, Ctr Immunol Viral Infect & Autoimmune Dis,INSERM, Paris, France
Elke Theander - Lund Univ, Malmo Univ Hosp, Dept Rheumatol, Lund, Sweden
Xiaomei Li - Anhui Prov Hosp, Dept Rheumatol & Immunol, Hefei, Peoples R China
Chiara Baldini - University of Pisa
Jacques-Eric Gottenberg - Univ Strasbourg, Strasbourg Univ Hosp, Dept Rheumatol, Strasbourg, France
Debashish Danda - Christian Med Coll & Hosp, Dept Clin Immunol, Vellore, Tamil Nadu, India
Luca Quartuccio - Univ Hosp Santa Maria Misericordia, Dept Med & Biol Sci, Clin Rheumatol, Udine, Italy
Roberta Priori - Sapienza University of Rome
Gabriela Hernandez-Molina - Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol Dept, Mexico City, DF, Mexico
Aike A. Kruize - Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands
Valeria Valim - Univ Fed Espirito Santo, Dept Med, Vitoria, Brazil
Marika Kvarnstrom - Karolinska Institutet
Damien Sene - Univ Paris VII, Assistance Publ Hop Paris, Hop Lariboisiere, Dept Med Interne, Paris, France
Roberto Gerli - University of Perugia
Sonja Praprotnik - Univ Med Ctr, Dept Rheumatol, Ljubljana, Slovenia
David Isenberg - UCL, Ctr Rheumatol, Div Med, London, England
Roser Solans - Hosp Hebron, Dept Internal Med, Barcelona, Spain
Maureen Rischmueller - The University of Adelaide
Seung-Ki Kwok - Catholic Univ Korea, Seoul St Marys Hosp, Coll Med, Div Rheumatol, Seoul, South Korea
Gunnel Nordmark - Uppsala University
Yasunori Suzuki - Kanazawa University
Roberto Giacomelli - Univ Laquila, Sch Med, Clin Unit Rheumatol, Laquila, Italy
Valerie Devauchelle-Pensec - Brest Univ Hosp, Rheumatol Dept, Brest, France
Michele Bombardieri - Queen Mary University of London
Benedikt Hofauer - Ludwig-Maximilians-Universität München
Hendrika Bootsma - University of Groningen
Johan G. Brun - Univ Bergen, Dept Clin Sci, Bergen, Norway
Guadalupe Fraile - Hosp Ramon & Cajal, Dept Internal Med, Madrid, Spain
Steven E. Carsons - SUNY Stony Brook, Allergy & Immunol Winthrop Univ Hosp, Div Rheumatol, Mineola, NY 11501 USA
Tamer A. Gheita - Cairo University
Jacques Morel - Teaching Hosp, Dept Rheumatol, Montpellier, France
Cristina Vollenveider - German Hosp, Buenos Aires, DF, Argentina
Fabiola Atzeni - IRCCS Galeazzi Orthoped Inst, Milan, Italy
Soledad Retamozo - Inst Univ Biomed Sci Univ Cordoba IUCBC, Hosp Privado Univ Cordoba, Cordoba, Argentina
Ildiko Fanny Horvath
Kathy Sivils
Thomas Mandl
Pulukool Sandhya - Christian Med Coll & Hosp, Dept Clin Immunol, Vellore, Tamil Nadu, India
Salvatore De Vita - Univ Hosp Santa Maria Misericordia, Dept Med & Biol Sci, Clin Rheumatol, Udine, Italy
Jorge Sanchez-Guerrero - Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Immunol & Rheumatol Dept, Mexico City, DF, Mexico
Eefje van der Heijden - Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands
Virginia Fernandes Moca Trevisani - Univ Fed Sao Paulo, Sao Paulo, Brazil
Marie Wahren-Herlenius - Karolinska Institutet
Xavier Mariette - Le Kremlin Bicetre Univ Paris Sud, Hop Univ Paris Sud, Assistance Publ Hop Paris,U1184, Ctr Immunol Viral Infect & Autoimmune Dis,INSERM, Paris, France
Manuel Ramos-Casals - Univ Barcelona, Hosp Clin, IDIBAPS CELLEX,Sjogren Syndrome Res Grp AGAUR, ICMiD,Dept Autoimmune Dis,Lab Autoimmune Dis Jose, Barcelona, Spain
EULAR-SS Task Force Big Data Conso
Détails de publication: Annals of the rheumatic diseases, Vol.76(6), pp.1042-1050
Éditeur: Bmj Publishing Group
Nombre de pages: 9
Note de subvention: INT15/00085 / Grants Fondo de Investigaciones Sanitarias (MRC); UK Research & Innovation (UKRI); Medical Research Council UK (MRC) MR/N003063/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 'Ajut per a la Recerca Josep Font' (PBZ, Hospital Clinic-Barcelona)
Identifiants: 99148713609311
Unité académique: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Langue: English
Type de ressource: Journal article