Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age

Seth Chekata Inzaule; Michael Jordan; Amandine Cournil; Marco Vitoria; Giovanni Ravasi; Fatim Cham; Linh-Vi Le; Janet Dzangare; Ndapewa Hamunime; Nicholus Mutenda; Avelin Aghokeng; Annez Bissek; Serge Billong; Pontiano Kaleebu; Meg Doherty; Silvia Bertagnolio

doi:10.1097/QAD.0000000000002277

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Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age

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Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age

Seth Chekata Inzaule, Michael Jordan, Amandine Cournil, Amandine Cournil, Marco Vitoria, Giovanni Ravasi, Fatim Cham, Linh-Vi Le, Janet Dzangare, Ndapewa Hamunime, …

AIDS. Official journal of the international AIDS Society, Vol.33(11), pp.1797-1799

01/09/2019

DOI: https://doi.org/10.1097/QAD.0000000000002277

Résumé

Use of dolutegravir-based first-line antiretroviral therapy (ART) in response to rising levels of pretreatment HIV drug resistance (PDR) to non-nucleoside reverse transcriptase inhibitors (NNRTIs) may be limited, given safety concerns for birth defects in women of child-bearing potential. Pooled data from 11 nationally representative surveys show that NNRTI PDR in women is nearly twice that in men, exceeding 10% in 8 of 11 countries monitored, suggesting the urgent need for a non-NNRTI-based ART regimen in this population.

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Titre: Increasing levels of pretreatment HIV drug resistance and safety concerns for dolutegravir use in women of reproductive age
Créateurs - sans rôle: Seth Chekata Inzaule - World Health Organization
Michael Jordan - Tufts University
Amandine Cournil - Université de Montpellier, Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Amandine Cournil - Université de Montpellier, Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Marco Vitoria - World Health Organization
Giovanni Ravasi - World Health Organization Regional Office for the Americas
Fatim Cham - World Health Organization Regional Office for Africa
Linh-Vi Le - World Health Organization Regional Office for the Western Pacific
Janet Dzangare - Ministry of Health
Ndapewa Hamunime - Ministry of Health and Social Services
Nicholus Mutenda - Ministry of Health and Social Services
Avelin Aghokeng - Université de Montpellier, Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Annez Bissek - Ministry of Public Health
Serge Billong - National Radiation Protection Agency of Cameroon
Pontiano Kaleebu - Uganda Virus Research Institute
Meg Doherty - World Health Organization
Silvia Bertagnolio - World Health Organization
Détails de publication: AIDS. Official journal of the international AIDS Society, Vol.33(11), pp.1797-1799
Identifiants: 99153358509311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article
Champs locaux: hal-04955285