Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study

Guillaume Martin-Blondel; François-Xavier Lescure; Lambert Assoumou; Charlotte Charpentier; Jean-Marc Chapplain; Thomas Perpoint; Gaspard Grouteau; Hugues Cordel; Gilles Pialoux; Jérome Pacanowski; Michael Thy; Adeline Bauvois; Didier Laureillard; Fadia Hamrouni; Michèle Algarte-Genin; Julien Poissy; Diane Descamps; Dominique Costagliola; Pierre Delobel; Jean Roch Le Henaff; Vincent Mear; Sandra Lagarrigues; Alais Frelat; Thomas De Nadai; Zara Steinmeyer; Arnaud del Bello; Stéphanie Ruiz; Benjamine Sarton; Elise Noel-Savina; Jacques Izopet; Nathan Peiffer-Smadja; Mathilde Gare; Diane Le Pluart; Christophe Rioux; Laurène Deconinck; Yazdan Yazdanpanah; Pierre Tattevin; Maude Bouscambert-Duchamp; Hodane Yonis; Paul Chabert; Youssouf Mohamed-Kassim; Nolan Hassold; Segolène Brichler; Julien Caliez; Thomas Rambaud; Marilucy Lopez-Sublet; Frédéric Adnet; Christia Palacios; Marwa Bachir; Marine Nadal; Mathieu Turpin; Antoine Parrot; Djeneba Fofana; Karine Lacombe; Emmanuelle Gras; Laura Levi; Laure Surgers; Ines Devred; Nadia Valin; Thibault Chiarabini; Jean Luc Meynard; Clara Duran; Elyanne Gault; Jean-Emmanuel Kahn; Elisabeth Rouveix; Guillaume Geri; Albert Sotto; Paul Loubet; Claire Roger; Marc Lambert; Ady Assaf; Laurence Bocket; Firouzé Bani-Sadr; Yohan N’guyen; Juliette Romaru; Maxime Hentzien; Thomas Gabas; Amélie Chabrol; Cecilia Billiou; Philippe Menager; Christophe Billy; Jean-Jacques Laurichesse; Fabrice Ketty N. Simba; Pauline Caraux Paz; Liliane Tinang; Agathe Bounhiol; Catherine Burnat; Sandrine Soriot-Thomas; Damien Basille; for the CoCliCo Study Group

doi:10.1186/s12879-022-07508-x

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Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study

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Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study

Guillaume Martin-Blondel, François-Xavier Lescure, Lambert Assoumou, Charlotte Charpentier, Jean-Marc Chapplain, Thomas Perpoint, Gaspard Grouteau, Hugues Cordel, Gilles Pialoux, Jérome Pacanowski, …

BMC infectious diseases, Vol.22(1), pp.540-9

13/06/2022

DOI: https://doi.org/10.1186/s12879-022-07508-x

PMID: 35698029

Résumé

Aged

Cohort Studies

COVID-19

Emerging diseases

Female

Hospitalization

Human health and pathology

Humans

Infectious diseases

Life Sciences

Male

Retrospective Studies

Santé publique et épidémiologie

SARS-CoV-2

Background: The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France.Methods: We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease.Results: We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%-aOR = 1.33 95% CI [1.03-1.72]).Conclusion: Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.

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Titre: Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study
Créateurs - sans rôle: Guillaume Martin-Blondel - Service Maladies infectieuses et tropicales [CHU Toulouse]
François-Xavier Lescure - Services de Maladies Infectieuses et Tropicales [CHU Bichat]
Lambert Assoumou - Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées [iPLesp]
Charlotte Charpentier - Infection, Anti-microbiens, Modélisation, Evolution
Jean-Marc Chapplain - Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Thomas Perpoint - Service des Maladies Infectieuses et Tropicales [Lyon]
Gaspard Grouteau - Service Maladies infectieuses et tropicales [CHU Toulouse]
Hugues Cordel - Service de maladies infectieuses et tropicales [CHU Avicenne]
Gilles Pialoux - CHU Tenon [AP-HP]
Jérome Pacanowski - CHU Saint-Antoine [AP-HP]
Michael Thy - Services de Maladies Infectieuses et Tropicales [CHU Bichat]
Adeline Bauvois - Service de médecine interne [CHU Ambroise Paré]
Didier Laureillard - Centre Hospitalier Universitaire de Nîmes
Fadia Hamrouni - Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées [iPLesp]
Michèle Algarte-Genin - Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées [iPLesp]
Julien Poissy - Unité de Glycobiologie Structurale et Fonctionnelle
Diane Descamps - Infection, Anti-microbiens, Modélisation, Evolution
Dominique Costagliola - Stratégies thérapeutiques contre l'infection VIH et les maladies virales associées [iPLesp]
Guillaume Martin-Blondel - Institut Toulousain des Maladies Infectieuses et Inflammatoires
Pierre Delobel - Institut Toulousain des Maladies Infectieuses et Inflammatoires
Jean Roch Le Henaff
Vincent Mear
Sandra Lagarrigues
Alais Frelat - Service Obstétrique [CHU Toulouse]
Thomas De Nadai - Gérontopôle
Zara Steinmeyer - Centre Hospitalier Universitaire de Toulouse
Arnaud del Bello - Département de Néphrologie et Transplantation d'organes [CHU Toulouse]
Stéphanie Ruiz - Pôle Anesthésie Réanimation [CHU de Toulouse]
Benjamine Sarton - Toulouse NeuroImaging Center
Elise Noel-Savina - Pôle Clinique des Voies respiratoires [CHU Toulouse]
Jacques Izopet - Institut Toulousain des Maladies Infectieuses et Inflammatoires
Nathan Peiffer-Smadja - Infection, Anti-microbiens, Modélisation, Evolution
Mathilde Gare - Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique
Diane Le Pluart - Hôpital Foch [Suresnes]
François-Xavier Lescure - Infection, Anti-microbiens, Modélisation, Evolution
Christophe Rioux - AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Laurène Deconinck
Yazdan Yazdanpanah
Diane Descamps
Charlotte Charpentier
Jean-Marc Chapplain
Pierre Tattevin
Thomas Perpoint
Maude Bouscambert-Duchamp
Hodane Yonis
Paul Chabert
Hugues Cordel
Youssouf Mohamed-Kassim
Nolan Hassold
Segolène Brichler
Julien Caliez
Thomas Rambaud
Marilucy Lopez-Sublet
Frédéric Adnet
Gilles Pialoux
Christia Palacios
Marwa Bachir
Marine Nadal
Mathieu Turpin
Antoine Parrot
Djeneba Fofana
Jérome Pacanowski
Karine Lacombe
Emmanuelle Gras
Laura Levi
Laure Surgers
Ines Devred
Nadia Valin
Thibault Chiarabini
Jean Luc Meynard
Adeline Bauvois
Clara Duran
Elyanne Gault
Jean-Emmanuel Kahn
Elisabeth Rouveix
Guillaume Geri
Didier Laureillard
Albert Sotto
Paul Loubet
Claire Roger
Marc Lambert - Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167
Ady Assaf
Laurence Bocket
Firouzé Bani-Sadr
Yohan N’guyen
Juliette Romaru
Maxime Hentzien
Thomas Gabas
Amélie Chabrol
Cecilia Billiou
Philippe Menager
Christophe Billy
Jean-Jacques Laurichesse
Fabrice Ketty N. Simba
Pauline Caraux Paz
Liliane Tinang
Agathe Bounhiol
Catherine Burnat
Sandrine Soriot-Thomas
Damien Basille - CHU Amiens-Picardie
for the CoCliCo Study Group
Détails de publication: BMC infectious diseases, Vol.22(1), pp.540-9
Éditeur: BioMed Central
Identifiants: 99140001309311
Unité académique: Virulence Bacterienne et Infections Chroniques - VBIC; Pathogenesis and Control of Chronic and Emerging Infections - PCCEI; Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article