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Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression
Journal article   Peer reviewed

Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression

Sarkis Sarkis, Gildas Belrose, Jean-Marie Peloponese, Stéphane Olindo, Raymond Césaire, Jean-Michel Mesnard and Antoine Gross
Journal of Clinical Virology, Vol.58(1), pp.295-298
09/2013
DOI: https://doi.org/10.1016/j.jcv.2013.05.006
PMID: 23756056

Abstract

HAM/TSP HTLV-1 IL-17 Osteopontin Aged Asymptomatic Diseases Female Gene Expression Profiling Gene Products, tax Human T-lymphotropic virus 1 Humans Interleukin-17 Male Middle Aged Paraparesis, Tropical Spastic CD4-Positive T-Lymphocytes Carrier State Cells, Cultured
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological inflammatory disease associated with a predominant infiltration of CD4+ T lymphocytes, which are the main subset of HTLV-1-infected cells. It has been demonstrated that in cell line the viral Tax protein transcriptionnally regulate expression of osteopontin, an inflammatory cytokine associated with Th17-related pathologies.
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