Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration Evidence from the EYE-RISK and European Eye Epidemiology Consortia

Johanna M. Colijn; Anneke den Hollander; Ayse Demirkan; Audrey Cougnard-Gregoire; Timo Verzijden; Eveline Kersten; Magda A. Meester-Smoor; Benedicte M. J. Merle; Grigorios Papageorgiou; Shahzad Ahmad; Monique T. Mulder; Miguel Angelo Costa; Pascale Benlian; Geir Bertelsen; Alain M. Bron; Birte Claes; Catherine Creuzot-Garcher; Maja Gran Erke; Sascha Fauser; Paul J. Foster; Christopher J. Hammond; Hans-Werner Hense; Carel B. Hoyng; Anthony P. Khawaja; Jean-Francois Korobelnik; Stefano Piermarocchi; Tatiana Segato; Rufino Silva; Eric H. Souied; Katie M. Williams; Cornelia M. van Duijn; Cecile Delcourt; Caroline C. W. Klaver; Niyazi Acar; Lebriz Altay; Eleftherios Anastosopoulos; Augusto Azuara-Blanco; Tos Berendschot; Arthur Bergen; Christine Binquet; Alan Bird; Martin Bobak; Morten Bogelund Larsen; Camiel Boon; Rupert Bourne; Lionel Bretillon; Rebecca Broe; Alain Bron; Gabrielle Buitendijk; Maria Luz Cachulo; Vittorio Capuano; Isabelle Carriere; Usha Chakravarthy; Michelle Chan; Petrus Chang; Johanna Colijn; Angela Cree; Phillippa Cumberland; Jose Cunha-Vaz; Vincent Daien; Eiko De Jong; Gabor Deak; Marie-Noelle Delyfer; Martha Dietzel; Pedro Faria; Claudia Farinha; Robert Finger; Astrid Fletcher; Paul Foster; Panayiota Founti; Theo Gorgels; Jakob Grauslund; Franz Grus; Christopher Hammond; Thomas Heesterbeek; Manuel Hermann; Rene Hoehn; Ruth Hogg; Frank Holz; Carel Hoyng; Nomdo Jansonius; Sarah Janssen; Eiko de Jonga; Anthony Khawaja; Caroline Klaver; Julia Lamparter; Melanie Le Goff; Terho Lehtimaki; Irene Leung; Andrew Lotery; Matthias Mauschitz; Magda Meester; Benedicte Merle; Verena Meyer Zu Westrup; Edoardo Midena; Stefania Miotto; Alireza Mirshahi; Sadek Mohan-Said; Michael Mueller; EYE-RISK Consortium

doi:10.1016/j.ophtha.2018.09.045

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Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration Evidence from the EYE-RISK and European Eye Epidemiology Consortia

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Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration Evidence from the EYE-RISK and European Eye Epidemiology Consortia

Johanna M. Colijn, Anneke den Hollander, Ayse Demirkan, Audrey Cougnard-Gregoire, Timo Verzijden, Eveline Kersten, Magda A. Meester-Smoor, Benedicte M. J. Merle, Grigorios Papageorgiou, Shahzad Ahmad, …

Ophthalmology (Rochester, Minn.), Vol.126(3), pp.393-406

01/03/2019

DOI: https://doi.org/10.1016/j.ophtha.2018.09.045

PMID: 30315903

Résumé

Life Sciences & Biomedicine

Ophthalmology

Science & Technology

Purpose: Genetic and epidemiologic studies have shown that lipid genes and high-density lipoproteins (HDLs) are implicated in age-related macular degeneration (AMD). We studied circulating lipid levels in relationship to AMD in a large European dataset. Design: Pooled analysis of cross-sectional data. Participants: Individuals (N = 30 953) aged 50 years or older participating in the European Eye Epidemiology (E3) consortium and 1530 individuals from the Rotterdam Study with lipid subfraction data. Methods: AMD features were graded on fundus photographs using the Rotterdam classification. Routine blood lipid measurements, genetics, medication, and potential confounders were extracted from the E3 database. In a subgroup of the Rotterdam Study, lipid subfractions were identified by the Nightingale biomarker platform. Random-intercepts mixed-effects models incorporating confounders and study site as a random effect were used to estimate associations. Main Outcome Measures: AMD features and stage; lipid measurements. Results: HDL was associated with an increased risk of AMD (odds ratio [OR], 1.21 per 1-mmol/l increase; 95% confidence interval [CI], 1.14-1.29), whereas triglycerides were associated with a decreased risk (OR, 0.94 per 1-mmol/l increase; 95% CI, 0.91-0.97). Both were associated with drusen size. Higher HDL raised the odds of larger drusen, whereas higher triglycerides decreases the odds. LDL cholesterol reached statistical significance only in the association with early AMD (P = 0.045). Regarding lipid subfractions, the concentration of extra-large HDL particles showed the most prominent association with AMD (OR, 1.24; 95% CI, 1.10-1.40). The cholesteryl ester transfer protein risk variant (rs17231506) for AMD was in line with increased HDL levels (P = 7.7 x 10(-7)), but lipase C risk variants (rs2043085, rs2070895) were associated in an opposite way (P = 1.0 x 10(-6) and P = 1.6 x 10(-4)). Conclusions: Our study suggested that HDL cholesterol is associated with increased risk of AMD and that triglycerides are negatively associated. Both show the strongest association with early AMD and drusen. Extra-large HDL subfractions seem to be drivers in the relationship with AMD, and variants in lipid genes play a more ambiguous role in this association. Whether systemic lipids directly influence AMD or represent lipid metabolism in the retina remains to be answered. (C) 2018 by the American Academy of Ophthalmology

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Titre: Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration Evidence from the EYE-RISK and European Eye Epidemiology Consortia
Créateurs - sans rôle: Johanna M. Colijn - Erasmus MC
Anneke den Hollander - Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Ophthalmol, Med Ctr, Nijmegen, Netherlands
Ayse Demirkan - Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
Audrey Cougnard-Gregoire - Inserm
Timo Verzijden - Erasmus MC, Dept Ophthalmol, Rotterdam, Netherlands
Eveline Kersten - Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Ophthalmol, Med Ctr, Nijmegen, Netherlands
Magda A. Meester-Smoor - Erasmus MC, Dept Ophthalmol, Rotterdam, Netherlands
Benedicte M. J. Merle - Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Grigorios Papageorgiou - Erasmus MC, Dept Biostat, Rotterdam, Netherlands
Shahzad Ahmad - Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
Monique T. Mulder - Erasmus MC, Dept Internal Med, Rotterdam, Netherlands
Miguel Angelo Costa - Assoc Innovat & Biomed Res Light & Image AIBILI, Coimbra, Portugal
Pascale Benlian - Univ Lille, UMR 8199 EGID, CHU Lille, Lille, France
Geir Bertelsen - UiT The Arctic University of Norway
Alain M. Bron - Univ Hosp, Dept Ophthalmol, Eye & Nutr Res Grp, Dijon, France
Birte Claes - Univ Munster, Inst Epidemiol & Social Med, Munster, Germany
Catherine Creuzot-Garcher - Univ Hosp, Dept Ophthalmol, Eye & Nutr Res Grp, Dijon, France
Maja Gran Erke - Oslo Univ Hosp, Dept Ophthalmol, Oslo, Norway
Sascha Fauser - Univ Hosp Cologne, Dept Ophthalmol, Cologne, Germany
Paul J. Foster - Moorfields Eye Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, London, England
Christopher J. Hammond - Kings Coll London, St Thomas Hosp, Sch Life Course Sci, Sect Acad Ophthalmol, London, England
Hans-Werner Hense - Univ Munster, Inst Epidemiol & Social Med, Munster, Germany
Carel B. Hoyng - Radboud University Nijmegen
Anthony P. Khawaja - Moorfields Eye Hosp NHS Fdn Trust, NIHR Biomed Res Ctr, London, England
Jean-Francois Korobelnik - Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, INSERM, UMR 1219, Bordeaux, France
Stefano Piermarocchi - University of Padua
Tatiana Segato - Univ Padua, Dept Ophthalmol, Padua, Italy
Rufino Silva - Assoc Innovat & Biomed Res Light & Image AIBILI, Coimbra, Portugal
Eric H. Souied - Univ Paris Est Creteil, Ctr Hosp Intercommunal Creteil, Dept Ophthalmol, Creteil, France
Katie M. Williams - Kings Coll London, St Thomas Hosp, Sch Life Course Sci, Sect Acad Ophthalmol, London, England
Cornelia M. van Duijn - Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands
Cecile Delcourt - Inserm
Caroline C. W. Klaver - Erasmus MC
Niyazi Acar - Inra Univ Burgundy, Dijon, France
Lebriz Altay - Univ Eye Hosp, Cologne, Germany
Eleftherios Anastosopoulos - Univ Thessaloniki, Thessaloniki, Greece
Augusto Azuara-Blanco - Queens Univ, Belfast, Antrim, North Ireland
Tos Berendschot - Univ Eye Clin Maastricht, Maastricht, Netherlands
Arthur Bergen - Netherlands Inst Neurosci KNAW, Amsterdam, Netherlands
Christine Binquet - Univ Hosp Dijon, Dijon, France
Alan Bird - Moorfields Eye Hosp, London, England
Martin Bobak - Lithuanian Univ Hlth Sci, Kaunas, Lithuania
Morten Bogelund Larsen - Univ Maastricht, Maastricht, Netherlands
Camiel Boon - Leiden Univ, Med Ctr, Leiden, Netherlands
Rupert Bourne - Univ Ruskin, Cambridge, England
Lionel Bretillon - Inra Univ Burgundy, Dijon, France
Rebecca Broe - Univ Southern Denmark, Odense, Denmark
Alain Bron - Univ Hosp Dijon, Dijon, France
Gabrielle Buitendijk - Erasmus MC, Rotterdam, Netherlands
Maria Luz Cachulo - AIBILI CHUC, Coimbra, Portugal
Vittorio Capuano - Univ Hosp Creteil, Creteil, France
Isabelle Carriere - Inserm
Usha Chakravarthy - Queens Univ, Belfast, Antrim, North Ireland
Michelle Chan - UCL Inst Ophthalmol, London, England
Petrus Chang - Queens Univ, Belfast, Antrim, North Ireland
Johanna Colijn - Erasmus MC
Angela Cree - Univ Southampton, Southampton, Hants, England
Phillippa Cumberland - UCL Inst Child Hlth, London, England
Jose Cunha-Vaz - CHUC, AIBILI, Coimbra, Portugal
Vincent Daien - INSERM, U1061, Montpellier, France
Eiko De Jong - Radboud Univ Nijmegen, Nijmegen, Netherlands
Gabor Deak - Med Univ Vienna, Vienna, Austria
Marie-Noelle Delyfer - Bordeaux Populat Hlth Res Ctr, UMR1219, Bordeaux, France
Anneke den Hollander - Radboud Univ Nijmegen, Nijmegen, Netherlands
Martha Dietzel - Univ Munster, Munster, Germany
Pedro Faria - AIBILI CHUC, Coimbra, Portugal
Claudia Farinha - AIBILI CHUC, Coimbra, Portugal
Robert Finger - University of Bonn
Astrid Fletcher - London Sch Hyg & Trop Med, London, England
Paul Foster - UCL Inst Ophthalmol, London, England
Panayiota Founti - Univ Thessaloniki, Thessaloniki, Greece
Theo Gorgels - Netherlands Inst Neurosci, KNAW, Amsterdam, Netherlands
Jakob Grauslund - Univ Southern Denmark, Odense, Denmark
Franz Grus - Univ Med Ctr Mainz, Mainz, Germany
Christopher Hammond - Moorfields Eye Hosp, London, England
Thomas Heesterbeek - Radboud Univ Nijmegen, Nijmegen, Netherlands
Manuel Hermann - Univ Eye Hosp, Cologne, Germany
Rene Hoehn - Univ Med Ctr, Mainz, Germany
Ruth Hogg - Queens Univ, Belfast, Antrim, North Ireland
Frank Holz - University of Bonn
Carel Hoyng - Radboud University Nijmegen
Nomdo Jansonius - Erasmus MC, Rotterdam, Netherlands
Sarah Janssen - Netherlands Inst Neurosci KNAW, Amsterdam, Netherlands
Eiko de Jonga - Radboud Univ Nijmegen, Nijmegen, Netherlands
Anthony Khawaja - Radboud Univ Nijmegen, Nijmegen, Netherlands
Caroline Klaver - Erasmus MC
Julia Lamparter - Univ Med Ctr Mainz, Mainz, Germany
Melanie Le Goff - Bordeaux Populat Hlth Res Ctr, UMR1219, Bordeaux, France
Terho Lehtimaki - University of Tampere
Irene Leung - Moorfields Eye Hosp, London, England
Andrew Lotery - Univ Southampton, Southampton, Hants, England
Matthias Mauschitz - INSERM, U1061, Montpellier, France
Magda Meester - Univ Ruskin, Cambridge, England
Benedicte Merle - Bordeaux Populat Hlth Res Ctr UMR1219, Bordeaux, France
Verena Meyer Zu Westrup - Univ Munster, Munster, Germany
Edoardo Midena - Univ Padua, Padua, Italy
Stefania Miotto - Univ Padua, Padua, Italy
Alireza Mirshahi - Dardenne Eye Hosp, Bonn, Germany
Sadek Mohan-Said - Inst Vis, Paris, France
Michael Mueller - Pirkanmaa Hosp Dist, Tampere, Finland
EYE-RISK Consortium
Détails de publication: Ophthalmology (Rochester, Minn.), Vol.126(3), pp.393-406
Éditeur: Elsevier
Nombre de pages: 14
Note de subvention: Genetic Laboratory of the Department of Internal Medicine, Erasmus Medical Center Universite de Bourgogne, Regional Council of Burgundy France (PARI Agrale 1) 014-93-015 / Research Institute for Diseases in the Elderly Landelijke Stichting voor Blinden en Slechtzienden Richard Desmond Charitable Trust 175.010.2005.011; 911-03-012 / Netherlands Organisation of Scientific Research (Nederlandse Organisatie voor Wetenschappelijk Onderzoek [NWO]) Investments Horiba ABX Montpellier FEDER (European Funding for Regional Economic Development) Department for Health through National Institute for Health Research Netherlands Organization for the Health Research and Development (ZonMw); Netherlands Organization for Health Research and Development
Identifiants: 99140199009311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article