Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Habre Walid; Disma Nicola; Virag Katalin; Becke Karin; Hansen Tom G; Jöhr Martin; Leva Brigitte; Morton Neil S; Vermeulen Petronella M; Zielinska Marzena; Boda Krisztina; Veyckemans Francis; Walter Klimscha; Regina Konecny; Robert Luntzer; Ulrike Morawk-Wintersperger; Franz Neiger; Lydia Rustemeyer; Christian Breschan; Denise Frey; Manuela Platzer; Reinhard Germann; Joachim Oeding; Birgit Stoegermüller; Bernhard Ziegler; Philipp Brotatsch; Anton Gutmann; Gerlinde Mausser; Brigitte Messerer; Wolfgang Toller; Maria Vittinghoff; Gregor Zangl; Natascha Seidel-Ahyai; Christoph Hochhold; Ruth Kroess; Peter Paal; Steven Cnudde; Patricia Coucke; Birgit Loveniers; John Mitchell; David Kahn; Thierry Pirotte; Caroline Pregardien; Francis Veyckemans; Marc Coppens; Stefan De Hert; Björn Heyse; Martine Neckebroek; Aliaksandra Parashchanka; Jurgen Van Limmen; Nancy Van Den Eynde; Caroline Vanpeteghem; Piet Wyffels; Michaël Lalot; Jean-Paul Lechat; France Stevens; Sari Casaer; Françoise De Groote; Françoise De Pooter; Andrée De Villé; Marc Gerin; Natalia Magasich; Cristel Sanchez Torres; Denise Van Deenen; Johan Berghmans; Dirk Himpe; Eva Roofthooft; Ellen Joukes; Carine Smitz; Veronique Van Reeth; Christel Huygens; Julie Lauweryns; Karen De Smet; Nadia Najafi; Jan Poelaert; Anne Van de Velde; Veerle Van Mossevelde; Ivan Bekavac; Diana Butkovic; Dubravka Heli Litvic; Ivana Kerovec Soric; Hrvoje Maretic; Djurdjica Moscatello; Ljiljana Popovic; Slobodan Micici; Ivana Stuck Tus; Lada Kalagac Fabris; Tatjana Simurina; Nina Sulen; Gordana Kesic-Valpotic; Dajana Djapic; Jirí Žurek; Lucie Jureckova; Iveta Mackova; Monika Skacel; Stanislava Weinlichova; Jan Divák; Michal Frelich; René Urbanec; Vera Biskupova; Vladimir Mixa; Jana Pavlickova; Arash Afshari; Morten Bøttger; Marguerite B Ellekvist; Mathias Johansen; Birgitte Ingeborg Madsen; Jens Christian Nilsson; Birgitte Mb Schousboe; Nicola G Clausen; Tom G Hansen; Nick Phaff Steen; Mari-Liis Ilmoja; Virge Tonise; Juri Karjagin; Reet Kikas; Mika Isohanni; Anniina Lyly; Annika Takala; Johanna Happo; Kai Kiviluoma; Kati Martikainen; Riku Aantaa; Tuula Manner; Sanna Vilo; Catherine Amory; Hugues Ludot; Patricia Lambotte; René Busche; Olivier Jacqmarcq; Corinne Lejus; Julien Corouge; Christian Erb; Delphine Garrigue; Patricia Gillet; Anne Laffargue; Veronique Lambelin; Hélène Le Freche; Daliana Peresbota; Pierre Richart; Jerome Berton; Catherine Chapotte; Laurent Colbus; Thierry Lehousse; Jean Monrigal; Catherine Baujard; Philippe Roulleau; Giuseppe Staiti; Hélène Batoz; Maryline Bordes; Anne Didier; Yann Hamonic; Sylvaine Lagarde; Karine Nouette-Gaulain; François Semjen; Brigitte Zaghet; Jacky Dekens; Axelle Delcuze; Hervé Dupont; Aurélien Legrand; Celine Raffoflandreur; Noémie Audren; Blandine Camus; Marielle Cartal; Chantal Chazelet; Isabelle Davin; Marion Guillier; Luc Desjeux; Claire Larcher; Elodie Grein; Mickeal Leclercq; Roxana Levitchi; Lilica Rosu; Dominique Simon; Aurélien Zang; Anne Migeon; Anne-Charlotte Gagey; Nathalie Bourdaud; Anne-Charlotte Carre; Frédéric Duflo; Jean-Claude Riche; Philippe Robert; Emilie Druot; Olivier Maupain; Gilles Orliaguet; Lucie Sabau; Hanna Taright; Lynn Uhrig; Juliette Verchere-Montmayeur; Lise Debrabant; Clotaire Pilla; Alexandre Podvin; Benjamin Roth; Souhayl Dahmani; Florence Julien-Marsollier; Nada Sabourdin; Bogdan Alexandri; Gilles Brezac; Francois de la Brière; Catherine Hayem; Elizabeth Lhubat; Jean Paul Mission; Charlotte Rémond; Christophe Dadure; Maud Maniora; Anais Marie; Philippe Pirat; Anne-Charlotte Saour; Chrystelle Sola; Claude Ecoffey; Eric Wodey; Christian Adam; Thomas Standl; Ehrenfried Schindler; Tomohiro Yamamoto; Michael Brackhahn; Christoph Bernhard Eich; Holger Guericke; Petra Kindermann; Michael Laschat; Cornel Schink; Frank Wappler; Claudia Hoehne; Natalia Skordou; Johanna Ulrici; Martin Jetzek-Zader; Peter Kienbaum; Tanja Meyer-Treschan; Olaf Picker; Maximilian S Schaefer; Golo Mielke; Sabine Baethge; Axel Ramminger; Martin Bauer; Matthias Bollinger; José Hinz; Michael Quintel; Sebastian G Russo; Michael Bauer; Dfominik Geil; Andreas Kortgen; Niels-Peter Preussler; Ulrich Hofmann; Manfred Raber; Doris Reindl; Karin Becke; Karin Oppenrieder; Bettina Schierlinger; Jens Roth; Wolfgang Funk; Thomas Fischer; Christian Gernoth; Christina Wiefelspütz; Hauke Volger; Nicole Zederer; Anja Diers; Matthias Huber; Clemens Schorer; Andreas Weyland; Konrad Schwarzkopf; Catharina Grau; Winfried Roth; Rolf Holy; Thomas Mader; Laura Peter; Hauke Supthut; Thomas Kuehhirt; Alexander Milde; Fritz Fiedler; Carsten Isselhorst; Ulrich Grundmann; Alexander Pattar; Jennifer Reinert; Birgit Ehm; Katrin Fritzsche; Ralf Gaebler; Patrick Meybohm; Maximilian Hein; Ines Guzman; Johanna Jokinen; Peter Kranke; Ulrich Goebel; Sarah Harris; Christoph Eisner; Miriam Ochsenreiter; Michael Schoeler; Elke Thil; Richard Ellerkmann; Andreas Hoeft; Claudia Neumann; Stefan Weber; Julia Keilhauer; Jan Kloessing; Michael Schramm; Uwe Trieschmann; Kristina Knauss; Barbara Sinner; Johannes Steinmann; Herbert Koessler; Evagelia Kalliardou; Anna Malisiova; Adelais Tsiotou; Pelagia Chloropoulou; Mpratzou Chrysi; Despoina Iordanidou; Merkourios Ntavlis; Krisztina B Boda; Christilynn Guerin; Janice Irwin; Claire Magner; Solmaz Nakhjavani; Brendan O'Hare; Deborah Galvin; Yosry Jamil; Carlos Lesmes; Yuri Barak; Haran Fisher; Ludmyla Kachko; Jacob Katz; Dmitry Kirilov; Michael Levinzon; Yair Manevich; Konstantin Nekrasov; Elia Peled; Elena Sanko; Dmitri Schmain; Olga Sheinkin; Eliahu Simhi; Alex Tarabikin; Evelina Trabkin; Irena Yagudaev; Yelena Zeitlin; Igor Zunser; Elisabetta Cerutti; Maria Maddalena Schellino; Silvia Valzan; Rosa Lucia Pinciroli; Luciano Bortone; Giorgia Cerati; Fabiana Salici; Leonardo Bussolin; Giuliana Rizzo; Francesca Rossetti; Laura Marchesini; Simonetta Tesoro; Brita De Lorenzo; Fabio Guarracino; Beate Kuppers; Marinella Astuto; Sofia Pitino; Rita Scalisi; Lucia Scordo; Sandra D'Alessandro; Luigi Dei Giudici; Ivano Farinelli; Giuseppe Lofino; Giuliano Marchetti; Sergio Giuseppe Picardo; Simone Reali; Alessandro Vittori; Francesco Antonio Idone; Maria Sammartino; Fabio Sbaraglia; Cinzia Barbera; Michela Bevilacqua; Valeria Cento; Nicola Disma; Svetlana Kotzeva; Leila Mameli; Giovanni Montobbio; Leandro Passariello; Cinzia Punzo; Rosanna Sileo; Rosanna Viacava; Claudia Volpe; Clelia Zanaboni; Edoardo Calderini; Daniele Genco; Simona Neri; Davide Ottolina; Anna Camporesi; Francesca Izzo; Ida Salvo; Andrea Wolfler; Andrea Sanna; Angela Sciascia; Paolo Stoia; Annamaria Guddo; Maria Lapi; Giorgio Ivani; Annalisa Longobardo; Valeria Mossetti; Dino Pedrotti; Maurizia Grazzini; Luisa Meneghini; Salvatore Metrangolo; Stefania Michelon; Carmelo Minardi; Costanza Tognon; Nicola Zadra; Ilaria Busi; Magda Khotcholava; Bruno Guido Locatelli; Valter Sonzogni; Giusi Starita; Nicole Almenrader; Caterina Aurilio; Pasquale Sansone; Raffaella Albarello; Paolo Bracci; Mariateresa Cecini; Maria Cristina Mondardini; Lorena Pasini; Milo Vason; Gianluca Zani; Roberto Zoppellari; Laura Pistidda; Andrea Cortegiani; Santi Maurizio Raineri; Antigona Hasani; Medita Hashimi; Agris Ancupans; Arta Barzdina; Zane Straume; Anda Zundane; Mikhail Chlopin; Dalia Gestautaite; Laura Lukosiene; Evelina Paliokaite; Ilona Razlevice; Inesa Armoniene; Aurelija Bernotiene; Vidunas Daugelavicius; Ilona Dockiene; Lina Gaidelyte; Nijole Saviciene; Jolita Krikstaponiene; Dominika Sidlovskaite-Baltake; Vladyslav Stasevski; Agne Vaitoskaite; David Gatt; Stephanie Mifsud; Simone Zammit; Celia Allison; Hamid Aslami; Susanne Eberl; Mireille F M van Stijn; Markus F Stevens; Kees Punt; Rob van Osch; Arthur Bauwman; Harm Scholten; Vesna Svircevic; Veronique Adriaens; Maaike Dirckx; Jaap Dogger; Ilse Dons-Sinke; Andreas Machotta; Xavier Moors; Mandana Rad; Lonneke Staals; Anouk van der Knijff-van Dortmont; Caroline van der Marel; Anne Sieben; Tim van der Zwan; Marianne Veldhuizen; David Alders; Wolfgang Buhre; Petronella M Vermeulen; Nicole Engel; Carine Vossen; Ravin Mahadewsing; Patrick Meijer; Volker Gerling; Roelof van der Schatte Olivier; Thea van Doorn; Kristy Vons Mark Hendriks; Sandra Lako; Gert Jan Scheffer; Luc Tielens; Marieke Voet; Anthony Absalom; Margot Bergsma; Vera Spanjer; Rob Spanjersberg; Yvette van de Riet; Martin Volkers; Jurgen C de Graaff; Geranne A J Hopman; Teus H Kappen; J Hannie; A M Megens; Sandra C Numan; Anton N J Schouten; Nigel M Turner; Désirée B M Van Der Werff; Renee T M Wensing; Erik Ephraim; Claire Nolte; Tore Reikvam; Ole Fredrik Lund; Lene Skaaden; Kari Marthe Ballovarre; Wenche Bakken Boerke; Guro Grindheim; Pal H H Lindenskov; Anne Beate Solas; Sjur Sponheim; Kyrre Ullensvang; Oddbjorn Viken; Inger Marie Drage; Kasper Gymoese Berthelsen; Bjørn Anders Kroken; Unni Bergland; Miroslaw Pryzmont; Mariola Talalaj; Malgorzata Wasiluk; Dorota Zalewska; Maria Damps; Jadzia Siemek-Mitela; Pawel Wieczorek; Magdalena Juzwa; Jowita Rosada-Kurasinska; Alicja Bartkowska-Sniatkowska; Maciej Cettler; Renata Kopycinska; Iwona Rudewicz; Jaek Sobczyk; Dariusz Wojciechowski; Artur Baranowski; Ewa Basiewicz; Magdalena Mierzewska-Schmidt; Wlodzimierz Retka; Piotr Sawicki; Magdalena Checinska; Marzena Zielinska; Magdalena Zurawska; Teresa Leal; Catia Mascarenhas; António Pedro Pina; Maria Joao Susano; Antonio Moniz; Maria Teresa Rocha; Carolina Calvao Santos; M Domingas Patuleia; Ricardo Pereira; Helena Roxo; Rosa Amaral; Isabel Guedes; Cristina Gomes; Marta Gonçalves; Helena Salgado; Maria Santos; Sara Rodrigues; Angela Sa; Elvira Machado; Sandra Pé d'Arca; Manuel Seabra; Ligia Mihaela Gheorghe; Constantin Ivascu; Lucia Moraru-Draghici; Mirela Suvejan; Remus Babici; Kovacs Eniko; Cristiana Hogea; Dubau Mihaela; Daraban Nicoleta; Danut Barbunc; Alina Maria Nistor; Violeta Stefan; Gabriela Catalina Ionescu; Irina Davidescu; Alina Teodora Nastase; Florin Dumitru Rusu; Victoria Badarau; Iulia Cindea; Melania Moscaliuc; Dana Olteanu; Luxita Petrescu; Daniela Ceuca; Irena Galinescu; Rodica Badeti; Alin Capusan; Cosmina Cucui-Cozma; Barbura Popescu; Luminita Cimpeanu; Mihaela-Petronela Birliba; Magdalena Miulescu; Stefania Balamat; Adriana Gurita; Luminita Ilie; Gabriel Mocioiu; Darina Pick; Rodica Sirghie; Radu Tabacaru; Irinel Trante; Lucian Horhota; Daniela Bandrabur; Tudor Ciobanu; Veaceslav Cuciuc; Valentin Munteanu; Valentin Olaru; Corneliu Paiu; Anca Savu; Oana Trifan; Anca Elena Malos; Anton Glazunov; Alexander Ivanov; Evgeny Poduskov; Alexander Popov; Igor Guskov; Alexander Lugovoy; Vladislav Nechaev; Alexey Ovezov; Mikhail Basov; Vladimir Kochkin; Vladimir Lazarev; Dmitri Chizhov; Ivan Ostreikov; Konstantin Tolasov; Ivana Budic; Vesna Marjanovic; Biljana Draskovic; Marina Pandurov; Jovana Simin; Vladimir Dolinaj; Dusanka Janjevic; Ana Mandras; Maja Mircetic; Sladjana Petrovic; Vlatka Rebac; Bojana Slavkovic; Vesna Stevanovic; Ana Velcev; Mirjana Knezevic; Irina Milojevic; Selena Puric; Irena Simic; Marija Stevic; Vladimir Stranjanac; Dusica Simic; Barbora Cabanova; Miloslav Hanula; Andry Grynyuk; Jelena Berger; Uros Cerne; Andraz Nastran; Dejan Pirc; Rok Popic; Spela Stupnik; Paloma Rubio; Cristina Del Río; Pilar Benito; Gema Pino; Ignacio Gutierrez; Andrea Gutierrez Valcarcel; Irene León Carsi; Anibal Perez Garcia; Sílvia López Galera; Joan Marco Valls; Laura Ricol Lainez; Andrea Vallejo Tarrat; David Artes; Ester Banus; Luca Chirichiello; Leidy De Abreu; Belen De Josemaria; M Helena Gaitan; Antonio Garces; Juan J Lazaro; Ferran Manen Berga; Dolors Molies; Enric Monclus; Montserrat Navaro; Carmen Pamies; Marina Perelló; Mar Prat; Laura Ribo; M Angeles Sanz; Silvia Serrano; Eva Sola Ruiz; Blanca Anuncia Escontrela Rodríguez; Andrea Maria Gago Martinez; Alberto Martínez Ruiz; Fausto De La Cruz Benito; Gustavo Gabilondo Garcia; Ever Martinez Maldonado; Bryant Noriega; Lara Oller Duque; Alberto Olmos Mendez; Antonio Perez-Ferrer; Francisco Reinoso Barbero; Ismael Acevedo Bambaren; Fernando Domínguez; Teresa Franco; Anabel Jiménez; Alicia Melero; Montserrat Feliu; Irene García; Núria Montferrer; Francisca Munar; Cristina Muro; Rosario Nuño; Remel Perera; Erika Schmucker; Glenda Börjesson; Lars Gillberg; Albert Castellheim; Kerstin Sandström; Annette Bauer; Torbjörn Roos; Lars Hedlund; Yann Boegli; Mirko Dolci; Carine Marcucci; Isabelle Spahr-Schopfer; Walid Habre; Michel Pellegrini; Malte Book; Loreen Errass; Christine Riggenbach; Mattias Casutt; Martin Hölzle; Thomas Hurni; Martin Jöhr; Jacqueline Mauch; Luciano Anselmi; Irene Anselmi; Alfred Jacomet; Markus Oberhauser; Stephanie Wossner; Angelika Zettl; Thomas Erb; Tomasz Mackiewicz; Helena Simitzes; Yetkin Ozer; Arzu Takil; Zekeriyya Alanoglu; Onat Bermede; K Sanem Cakar Turhan; Neslihan Alkis; Cigdem Yildirim Guclu; Basak Ceyda Meco; Zehra Hatipoglu; Dilek Ozcengiz; Zekine Begec; Huseyin Ilksen Toprak; Pinar Kendigelen; Ayse Cigdem Tütüncü; Meltem Savran Karadeniz; Tulay Seyhan Ozkan; Nuket Sivrikoz; Mustafa Kemal Arslantas; Ayse Hizal; Gülbin Tore Altun; Tumay Umuroglu; Sibel Baris; Zuleyha Kazak Bengisun; Galyna Goncharenko; Maksym Khrapak; Tetyana Klymenko; Vitaliy Pavlenko; Dmytro Prysiazhniuk; Olga Rudio; Mykhailo Varyvoda; Sergii Vodianytskyi; Ivanna Boryshkevych; Iryna Kyselova; Nikolay Trikash; Andrew Albokrinov; Valentina Perova-Sharonova; Vitaliy Sklyar; Denis Surkov; Amr Abdelaal; Nicola Barber; Sarah Checuti; Leisha Godsiff; Lynch Johanne; Joanna Simpson; Helen Underhill; Rishi Diwan; Nivedita Kelgeri; Nuria Masip; Radha Ravi; Steve Roberts; Annagrazia Cillis; Ritchie Marcus; Federica Merella; David Love; Paolo Baraggia; Victoria Bird; Joseph Hussey; Peter Alderson; Karen Bartholomew; Michael Moncreiff; Sarah Davidson; Alison Hare; Ami Kotecha; Corina Lee; Ganga Liyanage; Shivali Patel; Amee Samani; Mark Abou-Samra; Matthew Boyd; Laurence Hullatt; David Levy; Mark Pauling; Sarah-Jane Sharman; Natalie Smith; John Rutherford; Alison Cavalier; Christie Locke; Frederic Sage; Smita Bapat; Jacinda Hammerschlag; Ioannis Ioannou; Stephanie King; Rachel Pegg; Vishal Salota; Jonathan Sketcher; Muthu Thadsad; Deborah Zeitlin; Ewan Jack; Colin Lang; Samira Ahmed; Reema Ayyash; Francoise Bari; Sarah J Bell; Claire Elizabeth Biercamp; Sandra Briggs; Maria Gabriella Elena Clement; Mark Dalton; Mohamed Ali Eissa Eid; Monica Gandhi; Idse Harmen Herrema; Ranj Khaffaf; Savio Jeng Min Law; Joanna McClintock; Nicholas Ireland; Mohammed Majid Saleem; Fiona Smith; Marc Cohen; Clover-Ann Lee; Lizanne O'Donahue; Alex Powell; Ellen Rawlinson; Aarjan Snoek; Katja Weiss; Hugo Wellesley; Michael Crawford; Mostafa Abdel-Hafiz; Alexandra Day; Balaji Rajamani; Rita Saha; Dave Wright; Lew-Chin Chee; Stephanie Bew; Rachel Homer; Nalini Malarkkan; Juliet Wolfe Barry; Pradeep Angadi; Brid Cagney; Eric De Melo; Elsa Dekker; Emma Helm; Gareth Jones; Kawshala Peiris; William Russell; Patricia Slater; Puja Sodhi; Mike Browning; Trudie Phillips; Rachel Van Hecke; Vimty Muir; Piyush Singh; Tereza Soskova; Craig Cumming; Pamela Farquharson; Karen Pearson; Neil Shaw; Jonathan Whiteside; Emma Whyte; Gordon Byers; Kay Davies; Thomas Engelhardt; Isabella Faliszewski; Graham Johnston; Nils Kaufmann; Zuzana Kusnirikova; Graham Wilson; Peter Carachi; Andrew Makin; Brian Foster; Dariusz Lipczynski; Rebecca Mawer; William Rutherford; David Rogerson; Sarah Rushman; Christopher Taylor; William Tomlinson; Philippa Dix; Tom Woodward; Graham Bell; David Boyle; Marianne Cloherty; Julia Cullen; Pauline Cullen; Ross Fairgrieve; Robert Ghent; Russell Glasgow; Elena Gordeeva; Alison Harden; Sarah Hivey; Kevin Jerome; Lesley McKee; Neil Morton; Vicky Pribul; John Sinclair; Maria Steiner; Heather Steward; Lorraine Sweeney; Wendy Thomson; Jeanette Whiteside; Andrew Dalton; Mark Ross; Carolyn Smith; Claire Allen; Nicola Anders; Victoria Barlow; Mike Bassett; Leanne Darwin; Rachel Davison; Jacques Diacono; Amy Hobbs; Adel Hutchinson; Bernadette Lomas; Hannah Lonsdale; Leila Nasser; Vimmi Oshan; Pradip Patel; Christopher Raistrick; Victoria Scott-Warren; Laura Talbot; Carolynn Wai; Sophie Childs; Matthew Dickinson; Tom Bloomfield; Sweyn Garrioch; Karen Watson; James Gaynor; Richard Harrison; Juliette Lee; Elizabeth Blythe; Teresa Dorman; Ayman Eissa; James Ellwood; Ingrid Gooch; Robert Hearn; Vanessa Hodgetts; Robert John; Christine Kirton; Nadia Ladak; Judith Morgan; Nina Plant; Elizabeth Shepherd; Judith Short; Charles Stack; Simon Steel; Matthew Taylor; Deborah Thomas; Catharine Wilson; Elaine Wilson-Smith; Carol L Bradbury; Nageena Hussain; Antonia Mayell; Ahmed Mesbah; Arif Qureshi; Chandra Vaidyanath; Tim Geary; Chris Hawksworth; Tamaraichelvi Parasuraman; Nicole Perry; Indrani Banerjee; Katharine Barr; Patrick Butler; Jack Davies; Lisa Flewin; Richard Gande; James Montague; James Plumb; Thomas Pratt; Paul Sutherland; Hannah Vail; Andrew Wilkins; Catherine Hunter; Susan Russell; Alun Thomas; Mark Mifsud; Dominic Strachan; Brigitte Leva; Benoit Plichon; Pierre Harlet

doi:10.1016/S2213-2600(17)30116-9

Article de revue

Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe

Habre Walid, Disma Nicola, Virag Katalin, Becke Karin, Hansen Tom G, Jöhr Martin, Leva Brigitte, Morton Neil S, Vermeulen Petronella M, Zielinska Marzena, …

journal:THE LANCET RESPIRATORY MEDICINE

2017

DOI: https://doi.org/10.1016/S2213-2600(17)30116-9

PMID: 28363725

Résumé

BACKGROUND:Little is known about the incidence of severe critical events in children undergoing general anaesthesia in Europe. We aimed to identify the incidence, nature, and outcome of severe critical events in children undergoing anaesthesia, and the associated potential risk factors.METHODS:The APRICOT study was a prospective observational multicentre cohort study of children from birth to 15 years of age undergoing elective or urgent anaesthesia for diagnostic or surgical procedures. Children were eligible for inclusion during a 2-week period determined prospectively by each centre. There were 261 participating centres across 33 European countries. The primary endpoint was the occurence of perioperative severe critical events requiring immediate intervention. A severe critical event was defined as the occurrence of respiratory, cardiac, allergic, or neurological complications requiring immediate intervention and that led (or could have led) to major disability or death. This study is registered with ClinicalTrials.gov, number NCT01878760.FINDINGS:Between April 1, 2014, and Jan 31, 2015, 31 127 anaesthetic procedures in 30 874 children with a mean age of 6·35 years (SD 4·50) were included. The incidence of perioperative severe critical events was 5·2% (95% CI 5·0-5·5) with an incidence of respiratory critical events of 3·1% (2·9-3·3). Cardiovascular instability occurred in 1·9% (1·7-2·1), with an immediate poor outcome in 5·4% (3·7-7·5) of these cases. The all-cause 30-day in-hospital mortality rate was 10 in 10 000. This was independent of type of anaesthesia. Age (relative risk 0·88, 95% CI 0·86-0·90; p<0·0001), medical history, and physical condition (1·60, 1·40-1·82; p<0·0001) were the major risk factors for a serious critical event. Multivariate analysis revealed evidence for the beneficial effect of years of experience of the most senior anaesthesia team member (0·99, 0·981-0·997; p<0·0048 for respiratory critical events, and 0·98, 0·97-0·99; p=0·0039 for cardiovascular critical events), rather than the type of health institution or providers.INTERPRETATION:This study highlights a relatively high rate of severe critical events during the anaesthesia management of children for surgical or diagnostic procedures in Europe, and a large variability in the practice of paediatric anaesthesia. These findings are substantial enough to warrant attention from national, regional, and specialist societies to target education of anaesthesiologists and their teams and implement strategies for quality improvement in paediatric anaesthesia.FUNDING:European Society of Anaesthesiology.

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Titre: Incidence of severe critical events in paediatric anaesthesia (APRICOT): a prospective multicentre observational study in 261 hospitals in Europe
Créateurs - sans rôle: Habre Walid
Disma Nicola
Virag Katalin
Becke Karin
Hansen Tom G
Jöhr Martin
Leva Brigitte
Morton Neil S
Vermeulen Petronella M
Zielinska Marzena
Boda Krisztina
Veyckemans Francis
Walter Klimscha
Regina Konecny
Robert Luntzer
Ulrike Morawk-Wintersperger
Franz Neiger
Lydia Rustemeyer
Christian Breschan
Denise Frey
Manuela Platzer
Reinhard Germann
Joachim Oeding
Birgit Stoegermüller
Bernhard Ziegler
Philipp Brotatsch
Anton Gutmann
Gerlinde Mausser
Brigitte Messerer
Wolfgang Toller
Maria Vittinghoff
Gregor Zangl
Natascha Seidel-Ahyai
Christoph Hochhold
Ruth Kroess
Peter Paal
Steven Cnudde
Patricia Coucke
Birgit Loveniers
John Mitchell
David Kahn
Thierry Pirotte
Caroline Pregardien
Francis Veyckemans
Marc Coppens
Stefan De Hert
Björn Heyse
Martine Neckebroek
Aliaksandra Parashchanka
Jurgen Van Limmen
Nancy Van Den Eynde
Caroline Vanpeteghem
Piet Wyffels
Michaël Lalot
Jean-Paul Lechat
France Stevens
Sari Casaer
Françoise De Groote
Françoise De Pooter
Andrée De Villé
Marc Gerin
Natalia Magasich
Cristel Sanchez Torres
Denise Van Deenen
Johan Berghmans
Dirk Himpe
Eva Roofthooft
Ellen Joukes
Carine Smitz
Veronique Van Reeth
Christel Huygens
Julie Lauweryns
Karen De Smet
Nadia Najafi
Jan Poelaert
Anne Van de Velde
Veerle Van Mossevelde
Ivan Bekavac
Diana Butkovic
Dubravka Heli Litvic
Ivana Kerovec Soric
Hrvoje Maretic
Djurdjica Moscatello
Ljiljana Popovic
Slobodan Micici
Ivana Stuck Tus
Lada Kalagac Fabris
Tatjana Simurina
Nina Sulen
Gordana Kesic-Valpotic
Dajana Djapic
Jirí Žurek
Lucie Jureckova
Iveta Mackova
Monika Skacel
Stanislava Weinlichova
Jan Divák
Michal Frelich
René Urbanec
Vera Biskupova
Vladimir Mixa
Jana Pavlickova
Arash Afshari
Morten Bøttger
Marguerite B Ellekvist
Mathias Johansen
Birgitte Ingeborg Madsen
Jens Christian Nilsson
Birgitte Mb Schousboe
Nicola G Clausen
Tom G Hansen
Nick Phaff Steen
Mari-Liis Ilmoja
Virge Tonise
Juri Karjagin
Reet Kikas
Mika Isohanni
Anniina Lyly
Annika Takala
Johanna Happo
Kai Kiviluoma
Kati Martikainen
Riku Aantaa
Tuula Manner
Sanna Vilo
Catherine Amory
Hugues Ludot
Patricia Lambotte
René Busche
Olivier Jacqmarcq
Corinne Lejus
Julien Corouge
Christian Erb
Delphine Garrigue
Patricia Gillet
Anne Laffargue
Veronique Lambelin
Hélène Le Freche
Daliana Peresbota
Pierre Richart
Jerome Berton
Catherine Chapotte
Laurent Colbus
Thierry Lehousse
Jean Monrigal
Catherine Baujard
Philippe Roulleau
Giuseppe Staiti
Hélène Batoz
Maryline Bordes
Anne Didier
Yann Hamonic
Sylvaine Lagarde
Karine Nouette-Gaulain
François Semjen
Brigitte Zaghet
Jacky Dekens
Axelle Delcuze
Hervé Dupont
Aurélien Legrand
Celine Raffoflandreur
Noémie Audren
Blandine Camus
Marielle Cartal
Chantal Chazelet
Isabelle Davin
Marion Guillier
Luc Desjeux
Claire Larcher
Elodie Grein
Mickeal Leclercq
Roxana Levitchi
Lilica Rosu
Dominique Simon
Aurélien Zang
Anne Migeon
Anne-Charlotte Gagey
Nathalie Bourdaud
Anne-Charlotte Carre
Frédéric Duflo
Jean-Claude Riche
Philippe Robert
Emilie Druot
Olivier Maupain
Gilles Orliaguet
Lucie Sabau
Hanna Taright
Lynn Uhrig
Juliette Verchere-Montmayeur
Lise Debrabant
Clotaire Pilla
Alexandre Podvin
Benjamin Roth
Souhayl Dahmani
Florence Julien-Marsollier
Nada Sabourdin
Bogdan Alexandri
Gilles Brezac
Francois de la Brière
Catherine Hayem
Elizabeth Lhubat
Jean Paul Mission
Charlotte Rémond
Christophe Dadure
Maud Maniora
Anais Marie
Philippe Pirat
Anne-Charlotte Saour
Chrystelle Sola
Claude Ecoffey
Eric Wodey
Christian Adam
Thomas Standl
Ehrenfried Schindler
Tomohiro Yamamoto
Michael Brackhahn
Christoph Bernhard Eich
Holger Guericke
Petra Kindermann
Michael Laschat
Cornel Schink
Frank Wappler
Claudia Hoehne
Natalia Skordou
Johanna Ulrici
Martin Jetzek-Zader
Peter Kienbaum
Tanja Meyer-Treschan
Olaf Picker
Maximilian S Schaefer
Golo Mielke
Sabine Baethge
Axel Ramminger
Martin Bauer
Matthias Bollinger
José Hinz
Michael Quintel
Sebastian G Russo
Michael Bauer
Dfominik Geil
Andreas Kortgen
Niels-Peter Preussler
Ulrich Hofmann
Manfred Raber
Doris Reindl
Karin Becke
Karin Oppenrieder
Bettina Schierlinger
Jens Roth
Wolfgang Funk
Thomas Fischer
Christian Gernoth
Christina Wiefelspütz
Hauke Volger
Nicole Zederer
Anja Diers
Matthias Huber
Clemens Schorer
Andreas Weyland
Konrad Schwarzkopf
Catharina Grau
Winfried Roth
Rolf Holy
Thomas Mader
Laura Peter
Hauke Supthut
Thomas Kuehhirt
Alexander Milde
Fritz Fiedler
Carsten Isselhorst
Ulrich Grundmann
Alexander Pattar
Jennifer Reinert
Birgit Ehm
Katrin Fritzsche
Ralf Gaebler
Patrick Meybohm
Maximilian Hein
Ines Guzman
Johanna Jokinen
Peter Kranke
Ulrich Goebel
Sarah Harris
Christoph Eisner
Miriam Ochsenreiter
Michael Schoeler
Elke Thil
Richard Ellerkmann
Andreas Hoeft
Claudia Neumann
Stefan Weber
Julia Keilhauer
Jan Kloessing
Michael Schramm
Uwe Trieschmann
Kristina Knauss
Barbara Sinner
Johannes Steinmann
Herbert Koessler
Evagelia Kalliardou
Anna Malisiova
Adelais Tsiotou
Pelagia Chloropoulou
Mpratzou Chrysi
Despoina Iordanidou
Merkourios Ntavlis
Krisztina B Boda
Christilynn Guerin
Janice Irwin
Claire Magner
Solmaz Nakhjavani
Brendan O'Hare
Deborah Galvin
Yosry Jamil
Carlos Lesmes
Yuri Barak
Haran Fisher
Ludmyla Kachko
Jacob Katz
Dmitry Kirilov
Michael Levinzon
Yair Manevich
Konstantin Nekrasov
Elia Peled
Elena Sanko
Dmitri Schmain
Olga Sheinkin
Eliahu Simhi
Alex Tarabikin
Evelina Trabkin
Irena Yagudaev
Yelena Zeitlin
Igor Zunser
Elisabetta Cerutti
Maria Maddalena Schellino
Silvia Valzan
Rosa Lucia Pinciroli
Luciano Bortone
Giorgia Cerati
Fabiana Salici
Leonardo Bussolin
Giuliana Rizzo
Francesca Rossetti
Laura Marchesini
Simonetta Tesoro
Brita De Lorenzo
Fabio Guarracino
Beate Kuppers
Marinella Astuto
Sofia Pitino
Rita Scalisi
Lucia Scordo
Sandra D'Alessandro
Luigi Dei Giudici
Ivano Farinelli
Giuseppe Lofino
Giuliano Marchetti
Sergio Giuseppe Picardo
Simone Reali
Alessandro Vittori
Francesco Antonio Idone
Maria Sammartino
Fabio Sbaraglia
Cinzia Barbera
Michela Bevilacqua
Valeria Cento
Nicola Disma
Svetlana Kotzeva
Leila Mameli
Giovanni Montobbio
Leandro Passariello
Cinzia Punzo
Rosanna Sileo
Rosanna Viacava
Claudia Volpe
Clelia Zanaboni
Edoardo Calderini
Daniele Genco
Simona Neri
Davide Ottolina
Anna Camporesi
Francesca Izzo
Ida Salvo
Andrea Wolfler
Andrea Sanna
Angela Sciascia
Paolo Stoia
Annamaria Guddo
Maria Lapi
Giorgio Ivani
Annalisa Longobardo
Valeria Mossetti
Dino Pedrotti
Maurizia Grazzini
Luisa Meneghini
Salvatore Metrangolo
Stefania Michelon
Carmelo Minardi
Costanza Tognon
Nicola Zadra
Ilaria Busi
Magda Khotcholava
Bruno Guido Locatelli
Valter Sonzogni
Giusi Starita
Nicole Almenrader
Caterina Aurilio
Pasquale Sansone
Raffaella Albarello
Paolo Bracci
Mariateresa Cecini
Maria Cristina Mondardini
Lorena Pasini
Milo Vason
Gianluca Zani
Roberto Zoppellari
Laura Pistidda
Andrea Cortegiani
Santi Maurizio Raineri
Antigona Hasani
Medita Hashimi
Agris Ancupans
Arta Barzdina
Zane Straume
Anda Zundane
Mikhail Chlopin
Dalia Gestautaite
Laura Lukosiene
Evelina Paliokaite
Ilona Razlevice
Inesa Armoniene
Aurelija Bernotiene
Vidunas Daugelavicius
Ilona Dockiene
Lina Gaidelyte
Nijole Saviciene
Jolita Krikstaponiene
Dominika Sidlovskaite-Baltake
Vladyslav Stasevski
Agne Vaitoskaite
David Gatt
Stephanie Mifsud
Simone Zammit
Celia Allison
Hamid Aslami
Susanne Eberl
Mireille F M van Stijn
Markus F Stevens
Kees Punt
Rob van Osch
Arthur Bauwman
Harm Scholten
Vesna Svircevic
Veronique Adriaens
Maaike Dirckx
Jaap Dogger
Ilse Dons-Sinke
Andreas Machotta
Xavier Moors
Mandana Rad
Lonneke Staals
Anouk van der Knijff-van Dortmont
Caroline van der Marel
Anne Sieben
Tim van der Zwan
Marianne Veldhuizen
David Alders
Wolfgang Buhre
Petronella M Vermeulen
Nicole Engel
Carine Vossen
Ravin Mahadewsing
Patrick Meijer
Volker Gerling
Roelof van der Schatte Olivier
Thea van Doorn
Kristy Vons Mark Hendriks
Sandra Lako
Gert Jan Scheffer
Luc Tielens
Marieke Voet
Anthony Absalom
Margot Bergsma
Vera Spanjer
Rob Spanjersberg
Yvette van de Riet
Martin Volkers
Jurgen C de Graaff
Geranne A J Hopman
Teus H Kappen
J Hannie
A M Megens
Sandra C Numan
Anton N J Schouten
Nigel M Turner
Désirée B M Van Der Werff
Renee T M Wensing
Erik Ephraim
Claire Nolte
Tore Reikvam
Ole Fredrik Lund
Lene Skaaden
Kari Marthe Ballovarre
Wenche Bakken Boerke
Guro Grindheim
Pal H H Lindenskov
Anne Beate Solas
Sjur Sponheim
Kyrre Ullensvang
Oddbjorn Viken
Inger Marie Drage
Kasper Gymoese Berthelsen
Bjørn Anders Kroken
Unni Bergland
Miroslaw Pryzmont
Mariola Talalaj
Malgorzata Wasiluk
Dorota Zalewska
Maria Damps
Jadzia Siemek-Mitela
Pawel Wieczorek
Magdalena Juzwa
Jowita Rosada-Kurasinska
Alicja Bartkowska-Sniatkowska
Maciej Cettler
Renata Kopycinska
Iwona Rudewicz
Jaek Sobczyk
Dariusz Wojciechowski
Artur Baranowski
Ewa Basiewicz
Magdalena Mierzewska-Schmidt
Wlodzimierz Retka
Piotr Sawicki
Magdalena Checinska
Marzena Zielinska
Magdalena Zurawska
Teresa Leal
Catia Mascarenhas
António Pedro Pina
Maria Joao Susano
Antonio Moniz
Maria Teresa Rocha
Carolina Calvao Santos
M Domingas Patuleia
Ricardo Pereira
Helena Roxo
Rosa Amaral
Isabel Guedes
Cristina Gomes
Marta Gonçalves
Helena Salgado
Maria Santos
Sara Rodrigues
Angela Sa
Elvira Machado
Sandra Pé d'Arca
Manuel Seabra
Ligia Mihaela Gheorghe
Constantin Ivascu
Lucia Moraru-Draghici
Mirela Suvejan
Remus Babici
Kovacs Eniko
Cristiana Hogea
Dubau Mihaela
Daraban Nicoleta
Danut Barbunc
Alina Maria Nistor
Violeta Stefan
Gabriela Catalina Ionescu
Irina Davidescu
Alina Teodora Nastase
Florin Dumitru Rusu
Victoria Badarau
Iulia Cindea
Melania Moscaliuc
Dana Olteanu
Luxita Petrescu
Daniela Ceuca
Irena Galinescu
Rodica Badeti
Alin Capusan
Cosmina Cucui-Cozma
Barbura Popescu
Luminita Cimpeanu
Mihaela-Petronela Birliba
Magdalena Miulescu
Stefania Balamat
Adriana Gurita
Luminita Ilie
Gabriel Mocioiu
Darina Pick
Rodica Sirghie
Radu Tabacaru
Irinel Trante
Lucian Horhota
Daniela Bandrabur
Tudor Ciobanu
Veaceslav Cuciuc
Valentin Munteanu
Valentin Olaru
Corneliu Paiu
Anca Savu
Oana Trifan
Anca Elena Malos
Anton Glazunov
Alexander Ivanov
Evgeny Poduskov
Alexander Popov
Igor Guskov
Alexander Lugovoy
Vladislav Nechaev
Alexey Ovezov
Mikhail Basov
Vladimir Kochkin
Vladimir Lazarev
Dmitri Chizhov
Ivan Ostreikov
Konstantin Tolasov
Ivana Budic
Vesna Marjanovic
Biljana Draskovic
Marina Pandurov
Jovana Simin
Vladimir Dolinaj
Dusanka Janjevic
Ana Mandras
Maja Mircetic
Sladjana Petrovic
Vlatka Rebac
Bojana Slavkovic
Vesna Stevanovic
Ana Velcev
Mirjana Knezevic
Irina Milojevic
Selena Puric
Irena Simic
Marija Stevic
Vladimir Stranjanac
Dusica Simic
Barbora Cabanova
Miloslav Hanula
Andry Grynyuk
Jelena Berger
Uros Cerne
Andraz Nastran
Dejan Pirc
Rok Popic
Spela Stupnik
Paloma Rubio
Cristina Del Río
Pilar Benito
Gema Pino
Ignacio Gutierrez
Andrea Gutierrez Valcarcel
Irene León Carsi
Anibal Perez Garcia
Sílvia López Galera
Joan Marco Valls
Laura Ricol Lainez
Andrea Vallejo Tarrat
David Artes
Ester Banus
Luca Chirichiello
Leidy De Abreu
Belen De Josemaria
M Helena Gaitan
Antonio Garces
Juan J Lazaro
Ferran Manen Berga
Dolors Molies
Enric Monclus
Montserrat Navaro
Carmen Pamies
Marina Perelló
Mar Prat
Laura Ribo
M Angeles Sanz
Silvia Serrano
Eva Sola Ruiz
Blanca Anuncia Escontrela Rodríguez
Andrea Maria Gago Martinez
Alberto Martínez Ruiz
Fausto De La Cruz Benito
Gustavo Gabilondo Garcia
Ever Martinez Maldonado
Bryant Noriega
Lara Oller Duque
Alberto Olmos Mendez
Antonio Perez-Ferrer
Francisco Reinoso Barbero
Ismael Acevedo Bambaren
Fernando Domínguez
Teresa Franco
Anabel Jiménez
Alicia Melero
Montserrat Feliu
Irene García
Núria Montferrer
Francisca Munar
Cristina Muro
Rosario Nuño
Remel Perera
Erika Schmucker
Glenda Börjesson
Lars Gillberg
Albert Castellheim
Kerstin Sandström
Annette Bauer
Torbjörn Roos
Lars Hedlund
Yann Boegli
Mirko Dolci
Carine Marcucci
Isabelle Spahr-Schopfer
Walid Habre
Michel Pellegrini
Malte Book
Loreen Errass
Christine Riggenbach
Mattias Casutt
Martin Hölzle
Thomas Hurni
Martin Jöhr
Jacqueline Mauch
Luciano Anselmi
Irene Anselmi
Alfred Jacomet
Markus Oberhauser
Stephanie Wossner
Angelika Zettl
Thomas Erb
Tomasz Mackiewicz
Helena Simitzes
Yetkin Ozer
Arzu Takil
Zekeriyya Alanoglu
Onat Bermede
K Sanem Cakar Turhan
Neslihan Alkis
Cigdem Yildirim Guclu
Basak Ceyda Meco
Zehra Hatipoglu
Dilek Ozcengiz
Zekine Begec
Huseyin Ilksen Toprak
Pinar Kendigelen
Ayse Cigdem Tütüncü
Meltem Savran Karadeniz
Tulay Seyhan Ozkan
Nuket Sivrikoz
Mustafa Kemal Arslantas
Ayse Hizal
Gülbin Tore Altun
Tumay Umuroglu
Sibel Baris
Zuleyha Kazak Bengisun
Galyna Goncharenko
Maksym Khrapak
Tetyana Klymenko
Vitaliy Pavlenko
Dmytro Prysiazhniuk
Olga Rudio
Mykhailo Varyvoda
Sergii Vodianytskyi
Ivanna Boryshkevych
Iryna Kyselova
Nikolay Trikash
Andrew Albokrinov
Valentina Perova-Sharonova
Vitaliy Sklyar
Denis Surkov
Amr Abdelaal
Nicola Barber
Sarah Checuti
Leisha Godsiff
Lynch Johanne
Joanna Simpson
Helen Underhill
Rishi Diwan
Nivedita Kelgeri
Nuria Masip
Radha Ravi
Steve Roberts
Annagrazia Cillis
Ritchie Marcus
Federica Merella
David Love
Paolo Baraggia
Victoria Bird
Joseph Hussey
Peter Alderson
Karen Bartholomew
Michael Moncreiff
Sarah Davidson
Alison Hare
Ami Kotecha
Corina Lee
Ganga Liyanage
Shivali Patel
Amee Samani
Mark Abou-Samra
Matthew Boyd
Laurence Hullatt
David Levy
Mark Pauling
Sarah-Jane Sharman
Natalie Smith
John Rutherford
Alison Cavalier
Christie Locke
Frederic Sage
Smita Bapat
Jacinda Hammerschlag
Ioannis Ioannou
Stephanie King
Rachel Pegg
Vishal Salota
Jonathan Sketcher
Muthu Thadsad
Deborah Zeitlin
Ewan Jack
Colin Lang
Samira Ahmed
Reema Ayyash
Francoise Bari
Sarah J Bell
Claire Elizabeth Biercamp
Sandra Briggs
Maria Gabriella Elena Clement
Mark Dalton
Mohamed Ali Eissa Eid
Monica Gandhi
Idse Harmen Herrema
Ranj Khaffaf
Savio Jeng Min Law
Joanna McClintock
Nicholas Ireland
Mohammed Majid Saleem
Fiona Smith
Marc Cohen
Clover-Ann Lee
Lizanne O'Donahue
Alex Powell
Ellen Rawlinson
Aarjan Snoek
Katja Weiss
Hugo Wellesley
Michael Crawford
Mostafa Abdel-Hafiz
Alexandra Day
Balaji Rajamani
Rita Saha
Dave Wright
Lew-Chin Chee
Stephanie Bew
Rachel Homer
Nalini Malarkkan
Juliet Wolfe Barry
Pradeep Angadi
Brid Cagney
Eric De Melo
Elsa Dekker
Emma Helm
Gareth Jones
Kawshala Peiris
William Russell
Patricia Slater
Puja Sodhi
Mike Browning
Trudie Phillips
Rachel Van Hecke
Vimty Muir
Piyush Singh
Tereza Soskova
Craig Cumming
Pamela Farquharson
Karen Pearson
Neil Shaw
Jonathan Whiteside
Emma Whyte
Gordon Byers
Kay Davies
Thomas Engelhardt
Isabella Faliszewski
Graham Johnston
Nils Kaufmann
Zuzana Kusnirikova
Graham Wilson
Peter Carachi
Andrew Makin
Brian Foster
Dariusz Lipczynski
Rebecca Mawer
William Rutherford
David Rogerson
Sarah Rushman
Christopher Taylor
William Tomlinson
Philippa Dix
Tom Woodward
Graham Bell
David Boyle
Marianne Cloherty
Julia Cullen
Pauline Cullen
Ross Fairgrieve
Robert Ghent
Russell Glasgow
Elena Gordeeva
Alison Harden
Sarah Hivey
Kevin Jerome
Lesley McKee
Neil Morton
Vicky Pribul
John Sinclair
Maria Steiner
Heather Steward
Lorraine Sweeney
Wendy Thomson
Jeanette Whiteside
Andrew Dalton
Mark Ross
Carolyn Smith
Claire Allen
Nicola Anders
Victoria Barlow
Mike Bassett
Leanne Darwin
Rachel Davison
Jacques Diacono
Amy Hobbs
Adel Hutchinson
Bernadette Lomas
Hannah Lonsdale
Leila Nasser
Vimmi Oshan
Pradip Patel
Christopher Raistrick
Victoria Scott-Warren
Laura Talbot
Carolynn Wai
Sophie Childs
Matthew Dickinson
Tom Bloomfield
Sweyn Garrioch
Karen Watson
James Gaynor
Richard Harrison
Juliette Lee
Elizabeth Blythe
Teresa Dorman
Ayman Eissa
James Ellwood
Ingrid Gooch
Robert Hearn
Vanessa Hodgetts
Robert John
Christine Kirton
Nadia Ladak
Judith Morgan
Nina Plant
Elizabeth Shepherd
Judith Short
Charles Stack
Simon Steel
Matthew Taylor
Deborah Thomas
Catharine Wilson
Elaine Wilson-Smith
Carol L Bradbury
Nageena Hussain
Antonia Mayell
Ahmed Mesbah
Arif Qureshi
Chandra Vaidyanath
Tim Geary
Chris Hawksworth
Tamaraichelvi Parasuraman
Nicole Perry
Indrani Banerjee
Katharine Barr
Patrick Butler
Jack Davies
Lisa Flewin
Richard Gande
James Montague
James Plumb
Thomas Pratt
Paul Sutherland
Hannah Vail
Andrew Wilkins
Catherine Hunter
Susan Russell
Alun Thomas
Mark Mifsud
Dominic Strachan
Brigitte Leva
Benoit Plichon
Pierre Harlet
Détails de publication: journal:THE LANCET RESPIRATORY MEDICINE
Identifiants: 99139717709311
Unité académique: Institut de Génomique Fonctionnelle - IGF
Langue: English
Type de ressource: Journal article