Résumé
Introduction: healthcare-associated infections (HAIs) are a major public health problem, particularly in Guinea. The study aimed to determine the incidence and risk factors for the occurrence of HAIs.Methods: this prospective cohort study was conducted between August 2022 and January 2024 in the Conakry, Kankan, and Nzérékoré regions. The incidence of HAIs was calculated per 1,000 person-days, and a Cox regression model was used to identify risk factors.Results: among 6,759 patients (median age: 28 years) with a median hospital stay of 6 days (IQR: 3-9), 1,196 had HCAIs, with an incidence of 28.15 per 1,000 person-days [95% CI: 26.60%-29.80%]. Surgical site infections (SSIs) accounted for 86.45% of cases. Independent risk factors included health region (aHR = 0.46; p-value < 0.001), facility category (aHR = 3.05; p-value = 0.027), gender (aHR = 1.23; p-value = 0.006), diabetes (aHR = 1.79; p-value < 0.001) and timing of procedures (aHR = 1.45; p-value < 0.001).Conclusion: this study indicates high incidence rates despite existing prevention efforts. It highlights the need to improve prevention strategies by emphasizing follow-up on surgical schedules and paying attention to medical history, such as diabetes.