Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children

Danyel Lee; Jérémie Le Pen; Ahmad Yatim; Beihua Dong; Yann Aquino; Masato Ogishi; Rémi Pescarmona; Estelle Talouarn; Darawan Rinchai; Peng Zhang; Magali Perret; Zhiyong Liu; Iolanda Jordan; Sefika Elmas Bozdemir; Gulsum Iclal Bayhan; Camille Beaufils; Lucy Bizien; Aurelie Bisiaux; Weite Lei; Milena Hasan; Jie Chen; Christina Gaughan; Abhishek Asthana; Valentina Libri; Joseph Luna; Fabrice Jaffré; H.-Heinrich Hoffmann; Eleftherios Michailidis; Marion Moreews; Yoann Seeleuthner; Kaya Bilguvar; Shrikant Mane; Carlos Flores; Yu Zhang; Andrés Arias; Rasheed Bailey; Agatha Schlüter; Baptiste Milisavljevic; Benedetta Bigio; Tom Le Voyer; Marie Materna; Adrian Gervais; Marcela Moncada-Velez; Francesca Pala; Tomi Lazarov; Romain Levy; Anna-Lena Neehus; Jérémie Rosain; Jessica Peel; Yi-Hao Chan; Marie-Paule Morin; Rosa Maria Pino-Ramirez; Serkan Belkaya; Lazaro Lorenzo; Jordi Anton; Selket Delafontaine; Julie Toubiana; Fanny Bajolle; Victoria Fumadó; Marta Dediego; Nadhira Fidouh; Flore Rozenberg; Jordi Pérez-Tur; Shuibing Chen; Todd Evans; Frédéric Geissmann; Pierre Lebon; Susan Weiss; Damien Bonnet; Xavier Duval; Qiang Pan-Hammarström; Anna Planas; Isabelle Meyts; Filomeen Haerynck; Aurora Pujol; Vanessa Sancho-Shimizu; Clifford Dalgard; Jacinta Bustamante; Anne Puel; Stéphanie Boisson-Dupuis; Bertrand Boisson; Tom Maniatis; Qian Zhang; Paul Bastard; Luigi Notarangelo; Vivien Béziat; Rebeca Perez de Diego; Carlos Rodriguez-Gallego; Helen Su; Richard Lifton; Emmanuelle Jouanguy; Aurélie Cobat; Laia Alsina; Sevgi Keles; Elie Haddad; Laurent Abel; Alexandre Belot; Lluis Quintana-Murci; Charles Rice; Robert Silverman; Shen-Ying Zhang; Jean-Laurent Casanova; Loubna Alavoine; Sylvie Behillil; Charles Burdet; Charlotte Charpentier; Aline Dechanet; Diane Descamps; Jean-Luc Ecobichon; Vincent Enouf; Wahiba Frezouls; Nadhira Houhou; Ouifiya Kafif; Jonathan Lehacaut; Sophie Letrou; Bruno Lina; Jean-Christophe Lucet; Pauline Manchon; Mariama Nouroudine; Valentine Piquard; Caroline Quintin; Michael Thy; Sarah Tubiana; Sylvie van der Werf; Valérie Vignali; Benoit Visseaux; Yazdan Yazdanpanah; Abir Chahine; Nawal Waucquier; Maria-Claire Migaud; Dominique Deplanque; Félix Djossou; Mayka Mergeay-Fabre; Aude Lucarelli; Magalie Demar; Léa Bruneau; Patrick Gérardin; Adrien Maillot; Christine Payet; Bruno Laviolle; Fabrice Laine; Christophe Paris; Mireille Desille-Dugast; Julie Fouchard; Denis Malvy; Duc Nguyen; Thierry Pistone; Pauline Perreau; Valérie Gissot; Carole Le Goas; Samatha Montagne; Lucie Richard; Catherine Chirouze; Kévin Bouiller; Maxime Desmarets; Alexandre Meunier; Benjamin Lefèvre; Hélène Jeulin; Karine Legrand; Sandra Lomazzi; Bernard Tardy; Amandine Gagneux-Brunon; Frédérique Bertholon; Elisabeth Botelho-Nevers; Kouakam Christelle; Leturque Nicolas; Layidé Roufai; Karine Amat; Sandrine Couffin-Cadiergues; Hélène Espérou; Samia Hendou; Hassan Abolhassani; Sergio Aguilera-Albesa; Alessandro Aiuti; Ozge Metin Akcan; Nihal Akcay; Gulsum Alkan; Suzan Alkhater; Luis Miguel Allende; Yosunkaya Alper; Naima Amenzoui; Mark Anderson; Lisa Arkin; Melodie Aubart; Iryna Avramenko; Şehnaz Aydemir; Zeynep Gökçe Gayretli Aydin; Caner Aytekin; Gökhan Aytekin; Selma Erol Aytekin; Silvia Yumi Bando; Kathie Beland; Catherine Biggs; Agurtzane Bilbao Aburto; Geraldine Blanchard-Rohner; Daniel Blázquez-Gamero; Marketa Bloomfield; Dusan Bogunovic; Anastasia Bondarenko; Alessandro Borghesi; Amed Aziz Bousfiha; Oksana Boyarchuk; Petter Brodin; Yenan Bryceson; Giorgia Bucciol; Valeria Calcaterra; Giorgio Casari; Andre Cavalcanti; Jale Bengi Celik; George Chrousos; Roger Colobran; Antonio Condino-Neto; Francesca Conti; Megan Cooper; Taner Coskuner; Cyril Cyrus; Enza D’auria; Beth Drolet; Burcu Bursal Duramaz; Loubna El Zein; Marwa Elnagdy; Melike Emiroglu; Emine Hafize Erdeniz; Marianna Fabi; Hagit Baris Feldman; Jacques Fellay; Filip Fencl; Filippos Filippatos; Julie Freiss; Jiri Fremuth; Alenka Gagro; Blanca Garcia-Solis; Gianluca Vergine; Rafaela González-Montelongo; Yahya Gul; Belgin Gülhan; Sara Sebnem Kilic Gultekin; Marta Gut; Rabih Halwani; Lennart Hammarström; Nevin Hatipoğlu; James Heath; Sarah Henrickson; Elisa Hernandez-Brito; Ilse Hoffman; Levi Hoste; Elena Hsieh; Antonio Íñigo-Campos; Yuval Itan; Petr Jabandziev; Bahar Kandemir; Saliha Kanık-Yüksek; Hasan Kapakli; Adem Karbuz; Ozgur Kasapcopur; Robin Kechiche; Yasemin Kendir Demirkol; Omer Kilic; Stella Kim Hansen; Adam Klocperk; Yu-Lung Lau; Jan Lebl; José Lorenzo-Salazar; Carrie Lucas; Majistor Maglorius; Laura Marque; Yeray Novoa Medina; Abián Montesdeoca Melián; Alexios-Fotios Mentis; Michele Pato; Athanasios Michos; Joshua Milner; Trine Mogensen; Adrián Muñoz-Barrera; Serdar Nepesov; João Farela Neves; Ashley Ng; Lisa Ng; Antonio Novelli; Giuseppe Novelli; Fatma Nur Oz; J. Gonzalo Ocejo-Viñals; Satoshi Okada; Zerrin Orbak; Ahmet Osman Kilic; Hind Ouair; Şadiye Kübra Tüter Öz; Tayfun Özçelik; Esra Akyüz Özkan; Aslınur Özkaya Parlakay; Carlos Pato; Estela Paz-Artal; Simon Pelham; Isabelle Pellier; Quentin Philippot; Laura Planas-Serra; Samira Plassart; Petra Pokorna; Meltem Polat; Cecilia Poli; Carolina Prando; Laurent Renia; Jacques Rivière; Agustí Rodríguez-Palmero; Lucie Roussel; Luis Rubio-Rodriguez; Moro Salifu; Lumir Sasek; Laura Sasia; Anna Scherbina; Erica Schmitt; Anna Sediva; Esra Sevketoglu; Katerina Slaba; Ondrej Slaby; Ali Sobh; Jordi Solé-Violán; Pere Soler-Palacin; Lien de Somer; Betül Sözeri; András Spaan; Yuriy Stepanovskiy; Stuart Tangye; Gonul Tanir; Elizabeth Barbara Tatsi; Christian Thorball; Selda Hancerli Torun; Stuart Turvey; Mohammed Uddin; Emel Uyar; Juan Valencia-Ramos; Ana Maria van den Rym; Hulya Vatansev; Martín Castillo de Vera; François Vermeulen; Donald Vinh; Alla Volokha; Horst von Bernuth; Carine Wouters; Aysun Yahşi; Volkan Yarar; Osman Yesilbas; Mehmet Yıldız; Mayana Zatz; Pawel Zawadzki; Gianvincenzo Zuccotti

doi:10.1126/science.abo3627

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Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children

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Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children

Danyel Lee, Jérémie Le Pen, Ahmad Yatim, Beihua Dong, Yann Aquino, Masato Ogishi, Rémi Pescarmona, Estelle Talouarn, Darawan Rinchai, Peng Zhang, …

Science, Vol.379(6632)

10/02/2023

DOI: https://doi.org/10.1126/science.abo3627

PMID: 36538032

Résumé

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of , , or in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C.

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Titre: Inborn errors of OAS–RNase L in SARS-CoV-2–related multisystem inflammatory syndrome in children
Créateurs - sans rôle: Danyel Lee - Rockefeller University
Jérémie Le Pen - Rockefeller University
Ahmad Yatim - Université de Montpellier, Institut de Génétique Humaine - IGH
Beihua Dong - Cleveland Clinic Lerner College of Medicine
Yann Aquino - Sorbonne Université
Masato Ogishi - Rockefeller University
Rémi Pescarmona - Hôpital Lyon Sud
Estelle Talouarn - Inserm
Darawan Rinchai - Rockefeller University
Peng Zhang - Rockefeller University
Magali Perret - Hôpital Lyon Sud
Zhiyong Liu - Rockefeller University
Iolanda Jordan - Instituto de Salud Carlos III
Sefika Elmas Bozdemir
Gulsum Iclal Bayhan - Ankara Yıldırım Beyazıt University
Camille Beaufils - Université de Montréal
Lucy Bizien - Inserm
Aurelie Bisiaux - Institut Pasteur
Weite Lei
Milena Hasan - Institut Pasteur
Jie Chen - Rockefeller University
Christina Gaughan - Cleveland Clinic Lerner College of Medicine
Abhishek Asthana - Cleveland Clinic Lerner College of Medicine
Valentina Libri - Institut Pasteur
Joseph Luna - Case Western Reserve University
Fabrice Jaffré - Cornell University
H.-Heinrich Hoffmann - Rockefeller University
Eleftherios Michailidis - Emory University
Marion Moreews - Centre International de Recherche en Infectiologie
Yoann Seeleuthner - Institut des Maladies Génétiques Imagine
Kaya Bilguvar - Kent Hastanesi
Shrikant Mane - Yale University
Carlos Flores - Instituto de Salud Carlos III
Yu Zhang - Office of Extramural Research
Andrés Arias - Rockefeller University
Rasheed Bailey - Rockefeller University
Agatha Schlüter - Duran i Reynals Hospital
Baptiste Milisavljevic - Rockefeller University
Benedetta Bigio - Rockefeller University
Tom Le Voyer - Inserm
Marie Materna - Institut des Maladies Génétiques Imagine
Adrian Gervais - Institut des Maladies Génétiques Imagine
Marcela Moncada-Velez - Rockefeller University
Francesca Pala - National Institute of Allergy and Infectious Diseases
Tomi Lazarov - Memorial Sloan Kettering Cancer Center
Romain Levy - Inserm
Anna-Lena Neehus
Jérémie Rosain - Institut des Maladies Génétiques Imagine
Jessica Peel - Rockefeller University
Yi-Hao Chan
Marie-Paule Morin
Rosa Maria Pino-Ramirez
Serkan Belkaya - Bilkent University
Lazaro Lorenzo - Rockefeller University
Jordi Anton - Universitat de Barcelona
Selket Delafontaine - KU Leuven
Julie Toubiana - Institut Pasteur
Fanny Bajolle - Assistance Publique – Hôpitaux de Paris
Victoria Fumadó - Universitat de Barcelona
Marta Dediego - Centro Nacional de Biotecnología
Nadhira Fidouh - Université Claude Bernard Lyon 1
Flore Rozenberg - Hôpital Cochin
Jordi Pérez-Tur - Instituto de Investigación Sanitaria La Fe
Shuibing Chen - Cornell University
Todd Evans - Cornell University
Frédéric Geissmann - Memorial Sloan Kettering Cancer Center
Pierre Lebon
Susan Weiss - University of Pennsylvania
Damien Bonnet - Université Sorbonne Paris Nord
Xavier Duval - Hôpital Bichat-Claude-Bernard
Qiang Pan-Hammarström - Karolinska Institutet
Anna Planas - Institut d'Investigacions Biomèdiques de Barcelona
Isabelle Meyts - KU Leuven
Filomeen Haerynck - Consejo Superior de Investigaciones Científicas
Aurora Pujol - KU Leuven
Vanessa Sancho-Shimizu - Royal College of Paediatrics and Child Health
Clifford Dalgard - Uniformed Services University of the Health Sciences
Jacinta Bustamante - Royal College of Paediatrics and Child Health
Anne Puel - Institut des Maladies Génétiques Imagine
Stéphanie Boisson-Dupuis - Institut des Maladies Génétiques Imagine
Bertrand Boisson - Inserm
Tom Maniatis - Institut des Maladies Génétiques Imagine
Qian Zhang - Rockefeller University
Paul Bastard - New York Genome Center
Luigi Notarangelo - National Institute of Allergy and Infectious Diseases
Vivien Béziat - Inserm
Rebeca Perez de Diego
Carlos Rodriguez-Gallego - Inserm
Helen Su - Hospital La Paz Institute for Health Research
Richard Lifton - Universidad Fernando Pessoa Canarias
Emmanuelle Jouanguy - Institut des Maladies Génétiques Imagine
Aurélie Cobat - Inserm
Laia Alsina - Rockefeller University
Sevgi Keles - Institut des Maladies Génétiques Imagine
Elie Haddad - Université de Montréal
Laurent Abel - Institut des Maladies Génétiques Imagine
Alexandre Belot - Inserm
Lluis Quintana-Murci - Inserm
Charles Rice - Centre National de la Recherche Scientifique
Robert Silverman - Collège de France
Shen-Ying Zhang
Jean-Laurent Casanova
Loubna Alavoine - Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique
Sylvie Behillil
Charles Burdet
Charlotte Charpentier
Aline Dechanet
Diane Descamps
Xavier Duval - Hôpital Bichat-Claude-Bernard
Jean-Luc Ecobichon
Vincent Enouf
Wahiba Frezouls
Nadhira Houhou
Ouifiya Kafif
Jonathan Lehacaut
Sophie Letrou
Bruno Lina - Centre International de Recherche en Infectiologie
Jean-Christophe Lucet
Pauline Manchon
Mariama Nouroudine
Valentine Piquard
Caroline Quintin
Michael Thy
Sarah Tubiana - Biodiversité et Epidémiologie des Bactéries pathogènes - Biodiversity and Epidemiology of Bacterial Pathogens
Sylvie van der Werf
Valérie Vignali
Benoit Visseaux
Yazdan Yazdanpanah
Abir Chahine
Nawal Waucquier
Maria-Claire Migaud - Centre d'Investigation Clinique - Innovation Technologique de Lille
Dominique Deplanque
Félix Djossou
Mayka Mergeay-Fabre - Centre d'Investigation Clinique Antilles Guyane
Aude Lucarelli
Magalie Demar
Léa Bruneau
Patrick Gérardin
Adrien Maillot - Inserm
Christine Payet
Bruno Laviolle - Centre d'Investigation Clinique [Rennes]
Fabrice Laine - Centre d'Investigation Clinique [Rennes]
Christophe Paris - Centre d'Investigation Clinique [Rennes]
Mireille Desille-Dugast - Centre d'Investigation Clinique [Rennes]
Julie Fouchard - Centre d'Investigation Clinique [Rennes]
Denis Malvy
Duc Nguyen
Thierry Pistone
Pauline Perreau
Valérie Gissot
Carole Le Goas
Samatha Montagne
Lucie Richard
Catherine Chirouze
Kévin Bouiller
Maxime Desmarets
Alexandre Meunier
Benjamin Lefèvre
Hélène Jeulin
Karine Legrand
Sandra Lomazzi
Bernard Tardy
Amandine Gagneux-Brunon
Frédérique Bertholon
Elisabeth Botelho-Nevers
Kouakam Christelle
Leturque Nicolas
Layidé Roufai
Karine Amat
Sandrine Couffin-Cadiergues
Hélène Espérou
Samia Hendou
Laurent Abel - Institut des Maladies Génétiques Imagine
Hassan Abolhassani
Sergio Aguilera-Albesa
Alessandro Aiuti
Ozge Metin Akcan
Nihal Akcay
Gulsum Alkan
Suzan Alkhater
Luis Miguel Allende
Yosunkaya Alper
Naima Amenzoui
Mark Anderson
Lisa Arkin
Melodie Aubart
Iryna Avramenko
Şehnaz Aydemir
Zeynep Gökçe Gayretli Aydin
Caner Aytekin
Gökhan Aytekin
Selma Erol Aytekin
Silvia Yumi Bando
Kathie Beland
Serkan Belkaya - Bilkent University
Catherine Biggs
Agurtzane Bilbao Aburto
Geraldine Blanchard-Rohner
Daniel Blázquez-Gamero
Marketa Bloomfield
Dusan Bogunovic
Anastasia Bondarenko
Alessandro Borghesi
Amed Aziz Bousfiha
Oksana Boyarchuk
Petter Brodin
Yenan Bryceson
Giorgia Bucciol
Valeria Calcaterra
Giorgio Casari
Andre Cavalcanti
Jale Bengi Celik
George Chrousos
Roger Colobran
Antonio Condino-Neto
Francesca Conti
Megan Cooper
Taner Coskuner
Cyril Cyrus
Enza D’auria
Selket Delafontaine - KU Leuven
Beth Drolet
Burcu Bursal Duramaz
Loubna El Zein
Marwa Elnagdy
Melike Emiroglu
Emine Hafize Erdeniz
Marianna Fabi
Hagit Baris Feldman
Jacques Fellay
Filip Fencl
Filippos Filippatos
Julie Freiss
Jiri Fremuth
Alenka Gagro
Blanca Garcia-Solis
Gianluca Vergine
Rafaela González-Montelongo
Yahya Gul
Belgin Gülhan
Sara Sebnem Kilic Gultekin
Marta Gut
Rabih Halwani
Lennart Hammarström
Nevin Hatipoğlu
James Heath
Sarah Henrickson
Elisa Hernandez-Brito
Ilse Hoffman
Levi Hoste
Elena Hsieh
Antonio Íñigo-Campos
Yuval Itan
Petr Jabandziev
Bahar Kandemir
Saliha Kanık-Yüksek
Hasan Kapakli
Adem Karbuz
Ozgur Kasapcopur
Robin Kechiche
Yasemin Kendir Demirkol
Omer Kilic
Stella Kim Hansen
Adam Klocperk
Yu-Lung Lau
Jan Lebl
José Lorenzo-Salazar
Carrie Lucas
Majistor Maglorius
Laura Marque
Yeray Novoa Medina
Abián Montesdeoca Melián
Alexios-Fotios Mentis
Michele Pato
Athanasios Michos
Joshua Milner
Trine Mogensen
Adrián Muñoz-Barrera
Serdar Nepesov
João Farela Neves
Ashley Ng
Lisa Ng
Antonio Novelli
Giuseppe Novelli
Fatma Nur Oz
J. Gonzalo Ocejo-Viñals
Satoshi Okada
Zerrin Orbak
Ahmet Osman Kilic
Hind Ouair
Şadiye Kübra Tüter Öz
Tayfun Özçelik
Esra Akyüz Özkan
Aslınur Özkaya Parlakay
Carlos Pato
Estela Paz-Artal
Simon Pelham
Isabelle Pellier
Quentin Philippot
Laura Planas-Serra
Samira Plassart
Petra Pokorna
Meltem Polat
Cecilia Poli
Carolina Prando
Laurent Renia
Jacques Rivière
Agustí Rodríguez-Palmero
Lucie Roussel
Luis Rubio-Rodriguez
Moro Salifu
Lumir Sasek
Laura Sasia
Anna Scherbina
Erica Schmitt
Anna Sediva
Esra Sevketoglu
Katerina Slaba
Ondrej Slaby
Ali Sobh
Jordi Solé-Violán
Pere Soler-Palacin
Lien de Somer
Betül Sözeri
András Spaan
Yuriy Stepanovskiy
Stuart Tangye
Gonul Tanir
Elizabeth Barbara Tatsi
Christian Thorball
Selda Hancerli Torun
Stuart Turvey
Mohammed Uddin
Emel Uyar
Juan Valencia-Ramos
Ana Maria van den Rym
Hulya Vatansev
Martín Castillo de Vera
François Vermeulen
Donald Vinh
Alla Volokha
Horst von Bernuth
Carine Wouters
Aysun Yahşi
Volkan Yarar
Osman Yesilbas
Mehmet Yıldız
Mayana Zatz
Pawel Zawadzki
Gianvincenzo Zuccotti
Shen-Ying Zhang
Jean-Laurent Casanova
Détails de publication: Science, Vol.379(6632)
Note de subvention: The Laboratory of Human Genetics of Infectious Diseases is supported by the Howard Hughes Medical Institute, the Rockefeller University, the St. Giles Foundation, the National Institutes of Health (NIH) (R01AI088364 and R21AI160576), the National Center for Advancing Translational Sciences (NCATS), NIH Clinical and Translational Science Award (CTSA) program (UL1TR001866), the Yale Center for Mendelian Genomics and the GSP Coordinating Center funded by the National Human Genome Research Institute (NHGRI) (UM1HG006504 and U24HG008956), the Yale High-Performance Computing Center (S10OD018521), the Fisher Center for Alzheimer’s Research Foundation, the Meyer Foundation, the JBP Foundation, the French National Research Agency (ANR) under the “Investments for the Future” program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the ANR GenMISC (ANR-21-COVR-039), the ANRS-COV05, ANR GENVIR (ANR-20-CE93-003) and ANR AABIFNCOV (ANR-20-CO11-0001) projects, the ANR-RHU program (ANR-21-RHUS-08), the European Union’s Horizon 2020 research and innovation program under grant agreement 824110 (EASI-genomics), the HORIZON-HLTH-2021-DISEASE-04 program under grant agreement 01057100 (UNDINE), the ANR-RHU Program ANR-21-RHUS-08 (COVIFERON), the Square Foundation, Grandir – Fonds de solidarité pour l’enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Science, the French Ministry of Higher Education, Research, and Innovation (MESRI-COVID-19), Institut National de la Santé et de la Recherche Médicale (INSERM), and Paris Cité University. We acknowledge support from the National Institute of Allergy and Infectious Diseases (NIAID) of the NIH under award R01AI104887 to R.H.S. and S.R.W. The Laboratory of Human Evolutionary Genetics (Institut Pasteur) is supported by the Institut Pasteur, the Collège de France, the French Government’s Investissement d’Avenir program, Laboratoires d’Excellence “Integrative Biology of Emerging Infectious Diseases” (ANR-10-LABX-62-IBEID) and “Milieu Intérieur” (ANR-10-LABX-69-01), the Fondation de France (no. 00106080), the FRM (Equipe FRM DEQ20180339214 team), and the ANR COVID-19-POPCELL (ANR-21-CO14-0003-01). A.Puj. is supported by ACCI20-759 CIBERER, EasiGenomics H2020 Marató TV3 COVID 2021-31-33, the HORIZON-HLTH-2021-ID: 101057100 (UNDINE), the Horizon 2020 program under grant no. 824110 (EasiGenomics grant no. COVID-19/PID12342), and the CERCA Program/Generalitat de Catalunya. The Canarian Health System sequencing hub was funded by the Instituto de Salud Carlos III (COV20_01333 and COV20_01334), the Spanish Ministry of Science and Innovation (RTC-2017-6471-1; AEI/FEDER, UE), Fundación MAPFRE Guanarteme (OA21/131), and Cabildo Insular de Tenerife (CGIEU0000219140 and “Apuestas científicas del ITER para colaborar en la lucha contra la COVID-19”). The CoV-Contact Cohort was funded by the French Ministry of Health and the European Commission (RECOVER project). Our studies are also funded by the Ministry of Health of the Czech Republic Conceptual Development of Research Organization (FNBr, 65269705) and ANID COVID0999 funding in Chile. G. Novelli and A. Novelli are supported by Regione Lazio (Research Group Projects 2020) No. A0375-2020-36663, GecoBiomark. A.M.P., M.L.D., and J.P.-T. are supported by the Inmungen-CoV2 project of CSIC. This work was supported in part by the Intramural Research Program of the NIAID, NIH. The research work of A.M.P, M.L.D., and J.P.-T. was funded by the European Commission –NextGenerationEU (Regulation EU 2020/2094), through CSIC’s Global Health Platform (PTI Salud Global). I.M. is a senior clinical investigator at FWO Vlaanderen supported by a VIB GC PID grant, by FWO grants G0B5120N (DADA2) and G0E8420N, and by the Jeffrey Modell Foundation. I.M. holds an ERC-StG MORE2ADA2 grant and is also supported by ERN-RITA. A.Y. is supported by fellowships from the European Academy of Dermatology and Venereology and the Swiss National Science Foundation and by an Early Career Award from the Thrasher Research Fund. Y.-H.C. is supported by an A*STAR International Fellowship (AIF). M.O. was supported by the David Rockefeller Graduate Program, the New York Hideyo Noguchi Memorial Society (HNMS), the Funai Foundation for Information Technology (FFIT), the Honjo International Scholarship Foundation (HISF), and the National Cancer Institute (NCI) F99 Award (F99CA274708). A.A.A. was supported by Ministerio de Ciencia Tecnología e Innovación MINCIENCIAS, Colombia (111584467551/CT 415-2020). D.L. is supported by a fellowship from the FRM for medical residents and fellows. E.H. received funding from the Bank of Montreal Chair of Pediatric Immunology, Foundation of CHU Sainte-Justine, CIHR grants PCC-466901 and MM1-181123, and a Canadian Pediatric Society IMPACT study. Q.P.-H. received funding from the European Union’s Horizon 2020 research and innovation program (ATAC, 101003650), the Swedish Research Council, and the Knut and Alice Wallenberg Foundation. Work in the Laboratory of Virology and Infectious Disease was supported by NIH grants P01AI138398-S1, 2U19AI111825, R01AI091707-10S1, and R01AI161444; a George Mason University Fast Grant; the G. Harold and Leila Y. Mathers Charitable Foundation; the Meyer Foundation; and the Bawd Foundation. R.P.L. is on the board of directors of both Roche and the Roche subsidiary Genentech. J.L.P. was supported by a Francois Wallace Monahan Postdoctoral Fellowship at the Rockefeller University and by a European Molecular Biology Organization Long-Term Fellowship (ALTF 380-2018).
Identifiants: 99153526509311
Unité académique: Institut de Génétique Humaine - IGH
Langue: English
Type de ressource: Journal article
Champs locaux: hal-04089777