Impact of facial nerve resection in parotid cancer abutting the facial nerve without preoperative paralysis: a multicentric propensity score-based analysis

Florian Chatelet; Sylvie Chevret; Nicolas Fakhry; Caroline Even; Olivier Malard; Erwan de Monès; Nicolas Saroul; François Mouawad; Marie de Boutray; Olivier Mauvais; Sébastien Vergez; Diane Evrard; Christian Righini; Philippe Schultz; Robin Baudouin; Gilles Poissonnet; Sarah Atallah; Fabienne Haroun; Sylvain Morinière; Camille Evrard; Pierre Philouze; Agnès Paasche; Maria Lesnik; Yann Lelonge; Philippe Herman; Benjamin Verillaud; C. Ala-Eddine; K. Aubry; E. Babin; C. Bach; C. Badoual; A.C. Baglin; B. Barry; V. Bastit; B. Baujat; K. Benezery; R.J. Bensadoun; N. Benzerdjeb; M. Bernadach; C. Bertolus; J. Bettoni; A. Biet; D. Bodmer; P. Boisselier; C. Boulagnon-Rombi; L. Bozec; A. Bozorg Grayeli; E. Brenet; L. Brugel; G. Calais; V. Calugaru; S. Camby; O. Casiraghi; E. Cassagnau; C. Castain; J. Castelli; P. Ceruse; F. Chabolle; D. Chevalier; O. Choussy; M. Classe; F. Clatot; E. Colin; J.M. Constans; A. Coste; F. Coste; V. Costes; J.P. Cottier; A. Coutte; J.P. Cristofari; D. Cupissol; J. Delgrande; J.P. Delord; B. Devauchelle; L. Digue; G. Dolivet; M. Doré; S. Duflo; X. Dufour; C. Dupin; E. Eker; F. Espitalier; C. Even; C. Evrard; E. Fabiano; S. Faivre; N. Fakhry; F.R. Ferrand; J. Frandon; D. Franetti; L. de Gabory; C. Galy; M. Garcier; R. Garrel; H. Gauthier; L. Gilain; S. Guihard; S. Guillerm; C. Halimi; S. Hans; P. Herman; A. Houessinon; M. Hourseau; F. Huguet; E. Jadaud; R. Jankowski; C. Jeanne; F. Jegoux; M. Juliéron; R. Kaci; M.-C. Kaminsky; H. de Kermadec; F. Kolb; S. Kreps; M. Laadhari; J. Lacau Saint Guily; L. Laccoureye; M. Lae; F. Lagarde; A. Lagrange; B. Lallemant; M. Lamuraglia; P. Lang; M. Lapeyre; A. Lapierre; A. Lasne Cardon; C. Le Tourneau; G. Lefebvre; M. Lefevre; Y. Lelonge; X. Leroy; M. Lesnik; X. Liem; C. Linassier; P. Maingon; C. Majoufre; O. Malard; G. Malouf; C. Marchand; J.-P. Marie; T. Maurina; O. Mauvais; J.-C. Merol; J. Michel; G. Mineur; S. Mirafzal; H. Mirghani; A. Modesto; S. Molinier-Blossier; E. de Monès; S. Morinière; F. Mouawad; A. Moya-Plana; L. Muller; E. Musat; F. Nguyen; G. Noel; F.R. Obongo-Anga; M. Onea; H. Orliac; C. Page; V. Patron; J. Pestre; N. Pham Dang; P. Philouze; G. Poissonnet; C. Pons; C. Pouliquen; J.-M. Prades; A. Prevost; C. Queiros; A. Rahmani; A. Rambeau; L. Ramin; S. Renard; C.A. Righini; F. Rolland; E. Saada; F. Sacino; S. Salas; N. Saroul; P. Schultz; A. Simonaggio; O. Sterkers; V. Strunski; A. Sudaka; S. Xu-Shan; R. Taouachi; M. Tassart; S. Testelin; J. Thariat; M. Timar David; A. Timochenko; B. Toussaint; E. Uro Coste; G. Valette; T. van den Abbeele; A. Varoquaux; E. Vauleon; S. Vergez; B. Verillaud; J. Villa; A. Villepelet; M. Volondat; N. Vulquin; I. Wagner; M. Wassef; L. Webert; S. Wong

doi:10.1016/j.ejso.2024.108746

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Impact of facial nerve resection in parotid cancer abutting the facial nerve without preoperative paralysis: a multicentric propensity score-based analysis

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Impact of facial nerve resection in parotid cancer abutting the facial nerve without preoperative paralysis: a multicentric propensity score-based analysis

Florian Chatelet, Sylvie Chevret, Nicolas Fakhry, Caroline Even, Olivier Malard, Erwan de Monès, Nicolas Saroul, François Mouawad, Marie de Boutray, Olivier Mauvais, …

EJSO - European Journal of Surgical Oncology

10/2024

DOI: https://doi.org/10.1016/j.ejso.2024.108746

Abstract

Facial nerve

Parotid cancer

Surgery

Propensity score

ObjectivesThe management of the facial nerve (FN) is a major issue in parotid cancer, especially when there is no preoperative facial palsy and FN invasion is discovered intraoperatively. The aim of this study was to assess the impact of FN resection in patients with parotid cancer abutting the FN, without pretreatment facial palsy, using a propensity score matching.Materials and methodsData from all patients treated between 2009 and 2020 for a primary parotid cancer abutting or invading the FN but without pretreatment facial palsy were extracted from the national multicentric REFCOR database. Three different definitions of tumors abutting the FN were used for sensitivity analyses, in a retrospective setting. Propensity score matching was used to assess the impact of FN resection on disease-free survival (DFS), overall survival (OS) and locoregional recurrence-free survival (LRRFS).ResultsA total of 163 patients with parotid cancer abutting or invading the FN without pretreatment facial palsy were included. Among them, 99 patients (61%) underwent FN resection. After overlap weighting and multiple imputation, no benefit of FN resection over preservation was found in terms of OS (HR= 1.21, p= 0.6), DFS (HR= 0.88, p= 0.5) and LRRFS (HR= 0.99, p= 1).Sensitivity analyses revealed similar results, and no significant efficacy was found in the subgroup analyses.ConclusionIn this retrospective study with propensity score analysis, FN resection did not improve survival outcomes in patients without preoperative facial palsy treated surgically for a primary parotid cancer abutting the FN. In line with recent guidelines, the results of this study suggest that FN preservation should be considered whenever possible in this specific group of patients.

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Title: Impact of facial nerve resection in parotid cancer abutting the facial nerve without preoperative paralysis: a multicentric propensity score-based analysis
Creators - without role: Florian Chatelet - Sorbonne Paris Cité
Sylvie Chevret - Hôpital Saint-Louis
Nicolas Fakhry - Centre National de la Recherche Scientifique
Caroline Even - Institut Gustave Roussy
Olivier Malard - RMeS - Regenerative Medicine and Skeleton
Erwan de Monès - Laboratory for the Bioengineering of Tissues
Nicolas Saroul - Centre Hospitalier Universitaire de Clermont-Ferrand
François Mouawad - Miniaturisation pour la Synthèse, l'Analyse et la Protéomique
Marie de Boutray - Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier
Olivier Mauvais - Centre Hospitalier Universitaire de Besançon
Sébastien Vergez - Centre Hospitalier Universitaire de Toulouse
Diane Evrard - Hôpital Bichat-Claude-Bernard
Christian Righini - Centre Hospitalier Universitaire de Grenoble
Philippe Schultz - Hôpitaux Universitaires de Strasbourg
Robin Baudouin - Université de Versailles Saint-Quentin-en-Yvelines
Gilles Poissonnet - Centre Hospitalier Universitaire de Nice
Sarah Atallah - Assistance Publique – Hôpitaux de Paris
Fabienne Haroun - Sorbonne Paris Cité
Sylvain Morinière - Centre Hospitalier Universitaire de Tours
Camille Evrard - Centre Hospitalier Universitaire de Poitiers
Pierre Philouze - Hospices Civils de Lyon
Agnès Paasche - Centre Hospitalier Universitaire Amiens-Picardie
Maria Lesnik
Yann Lelonge
Philippe Herman
Benjamin Verillaud
C. Ala-Eddine
K. Aubry
E. Babin
C. Bach
C. Badoual
A.C. Baglin
B. Barry
V. Bastit
B. Baujat
K. Benezery
R.J. Bensadoun
N. Benzerdjeb
M. Bernadach
C. Bertolus
J. Bettoni - Centre Hospitalier Universitaire Amiens-Picardie
A. Biet
D. Bodmer
P. Boisselier
C. Boulagnon-Rombi
L. Bozec
A. Bozorg Grayeli
E. Brenet
L. Brugel
G. Calais
V. Calugaru
S. Camby
O. Casiraghi
E. Cassagnau
C. Castain
J. Castelli
P. Ceruse
F. Chabolle
D. Chevalier
O. Choussy
M. Classe
F. Clatot
E. Colin
J.M. Constans - Centre Hospitalier Universitaire Amiens-Picardie
A. Coste
F. Coste
V. Costes
J.P. Cottier
A. Coutte - Centre Hospitalier Universitaire Amiens-Picardie
J.P. Cristofari
D. Cupissol
J. Delgrande
J.P. Delord
B. Devauchelle - Centre Hospitalier Universitaire Amiens-Picardie
L. Digue
G. Dolivet
M. Doré
S. Duflo
X. Dufour
C. Dupin
E. Eker
F. Espitalier
C. Even - Institut Gustave Roussy
C. Evrard - Centre Hospitalier Universitaire de Poitiers
E. Fabiano
S. Faivre
N. Fakhry - Centre National de la Recherche Scientifique
F.R. Ferrand
J. Frandon
D. Franetti
L. de Gabory
C. Galy
M. Garcier
R. Garrel
H. Gauthier
L. Gilain
S. Guihard
S. Guillerm
C. Halimi
S. Hans
P. Herman
A. Houessinon
M. Hourseau
F. Huguet
E. Jadaud
R. Jankowski
C. Jeanne
F. Jegoux
M. Juliéron
R. Kaci
M.-C. Kaminsky
H. de Kermadec
F. Kolb
S. Kreps
M. Laadhari
J. Lacau Saint Guily
L. Laccoureye
M. Lae
F. Lagarde
A. Lagrange
B. Lallemant
M. Lamuraglia
P. Lang
M. Lapeyre
A. Lapierre
A. Lasne Cardon
C. Le Tourneau
G. Lefebvre
M. Lefevre
Y. Lelonge
X. Leroy
M. Lesnik
X. Liem
C. Linassier
P. Maingon
C. Majoufre
O. Malard - RMeS - Regenerative Medicine and Skeleton
G. Malouf
C. Marchand
J.-P. Marie
T. Maurina
O. Mauvais - Centre Hospitalier Universitaire de Besançon
J.-C. Merol
J. Michel
G. Mineur
S. Mirafzal
H. Mirghani
A. Modesto
S. Molinier-Blossier
E. de Monès - Laboratory for the Bioengineering of Tissues
S. Morinière - Centre Hospitalier Universitaire de Tours
F. Mouawad - Miniaturisation pour la Synthèse, l'Analyse et la Protéomique
A. Moya-Plana
L. Muller
E. Musat
F. Nguyen
G. Noel
F.R. Obongo-Anga
M. Onea
H. Orliac
C. Page
V. Patron
J. Pestre
N. Pham Dang
P. Philouze - Hospices Civils de Lyon
G. Poissonnet - Centre Hospitalier Universitaire de Nice
C. Pons
C. Pouliquen
J.-M. Prades
A. Prevost
C. Queiros
A. Rahmani
A. Rambeau
L. Ramin
S. Renard
C.A. Righini - Centre Hospitalier Universitaire de Grenoble
F. Rolland
E. Saada
F. Sacino
S. Salas
N. Saroul - Centre Hospitalier Universitaire de Clermont-Ferrand
P. Schultz - Hôpitaux Universitaires de Strasbourg
A. Simonaggio
O. Sterkers
V. Strunski
A. Sudaka
S. Xu-Shan
R. Taouachi
M. Tassart
S. Testelin - Centre Hospitalier Universitaire Amiens-Picardie
J. Thariat
M. Timar David
A. Timochenko
B. Toussaint
E. Uro Coste
G. Valette
T. van den Abbeele
A. Varoquaux
E. Vauleon
S. Vergez - Centre Hospitalier Universitaire de Toulouse
B. Verillaud
J. Villa
A. Villepelet
M. Volondat
N. Vulquin
I. Wagner
M. Wassef
L. Webert
S. Wong
Publication Details: EJSO - European Journal of Surgical Oncology
Identifiers: 9934185609311
Academic Unit: Laboratoire d'Informatique de Robotique et de Microélectronique de Mtp - LIRMM
Language: English
Resource Type: Journal article
Local Fields: hal-04732053