Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer

Jane Bayani; Miltiadis Paliouras; Chris Planque; Shannon J. C. Shan; Cassandra Graham; Jeremy A. Squire; Eleftherios P. Diamandis

doi:10.1016/j.molonc.2008.07.001

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Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer

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Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer

Jane Bayani, Miltiadis Paliouras, Chris Planque, Shannon J. C. Shan, Cassandra Graham, Jeremy A. Squire et Eleftherios P. Diamandis

Molecular oncology, Vol.2(3), pp.250-260

10/2008

DOI: https://doi.org/10.1016/j.molonc.2008.07.001

PMID: 19383346

Résumé

Life Sciences & Biomedicine

Oncology

Science & Technology

The tissue kallikrein (KLK) genes are a new source for biomarkers in ovarian cancer. However, there has been no systematic analysis of copy number and structural rearrangements related to their protein expression. Chromosomal rearrangements and copy number changes of the KLK region were studied by FISH with protein levels measured by ELISA. Ovarian cancer and cell lines revealed the KLK region was subject to copy number imbalances or involved in unbalanced translocations and were associated with increased protein expression of KLKs 5, 6, 7, 8, 9, 10 and 11. in this initial study, we introduce the potential for long-range chromosomal effects and copy number as a mechanism for the previously reported aberrant expression of many KLK genes in ovarian cancers. (C) 2008 Federation of European Biochemical Societies Published by Elsevier B.V. All rights reserved

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Détails

Titre: Impact of cytogenetic and genomic aberrations of the kallikrein locus in ovarian cancer
Créateurs - sans rôle: Jane Bayani - Univ Hlth Network, Princess Margaret Hosp, Ontario Canc Inst, Dept Appl Mol Oncol, Toronto, ON M5G 2M9, Canada
Miltiadis Paliouras - Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5T 3L9, Canada
Chris Planque - Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5T 3L9, Canada
Shannon J. C. Shan - Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA
Cassandra Graham - Univ Hlth Network, Princess Margaret Hosp, Ontario Canc Inst, Dept Appl Mol Oncol, Toronto, ON M5G 2M9, Canada
Jeremy A. Squire - Queens Univ, Richardson Lab, Dept Pathol & Mol Med, Kingston, ON K7L 3N6, Canada
Eleftherios P. Diamandis - Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5T 3L9, Canada
Détails de publication: Molecular oncology, Vol.2(3), pp.250-260
Éditeur: Wiley
Nombre de pages: 11
Note de subvention: Ontario Ministry of Research and Innovation; Ministere de la Recherche et de l'Innovation (MRI) Ontario Cancer Biomarker Network Ontario Institute for Cancer Research
Identifiants: 99162823209311
Unité académique: Institut de Recherche en Cancérologie de Montpellier - IRCM
Langue: English
Type de ressource: Journal article