Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society

C. Lebrun; S. Vukusic; V. Abadie; C. Achour; F. Ader; H. Alchaar; A. Alkhedr; F. Andreux; G. Androdias; R. Arjmand; Bertrand Audoin; D. Audry; D. Aufauvre; C. Autreaux; X. Ayrignac; M. Bailbe; M. Benazet; C. Bensa; D. Bensmail; Eric Berger; P. Bernady; Y. Bertagna; D. Biotti; A. Blanchard-Dauphin; Jérémie Bonenfant; M. Bonnan; B. Bonnemain; F. Borgel; E. Botelho-Nevers; S. Boucly; Bertrand Bourre; C. Boutière; P. Branger; D. Brassat; S. Bresch; V. Breuil; Bruno Brochet; H. Brugeilles; P. Bugnon; Philippe Cabre; Jean-Philippe Camdessanché; C. Carra-Dalière; Olivier Casez; J.-M. Chamouard; B. Chassande; P. Chataignier; M. Chbicheb; A. Chenet; Jonathan Ciron; Pierre Clavelou; M. Cohen; R. Colamarino; N. Collongues; I. Coman; P.-R. Corail; S. Courtois; M. Coustans; Alain Créange; E. Creisson; N. Daluzeau; C. Davenas; J. de Seze; Marc Debouverie; R. Depaz; N. Derache; L. Divio; X. Douay; C. Dulau; F. Durand-Dubief; G. Edan; Z. Elias; O. Fagniez; M. Faucher; J.-M. Faucheux; M. Fournier; A. Gagneux-Brunon; P. Gaida; P. Galli; P. Gallien; J. Gaudelus; D. Gault; A. Gayou; M. Genevray; A. Gentil; J. Gere; L. Gignoux; M. Giroux; P. Givron; O. Gout; J. Grimaud; A.-M. Guennoc; N. Hadhoum; P. Hautecoeur; Olivier Heinzlef; M. Jaeger; S. Jeannin; L. Kremer; A. Kwiatkowski; Pierre Labauge; Céline Labeyrie; S. Lachaud; I. Laffont; C. Lanctin-Garcia; J. Lannoy; L. Lanotte; David A. Laplaud; D. Latombe; M. Lauxerois; Emmanuelle Le Page; Christine Lebrun-Frenay; P. Lejeune; P. Lejoyeux; B. Lemonnier; Emmanuelle Leray; C.-M. Loche; C. Louapre; Catherine Lubetzki; A. Maarouf; B. Mada; L. Magy; E. Maillart; E. Manchon; R. Marignier; P. Marque; G. Mathey; A. Maurousset; C. Mekies; M. Merienne; L. Michel; A.-M. Milor; X. Moisset; Alexis Montcuquet; Thibault Moreau; N. Morel; M. Moussa; J.-P. Naudillon; M. Normand; P. Olive; J.-C. Ouallet; Olivier Outteryck; C. Pacault; C. Papeix; Ivania Patry; D. Peaureaux; Jean Pelletier; B. Pichon; S. Pittion; E. Planque; M.-C. Pouget; V. Pourcher; C. Radot; I. Robert; F. Rocher; A. Ruet; C. Saint-Val; J.-Y. Salle; A. Salmon; E. Sartori; S. Schaeffer; B. Stankhof; F. Taithe; Eric Thouvenot; C. Tizon; Ayman Tourbah; P. Tourniaire; M. Vaillant; Patrick Vermersch; S. Vidil; A. Wahab; M.-H. Warter; S. Wiertlewski; B. Wiplosz; B. Wittwer; C. Zaenker; H. Zephir

doi:10.1016/j.neurol.2019.04.001

Back

Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society

Journal article

Peer reviewed

Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society

C. Lebrun, S. Vukusic, V. Abadie, C. Achour, F. Ader, H. Alchaar, A. Alkhedr, F. Andreux, G. Androdias, R. Arjmand, …

Revue Neurologique, Vol.175(6), pp.341-357

06/2019

DOI: https://doi.org/10.1016/j.neurol.2019.04.001

PMID: 31036391

Abstract

Prevention

Multiple sclerosis

Immunization

Infection

Vaccine

Objectives: To establish recommendations on immunization for patients with multiple sclerosis (MS).Background: Vaccines have been suspected in the past to trigger MS and relapses. With the extension of the immunoactive treatment arsenal, other concerns have been raised more recently about an increased risk of infection or a decreased effectiveness of immunization in immunosuppressed patients.Methods: The French Group for Recommendations into Multiple Sclerosis (France4MS) performed a systematic search of papers in Medline and other university databases (January 1975-June 2018). The RAND/UCLA appropriateness method was chosen to review the scientific literature and to formalize the degree of agreement among experts on 5 clinical questions related to immunization and MS. Readers from the steering committee conducted a systematic analysis, wrote a critical synthesis and prepared a list of proposals that were evaluated by a rating group of 28 MS experts. The final version of the recommendations was finally reviewed by a reading group of 110 health care professionals and classified as appropriate, inappropriate or uncertain.Results: Neurologists should verify the vaccination status as soon as MS is diagnosed and before disease-modifying treatments (DMTs) are introduced. The French vaccination schedule applies to MS patients and seasonal influenza vaccination is recommended. In the case of treatment-induced immunosuppression, MS patients should be informed about the risk of infection and the vaccination standards of the French High Council of Health should be applied. Live attenuated vaccines are contra-indicated in patients recently treated with immunosuppressive drugs, including corticosteroids; other vaccines can be proposed whatever the treatment, but their effectiveness may be partly reduced with some drugs.Conclusion: Physicians and patients should be aware of the updated recommendations for immunizations of patients with MS.

Files and links (1)

url

Find in HALView

Metrics

2 Record Views

See more details

Details

Title: Immunization and multiple sclerosis: Recommendations from the French Multiple Sclerosis Society
Creators - without role: C. Lebrun - Université Côte d'Azur
S. Vukusic - Hôpital Lyon Sud
V. Abadie
C. Achour
F. Ader - Hospices Civils de Lyon
H. Alchaar
A. Alkhedr
F. Andreux - Biogéosciences
G. Androdias
R. Arjmand
Bertrand Audoin - Centre de Résonance Magnétique Biologique et Médicale
D. Audry
D. Aufauvre
C. Autreaux
X. Ayrignac - Centre Hospitalier Universitaire de Montpellier
M. Bailbe
M. Benazet
C. Bensa
D. Bensmail
Eric Berger
P. Bernady
Y. Bertagna
D. Biotti
A. Blanchard-Dauphin
Jérémie Bonenfant - Hôpital Pontchaillou
M. Bonnan
B. Bonnemain
F. Borgel
E. Botelho-Nevers - Centre Hospitalier Universitaire de Saint-Étienne
S. Boucly
Bertrand Bourre
C. Boutière - Hôpital de la Timone
P. Branger
D. Brassat - Centre de Résonance Magnétique Biologique et Médicale
S. Bresch - Centre Val de Loire
V. Breuil - Génétique, physiopathologie et ingénierie du tissu osseux
Bruno Brochet - Centre de Résonance Magnétique Biologique et Médicale
H. Brugeilles
P. Bugnon
Philippe Cabre
Jean-Philippe Camdessanché
C. Carra-Dalière
Olivier Casez
J.-M. Chamouard
B. Chassande
P. Chataignier
M. Chbicheb
A. Chenet - Service d'Etudes du Comportement des Matériaux de Conditionnement
Jonathan Ciron
Pierre Clavelou - Centre de Résonance Magnétique Biologique et Médicale
M. Cohen
R. Colamarino
N. Collongues - Centre de Résonance Magnétique Biologique et Médicale
I. Coman
P.-R. Corail
S. Courtois
M. Coustans - Service de Neurologie [Rennes] = Neurology [Rennes]
Alain Créange - Excitabilité Nerveuse et Thérapeutique
E. Creisson
N. Daluzeau
C. Davenas
J. de Seze - Centre de Résonance Magnétique Biologique et Médicale
Marc Debouverie - Maladies chroniques, santé perçue, et processus d'adaptation
R. Depaz
N. Derache
L. Divio
X. Douay
C. Dulau
F. Durand-Dubief - Chimie et Biologie des Membranes et des Nanoobjects
G. Edan - Service de Neurologie [Rennes] = Neurology [Rennes]
Z. Elias
O. Fagniez
M. Faucher
J.-M. Faucheux
M. Fournier - Combustion Research Facility
A. Gagneux-Brunon - Centre Hospitalier Universitaire de Saint-Étienne
P. Gaida
P. Galli
P. Gallien
J. Gaudelus - Hôpital Jean-Verdier
D. Gault - Kuriwa Observatory
A. Gayou
M. Genevray
A. Gentil
J. Gere
L. Gignoux
M. Giroux
P. Givron
O. Gout - Fondation Ophtalmologique Adolphe de Rothschild
J. Grimaud
A.-M. Guennoc
N. Hadhoum
P. Hautecoeur
Olivier Heinzlef
M. Jaeger
S. Jeannin
L. Kremer - Institut de Biologie et de Chimie des Protéines
A. Kwiatkowski
Pierre Labauge - Centre de Résonance Magnétique Biologique et Médicale
Céline Labeyrie
S. Lachaud
I. Laffont - Université de Montpellier, EuroMov Digital Health in Motion - EuroMov DHM
C. Lanctin-Garcia
J. Lannoy
L. Lanotte
David A. Laplaud - Center for Research in Transplantation and Translational Immunology
D. Latombe
M. Lauxerois
Emmanuelle Le Page - Hôpital Pontchaillou
Christine Lebrun-Frenay - Observatoire de la Côte d’Azur
P. Lejeune
P. Lejoyeux
B. Lemonnier
Emmanuelle Leray - École des Hautes Études en Santé Publique
C.-M. Loche
C. Louapre - Institut du Cerveau
Catherine Lubetzki - Biologie des Interactions Neurones / Glie
A. Maarouf - Centre de Résonance Magnétique Biologique et Médicale
B. Mada
L. Magy - Centre de Résonance Magnétique Biologique et Médicale
E. Maillart - Pitié-Salpêtrière Hospital
E. Manchon
R. Marignier - Centre de Recherche en Neurosciences de Lyon
P. Marque
G. Mathey - Maladies chroniques, santé perçue, et processus d'adaptation
A. Maurousset
C. Mekies
M. Merienne - Institut de Biologie et de Chimie des Protéines
L. Michel
A.-M. Milor
X. Moisset - Centre Hospitalier Universitaire de Clermont-Ferrand
Alexis Montcuquet
Thibault Moreau
N. Morel
M. Moussa
J.-P. Naudillon
M. Normand
P. Olive
J.-C. Ouallet
Olivier Outteryck
C. Pacault
C. Papeix - Sorbonne Université
Ivania Patry - Centre Hospitalier Universitaire de Besançon
D. Peaureaux
Jean Pelletier - Automation and Process Engineering Laboratory
B. Pichon - Université de Lorraine
S. Pittion
E. Planque
M.-C. Pouget
V. Pourcher - Sorbonne Université
C. Radot
I. Robert
F. Rocher
A. Ruet - Swiss National Science Foundation
C. Saint-Val
J.-Y. Salle
A. Salmon
E. Sartori
S. Schaeffer
B. Stankhof
F. Taithe - Centre Hospitalier Universitaire de Clermont-Ferrand
Eric Thouvenot - Centre de Résonance Magnétique Biologique et Médicale
C. Tizon
Ayman Tourbah - Centre Hospitalier Universitaire de Reims
P. Tourniaire
M. Vaillant - Center for Clinical Studies
Patrick Vermersch - Centre de Résonance Magnétique Biologique et Médicale
S. Vidil
A. Wahab
M.-H. Warter
S. Wiertlewski - Service de neurologie [Nantes]
B. Wiplosz
B. Wittwer
C. Zaenker
H. Zephir - Centre de Résonance Magnétique Biologique et Médicale
Publication Details: Revue Neurologique, Vol.175(6), pp.341-357
Grant note: Hospices Civils de Lyon
Identifiers: 9936917609311
Academic Unit: EuroMov Digital Health in Motion - EuroMov DHM
Language: English
Resource Type: Journal article
Local Fields: hal-02546158