Identification of p-Aminobenzylamine Derivatives as Dual Non-Covalent Inhibitors of the Transmembrane Host Proteases TMPRSS2 and HAT Proteases with Anti-viral Potential

Hélène Carvaillo; Ashok Dussol; Nancy Chaaya; Sara Kadri; Feryel Soualmia; Nicolas Masurier; Chahrazade El Amri

doi:10.1039/D5MD00680E

Retour

Identification of p-Aminobenzylamine Derivatives as Dual Non-Covalent Inhibitors of the Transmembrane Host Proteases TMPRSS2 and HAT Proteases with Anti-viral Potential

Article de revue

Open Access

Avec comité de lecture

Identification of p-Aminobenzylamine Derivatives as Dual Non-Covalent Inhibitors of the Transmembrane Host Proteases TMPRSS2 and HAT Proteases with Anti-viral Potential

Hélène Carvaillo, Ashok Dussol, Nancy Chaaya, Sara Kadri, Feryel Soualmia, Nicolas Masurier et Chahrazade El Amri

RSC Medicinal Chemistry

2025

DOI: https://doi.org/10.1039/D5MD00680E

Résumé

TMPRSS2 and HAT (or TMPRSS11D) are host serine proteases critically involved in the entry of several respiratory viruses, including SARS-CoV-2. To our knowledge, no dual inhibitors targeting both enzymes have...

Fichiers et liens (2)

url

Find in HALAfficher

url

https://doi.org/10.1039/D5MD00680EAfficher

Published (Version of record) Ouvrir

Indicateurs

1 Consultations de la notice

Détails

Titre: Identification of p-Aminobenzylamine Derivatives as Dual Non-Covalent Inhibitors of the Transmembrane Host Proteases TMPRSS2 and HAT Proteases with Anti-viral Potential
Créateurs - sans rôle: Hélène Carvaillo - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Ashok Dussol - Institut de Biologie Paris-Seine
Nancy Chaaya - Institut de Biologie Paris-Seine
Sara Kadri
Feryel Soualmia - Sorbonne Université
Nicolas Masurier - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Chahrazade El Amri - Institut de Biologie Paris-Seine
Détails de publication: RSC Medicinal Chemistry
Identifiants: 99152822009311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-05348252