Identification of common variants associated with human hippocampal and intracranial volumes

Jason J Stein; Sarah Medland; Alejandro Arias Vasquez; Derrek D Hibar; Rudy E Senstad; Anderson M Winkler; Roberto Toro; Katja Appel; Richard Bartecek; Ørjan Bergmann; Manon Bernard; Andrew A Brown; Dara D Cannon; M Mallar Chakravarty; Andrea Christoforou; Martin Domin; Oliver Grimm; Marisa Hollinshead; Avram J Holmes; Georg Homuth; Jouke-Jan Hottenga; Camilla Langan; Lorna Lopez; Narelle Hansell; Kristy S Hwang; Sungeun Kim; Gonzalo Laje; Phil Lee; Xinmin Liu; Eva Loth; Anbarasu Lourdusamy; Morten Mattingsdal; Sebastian Mohnke; Susana Muñoz Maniega; Kwangsik Nho; Allison C Nugent; Carol O'Brien; Martina Papmeyer; Benno Pütz; Adaikalavan Ramasamy; Jerod Rasmussen; Mark Rijpkema; Shannon L Risacher; J Cooper Cooper Roddey; Emma Rose; Mina Ryten; Li Shen; Emma Sprooten; Eric Strengman; Alexander Teumer; Daniah Trabzuni; Jessica Turner; Kristel van Eijk; Theo M van Erp; Marie-Jose van Tol; Katharina Wittfeld; Christiane Wolf; Saskia Woudstra; Andre Aleman; Saud Alhusaini; Laura Almasy; Elisabeth Binder; David G Brohawn; Rita Cantor; Melanie A Carless; Aiden Corvin; Michael Czisch; Joanne E Curran; Gail Davies; Marcio a A de Almeida; Norman Delanty; Chantal Depondt; Ravi Duggirala; Thomas Dyer; Susanne Erk; Jesen Fagerness; Peter Fox; Nelson B. Freimer; Michael Gill; Harald H H Göring; Donald J Hagler; David Hoehn; Florian Holsboer; Martine Hoogman; Norbert Hosten; Neda M Jahanshad; Matthew Johnson; Dalia Kasperaviciute; Jack Kent; Peter M Kochunov; Jack L Lancaster; Stephen M Lawrie; David C Liewald; René Mandl; Mar Matarin; Manuel Mattheisen; Eva Meisenzahl; Ingrid Melle; Eric K Moses; Thomas W. Mühleisen; Matthias Nauck; Markus M. Nöthen; Rene L Olvera; Massimo Pandolfo; G Bruce Pike; Ralf Puls; Ivar Reinvang; Miguel E Rentería; Marcella Rietschel; Joshua L Roffman; Natalie A Royle; Dan Rujescu; Jonathan Savitz; Hugo G Schnack; Knut Schnell; Nina Seiferth; Colin Smith; Vidar Steen; Maria C Valdés Hernández; Martijn D van den Heuvel; Nic J van Der Wee; Neeltje E M van Haren; Joris A Veltman; Henry Völzke; Robert Walker; Lars Westlye; Christopher D Whelan; Ingrid Agartz; Dorret Boomsma; Gianpiero L Cavalleri; Anders J Dale; Srdjan Djurovic; Wayne Drevets; Peter Hagoort; Jérémy Hall; Andreas Heinz; Clifford R Jack; Tatiana Foroud; Stephanie Le Hellard; Fabio Macciardi; Grant W. Montgomery; Jean Baptiste Poline; David Porteous; Sanjay Sisodiya; John M Starr; Jessika Sussmann; Arthur W. Toga; Dick J Veltman; Henrik Walter; Michael Weiner; Joshua Bis; M Arfan Ikram; Vilmundur Gudnason; Christophe Tzourio; Meike Vernooij; Lenore J Launer; Charles Decarli; Sudha Seshadri; Ole A. Andreassen; Liana G Apostolova; Mark Bastin; John Blangero; Han G. Brunner; Randy L Buckner; Sven Cichon; Giovanni Coppola; Greig G de Zubicaray; Ian Deary; Gary Donohoe; Eco de Geus; Thomas Espeseth; Guillén Fernández; David D Glahn; Hans J Grabe; John Hardy; Derek Morris; Hilleke D Hulshoff Pol; Mark Jenkinson; Rene Kahn; Bertram Müller-Myhsok; Albert V. Smith; Colm Mcdonald; Andrew Mcintosh; Francis J. Mcmahon; Katie M Mcmahon; Andreas Meyer-Lindenberg; Thomas E Nichols; Roel A. Ophoff; Tomas Paus; Zdenka Pausova; Brenda Penninx; Steven G Potkin; Philipp G Sämann; Andrew Saykin; Gunter Schumann; Jordan W. Smoller; Joanna Wardlaw; Michael E Weale; Nicholas G Martin; Barbara Franke; Margaret Wright; Paul M. Thompson

doi:10.1038/ng.2250

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Identification of common variants associated with human hippocampal and intracranial volumes

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Identification of common variants associated with human hippocampal and intracranial volumes

Jason J Stein, Sarah Medland, Alejandro Arias Vasquez, Derrek D Hibar, Rudy E Senstad, Anderson M Winkler, Roberto Toro, Katja Appel, Richard Bartecek, Ørjan Bergmann, …

Nature Genetics, Vol.44(5), pp.552-561

15/04/2012

DOI: https://doi.org/10.1038/ng.2250

PMCID: PMC3635491

PMID: 22504417

Résumé

Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10(-7)).

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Détails

Titre: Identification of common variants associated with human hippocampal and intracranial volumes
Créateurs - sans rôle: Jason J Stein - David Geffen School of Medicine [Los Angeles]
Sarah Medland - QIMR Berghofer Medical Research Institute
Alejandro Arias Vasquez - Radboud University Nijmegen
Derrek D Hibar - David Geffen School of Medicine [Los Angeles]
Rudy E Senstad - Radboud University Nijmegen
Anderson M Winkler - Hartford Hospital
Roberto Toro - Institut Pasteur
Katja Appel - Yale University
Richard Bartecek - Gènes, synapses et cognition
Ørjan Bergmann - Heidelberg University
Manon Bernard - Hospital for Sick Children
Andrew A Brown - University of Oslo
Dara D Cannon - National University of Ireland
M Mallar Chakravarty - University of Oslo
Andrea Christoforou - Ollscoil na Gaillimhe – University of Galway
Martin Domin - Universität Greifswald
Oliver Grimm - University of Bergen
Marisa Hollinshead - Universitätsmedizin Greifswald
Avram J Holmes - Harvard University
Georg Homuth - Howard Hughes Medical Institute
Jouke-Jan Hottenga - Vrije Universiteit Amsterdam
Camilla Langan - Universität Greifswald
Lorna Lopez - University of Edinburgh
Narelle Hansell - Ollscoil na Gaillimhe – University of Galway
Kristy S Hwang - University of Edinburgh
Sungeun Kim - QIMR Berghofer Medical Research Institute
Gonzalo Laje - United States Department of Health and Human Services
Phil Lee - Indiana University School of Medicine
Xinmin Liu - National Institute of Mental Health
Eva Loth - Medical Research Council
Anbarasu Lourdusamy - United States Department of Health and Human Services
Morten Mattingsdal - King's College London
Sebastian Mohnke - King's College London
Susana Muñoz Maniega - Sørlandet Sykehus
Kwangsik Nho - Indiana University School of Medicine
Allison C Nugent - University of Edinburgh
Carol O'Brien
Martina Papmeyer - Royal Edinburgh Hospital
Benno Pütz - Max Planck Institute of Psychiatry
Adaikalavan Ramasamy - King's College London
Jerod Rasmussen - Max Planck Institute of Psychiatry
Mark Rijpkema - Radboud University Nijmegen
Shannon L Risacher - Indiana University – Purdue University Indianapolis
J Cooper Cooper Roddey
Emma Rose - Trinity College Dublin
Mina Ryten - University Medical Center Utrecht
Li Shen - Trinity College Dublin
Emma Sprooten - Royal Edinburgh Hospital
Eric Strengman - University Medical Center Utrecht
Alexander Teumer - University of Edinburgh
Daniah Trabzuni - University Medical Center Utrecht
Jessica Turner - Universität Greifswald
Kristel van Eijk - University College London
Theo M van Erp - Department of Psychiatry and Human Behavior [Irvine]
Marie-Jose van Tol - Leiden University Medical Center
Katharina Wittfeld - Universität Greifswald
Christiane Wolf - Leiden University Medical Center
Saskia Woudstra - Universität Greifswald
Andre Aleman - University Medical Center Groningen
Saud Alhusaini - Royal College of Surgeons in Ireland
Laura Almasy - Texas Biomedical Research Institute
Elisabeth Binder - Royal College of Surgeons in Ireland
David G Brohawn - Massachusetts General Hospital
Rita Cantor - University of California, Los Angeles
Melanie A Carless - Texas Biomedical Research Institute
Aiden Corvin - Trinity College Dublin
Michael Czisch - Max Planck Institute of Psychiatry
Joanne E Curran - Texas Biomedical Research Institute
Gail Davies - Max Planck Institute of Psychiatry
Marcio a A de Almeida
Norman Delanty - University of Edinburgh
Chantal Depondt - Texas Biomedical Research Institute
Ravi Duggirala - Royal College of Surgeons in Ireland
Thomas Dyer - Université Libre de Bruxelles
Susanne Erk - Texas Biomedical Research Institute
Jesen Fagerness - Massachusetts General Hospital
Peter Fox - The University of Texas Health Science Center at San Antonio
Nelson B. Freimer - University of California, Los Angeles
Michael Gill - Trinity College Dublin
Harald H H Göring - Texas Biomedical Research Institute
Donald J Hagler - Trinity College Dublin
David Hoehn - Max Planck Institute of Psychiatry
Florian Holsboer
Martine Hoogman - Radboud University Nijmegen
Norbert Hosten - Universität Greifswald
Neda M Jahanshad - Radboud University Nijmegen
Matthew Johnson - Universitätsmedizin Greifswald
Dalia Kasperaviciute - University of California, Los Angeles
Jack Kent - Texas Biomedical Research Institute
Peter M Kochunov - The University of Texas Health Science Center at San Antonio
Jack L Lancaster - Texas Biomedical Research Institute
Stephen M Lawrie - The University of Texas Health Science Center at San Antonio
David C Liewald - University of Edinburgh
René Mandl - University Medical Center [Utrecht]
Mar Matarin - University College London
Manuel Mattheisen - University Medical Center Utrecht
Eva Meisenzahl - University College London
Ingrid Melle - University of Oslo
Eric K Moses - Texas Biomedical Research Institute
Thomas W. Mühleisen - Life & Brain
Matthias Nauck
Markus M. Nöthen
Rene L Olvera
Massimo Pandolfo
G Bruce Pike
Ralf Puls - Universität Greifswald
Ivar Reinvang
Miguel E Rentería - QIMR Berghofer Medical Research Institute
Marcella Rietschel - Universität Heidelberg [Heidelberg] = Heidelberg University
Joshua L Roffman
Natalie A Royle - University of Edinburgh
Dan Rujescu
Jonathan Savitz
Hugo G Schnack - University Medical Center [Utrecht]
Knut Schnell
Nina Seiferth
Colin Smith - Laboratoire des Symbioses Tropicales et Méditerranéennes
Vidar Steen - University of Bergen
Maria C Valdés Hernández - University of Edinburgh
Martijn D van den Heuvel - University Medical Center [Utrecht]
Nic J van Der Wee
Neeltje E M van Haren - University Medical Center [Utrecht]
Joris A Veltman - Radboud University Medical Center
Henry Völzke
Robert Walker
Lars Westlye
Christopher D Whelan
Ingrid Agartz - University of Oslo
Dorret Boomsma - Vrije Universiteit Amsterdam
Gianpiero L Cavalleri
Anders J Dale
Srdjan Djurovic - University of Oslo
Wayne Drevets
Peter Hagoort - Radboud University Medical Center
Jérémy Hall
Andreas Heinz - Charité - Universitätsmedizin Berlin
Clifford R Jack
Tatiana Foroud
Stephanie Le Hellard - University of Bergen
Fabio Macciardi - University of California [Irvine]
Grant W. Montgomery - QIMR Berghofer Medical Research Institute
Jean Baptiste Poline
David Porteous - University of Edinburgh
Sanjay Sisodiya - UCL Queen Square Institute of Neurology
John M Starr - University of Edinburgh
Jessika Sussmann
Arthur W. Toga - David Geffen School of Medicine [Los Angeles]
Dick J Veltman
Henrik Walter
Michael Weiner - University of California [San Francisco]
Joshua Bis - Department of Medicine
M Arfan Ikram - Erasmus MC
Vilmundur Gudnason
Christophe Tzourio
Meike Vernooij - QIMR Berghofer Medical Research Institute
Lenore J Launer
Charles Decarli
Sudha Seshadri
Ole A. Andreassen - University of Oslo
Liana G Apostolova - David Geffen School of Medicine [Los Angeles]
Mark Bastin - University of Edinburgh
John Blangero
Han G. Brunner - Radboud University Medical Center
Randy L Buckner - Harvard University
Sven Cichon
Giovanni Coppola - Studi
Greig G de Zubicaray - School of Psychology, University of Queensland
Ian Deary - University of Edinburgh
Gary Donohoe
Eco de Geus - Vrije Universiteit Amsterdam
Thomas Espeseth - University of Oslo
Guillén Fernández - Radboud University Medical Center
David D Glahn - Hartford Hospital
Hans J Grabe - Universität Greifswald
John Hardy - Lancaster University
Derek Morris
Hilleke D Hulshoff Pol - University Medical Center [Utrecht]
Mark Jenkinson
Rene Kahn - University Medical Center [Utrecht]
Bertram Müller-Myhsok
Albert V. Smith - University of Iceland
Colm Mcdonald - National University of Ireland
Andrew Mcintosh
Francis J. Mcmahon
Katie M Mcmahon - Centre for Advanced Imaging
Andreas Meyer-Lindenberg - Universität Heidelberg [Heidelberg] = Heidelberg University
Thomas E Nichols
Roel A. Ophoff - University Medical Center [Utrecht]
Tomas Paus - McConnell Brain Imaging Centre
Zdenka Pausova - University of Toronto
Brenda Penninx
Steven G Potkin
Philipp G Sämann
Andrew Saykin - David Geffen School of Medicine [Los Angeles]
Gunter Schumann - King's College London
Jordan W. Smoller - Stanley Center for Psychiatric Research
Joanna Wardlaw - University of Edinburgh
Michael E Weale
Nicholas G Martin - QIMR Berghofer Medical Research Institute
Barbara Franke - Radboud University Medical Center
Margaret Wright - QIMR Berghofer Medical Research Institute
Paul M. Thompson - David Geffen School of Medicine [Los Angeles]
Détails de publication: Nature Genetics, Vol.44(5), pp.552-561
Identifiants: 99161757409311
Unité académique: Université de Montpellier
Langue: English
Type de ressource: Journal article
Champs locaux: pasteur-01967151