ISG20, an actor of the innate immune response.

Genevieve Degols; Patrick Eldin; Nadir Mechti

doi:10.1016/j.biochi.2007.03.006

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ISG20, an actor of the innate immune response.

Journal article

Peer reviewed

ISG20, an actor of the innate immune response.

Genevieve Degols, Patrick Eldin and Nadir Mechti

Biochimie, Vol.89(6-7), pp.831-5

2007

DOI: https://doi.org/10.1016/j.biochi.2007.03.006

PMID: 17445960

Abstract

Amino Acid Sequence

Animals

RNA Viruses

RNA, Small Interfering

Toll-Like Receptors

Cell Line

Exonucleases

Humans

Immunity, Natural

Inflammation

Interferons

Models, Biological

Molecular Sequence Data

The interferon (IFN) system is a major effector of the innate immunity that allows time for the subsequent establishment of an adaptive immune response against wide-range pathogens. The effectiveness of IFN to control initial infection requires the cooperation between several pathways induced in the target cells. Recent studies that highlight the implication of the 3'-5' exonuclease ISG20 (IFN Stimulated Gene product of 20 kDa) in the host's defenses against pathogens are summarised in this review.

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Title: ISG20, an actor of the innate immune response.
Creators - without role: Genevieve Degols - Université de Montpellier, Institut de Recherche en Infectiologie de Montpellier - IRIM
Patrick Eldin - Université de Montpellier, Institut de Recherche en Infectiologie de Montpellier - IRIM
Nadir Mechti - Université de Montpellier, Institut de Recherche en Infectiologie de Montpellier - IRIM
Publication Details: Biochimie, Vol.89(6-7), pp.831-5
Identifiers: 9944081709311
Academic Unit: Institut de Recherche en Infectiologie de Montpellier - IRIM
Language: English
Resource Type: Journal article
Local Fields: hal-00257627