Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors

Anna Di Fiore; Alessandro Vergara; Marco Caterino; Vincenzo Alterio; Simona Maria Monti; Joanna Ombouma; Pascal Dumy; Daniela Vullo; Claudiu Supuran; Jean-Yves Winum; Giuseppina de Simone

doi:10.1039/C5CC03711E

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Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors

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Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors

Anna Di Fiore, Alessandro Vergara, Marco Caterino, Vincenzo Alterio, Simona Maria Monti, Joanna Ombouma, Pascal Dumy, Daniela Vullo, Claudiu Supuran, Jean-Yves Winum, …

Chemical Communications, Vol.51(57), pp.11519-11522

2015

DOI: https://doi.org/10.1039/C5CC03711E

Résumé

Hydroxylamine-O-sulfonamide, a molecule incorporating two zinc-binding groups (ZBGs), has been investigated as a carbonic anhydraseinhibitor (CAI) by means of kinetic, crystallographic and Ramanspectroscopy studies, highlighting interesting results on its mecha-nism of action. These data can be exploited to design new, effectiveand selective CAIs.

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Titre: Hydroxylamine-O-sulfonamide is a versatile lead compound for the development of carbonic anhydrase inhibitors
Créateurs - sans rôle: Anna Di Fiore - Institute of Biostructure and Bioimaging
Alessandro Vergara - Institute of Biostructure and Bioimaging
Marco Caterino - Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
Vincenzo Alterio - Institute of Biostructure and Bioimaging
Simona Maria Monti - Institute of Biostructure and Bioimaging
Joanna Ombouma - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Pascal Dumy - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Daniela Vullo - Florence (Netherlands)
Claudiu Supuran - Polo d’Innovazione di Genomica
Jean-Yves Winum - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Giuseppina de Simone - Institute of Biostructure and Bioimaging
Détails de publication: Chemical Communications, Vol.51(57), pp.11519-11522
Note de subvention: This work was supported by a grant by CNR-DSB. Progetto Bandiera “InterOmics”. AV acknowledges “POR BIP (Bioindustrial Processes)” for a research grant.
Identifiants: 99152253909311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-03546192