Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial

Karim Asehnoune; Philippe Seguin; Jeremy Allary; Fanny Feuillet; Sigismond Lasocki; Fabrice Cook; Hervé Floch; Russell Chabanne; Thomas Geeraerts; Claire Roger; Pierre F. Perrigault; Jean L. Hanouz; Anne C. Lukaszewicz; Matthieu Biais; Perrine Boucheix; Claire Dahyot-Fizelier; Xavier Capdevila; Pierre J. Mahe; Pascale Le Maguet; Catherine Paugam-Burtz; Soizic Gergaud; Benoît Plaud; Jean M. Constantin; Yannick Mallédant; Laurent Flet; Véronique Sébille; Antoine Roquilly

doi:10.1016/S2213-2600(14)70144-4

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Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial

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Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial

Karim Asehnoune, Philippe Seguin, Jeremy Allary, Fanny Feuillet, Sigismond Lasocki, Fabrice Cook, Hervé Floch, Russell Chabanne, Thomas Geeraerts, Claire Roger, …

The Lancet Respiratory Medicine, Vol.2(9), pp.706--716

2014

DOI: https://doi.org/10.1016/S2213-2600(14)70144-4

PMID: 25066331

Abstract

Adolescent

Pneumonia

Adrenal Insufficiency

Adult

Aged

Anti-Inflammatory Agents

Non-Steroidal

Brain Injuries

Double-Blind Method

Female

Intensive Care Units

Humans

Middle Aged

Male

Intention to Treat Analysis

Hydrocortisone

Fludrocortisone

Ventilator-Associated

Young Adult

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Title: Hydrocortisone and fludrocortisone for prevention of hospital-acquired pneumonia in patients with severe traumatic brain injury (Corti-TC): a double-blind, multicentre phase 3, randomised placebo-controlled trial
Creators - without role: Karim Asehnoune - Centre Hospitalier Universitaire de Nantes
Philippe Seguin - Université de Rennes
Jeremy Allary - Hôpital Beaujon
Fanny Feuillet - Nantes Université
Sigismond Lasocki - Centre Hospitalier Universitaire d'Angers
Fabrice Cook - Assistance Publique – Hôpitaux de Paris
Hervé Floch - Centre Hospitalier Régional Universitaire de Brest
Russell Chabanne - Centre Hospitalier Universitaire de Clermont-Ferrand
Thomas Geeraerts - Université Toulouse III - Paul Sabatier
Claire Roger - Centre Hospitalier Universitaire de Nîmes
Pierre F. Perrigault - Hôpital Gui de Chauliac
Jean L. Hanouz
Anne C. Lukaszewicz - Assistance Publique – Hôpitaux de Paris
Matthieu Biais - Centre Hospitalier Universitaire de Bordeaux
Perrine Boucheix - Centre Hospitalier Universitaire de Grenoble
Claire Dahyot-Fizelier - Centre Hospitalier Universitaire de Poitiers
Xavier Capdevila - Université de Montpellier, Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Pierre J. Mahe - Centre Hospitalier Universitaire de Nantes
Pascale Le Maguet - Université de Rennes
Catherine Paugam-Burtz - Hôpital Beaujon
Soizic Gergaud - Centre Hospitalier Universitaire d'Angers
Benoît Plaud - Assistance Publique – Hôpitaux de Paris
Jean M. Constantin - Centre Hospitalier Universitaire de Clermont-Ferrand
Yannick Mallédant - Centre Hospitalier Universitaire de Rennes
Laurent Flet - Service de Pharmacie
Véronique Sébille - Zimmer Biomet
Antoine Roquilly - Centre Hospitalier Universitaire de Nantes
Publication Details: The Lancet Respiratory Medicine, Vol.2(9), pp.706--716
Identifiers: 9947795509311
Academic Unit: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp; Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE
Language: English
Resource Type: Journal article
Local Fields: hal-01220644