Human Plasmodium vivax diversity, population structure and evolutionary origin

Virginie Rougeron; Eric Elguero; Céline Arnathau; Beatriz Acuña Hidalgo; Durand Patrick; Sandrine Houzé; Antoine Berry; Sedigheh Zakeri; Rashidul Haque; Mohammad Shafiul Alam; François H Nosten; Carlo Severini; Tamirat Gebru Woldearegai; Benjamin Mordmüller; Peter Gottfried Kremsner; Lilia González-Cerón; Gustavo Fontecha; Dionicia Gamboa; Lise Musset; Eric Legrand; Oscar Noya; Tepanata Pumpaibool; Pingchai Harnyuttanakorn; Khadijetou Mint Lekweiry; Musab Mohamad Albsheer; Muzamil Mahdi Abdel Hamid; Ali Ould Mohamed Salem Boukary; Jean-Francois Trape; Francois Renaud; Franck Prugnolle

doi:10.1371/journal.pntd.0008072

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Human Plasmodium vivax diversity, population structure and evolutionary origin

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Human Plasmodium vivax diversity, population structure and evolutionary origin

Virginie Rougeron, Eric Elguero, Céline Arnathau, Beatriz Acuña Hidalgo, Durand Patrick, Sandrine Houzé, Antoine Berry, Sedigheh Zakeri, Rashidul Haque, Mohammad Shafiul Alam, …

PLoS Neglected Tropical Diseases, Vol.14(3)

09/03/2020

DOI: https://doi.org/10.1371/journal.pntd.0008072

PMCID: PMC7082039

PMID: 32150544

Abstract

Genetic Variation

Genotype

Genotyping Techniques

Global Health

Humans

Malaria, Vivax / parasitology

Plasmodium vivax / classification

Plasmodium vivax / genetics

Plasmodium vivax / isolation & purification

More than 200 million malaria clinical cases are reported each year due to Plasmodium vivax, the most widespread Plasmodium species in the world. This species has been neglected and understudied for a long time, due to its lower mortality in comparison with Plasmodium falciparum. A renewed interest has emerged in the past decade with the discovery of antimalarial drug resistance and of severe and even fatal human cases. Nonetheless, today there are still significant gaps in our understanding of the population genetics and evolutionary history of P. vivax, particularly because of a lack of genetic data from Africa. To address these gaps, we genotyped 14 microsatellite loci in 834 samples obtained from 28 locations in 20 countries from around the world. We discuss the worldwide population genetic structure and diversity and the evolutionary origin of P. vivax in the world and its introduction into the Americas. This study demonstrates the importance of conducting genome-wide analyses of P. vivax in order to unravel its complex evolutionary history.

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Title: Human Plasmodium vivax diversity, population structure and evolutionary origin
Creators - without role: Virginie Rougeron - Université de Montpellier
Eric Elguero - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Céline Arnathau - Université de Montpellier
Beatriz Acuña Hidalgo - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Durand Patrick - Health, Emergence, Adaptation and Transmission
Sandrine Houzé - Hôpital Bichat-Claude-Bernard
Antoine Berry - Centre de Physiopathologie de Toulouse-Purpan
Sedigheh Zakeri - Pasteur Institute of Iran
Rashidul Haque - International Centre for Diarrhoeal Disease Research
Mohammad Shafiul Alam - International Centre for Diarrhoeal Disease Research
François H Nosten - Mahidol Oxford Tropical Medicine Research Unit
Carlo Severini - Istituto Superiore di Sanità
Tamirat Gebru Woldearegai - Institute for Tropical Medicine = Institut für Tropenmedizin, Reisemedizin, Humanparasitolgie [Tübingen, Allemagne]
Benjamin Mordmüller - University of Tübingen
Peter Gottfried Kremsner - University of Tübingen
Lilia González-Cerón - Centro Regional de Investigación en Salud Pública = Regional Centre of Research in Public Health [Tapachula, Mexique]
Gustavo Fontecha - National Autonomous University of Honduras
Dionicia Gamboa - Universidad Peruana Cayetano Heredia
Lise Musset - Institut Pasteur de la Guyane
Eric Legrand - Institut Pasteur
Oscar Noya - Ministerio del Poder Popular para la Educación Universitaria, Ciencia y Tecnología
Tepanata Pumpaibool - Chulalongkorn University
Pingchai Harnyuttanakorn - Chulalongkorn University
Khadijetou Mint Lekweiry - University of Nouakchott Al Aasriya
Musab Mohamad Albsheer - University of Khartoum
Muzamil Mahdi Abdel Hamid - University of Khartoum
Ali Ould Mohamed Salem Boukary - Aix-Marseille Université
Jean-Francois Trape - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Francois Renaud - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Franck Prugnolle - Université de Montpellier, Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Publication Details: PLoS Neglected Tropical Diseases, Vol.14(3)
Grant note: Authors thank the ANR Tremplin EVAD 2017, IRD and CNRS-INEE.
Identifiers: 9935678309311
Academic Unit: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Language: English
Resource Type: Journal article
Local Fields: pasteur-02567249