Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Jérémie Rosain; Anna-Lena Neehus; Jérémy Manry; Rui Yang; Jérémie Le Pen; Wassim Daher; Zhiyong Liu; Yi-Hao Chan; Natalia Tahuil; Özden Türel; Mathieu Bourgey; Masato Ogishi; Jean-Marc Doisne; Helena M Izquierdo; Takayoshi Shirasaki; Tom Le Voyer; Antoine Guérin; Paul Bastard; Marcela Moncada-Vélez; Ji Eun Han; Taushif Khan; Franck Rapaport; Seon-Hui Hong; Andrew Cheung; Kathrin Haake; Barbara C Mindt; Laura Pérez; Quentin Philippot; Danyel Lee; Peng Zhang; Darawan Rinchai; Fatima Al Ali; Manar Mahmoud Ahmad Ata; Mahbuba Rahman; Jessica N Peel; Søren Heissel; Henrik Molina; Yasemin Kendir-Demirkol; Rasheed Bailey; Shuxiang Zhao; Jonathan Bohlen; Mathieu Mancini; Yoann Seeleuthner; Marie Roelens; Lazaro Lorenzo; Camille Soudée; María Elvira Josefina Paz; María Laura González; Mohamed Jeljeli; Jean Soulier; Serge Romana; Anne-Sophie L’honneur; Marie Materna; Rubén Martínez-Barricarte; Mathieu Pochon; Carmen Oleaga-Quintas; Alexandre Michev; Mélanie Migaud; Romain Lévy; Marie-Alexandra Alyanakian; Flore Rozenberg; Carys A Croft; Guillaume Vogt; Jean-François Emile; Laurent Kremer; Cindy S Ma; Jörg H Fritz; Stanley M Lemon; András N Spaan; Nicolas Manel; Laurent Abel; Margaret R Macdonald; Stéphanie Boisson-Dupuis; Nico Marr; Stuart G Tangye; James P Di Santo; Qian Zhang; Shen-Ying Zhang; Charles M Rice; Vivien Béziat; Nico Lachmann; David Langlais; Jean-Laurent Casanova; Philippe Gros; Jacinta Bustamante

doi:10.1016/j.cell.2022.12.038

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Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Journal article

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Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

Jérémie Rosain, Anna-Lena Neehus, Jérémy Manry, Rui Yang, Jérémie Le Pen, Wassim Daher, Zhiyong Liu, Yi-Hao Chan, Natalia Tahuil, Özden Türel, …

Cell, Vol.186(3), pp.621 - 645.e33

02/2023

DOI: https://doi.org/10.1016/j.cell.2022.12.038

PMCID: PMC9907019

PMID: 36736301

Abstract

inborn errors of immunity

Mycobacterium

interferon-γ

interferon-stimulated gene

IRF1

viruses

macrophages

Highlights d Inherited complete human IRF1 deficiency underlies severe mycobacterial disease d Human IRF1 is essential for IFN-g-dependent macrophagic immunity to mycobacteria d Human IRF1 is essential for IFN-g-and STAT1-dependent immunity to mycobacteria d Human IRF1 is largely redundant for IFN-a/b-dependent antiviral intrinsic immunity Authors Je ´re ´mie Rosain,

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Title: Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
Creators - without role: Jérémie Rosain - Inserm
Anna-Lena Neehus - Medizinische Hochschule Hannover
Jérémy Manry - Université Paris Cité
Rui Yang - Rockefeller University
Jérémie Le Pen - Rockefeller University
Wassim Daher - Université de Montpellier, Institut de Recherche en Infectiologie de Montpellier - IRIM
Zhiyong Liu - Rockefeller University
Yi-Hao Chan - Yong Loo Lin School of Medicine [Singapore]
Natalia Tahuil - Hospital del Niño Jesus, San Miguel de Tucumán
Özden Türel - Bezmiâlem Vakıf Üniversitesi
Mathieu Bourgey - Ontario Genomics
Masato Ogishi - Rockefeller University
Jean-Marc Doisne - Immunité Innée - Innate Immunity
Helena M Izquierdo - Université Paris Sciences et Lettres
Takayoshi Shirasaki - University of North Carolina at Chapel Hill
Tom Le Voyer - Inserm
Antoine Guérin - Garvan Institute of Medical Research
Paul Bastard - Human Genetic of Infectious Diseases
Marcela Moncada-Vélez - Rockefeller University
Ji Eun Han - Rockefeller University
Taushif Khan - Sidra Medicine [Doha, Qatar]
Franck Rapaport - Rockefeller University
Seon-Hui Hong - Rockefeller University
Andrew Cheung - Rockefeller University
Kathrin Haake - Medizinische Hochschule Hannover
Barbara C Mindt - McGill University
Laura Pérez - Garrahan Hospital
Quentin Philippot - Inserm
Danyel Lee - Human Genetic of Infectious Diseases
Peng Zhang - Rockefeller University
Darawan Rinchai - Rockefeller University
Fatima Al Ali - Sidra Medicine [Doha, Qatar]
Manar Mahmoud Ahmad Ata - Sidra Medicine [Doha, Qatar]
Mahbuba Rahman - Sidra Medicine [Doha, Qatar]
Jessica N Peel - Rockefeller University
Søren Heissel - Rockefeller University
Henrik Molina - Rockefeller University
Yasemin Kendir-Demirkol - Rockefeller University
Rasheed Bailey - Rockefeller University
Shuxiang Zhao - Rockefeller University
Jonathan Bohlen - Human Genetic of Infectious Diseases
Mathieu Mancini - McGill University
Yoann Seeleuthner - Human Genetic of Infectious Diseases
Marie Roelens - Assistance Publique – Hôpitaux de Paris
Lazaro Lorenzo - Human Genetic of Infectious Diseases
Camille Soudée - Human Genetic of Infectious Diseases
María Elvira Josefina Paz - Centro Científico Tecnológico - Tucumán
María Laura González - Centro Científico Tecnológico - Tucumán
Mohamed Jeljeli - Hôpital Cochin
Jean Soulier - Inserm
Serge Romana - Université Paris Cité
Anne-Sophie L’honneur - Hôpital Cochin
Marie Materna - Human Genetic of Infectious Diseases
Rubén Martínez-Barricarte - Vanderbilt University Medical Center
Mathieu Pochon - Human Genetic of Infectious Diseases
Carmen Oleaga-Quintas - Université Paris Cité
Alexandre Michev - Human Genetic of Infectious Diseases
Mélanie Migaud - Human Genetic of Infectious Diseases
Romain Lévy - Human Genetic of Infectious Diseases
Marie-Alexandra Alyanakian - Institut Necker Enfants Malades
Flore Rozenberg - Hôpital Cochin
Carys A Croft - Inserm
Guillaume Vogt - Institut Pasteur
Jean-François Emile - Hôpital Ambroise Paré [AP-HP]
Laurent Kremer - Université de Montpellier
Cindy S Ma - Garvan Institute of Medical Research
Jörg H Fritz - McGill University
Stanley M Lemon - University of North Carolina at Chapel Hill
András N Spaan - Rockefeller University
Nicolas Manel - Université Paris Sciences et Lettres
Laurent Abel - Human Genetic of Infectious Diseases
Margaret R Macdonald - Rockefeller University
Stéphanie Boisson-Dupuis - Human Genetic of Infectious Diseases
Nico Marr - Hamad bin Khalifa University
Stuart G Tangye - Garvan Institute of Medical Research
James P Di Santo - Inserm
Qian Zhang - Inserm
Shen-Ying Zhang - Imagine - Institut des maladies génétiques (IHU)
Charles M Rice - Rockefeller University
Vivien Béziat - Human Genetic of Infectious Diseases
Nico Lachmann - Medizinische Hochschule Hannover
David Langlais - McGill University
Jean-Laurent Casanova - Rockefeller University
Philippe Gros - McGill University
Jacinta Bustamante - Assistance Publique – Hôpitaux de Paris
Publication Details: Cell, Vol.186(3), pp.621 - 645.e33
Grant note: The Laboratory of Human Genetics of Infectious Diseases is supported in part by grants from Inserm, Paris Cité University, the St. Giles Foundation, The Rockefeller University, the Center for Clinical and Translational Science (UL1TR001866), the National Center for Research Resources and the National Center for Advancing Sciences, the National Institutes of Health (NIH), (R01AI095983, R01AI088364, R01AI163029, and U19AI162568), the National Institute of Allergy and Infectious Diseases, the French National Research Agency (ANR) under the “Investments for the future” program (ANR-10-IAHU-01), the Integrative Biology of Emerging Infectious Diseases Laboratory of Excellence (ANR-10-LABX-62-IBEID), the French Foundation for Medical Research (FRM) (EQU201903007798), the ANRS Nord-Sud (ANRS-COV05), ANRS (ECTZ170784-ANRS0073), GENVIR (ANR-20-CE93-003), GENMSMD (ANR-16-CE17-0005-01), AABIFNCOV (ANR-20-CO11-0001), GenMIS-C (ANR-21-COVR-0039), SUNLIVE (ANR-19-CE15-0012-01), MAFMACRO (ANR-22-CE92-0008) grants, Ecos-NORD (ECOS N°C19S01), the Fisher Center for Alzheimer's Research Foundation, the Meyer Foundation, the JPB Foundation, the European Union’s Horizon 2020 research and innovation program (824110, EASI-Genomics), the Square Foundation, Grandir–Fonds de solidarité pour l’Enfance, the Fondation du Souffle, the SCOR Corporate Foundation for Science, the French Ministry of Higher Education, Research, and Innovation (MESRI-COVID-19), and REACTing-INSERM. The Laboratory of Virology and Infectious Disease was supported in part by the NIH (R01AI091707-10 to C.M.R.). J.L.P. was supported by the Francois Wallace Monahan Postdoctoral Fellowship at The Rockefeller University and the European Molecular Biology Organization Long-Term Fellowship (ALTF 380-2018). N. Marr was supported by Sidra Medicine and the Qatar National Research Fund (NPRP9-251-3-045). The Yale Center for Mendelian Genomics (UM1HG006504) was funded by the National Human Genome Research Institute, the Yale GSP Coordinating Center (U24 HG008956), and the Yale High-Performance Computing Center (S10OD018521). This research was partly supported by Calcul Québec, Compute Canada Canadian Institutes of Health Research (CIHR) Project Grant to D. Langlais. (#168959) and a CIHR Foundation Grant (to P.G.). D. Langlais was also supported by an FRQS Chercheur-Boursier Junior 1 Award and the Calgary Foundation for Innovation John R. Evans Leaders Fund. P.G. is supported by a Distinguished James McGill Professorship award from McGill University. S.M.L is supported by the NIH: R01-AI103083 and R01-AI150095. J.R. was supported by poste d’accueil Inserm”. J.R., P.B., and T.L.V were supported by the MD-PhD program of the Imagine Institute by the Bettencourt Schueller Foundation. N.L received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (852178 grant), German Research Foundation,(DFG) under Germany’s Excellence Strategy—EXC 2155—project number 390874280 and REBIRTH “Förderung aus Mitteln des Niedersächsischen Vorab”. A.-L.N. was supported by the international PhD program of the Imagine Institute, by the Bettencourt Schueller Foundation and the fin de thèse FRM program (FDT202204015102). R.Y. was supported by the Sackler Center for Biomedicine and Nutrition, the Shapiro-Silverberg Fund for the Advancement of Translational Research at the Center for Clinical and Translational Science of the Rockefeller University, and the Research Grant Program from the Immune Deficiency Foundation. D. Lee. was supported by FRMfellowship (FDM202006011282). C.S.M was supported by an Early-Mid Career Research Fellowship from the Department of Health of the New South Wales Government of Australia. S.G.T was supported by an NHMRC Leadership 3 Investigator Grant (1176665) and NHMRC grant (1113904). M.O. was supported by the David Rockefeller Graduate Program, the Funai Foundation for Information Technology, the Honjo International Scholarship Foundation, and the New York Hideyo Noguchi Memorial Society. This work was supported by grants from ANRS (ECTZ118797), Sidaction (20-2-AEQ-12822-2), and FRM (EQU202103012774) to N. Manel, and H.I. was supported by fellowships from Institut Curie, Seneca Foundation (20941/PD/18), and ANRS (ECTZ171453). A.N.S. was supported in part by the European Union’s Horizon 2020 research and innovation program (789645 Marie Sklodowska-Curie grant). Y.-H.C. is supported by an A∗STAR International Fellowship. J. Bohlen is an EMBO postdoctoral fellow. We thank the NIH Tetramer Core Facility (NTCF) for providing the 5-OP-RU-loaded MR1 tetramer, which was developed jointly with Dr. James McCluskey, Dr. Jamie Rossjohn, and Dr. David Fairlie.
Identifiers: 9935147909311
Academic Unit: Institut de Recherche en Infectiologie de Montpellier - IRIM
Language: English
Resource Type: Journal article
Local Fields: pasteur-04130575