How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Craig Willis; Marco Calvaruso; Debora Angeloni; Sarah Baatout; Alexandra Benchoua; Juergen Bereiter-Hahn; Daniele Bottai; Judith-Irina Buchheim; Eugénie Carnero-Diaz; Sara Castiglioni; Duccio Cavalieri; Gabriele Ceccarelli; Alexander Chouker; Francesca Cialdai; Gianni Ciofani; Giuseppe Coppola; Gabriella Cusella; Andrea Degl’innocenti; Jean-Francois Desaphy; Jean-Pol Frippiat; Michael Gelinsky; Giada Genchi; Maria Grano; Daniela Grimm; Alain Guignandon; Raúl Herranz; Christine Hellweg; Carlo Saverio Iorio; Thodoris Karapantsios; Jack van Loon; Matteo Lulli; Jeanette Maier; Jos Malda; Emina Mamaca; Lucia Morbidelli; Andreas Osterman; Aleksandr Ovsianikov; Francesco Pampaloni; Elizabeth Pavezlorie; Veronica Pereda-Campos; Cyrille Przybyla; Petra Rettberg; Angela Maria Rizzo; Kate Robson-Brown; Leonardo Rossi; Giorgio Russo; Alessandra Salvetti; Chiara Risaliti; Daniela Santucci; Matthias Sperl; Kevin Tabury; Sara Tavella; Christiane Thielemann; Ronnie Willaert; Monica Monici; Nathaniel Szewczyk

doi:10.1038/s41526-024-00395-3

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How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

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How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?

Craig Willis, Marco Calvaruso, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Eugénie Carnero-Diaz, Sara Castiglioni, …

NPJ Microgravity, Vol.10(1)

01/05/2024

DOI: https://doi.org/10.1038/s41526-024-00395-3

PMCID: PMC11063135

PMID: 38693246

Abstract

Periodically, the European Space Agency (ESA) updates scientific roadmaps in consultation with the scientific community. The ESA SciSpacE Science Community White Paper (SSCWP) 9, “Biology in Space and Analogue Environments”, focusses in 5 main topic areas, aiming to address key community-identified knowledge gaps in Space Biology. Here we present one of the identified topic areas, which is also an unanswered question of life science research in Space: “How to Obtain an Integrated Picture of the Molecular Networks Involved in Adaptation to Microgravity in Different Biological Systems?” The manuscript reports the main gaps of knowledge which have been identified by the community in the above topic area as well as the approach the community indicates to address the gaps not yet bridged. Moreover, the relevance that these research activities might have for the space exploration programs and also for application in industrial and technological fields on Earth is briefly discussed.

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Title: How to obtain an integrated picture of the molecular networks involved in adaptation to microgravity in different biological systems?
Creators - without role: Craig Willis - University of Bradford
Marco Calvaruso - Institute of Molecular Bioimaging and Physiology
Debora Angeloni - Scuola Superiore Sant'Anna
Sarah Baatout - Belgian Nuclear Research Centre
Alexandra Benchoua - Institut des Cellules Souches pour le Traitement et l'Étude des Maladies Monogéniques
Juergen Bereiter-Hahn - Goethe University Frankfurt
Daniele Bottai - University of Milan
Judith-Irina Buchheim - Ludwig-Maximilians-Universität München
Eugénie Carnero-Diaz - École Pratique des Hautes Études
Sara Castiglioni - University of Milan
Duccio Cavalieri - University of Florence
Gabriele Ceccarelli - University of Pavia
Alexander Chouker - LMU Klinikum
Francesca Cialdai - University of Florence
Gianni Ciofani - Italian Institute of Technology
Giuseppe Coppola - Institute of Applied Science and Intelligent Systems
Gabriella Cusella - University of Pavia
Andrea Degl’innocenti - Italian Institute of Technology
Jean-Francois Desaphy - University of Bari Aldo Moro
Jean-Pol Frippiat - Stress, immunité, pathogènes
Michael Gelinsky - TU Dresden
Giada Genchi - Italian Institute of Technology
Maria Grano - University of Bari Aldo Moro
Daniela Grimm - Otto-von-Guericke University Magdeburg
Alain Guignandon - Inserm
Raúl Herranz - Centro de Investigaciones Biológicas Margarita Salas
Christine Hellweg - Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
Carlo Saverio Iorio - Université Libre de Bruxelles
Thodoris Karapantsios - Aristotle University of Thessaloniki
Jack van Loon - Amsterdam University Medical Centers
Matteo Lulli - University of Florence
Jeanette Maier - University of Milan
Jos Malda - Utrecht University
Emina Mamaca - Ifremer
Lucia Morbidelli - University of Siena
Andreas Osterman - Ludwig-Maximilians-Universität München
Aleksandr Ovsianikov - TU Wien
Francesco Pampaloni - Goethe University Frankfurt
Elizabeth Pavezlorie - Ludwig Boltzmann Institute for Digital Health and Prevention
Veronica Pereda-Campos - Université Toulouse III - Paul Sabatier
Cyrille Przybyla - Ifremer
Petra Rettberg - Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
Angela Maria Rizzo - University of Milan
Kate Robson-Brown - University of Bristol
Leonardo Rossi - University of Pisa
Giorgio Russo - Institute of Molecular Bioimaging and Physiology
Alessandra Salvetti - University of Pisa
Chiara Risaliti - University of Florence
Daniela Santucci - Istituto Superiore di Sanità
Matthias Sperl - Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
Kevin Tabury - Belgian Nuclear Research Centre
Sara Tavella - Ospedale Policlinico San Martino
Christiane Thielemann - Aschaffenburg University of Applied Sciences
Ronnie Willaert - Vrije Universiteit Brussel
Monica Monici - University of Florence
Nathaniel Szewczyk - Ohio University
Publication Details: NPJ Microgravity, Vol.10(1)
Identifiers: 9937479909311
Academic Unit: MARine Biodiversity, Exploitation & Conservation - MARBEC
Language: English
Resource Type: Journal article
Local Fields: hal-04569486