How do gravity alterations affect animal and human systems at a cellular/tissue level?

Francesca Cialdai; Austin Brown; Cory Baumann; Debora Angeloni; Sarah Baatout; Alexandra Benchoua; Juergen Bereiter-Hahn; Daniele Bottai; Judith-Irina Buchheim; Marco Calvaruso; Eugénie Carnero-Diaz; Sara Castiglioni; Duccio Cavalieri; Gabriele Ceccarelli; Alexander Choukér; Gianni Ciofani; Giuseppe Coppola; Gabriella Cusella; Andrea Degl’innocenti; Jean-Francois Desaphy; Jean-Pol Frippiat; Michael Gelinsky; Giada Genchi; Maria Grano; Daniela Grimm; Alain Guignandon; Christiane Hahn; Jason Hatton; Raúl Herranz; Christine Hellweg; Carlo Saverio Iorio; Thodoris Karapantsios; Jack van Loon; Matteo Lulli; Jeanette Maier; Jos Malda; Emina Mamaca; Lucia Morbidelli; Angelique van Ombergen; Andreas Osterman; Aleksandr Ovsianikov; Francesco Pampaloni; Elizabeth Pavezlorie; Veronica Pereda-Campos; Cyrille Przybyla; Christopher Puhl; Petra Rettberg; Chiara Risaliti; Angela Maria Rizzo; Kate Robson-Brown; Leonardo Rossi; Giorgio Russo; Alessandra Salvetti; Daniela Santucci; Matthias Sperl; Felice Strollo; Kevin Tabury; Sara Tavella; Christiane Thielemann; Ronnie Willaert; Nathaniel Szewczyk; Monica Monici

doi:10.1038/s41526-023-00330-y

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How do gravity alterations affect animal and human systems at a cellular/tissue level?

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How do gravity alterations affect animal and human systems at a cellular/tissue level?

Francesca Cialdai, Austin Brown, Cory Baumann, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Marco Calvaruso, …

NPJ Microgravity, Vol.9(1)

12/2023

DOI: https://doi.org/10.1038/s41526-023-00330-y

Abstract

medical research

systems biology

The present white paper concerns the indications and recommendations of the SciSpacE Science Community to make progress in filling the gaps of knowledge that prevent us from answering the question: “How Do Gravity Alterations Affect Animal and Human Systems at a Cellular/Tissue Level?” This is one of the five major scientific issues of the ESA roadmap “Biology in Space and Analogue Environments”. Despite the many studies conducted so far on spaceflight adaptation mechanisms and related pathophysiological alterations observed in astronauts, we are not yet able to elaborate a synthetic integrated model of the many changes occurring at different system and functional levels. Consequently, it is difficult to develop credible models for predicting long-term consequences of human adaptation to the space environment, as well as to implement medical support plans for long-term missions and a strategy for preventing the possible health risks due to prolonged exposure to spaceflight beyond the low Earth orbit (LEO). The research activities suggested by the scientific community have the aim to overcome these problems by striving to connect biological and physiological aspects in a more holistic view of space adaptation effects.

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Title: How do gravity alterations affect animal and human systems at a cellular/tissue level?
Creators - without role: Francesca Cialdai - University of Florence
Austin Brown - Ohio University
Cory Baumann - Ohio University
Debora Angeloni - Scuola Superiore Sant'Anna
Sarah Baatout - Belgian Nuclear Research Centre
Alexandra Benchoua - Association Francaise contre les Myopathies
Juergen Bereiter-Hahn - Goethe University Frankfurt
Daniele Bottai - University of Milan
Judith-Irina Buchheim - Ludwig-Maximilians-Universität München
Marco Calvaruso - National Research Council
Eugénie Carnero-Diaz - Sorbonne Université
Sara Castiglioni - University of Milan
Duccio Cavalieri - University of Florence
Gabriele Ceccarelli - University of Pavia
Alexander Choukér - Ludwig-Maximilians-Universität München
Gianni Ciofani - Italian Institute of Technology
Giuseppe Coppola - Institute of Applied Science and Intelligent Systems
Gabriella Cusella - University of Pavia
Andrea Degl’innocenti - University of Siena
Jean-Francois Desaphy - University of Bari Aldo Moro
Jean-Pol Frippiat - Stress, immunité, pathogènes
Michael Gelinsky - TU Dresden
Giada Genchi - Italian Institute of Technology
Maria Grano - University of Bari Aldo Moro
Daniela Grimm - Aarhus University
Alain Guignandon - Université Jean Monnet
Christiane Hahn - European Space Agency
Jason Hatton - European Space Agency
Raúl Herranz - Centro de Investigaciones Biológicas Margarita Salas
Christine Hellweg - Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
Carlo Saverio Iorio - Université Libre de Bruxelles
Thodoris Karapantsios - Aristotle University of Thessaloniki
Jack van Loon - Amsterdam University Medical Centers
Matteo Lulli - University of Florence
Jeanette Maier - University of Milan
Jos Malda - Utrecht University
Emina Mamaca - Ifremer
Lucia Morbidelli - University of Siena
Angelique van Ombergen - European Space Agency
Andreas Osterman - Ludwig-Maximilians-Universität München
Aleksandr Ovsianikov - TU Wien
Francesco Pampaloni - Goethe University Frankfurt
Elizabeth Pavezlorie - Ludwig Boltzmann Institute for Digital Health and Prevention
Veronica Pereda-Campos - Université Toulouse III - Paul Sabatier
Cyrille Przybyla - Université de Montpellier, MARine Biodiversity, Exploitation & Conservation - MARBEC
Christopher Puhl - Agence Spatiale Européenne = European Space Agency
Petra Rettberg - DLR Institute of Aerospace Medicine
Chiara Risaliti - University of Florence
Angela Maria Rizzo - University of Milan
Kate Robson-Brown - University of Bristol
Leonardo Rossi - University of Pisa
Giorgio Russo - Institute of Molecular Bioimaging and Physiology
Alessandra Salvetti - University of Pisa
Daniela Santucci - Istituto Superiore di Sanità
Matthias Sperl - Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
Felice Strollo - Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
Kevin Tabury - Belgian Nuclear Research Centre
Sara Tavella - Ospedale Policlinico San Martino
Christiane Thielemann - Aschaffenburg University of Applied Sciences
Ronnie Willaert - Vrije Universiteit Brussel
Nathaniel Szewczyk - Ohio University
Monica Monici - University of Florence
Publication Details: NPJ Microgravity, Vol.9(1)
Identifiers: 9936700909311
Academic Unit: MARine Biodiversity, Exploitation & Conservation - MARBEC
Language: English
Resource Type: Journal article
Local Fields: hal-04264352