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How are nucleosomes disrupted during transcription elongation?
Article de revue

How are nucleosomes disrupted during transcription elongation?

Jordanka Zlatanova et Jean-Marc Victor
HFSP Journal, Vol.3(6), pp.373-378
01/12/2009
PMID: 20514129

Résumé

Multidisciplinary Sciences Science & Technology Science & Technology - Other Topics
Chromatin structure is a powerful tool to regulate eukaryotic transcription. Moreover, nucleosomes are constantly remodeled, disassembled, and reassembled in the body of transcribed genes. Here we propose a general model that explains, in quantitative terms, how transcription elongation affects nucleosome structure at a distance as a result of the positive torque the polymerases create as they translocate along DNA templates. [DOI: 10.2976/1.3249971]

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