How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Trent Davis; Kevin Tabury; Shouan Zhu; Debora Angeloni; Sarah Baatout; Alexandra Benchoua; Juergen Bereiter-Hahn; Daniele Bottai; Judith-Irina Buchheim; Marco Calvaruso; Eugénie Carnero-Diaz; Sara Castiglioni; Duccio Cavalieri; Gabriele Ceccarelli; Alexander Choukér; Francesca Cialdai; Gianni Ciofani; Giuseppe Coppola; Gabriella Cusella; Andrea Degl’innocenti; Jean-Francois Desaphy; Jean-Pol Frippiat; Michael Gelinsky; Giada Genchi; Maria Grano; Daniela Grimm; Alain Guignandon; Christiane Hahn; Jason Hatton; Raúl Herranz; Christine Hellweg; Carlo Saverio Iorio; Thodoris Karapantsios; Jack J.W.A. van Loon; Matteo Lulli; Jeanette Maier; Jos Malda; Emina Mamaca; Lucia Morbidelli; Angelique van Ombergen; Andreas Osterman; Aleksandr Ovsianikov; Francesco Pampaloni; Elizabeth Pavezlorie; Veronica Pereda-Campos; Cyrille Przybyla; Christopher Puhl; Petra Rettberg; Angela Maria Rizzo; Kate Robson-Brown; Leonardo Rossi; Giorgio Russo; Alessandra Salvetti; Daniela Santucci; Matthias Sperl; Sara Tavella; Christiane Thielemann; Ronnie Willaert; Nathaniel Szewczyk; Monica Monici

doi:10.1038/s41526-024-00357-9

Back

How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Journal article

Open access

How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?

Trent Davis, Kevin Tabury, Shouan Zhu, Debora Angeloni, Sarah Baatout, Alexandra Benchoua, Juergen Bereiter-Hahn, Daniele Bottai, Judith-Irina Buchheim, Marco Calvaruso, …

NPJ Microgravity, Vol.10(1)

10/02/2024

DOI: https://doi.org/10.1038/s41526-024-00357-9

PMCID: PMC10858953

PMID: 38341423

Abstract

Abstract Progress in mechanobiology allowed us to better understand the important role of mechanical forces in the regulation of biological processes. Space research in the field of life sciences clearly showed that gravity plays a crucial role in biological processes. The space environment offers the unique opportunity to carry out experiments without gravity, helping us not only to understand the effects of gravitational alterations on biological systems but also the mechanisms underlying mechanoperception and cell/tissue response to mechanical and gravitational stresses. Despite the progress made so far, for future space exploration programs it is necessary to increase our knowledge on the mechanotransduction processes as well as on the molecular mechanisms underlying microgravity-induced cell and tissue alterations. This white paper reports the suggestions and recommendations of the SciSpacE Science Community for the elaboration of the section of the European Space Agency roadmap “Biology in Space and Analogue Environments” focusing on “How are cells and tissues influenced by gravity and what are the gravity perception mechanisms?” The knowledge gaps that prevent the Science Community from fully answering this question and the activities proposed to fill them are discussed.

Files and links (2)

url

Find in HALView

url

https://doi.org/10.1038/s41526-024-00357-9View

Published (Version of record) Open

Metrics

1 Record Views

See more details

Details

Title: How are cell and tissue structure and function influenced by gravity and what are the gravity perception mechanisms?
Creators - without role: Trent Davis - Ohio University
Kevin Tabury - Belgian Nuclear Research Centre
Shouan Zhu - Ohio University
Debora Angeloni - Scuola Superiore Sant'Anna
Sarah Baatout - Belgian Nuclear Research Centre
Alexandra Benchoua - Association Francaise contre les Myopathies
Juergen Bereiter-Hahn - Goethe University Frankfurt
Daniele Bottai - University of Milan
Judith-Irina Buchheim - Ludwig-Maximilians-Universität München
Marco Calvaruso - Institute of Molecular Bioimaging and Physiology
Eugénie Carnero-Diaz - Sorbonne Université
Sara Castiglioni - University of Milan
Duccio Cavalieri - University of Florence
Gabriele Ceccarelli - University of Pavia
Alexander Choukér - LMU Klinikum
Francesca Cialdai - University of Florence
Gianni Ciofani - Italian Institute of Technology
Giuseppe Coppola - Institute of Applied Science and Intelligent Systems
Gabriella Cusella - University of Pavia
Andrea Degl’innocenti - University of Siena
Jean-Francois Desaphy - University of Bari Aldo Moro
Jean-Pol Frippiat - Stress, immunité, pathogènes
Michael Gelinsky - TU Dresden
Giada Genchi - Italian Institute of Technology
Maria Grano - University of Bari Aldo Moro
Daniela Grimm - Otto-von-Guericke University Magdeburg
Alain Guignandon - Université Jean Monnet
Christiane Hahn - European Space Research and Technology Centre
Jason Hatton - European Space Research and Technology Centre
Raúl Herranz - Centro de Investigaciones Biológicas Margarita Salas
Christine Hellweg - Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
Carlo Saverio Iorio - Université Libre de Bruxelles
Thodoris Karapantsios - Aristotle University of Thessaloniki
Jack J.W.A. van Loon - Amsterdam University Medical Centers
Matteo Lulli - University of Florence
Jeanette Maier - University of Milan
Jos Malda - Utrecht University
Emina Mamaca - Ifremer
Lucia Morbidelli - University of Siena
Angelique van Ombergen - European Space Research and Technology Centre
Andreas Osterman - Ludwig-Maximilians-Universität München
Aleksandr Ovsianikov - TU Wien
Francesco Pampaloni - Goethe University Frankfurt
Elizabeth Pavezlorie - Ludwig Boltzmann Institute for Digital Health and Prevention
Veronica Pereda-Campos - Université Toulouse III - Paul Sabatier
Cyrille Przybyla - Université de Montpellier, MARine Biodiversity, Exploitation & Conservation - MARBEC
Christopher Puhl - European Space Research and Technology Centre
Petra Rettberg - Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
Angela Maria Rizzo - University of Milan
Kate Robson-Brown - University of Bristol
Leonardo Rossi - University of Pisa
Giorgio Russo - Institute of Molecular Bioimaging and Physiology
Alessandra Salvetti - University of Pisa
Daniela Santucci - Istituto Superiore di Sanità
Matthias Sperl - Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR)
Sara Tavella - Ospedale Policlinico San Martino
Christiane Thielemann - Aschaffenburg University of Applied Sciences
Ronnie Willaert - Vrije Universiteit Brussel
Nathaniel Szewczyk - Ohio University
Monica Monici - University of Florence
Publication Details: NPJ Microgravity, Vol.10(1)
Identifiers: 9937690009311
Academic Unit: MARine Biodiversity, Exploitation & Conservation - MARBEC
Language: English
Resource Type: Journal article
Local Fields: hal-04450577