Host-Directed Therapies for Tackling Multi-Drug Resistant Tuberculosis: Learning From the Pasteur-Bechamp Debates

Alimuddin Zumla; Markus Maeurer; Jeremiah Chakaya; Michael Hoelscher; Francine Ntoumi; Roxana Rustomjee; Cristina Vilaplana; Dorothy Yeboah-Manu; Voahangy Rasolofo; Paula Munderi; Nalini Singh; Eleni Aklillu; Nesri Padayatchi; Eusebio Macete; Nathan Kapata; Modest Mulenga; Gibson Kibiki; Sayoki Mfinanga; Thomas Nyirenda; Leonard Mboko; Alberto L. Garcia-Basteiro; Niaina Rakotosamimanana; Matthew Bates; Peter Mwaba; Klaus Reither; Sebastien Gagneux; Sarah Edwards; Elirehema Mfinanga; Salim Abdulla; Pere-Joan Cardona; James B. W. Russell; Vanya Gant; Mahdad Noursadeghi; Paul Elkington; Maryline Bonnet; Clara Menendez; Tandakha N. Dieye; Bassirou Diarra; Almoustapha Maiga; Abraham Aseffa; Shreemanta Parida; Christian Wejse; Eskild Petersen; Pontiano Kaleebu; Matt Oliver; Gill Craig; Tumena Corrah; Leopold Tientcheu; Martin Antonio; Timothy D. McHugh; Aziz Sheikh; Giuseppe Ippolito; Gita Ramjee; Stefan H. E. Kaufmann; Gavin Churchyard; Adrie J. C. Steyn; Martin P. Grobusch; Ian Sanne; Neil Martinson; Rajhmun Mandansein; Robert J. Wilkinson; Robert S. Wallis; Bongani Mayosi; Marco Schito; Host-Directed Therapies Network HD

doi:10.1093/cid/civ631

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Host-Directed Therapies for Tackling Multi-Drug Resistant Tuberculosis: Learning From the Pasteur-Bechamp Debates

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Host-Directed Therapies for Tackling Multi-Drug Resistant Tuberculosis: Learning From the Pasteur-Bechamp Debates

Alimuddin Zumla, Markus Maeurer, Jeremiah Chakaya, Michael Hoelscher, Francine Ntoumi, Roxana Rustomjee, Cristina Vilaplana, Dorothy Yeboah-Manu, Voahangy Rasolofo, Paula Munderi, …

Clinical infectious diseases, Vol.61(9), pp.1432-1438

01/11/2015

DOI: https://doi.org/10.1093/cid/civ631

PMID: 26219693

Résumé

Immunology

Infectious Diseases

Life Sciences & Biomedicine

Microbiology

Science & Technology

Tuberculosis remains a global emergency causing an estimated 1.5 million deaths annually. For several decades the major focus of tuberculosis treatment has been on antibiotic development targeting Mycobacterium tuberculosis. The lengthy tuberculosis treatment duration and poor treatment outcomes associated with multi-drug resistant tuberculosis (MDR-TB) are of major concern. The sparse new tuberculosis drug pipeline and widespread emergence of MDR-TB signal an urgent need for more innovative interventions to improve treatment outcomes. Building on the historical Pasteur-Bechamp debates on the role of the "microbe" vs the "host internal milieu" in disease causation, we make the case for parallel investments into host-directed therapies (HDTs). A range of potential HDTs are now available which require evaluation in randomized controlled clinical trials as adjunct therapies for shortening the duration of tuberculosis therapy and improving treatment outcomes for drug-susceptible tuberculosis and MDR-TB. Funder initiatives that may enable further research into HDTs are described.

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Titre: Host-Directed Therapies for Tackling Multi-Drug Resistant Tuberculosis: Learning From the Pasteur-Bechamp Debates
Créateurs - sans rôle: Alimuddin Zumla - UCL, Ctr Clin Microbiol, Div Infect Immun, London, England
Markus Maeurer - Karolinska Inst, Dept Lab Med, Therapeut Immunol, Stockholm, Sweden
Jeremiah Chakaya - Kenya Govt Med Res Ctr, Nairobi, Kenya
Michael Hoelscher - DZIF German Ctr Infect Res, Munich, Germany
Francine Ntoumi - Fdn Congolaise Rech Med, Brazzaville, Rep Congo
Roxana Rustomjee - MRC, Cape Town, South Africa
Cristina Vilaplana - Unitat TB Expt Fundacio Inst Invest Ciencies Salu, Labs Recerca Can Ruti Campus, Barcelona, Spain
Dorothy Yeboah-Manu - University of Ghana
Voahangy Rasolofo - Inst Pasteur Madagascar, Mycobacteria Unit, Antananarivo, Madagascar
Paula Munderi - Uganda Virus Res Inst, HIV Care Res Program, MRC Res Unit, Entebbe, Uganda
Nalini Singh - Inkosi Albert Luthuli Cent Hosp, Durban, South Africa
Eleni Aklillu - Karolinska Inst, Div Clin Pharmacol, Dept Lab Med, Stockholm, Sweden
Nesri Padayatchi - Ctr AIDS Prevent Res South Africa CAPRISA, SAMRC CAPRISA HIV TB Pathogenesis & Treatment Res, Durban, South Africa
Eusebio Macete - Ctr Invest Saude Manhica, Maputo, Mozambique
Nathan Kapata - Univ Teaching Hosp, UNZA UCLMS Res & Training Project, Lusaka, Zambia
Modest Mulenga - Trop Dis Res Ctr, Ndola, Zambia
Gibson Kibiki - Kilimanjaro Clin Res Inst KCRI, Kilimanjaro, Tanzania
Sayoki Mfinanga - Natl Inst Med Res NIMR, Muhimbili Med Res Ctr, Dar Es Salaam, Tanzania
Thomas Nyirenda - EDCTP, Cape Town, South Africa
Leonard Mboko - Univ Munich, Med Ctr, Div Infect Dis & Trop Med, Marchioninistr 15, D-81377 Munich, Germany
Alberto L. Garcia-Basteiro - Ctr Invest Saude Manhica, Maputo, Mozambique
Niaina Rakotosamimanana - Inst Pasteur Madagascar, Mycobacteria Unit, Antananarivo, Madagascar
Matthew Bates - Univ Teaching Hosp, UNZA UCLMS Res & Training Project, Lusaka, Zambia
Peter Mwaba - Univ Teaching Hosp, UNZA UCLMS Res & Training Project, Lusaka, Zambia
Klaus Reither - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Sebastien Gagneux - Swiss Trop & Publ Hlth Inst, Basel, Switzerland
Sarah Edwards - NIHR Biomed Res Ctr, London, England
Elirehema Mfinanga - Ifakara Hlth Inst, Bagamoyo, Tanzania
Salim Abdulla - Ifakara Hlth Inst, Dar Es Salaam, Tanzania
Pere-Joan Cardona - Unitat TB Expt Fundacio Inst Invest Ciencies Salu, Labs Recerca Can Ruti Campus, Barcelona, Spain
James B. W. Russell - Univ Sierra Leone, Coll Med & Allied Hlth Sci, Connaught Hosp, Dept Internal Med, Freetown, Sierra Leone
Vanya Gant - Univ Coll London Hosp NHS Fdn Trust, Dept Microbiol, London, England
Mahdad Noursadeghi - Univ Coll London Hosp NHS Fdn Trust, Dept Microbiol, London, England
Paul Elkington - Univ Southampton, Resp Med Dept, Southampton, Hants, England
Maryline Bonnet - IRD, Epictr, Paris, France
Clara Menendez - Barcelona Inst Global Hlth, ISGlobal, Barcelona, Spain
Tandakha N. Dieye - Le Dantec Hosp, Immunol Unit, Lab Bacteriol Virol, Labs Natl Blood Transfus Ctr, Dakar, Senegal
Bassirou Diarra - Univ STT, SEREFO HIV TB Res & Training CenteHIV TB Res Trai, FMOS, Bamako, Mali
Almoustapha Maiga - Univ STT, SEREFO HIV TB Res & Training CenteHIV TB Res Trai, FMOS, Bamako, Mali
Abraham Aseffa - AHRI, Addis Ababa, Ethiopia
Shreemanta Parida - Karolinska Inst, Dept Lab Med, Therapeut Immunol, Stockholm, Sweden
Christian Wejse - Aarhus University
Eskild Petersen - Aarhus Univ, Dept Infect Dis, Aarhus, Denmark
Pontiano Kaleebu - Uganda Med Res Council, Kampala, Uganda
Matt Oliver - Results UK, London, England
Gill Craig - City Univ London, Sch Hlth Sci, London EC1V 0HB, England
Tumena Corrah - Northwick Pk Hosp & Clin Res Ctr, Dept Infect & Trop Dis, London, England
Leopold Tientcheu - MRC, Banjul, Gambia
Martin Antonio - MRC, Banjul, Gambia
Timothy D. McHugh - UCL, Ctr Clin Microbiol, Div Infect Immun, London, England
Aziz Sheikh - Univ Edinburgh, Ctr Med Informat, Usher Inst Populat Hlth Sci & Informat, Edinburgh, Midlothian, Scotland
Giuseppe Ippolito - Natl Inst Infect Dis Lazzar Spallanzani, Rome, Italy
Gita Ramjee - MRC, HIV Prevent Res Unit, Durban, South Africa
Stefan H. E. Kaufmann - Max Planck Inst Infekt Biol, Dept Immunol, D-10117 Berlin, Germany
Gavin Churchyard - Aurum Inst, Johannesburg, South Africa
Adrie J. C. Steyn - Nelson R Mandela Sch Med, KwaZulu Natal Res Inst TB & HIV, K RITH Tower Bldg, Durban, South Africa
Martin P. Grobusch - University of Amsterdam
Ian Sanne - Univ Witwatersrand, Right Care, Johannesburg, South Africa
Neil Martinson - Publ Hlth Res Unit, Soweto, South Africa
Rajhmun Mandansein - Univ KwaZulu Natal, Inkosi Albert Luthuli Cent Hosp, Dept Cardiothorac Surg, Durban, South Africa
Robert J. Wilkinson - Univ Cape Town, Clin Infect Dis Res Initiat, Inst Infect Dis & Mol Med, ZA-7700 Rondebosch, South Africa
Robert S. Wallis - Aurum Inst, Johannesburg, South Africa
Bongani Mayosi - Groote Schuur Hosp, Dept Med, ZA-7925 Cape Town, South Africa
Marco Schito - Crit Path Inst, Crit Path TB Drug Regimens, Tucson, AZ USA
Host-Directed Therapies Network HD
Détails de publication: Clinical infectious diseases, Vol.61(9), pp.1432-1438
Éditeur: Oxford Univ Press
Nombre de pages: 7
Note de subvention: 104803/Z/14/Z / Wellcome Trust; European Commission 10218 / The Francis Crick Institute 104803 / Wellcome Trust; European Commission
Identifiants: 99158640509311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article