Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

Daniel E. Neafsey; Robert M. Waterhouse; Mohammad R. Abai; Sergey S. Aganezov; Max A. Alekseyev; James E. Allen; James Amon; Bruno Arca; Peter Arensburger; Gleb Artemov; Lauren A. Assour; Hamidreza Basseri; Aaron Berlin; Bruce W. Birren; Stephanie A. Blandin; Andrew I. Brockman; Thomas R. Burkot; Austin Burt; Clara S. Chan; Cedric Chauve; Joanna C. Chiu; Mikkel Christensen; Carlo Costantini; Victoria L. M. Davidson; Elena Deligianni; Tania Dottorini; Vicky Dritsou; Stacey B. Gabriel; Wamdaogo M. Guelbeogo; Andrew B. Hall; Mira V. Han; Thaung Hlaing; Daniel S. T. Hughes; Adam M. Jenkins; Xiaofang Jiang; Irwin Jungreis; Evdoxia G. Kakani; Maryam Kamali; Petri Kemppainen; Ryan C. Kennedy; Ioannis K. Kirmitzoglou; Lizette L. Koekemoer; Njoroge Laban; Nicholas Langridge; Mara K. N. Lawniczak; Manolis Lirakis; Neil F. Lobo; Ernesto Lowy; Robert M. MacCallum; Chunhong Mao; Gareth Maslen; Charles Mbogo; Jenny McCarthy; Kristin Michel; Sara N. Mitchell; Wendy Moore; Katherine A. Murphy; Anastasia N. Naumenko; Tony Nolan; Eva M. Novoa; Samantha O'Loughlin; Chioma Oringanje; Mohammad A. Oshaghi; Nazzy Pakpour; Philippos A. Papathanos; Ashley N. Peery; Michael Povelones; Anil Prakash; David P. Price; Ashok Rajaraman; Lisa J. Reimer; David C. Rinker; Antonis Rokas; Tanya L. Russell; N'Fale Sagnon; Maria V. Sharakhova; Terrance Shea; Felipe A. Simao; Frederic Simard; Michel A. Slotman; Pradya Somboon; Vladimir Stegniy; Claudio J. Struchiner; Gregg W. C. Thomas; Marta Tojo; Pantelis Topalis; Jose M. C. Tubio; Maria F. Unger; John Vontas; Catherine Walton; Craig S. Wilding; Judith H. Willis; Yi-Chieh Wu; Guiyun Yan; Evgeny M. Zdobnov; Xiaofan Zhou; Flaminia Catteruccia; George K. Christophides; Frank H. Collins; Robert S. Cornman; Andrea Crisanti; Martin J. Donnelly; Scott J. Emrich; Michael C. Fontaine; William Gelbart; Matthew W. Hahn; Immo A. Hansen; Paul I. Howell; Fotis C. Kafatos; Manolis Kellis; Daniel Lawson; Christos Louis; Shirley Luckhart; Marc A. T. Muskavitch; Jose M. Ribeiro; Michael A. Riehle; Igor V. Sharakhov; Zhijian Tu; Laurence J. Zwiebel; Nora J. Besansky

doi:10.1126/science.1258522

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Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

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Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes

Daniel E. Neafsey, Robert M. Waterhouse, Mohammad R. Abai, Sergey S. Aganezov, Max A. Alekseyev, James E. Allen, James Amon, Bruno Arca, Peter Arensburger, Gleb Artemov, …

Science (American Association for the Advancement of Science), Vol.347(6217), pp.43-43

02/01/2015

DOI: https://doi.org/10.1126/science.1258522

PMID: 25554792

Résumé

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning similar to 100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.

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Titre: Highly evolvable malaria vectors: The genomes of 16 Anopheles mosquitoes
Créateurs - sans rôle: Daniel E. Neafsey - Broad Institute
Robert M. Waterhouse - MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA
Mohammad R. Abai - Univ Tehran Med Sci, Dept Med Entomol & Vector Control, Sch Publ Hlth, Tehran, Iran
Sergey S. Aganezov - George Washington University
Max A. Alekseyev - George Washington University
James E. Allen - EMBL EBI, Cambridge CB10 1SD, England
James Amon - Minist Hlth, Natl Vector Borne Dis Control Programme, Port Vila, Tafea Province, Vanuatu
Bruno Arca - Univ Roma La Sapienza, Div Parasitol, Dept Publ Hlth & Infect Dis, I-00185 Rome, Italy
Peter Arensburger - Calif State Polytech Pomona, Dept Biol Sci, Pomona, CA 91768 USA
Gleb Artemov - Tomsk State Univ, Tomsk 634050, Russia
Lauren A. Assour - Univ Notre Dame, Eck Inst Global Hlth, Dept Comp Sci & Engn, Notre Dame, IN 46556 USA
Hamidreza Basseri - Univ Tehran Med Sci, Dept Med Entomol & Vector Control, Sch Publ Hlth, Tehran, Iran
Aaron Berlin - Broad Inst, Genome Sequencing & Anal Program, Cambridge, MA 02142 USA
Bruce W. Birren - Broad Inst, Genome Sequencing & Anal Program, Cambridge, MA 02142 USA
Stephanie A. Blandin - Inserm
Andrew I. Brockman - Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
Thomas R. Burkot - James Cook Univ, Australian Inst Trop Hlth Med, Fac Med Hlth & Mol Sci, Cairns 4870, Australia
Austin Burt - Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Ascot SL5 7PY, Berks, England
Clara S. Chan - MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA
Cedric Chauve - Simon Fraser University
Joanna C. Chiu - Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA
Mikkel Christensen - EMBL EBI, Cambridge CB10 1SD, England
Carlo Costantini - Inst Rech Dev, Unites Mixtes Rech Malad Infect & Vecteurs Ecol G, F-64501 Montpellier, France
Victoria L. M. Davidson - Kansas State Univ, Div Biol, Manhattan, KS 66506 USA
Elena Deligianni - Fdn Res & Technol, Inst Mol Biol & Biotechnol, GR-70013 Iraklion, Crete, Greece
Tania Dottorini - Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
Vicky Dritsou - Univ Perugia, Ctr Funct Genom, I-06100 Perugia, Italy
Stacey B. Gabriel - Broad Inst, Cambridge, MA 02142 USA
Wamdaogo M. Guelbeogo - Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso
Andrew B. Hall - Virginia Polytech Inst & State Univ, Program Genet Bioinformat & Computat Biol, Blacksburg, VA 24061 USA
Mira V. Han - Univ Nevada, Sch Life Sci, Las Vegas, NV 89154 USA
Thaung Hlaing - Dept Med Res, Dagon Township 11191, Yangon, Myanmar
Daniel S. T. Hughes - EMBL EBI, Cambridge CB10 1SD, England
Adam M. Jenkins - Boston Coll, Chestnut Hill, MA 02467 USA
Xiaofang Jiang - Virginia Polytech Inst & State Univ, Program Genet Bioinformat & Computat Biol, Blacksburg, VA 24061 USA
Irwin Jungreis - MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA
Evdoxia G. Kakani - Harvard University
Maryam Kamali - Virginia Polytech Inst & State Univ, Dept Entomol, Blacksburg, VA 24061 USA
Petri Kemppainen - Univ Manchester, Fac Life Sci, Computat Evolutionary Biol Grp, Oxford M13 9PT, England
Ryan C. Kennedy - Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA
Ioannis K. Kirmitzoglou - Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
Lizette L. Koekemoer - University of the Witwatersrand
Njoroge Laban - Natl Museums Kenya, Nairobi, Kenya
Nicholas Langridge - EMBL EBI, Cambridge CB10 1SD, England
Mara K. N. Lawniczak - Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
Manolis Lirakis - Univ Crete, Dept Biol, GR-70013 Iraklion, Greece
Neil F. Lobo - University of Notre Dame
Ernesto Lowy - EMBL EBI, Cambridge CB10 1SD, England
Robert M. MacCallum - Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
Chunhong Mao - Virginia Polytech Inst & State Univ, Virginia Bioinformat Inst, Blacksburg, VA 24061 USA
Gareth Maslen - European Bioinformatics Institute
Charles Mbogo - Ctr Geog Med Res, Kenya Med Res Inst, Wellcome Trust Res Programme, Kilifi, Kenya
Jenny McCarthy - Calif State Polytech Pomona, Dept Biol Sci, Pomona, CA 91768 USA
Kristin Michel - Kansas State Univ, Div Biol, Manhattan, KS 66506 USA
Sara N. Mitchell - Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
Wendy Moore - Univ Arizona, Dept Entomol, Tucson, AZ 85721 USA
Katherine A. Murphy - Univ Calif Davis, Dept Entomol & Nematol, Davis, CA 95616 USA
Anastasia N. Naumenko - Virginia Polytech Inst & State Univ, Dept Entomol, Blacksburg, VA 24061 USA
Tony Nolan - Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
Eva M. Novoa - MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA
Samantha O'Loughlin - Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, Ascot SL5 7PY, Berks, England
Chioma Oringanje - Univ Arizona, Dept Entomol, Tucson, AZ 85721 USA
Mohammad A. Oshaghi - University of Tehran
Nazzy Pakpour - Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA
Philippos A. Papathanos - Univ London Imperial Coll Sci Technol & Med, Dept Life Sci, London SW7 2AZ, England
Ashley N. Peery - Virginia Polytech Inst & State Univ, Dept Entomol, Blacksburg, VA 24061 USA
Michael Povelones - Univ Penn, Sch Vet Med, Dept Pathol, Philadelphia, PA 19104 USA
Anil Prakash - Indian Council Med Res, Reg Med Res Ctr NE, Dibrugarh 786001, Assam, India
David P. Price - New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA
Ashok Rajaraman - Simon Fraser Univ, Dept Math, Burnaby, BC V5A 1S6, Canada
Lisa J. Reimer - Univ Liverpool Liverpool Sch Trop Med, Dept Vector Biol, Liverpool L3 5QA, Merseyside, England
David C. Rinker - Vanderbilt Univ, Med Ctr, Ctr Human Genet Res, Nashville, TN 37235 USA
Antonis Rokas - Vanderbilt Univ, Med Ctr, Ctr Human Genet Res, Nashville, TN 37235 USA
Tanya L. Russell - James Cook Univ, Australian Inst Trop Hlth Med, Fac Med Hlth & Mol Sci, Cairns 4870, Australia
N'Fale Sagnon - Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso
Maria V. Sharakhova - Virginia Polytech Inst & State Univ, Dept Entomol, Blacksburg, VA 24061 USA
Terrance Shea - Broad Inst, Genome Sequencing & Anal Program, Cambridge, MA 02142 USA
Felipe A. Simao - Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland
Frederic Simard - Inst Rech Dev, Unites Mixtes Rech Malad Infect & Vecteurs Ecol G, F-64501 Montpellier, France
Michel A. Slotman - Texas A&M Univ, Dept Entomol, College Stn, TX 77807 USA
Pradya Somboon - Chiang Mai Univ, Fac Med, Dept Parasitol, Chiang Mai 50200, Thailand
Vladimir Stegniy - Tomsk State Univ, Tomsk 634050, Russia
Claudio J. Struchiner - Fundacao Oswaldo Cruz, Rio De Janeiro, RJ, Brazil
Gregg W. C. Thomas - Indiana Univ, Sch Informat & Comp, Bloomington, IN 47405 USA
Marta Tojo - Univ Santiago de Compostela, Inst Invest Sanitarias, Ctr Res Mol Med & Chron Dis, Sch Med,Dept Physiol, La Coruna, Spain
Pantelis Topalis - Fdn Res & Technol, Inst Mol Biol & Biotechnol, GR-70013 Iraklion, Crete, Greece
Jose M. C. Tubio - Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England
Maria F. Unger - University of Notre Dame
John Vontas - University of Crete
Catherine Walton - Univ Manchester, Fac Life Sci, Computat Evolutionary Biol Grp, Oxford M13 9PT, England
Craig S. Wilding - Liverpool John Moores Univ, Sch Nat Sci & Psychol, Liverpool L3 3AF, Merseyside, England
Judith H. Willis - Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA
Yi-Chieh Wu - MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA
Guiyun Yan - Univ Calif Irvine, Coll Hlth Sci, Program Publ Hlth, Irvine, CA 92697 USA
Evgeny M. Zdobnov - Univ Geneva, Sch Med, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland
Xiaofan Zhou - Vanderbilt Univ, Dept Biol Sci, Nashville, TN 37235 USA
Flaminia Catteruccia - Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
George K. Christophides - University of London
Frank H. Collins - Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA
Robert S. Cornman - Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA
Andrea Crisanti - University of London
Martin J. Donnelly - University of Liverpool
Scott J. Emrich - University of Notre Dame
Michael C. Fontaine - Univ Notre Dame, Eck Inst Global Hlth, Notre Dame, IN 46556 USA
William Gelbart - Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
Matthew W. Hahn - Indiana University
Immo A. Hansen - New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA
Paul I. Howell - Ctr Dis Control & Prevent, Atlanta, GA 30329 USA
Fotis C. Kafatos - University of London
Manolis Kellis - MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA
Daniel Lawson - EMBL EBI, Cambridge CB10 1SD, England
Christos Louis - Fdn Res & Technol, Inst Mol Biol & Biotechnol, GR-70013 Iraklion, Crete, Greece
Shirley Luckhart - Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA
Marc A. T. Muskavitch - Boston Coll, Chestnut Hill, MA 02467 USA
Jose M. Ribeiro - NIAID, Lab Malaria & Vector Res, Rockville, MD 20852 USA
Michael A. Riehle - Univ Arizona, Dept Entomol, Tucson, AZ 85721 USA
Igor V. Sharakhov - Virginia Polytech Inst & State Univ, Program Genet Bioinformat & Computat Biol, Blacksburg, VA 24061 USA
Zhijian Tu - Virginia Polytech Inst & State Univ, Program Genet Bioinformat & Computat Biol, Blacksburg, VA 24061 USA
Laurence J. Zwiebel - Vanderbilt Univ & Med Ctr, Dept Biol Sci, Inst Chem Biol, Nashville, TN 37235 USA
Nora J. Besansky - University of Notre Dame
Détails de publication: Science (American Association for the Advancement of Science), Vol.347(6217), pp.43-43
Éditeur: Amer Assoc Advancement Science
Nombre de pages: 9
Note de subvention: 0644282 / Div Of Biological Infrastructure; National Science Foundation (NSF); NSF - Directorate for Biological Sciences (BIO) T32GM080178 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) G1100339 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission 1462107 / Div Of Information & Intelligent Systems; National Science Foundation (NSF); NSF - Directorate for Computer & Information Science & Engineering (CISE) PRJNA67511 / National Center for Biotechnology Information R56AI107263 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) U54HG003067 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) G1100339 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
Identifiants: 99147947709311
Unité académique: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Langue: English
Type de ressource: Journal article