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Higher Anti-Tumor Efficacy of the Dual HER3-EGFR Antibody MEHD7945a Combined with Ionizing Irradiation in Cervical Cancer Cells
Journal article   Open access   Peer reviewed

Higher Anti-Tumor Efficacy of the Dual HER3-EGFR Antibody MEHD7945a Combined with Ionizing Irradiation in Cervical Cancer Cells

Laura Bourillon, Sylvain Demontoy, Alexis Lenglet, Alexandre Zampieri, Julien Fraisse, Marta Jarlier, Florence Boissière-Michot, Hélène Perrochia, Gauthier Rathat, Véronique Garambois, …
International Journal of Radiation Oncology, Biology, Physics, Vol.106(5), pp.1039-1051
04/2020
DOI: https://doi.org/10.1016/j.ijrobp.2019.12.020

Abstract

Targeting EGFR and HER3 with a specific dual antibody (MEHD7945A) enhanced irradiation efficacy in vitro (cervical cancer cell lines) and in vivo (xenografted mice) in an additive way. Moreover, our study suggests that co-expression of EGFR and HER3 could be a candidate prognostic biomarker of poor overall survival in patients with cervical cancer. These preliminary results should be confirmed in a study with a larger sample.
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