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High throughput mechanochemistry: application to parallel synthesis of benzoxazines
Article de revue   Avec comité de lecture

High throughput mechanochemistry: application to parallel synthesis of benzoxazines

K. Martina, L. Rotolo, A. Porcheddu, F. Delogu, S. R. Bysouth, G. Cravotto et E. Colacino
Chemical communications (Cambridge, England), Vol.54(5), pp.551-554
11/01/2018
PMID: 29292460

Résumé

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
We describe herein an unprecedented mechanochemical "parallel synthesis'' of 3,4-dihydro-2H-benzo[e][1,3] oxazine derivatives via a one pot three component reaction. The new milling system uses a multiposition jar (variable sizes are possible), allowing for the processing of up to 12 samples simultaneously, leading to the formation of a fungicide and a building block for polymer preparation with higher throughput compared to standard milling devices.

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