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High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, B. abortus, and B. melitensis.
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High susceptibility of human dendritic cells to invasion by the intracellular pathogens Brucella suis, B. abortus, and B. melitensis.

Elisabeth Billard, Chantal Cazevieille, Jacques Dornand et Antoine Gross
Infection and Immunity, Vol.73(12), p.8418-24
12/2005
PMCID: PMC1307067
PMID: 16299342

Résumé

Brucella melitensis Brucella suis Brucellosis Dendritic Cells Humans Macrophages Brucella abortus
Bacteria from the Brucella genus are able to survive and proliferate within macrophages. Because they are phylogenetically closely related to macrophages, myeloid dendritic cells (DCs) constitute potential targets for Brucella bacteria. Here we report that DCs display a great susceptibility to Brucella infection. Therefore, DCs might serve as a reservoir and be important for the development of Brucella bacteria within their host.

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