High-flow nasal oxygen vs. standard oxygen therapy in immunocompromised patients with acute respiratory failure: study protocol for a randomized controlled trial

Élie Azoulay; Virginie Lemiale; Djamel Mokart; Saad Nseir; Laurent Argaud; Frédéric Pène; Loay Kontar; Fabrice Bruneel; Kada Klouche; François Barbier; Jean Reignier; Anabelle Stoclin; Guillaume Louis; Jean-Michel Constantin; Julien Mayaux; Florent Wallet; Achille Kouatchet; Vincent Peigne; Pierre Perez; Christophe Girault; Samir Jaber; Johanna Oziel; Martine Nyunga; Nicolas Terzi; Lila Bouadma; Christine Lebert; Alexandre Lautrette; Naike Bige; Jean-Herlé Raphalen; Laurent Papazian; Antoine Rabbat; Michaël Darmon; Sylvie Chevret; Alexandre Demoule

doi:10.1186/s13063-018-2492-z

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High-flow nasal oxygen vs. standard oxygen therapy in immunocompromised patients with acute respiratory failure: study protocol for a randomized controlled trial

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High-flow nasal oxygen vs. standard oxygen therapy in immunocompromised patients with acute respiratory failure: study protocol for a randomized controlled trial

Élie Azoulay, Virginie Lemiale, Djamel Mokart, Saad Nseir, Laurent Argaud, Frédéric Pène, Loay Kontar, Fabrice Bruneel, Kada Klouche, François Barbier, …

Trials, Vol.19(1)

12/2018

DOI: https://doi.org/10.1186/s13063-018-2492-z

PMID: 29506579

Abstract

Acute respiratory failure

High-flow oxygen

Immunocompromised Hematology

Immunosuppression

Intubation

Mortality

Oxygen

Acute respiratory failure (ARF) is the leading reason for intensive care unit (ICU) admission in immunocompromised patients. High-flow nasal oxygen (HFNO) therapy is an alternative to standard oxygen. By providing warmed and humidified gas, HFNO allows the delivery of higher flow rates via nasal cannula devices, with FiO2 values of nearly 100%. Benefits include alleviation of dyspnea and discomfort, decreased respiratory distress and decreased mortality in unselected patients with acute hypoxemic respiratory failure. However, in preliminary reports, HFNO benefits are controversial in immunocompromised patients in whom it has never been properly evaluated.

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Title: High-flow nasal oxygen vs. standard oxygen therapy in immunocompromised patients with acute respiratory failure: study protocol for a randomized controlled trial
Creators - without role: Élie Azoulay - Université Paris Cité
Virginie Lemiale - Hôpital Saint-Louis
Djamel Mokart - Institut Paoli-Calmettes
Saad Nseir - Centre Hospitalier Universitaire de Lille
Laurent Argaud - Hospices Civils de Lyon
Frédéric Pène - Hôpital Cochin
Loay Kontar - Centre Hospitalier Universitaire Amiens-Picardie
Fabrice Bruneel - Hôpital André Mignot
Kada Klouche - Centre Hospitalier Universitaire de Montpellier
François Barbier - Institut de recherche en horticulture et semences
Jean Reignier - Centre Hospitalier Universitaire de Nantes
Anabelle Stoclin - Institut Gustave Roussy
Guillaume Louis - Centre Hospitalier Régional de Metz-Thionville
Jean-Michel Constantin - Charmo University
Julien Mayaux - Sorbonne Université
Florent Wallet - Hôpital Lyon Sud
Achille Kouatchet - Centre Hospitalier Universitaire d'Angers
Vincent Peigne - Centre Hospitalier Métropole Savoie
Pierre Perez - Centre Hospitalier Régional et Universitaire de Nancy
Christophe Girault - Hôpital Charles-Nicolle
Samir Jaber - Centre Hospitalier Universitaire de Montpellier
Johanna Oziel - Université Sorbonne Paris Nord
Martine Nyunga - Centre Hospitalier de Roubaix
Nicolas Terzi - Centre Hospitalier Universitaire de Grenoble
Lila Bouadma - Hôpital Bichat-Claude-Bernard
Christine Lebert - Centre Hospitalier Départemental Vendée
Alexandre Lautrette - Centre Hospitalier Universitaire de Clermont-Ferrand
Naike Bige - Hôpital Saint-Antoine
Jean-Herlé Raphalen
Laurent Papazian - Hôpital Nord
Antoine Rabbat - Hôpital Cochin
Michaël Darmon - Hôpital Nord
Sylvie Chevret - Hôpital Saint-Louis
Alexandre Demoule - Sorbonne Université
Publication Details: Trials, Vol.19(1)
Identifiers: 9936621809311
Academic Unit: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Language: English
Resource Type: Journal article
Local Fields: hal-01790547