Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues

Siham El Fangour; Laurence Balas; Jean-Claude Rossi; Andrey Fedenyuk; Natalia Gretskaya; Mikhail Bobrov; Vladimir Bezuglov; Cecilia J. Hillard; Thierry Durand

doi:10.1016/S0960-894X(03)00348-2

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Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues

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Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues

Siham El Fangour, Laurence Balas, Jean-Claude Rossi, Andrey Fedenyuk, Natalia Gretskaya, Mikhail Bobrov, Vladimir Bezuglov, Cecilia J. Hillard et Thierry Durand

Bioorganic & medicinal chemistry letters, Vol.13(12), pp.1977-1980

16/06/2003

DOI: https://doi.org/10.1016/S0960-894X(03)00348-2

PMID: 12781177

Résumé

Three new endocannabinoid analogues in which amide moiety was replaced either by oxomethylene group or ester moiety with simultaneous substitution of both α-hydrogens with methyl groups were synthesized and their abilities to interact with CB1-receptor and FAAH were investigated. Graphic

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Détails

Titre: Hemisynthesis and preliminary evaluation of novel endocannabinoid analogues
Créateurs - sans rôle: Siham El Fangour - UMR CNRS 5074, Faculté de Pharmacie, 15 av. C. Flahault, BP 14491, F-34093 Montpellier Cedex 5, France
Laurence Balas - UMR CNRS 5074, Faculté de Pharmacie, 15 av. C. Flahault, BP 14491, F-34093 Montpellier Cedex 5, France
Jean-Claude Rossi - UMR CNRS 5074, Faculté de Pharmacie, 15 av. C. Flahault, BP 14491, F-34093 Montpellier Cedex 5, France
Andrey Fedenyuk - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., 117437 Moscow, Russia
Natalia Gretskaya - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., 117437 Moscow, Russia
Mikhail Bobrov - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., 117437 Moscow, Russia
Vladimir Bezuglov - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., 117437 Moscow, Russia
Cecilia J. Hillard - Department of Pharmacology and Toxicology, Medicinal College of Wisconsin, Milwaukee, WI 53226, USA
Thierry Durand - UMR CNRS 5074, Faculté de Pharmacie, 15 av. C. Flahault, BP 14491, F-34093 Montpellier Cedex 5, France
Détails de publication: Bioorganic & medicinal chemistry letters, Vol.13(12), pp.1977-1980
Éditeur: Elsevier Ltd
Nombre de pages: 4
Identifiants: 99138909609311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article