Glutamate transporter blockers: enantiomerically pure (2S,3S)- and (2S,3R)-3-methyl glutamic acids

J. Wehbe; Valérie Rolland; M.L. Roumestant; J. Martinez

doi:10.1016/S0957-4166(03)00127-7

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Glutamate transporter blockers: enantiomerically pure (2S,3S)- and (2S,3R)-3-methyl glutamic acids

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Glutamate transporter blockers: enantiomerically pure (2S,3S)- and (2S,3R)-3-methyl glutamic acids

J. Wehbe, Valérie Rolland, M.L. Roumestant and J. Martinez

Tetrahedron: Asymmetry, Vol.14(9), pp.1123-1126

05/2003

DOI: https://doi.org/10.1016/S0957-4166(03)00127-7

Abstract

A short four-step synthesis of (2S,3R)- and (2S,3S)-3-methyl glutamic acids is reported; the (2S,3R) isomer presented a significant inhibitory effect on glutamate transport.

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Title: Glutamate transporter blockers: enantiomerically pure (2S,3S)- and (2S,3R)-3-methyl glutamic acids
Creators - without role: J. Wehbe - Laboratoire des Amino-acides Peptides et Protéines
Valérie Rolland - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
M.L. Roumestant - Laboratoire des Amino-acides Peptides et Protéines
J. Martinez - Institut des Biomolécules Max Mousseron
Publication Details: Tetrahedron: Asymmetry, Vol.14(9), pp.1123-1126
Identifiers: 9944656809311
Academic Unit: Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-04648113