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Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress
Article de revue   Open Access   Avec comité de lecture

Glucocorticoid-dependent REDD1 expression reduces muscle metabolism to enable adaptation under energetic stress

Florian A Britto, Fabienne Cortade, Yassine Belloum, Marine Blaquière, Yann Gallot, Aurélie Docquier, Allan Pagano, Elodie Jublanc, Nadia Bendridi, Christelle Koechlin-Ramonatxo, …
BMC Biology, Vol.16(1)
12/2018
DOI: https://doi.org/10.1186/s12915-018-0525-4
PMID: 29895328

Résumé

Exercise mTOR Mitochondria Energy expenditure Fasting Hypoxia MAMs Metabolism Skeletal muscle
Skeletal muscle atrophy is a common feature of numerous chronic pathologies and is correlated with patient mortality. The REDD1 protein is currently recognized as a negative regulator of muscle mass through inhibition of the Akt/mTORC1 signaling pathway. REDD1 expression is notably induced following glucocorticoid secretion, which is a component of energy stress responses.

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