Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Antonio J Vallejo-Vaz; Christophe AT Stevens; Alexander RM Lyons; Kanika I Dharmayat; Tomas Freiberger; G Kees Hovingh; Pedro Mata; Frederick J Raal; Raul D Santos; Handrean Soran; Gerald F Watts; Marianne Abifadel; Carlos A Aguilar-Salinas; Khalid F Alhabib; Mutaz Alkhnifsawi; Wael Almahmeed; Fahad Alnouri; Rodrigo Alonso; Khalid Al-Rasadi; Ahmad Al-Sarraf; Nasreen Al-Sayed; Francisco Araujo; Tester F Ashavaid; Maciej Banach; Sophie Béliard; Marianne Benn; Christoph J Binder; Martin P Bogsrud; Mafalda Bourbon; Krzysztof Chlebus; Pablo Corral; Kairat Davletov; Olivier S Descamps; Ronen Durst; Marat Ezhov; Dan Gaita; Jacques Genest; Urh Groselj; Mariko Harada-Shiba; Kirsten B Holven; Meral Kayikcioglu; Weerapan Khovidhunkit; Katarina Lalic; Gustavs Latkovskis; Ulrich Laufs; Evangelos Liberopoulos; Marcos M Lima-Martinez; Jie Lin; Vincent Maher; A David Marais; Winfried März; Erkin Mirrakhimov; André R Miserez; Olena Mitchenko; Hapizah Nawawi; Børge G Nordestgaard; Andrie G Panayiotou; György Paragh; Zaneta Petrulioniene; Belma Pojskic; Arman Postadzhiyan; Katarina Raslova; Ashraf Reda; Željko Reiner; Fouzia Sadiq; Wilson Ehidiamen Sadoh; Heribert Schunkert; Aleksandr B Shek; Mario Stoll; Erik Stroes; Ta-Chen Su; Tavintharan Subramaniam; Andrey V Susekov; Myra Tilney; Brian Tomlinson; Thanh Huong Truong; Alexandros D Tselepis; Anne Tybjæg-Hansen; Alejandra Vázquez Cárdenas; Margus Viigimaa; Luya Wang; Shizuya Yamashita; Lale Tokgozoglu; Alberico L Catapano; Kausik K Ray; John JP Kastelein; Eric Bruckert; Branislav Vohnout; Laura Schreier; Jing Pang; Christoph Ebenbichler; Hans Dieplinger; Reinhold Innerhofer; Yvonne Winhofer-Stöckl; Susanne Greber-Platzer; Konstantin Krychtiuk; Walter Speidl; Hermann Toplak; Kurt Widhalm; Thomas Stulnig; Kurt Huber; Florian Höllerl; Gersina Rega-Kaun; Lucas Kleemann; Martin Mäser; Sabine Scholl-Bürgi; Christoph Säly; Florian J Mayer; Gaelle Sablon; Eric Tarantino; Charlotte Nzeyimana; Lamija Pojskic; Ibrahim Sisic; Azra D Nalbantic; Cinthia E Jannes; Alexandre C Pereira; Jose E Krieger; Ivo Petrov; Assen Goudev; Fedya Nikolov; Snejana Tisheva; Yoto Yotov; Ivajlo Tzvetkov; Alexis Baass; Jean Bergeron; Sophie Bernard; Diane Brisson; Liam R Brunham; Lubomira Cermakova; Patrick Couture; Gordon A Francis; Daniel Gaudet; Robert A Hegele; Etienne Khoury; GB John Mancini; Brian W McCrindle; Martine Paquette; Isabelle Ruel; Ada Cuevas; Sylvia Asenjo; Xumin Wang; Kang Meng; Xiantao Song; Qiang Yong; Tao Jiang; Ziyou Liu; Yanyu Duan; Jing Hong; Pucong Ye; Yan Chen; Jianguang Qi; Zesen Liu; Yuntao Li; Chaoyi Zhang; Jie Peng; Ya Yang; Wei Yu; Qian Wang; Hui Yuan; Shitong Cheng; Long Jiang; Mei Chong; Jian Jiao; Yue Wu; Wenhui Wen; Liyuan Xu; Ruiying Zhang; Yichen Qu; Jianxun He; Xuesong Fan; Zhenjia Wang; Elaine Chow; Ivan Pećin; Dražen Perica; Phivos Symeonides; Michal Vrablik; Richard Ceska; Vladimir Soska; Lukas Tichy; Vera Adamkova; Jana Franekova; Renata Cifkova; Pavel Kraml; Katerina Vonaskova; Jana Cepova; Magdalena Dusejovska; Lenka Pavlickova; Vladimir Blaha; Hana Rosolova; Barbora Nussbaumerova; Roman Cibulka; Helena Vaverkova; Lubica Cibickova; Zdenka Krejsova; Katerina Rehouskova; Pavel Malina; Milena Budikova; Vaclava Palanova; Lucie Solcova; Alena Lubasova; Helena Podzimkova; Juraj Bujdak; Jiri Vesely; Marta Jordanova; Tomas Salek; Robin Urbanek; Stanislav Zemek; Jan Lacko; Hana Halamkova; Sona Machacova; Sarka Mala; Eva Cubova; Katerina Valoskova; Lukas Burda; Ahmed Bendary; Ihab Daoud; Sameh Emil; Atef Elbahry; Samir Rafla; Osama Sanad; Ghada Kazamel; Mohamed Ashraf; Mohamed Sobhy; Amro El-Hadidy; Mohamed A Shafy; Saif Kamal; Mohamed Bendary; Grete Talviste; Denis Angoulvant; Franck Boccara; Bertrand Cariou; Valérie Carreau; Alain Carrie; Sybil Charrieres; Yves Cottin; Mathilde Di-Fillipo; Pierre H Ducluzeau; Sonia Dulong; Vincent Durlach; Michel Farnier; Emile Ferrari; Dorota Ferrieres; Jean Ferrieres; Antonio Gallo; Regis hankard; Jocelyne Inamo; Julie Lemale; Philippe Moulin; François Paillard; Noel Peretti; Agnès Perrin; Alain Pradignac; Jean P Rabes; Vincent Rigalleau; Ariane Sultan; François Schiele; Patrick Tounian; René Valero; Bruno Verges; Cécile Yelnik; Olivier Ziegler; Ira A Haack; Nina Schmidt; Alexander Dressel; Isabel Klein; Jutta Christmann; Antonia Sonntag; Christine Stumpp; Diana Boger; Dana Biedermann; Monica MN Usme; F Ulrich Beil; Gerald Klose; Christel König; Ioanna Gouni-Berthold; Britta Otte; Gereon Böll; Anja Kirschbaum; Jürgen Merke; Johannes Scholl; Thomas Segiet; Marco Gebauer; Florentina Predica; Manfred Mayer; Frank Leistikow; Sabine Füllgraf-Horst; Cornelius Müller; Melanie Schüler; Judith Wiener; Konrad Hein; Peter Baumgartner; Stefan Kopf; Reinhold Busch; Michael Schömig; Stephan Matthias; Nicole Allendorf-Ostwald; Bruno Fink; Dieter Böhm; Alexander Jäkel; Ann-Cathrin Koschker; Rüdiger Schweizer; Anja Vogt; Klaus Parhofer; Wolfgang König; Wibke Reinhard; Andrea Bäßler; Alexander Stadelmann; Volker Schrader; Julius Katzmann; Adrienne Tarr; Elisabeth Steinhagen-Thiessen; Ursula Kassner; Gerret Paulsen; Jürgen Homberger; Claudia Zemmrich; Wolfgang Seeger; Kathrin Biolik; Dorothee Deiss; Corinna Richter; Elina Pantchechnikova; Elena Dorn; Ulrike Schatz; Ulrich Julius; Antje Spens; Tobias Wiesner; Michael Scholl; Christos V Rizos; Nikolaos Sakkas; Moses Elisaf; Ioannis Skoumas; Konstantinos Tziomalos; Loukianos Rallidis; Vasileios Kotsis; Michalis Doumas; Vasileios Athyros; Emmanouil Skalidis; Genovefa Kolovou; Anastasia Garoufi; Eleni Bilianou; Iosif Koutagiar; Dimitrios Agapakis; Estela Kiouri; Christina Antza; Niki Katsiki; Evangelos Zacharis; Achilleas Attilakos; George Sfikas; Charalambos Koumaras; Panagiotis Anagnostis; Georgia Anastasiou; George Liamis; Amalia-Despoina Koutsogianni; Zsolt Karányi; Mariann Harangi; László Bajnok; Mária Audikovszky; László Márk; Béla Benczúr; István Reiber; Gergely Nagy; András Nagy; Lakshmi L Reddy; Swarup AV Shah; Chandrashekhar K Ponde; Jamshed J Dalal; Jitendra PS Sawhney; Ishwar C Verma; Mays Altaey; Khalid Al-Jumaily; Dilshad Rasul; Ali F Abdalsahib; Amer A Jabbar; Mohanad Al-ageedi; Ruth Agar; Hofit Cohen; Avishay Ellis; Dov Gavishv; Dror Harats; Yaacov Henkin; Hila Knobler; Leah Leavit; Eran Leitersdorf; Ardon Rubinstein; Daniel Schurr; Shoshi Shpitzen; Auryan Szalat; Manuela Casula; Veronica Zampoleri; Marta Gazzotti; Elena Olmastroni; Kota Matsuki; Mika Hori; Masatsune Ogura; Daisaku Masuda; Takuya Kobayashi; Kumiko Nagahama; Mohammed Al-Jarallah; Mirjana Radovic; Olga Lunegova; Erkayim Bektasheva; Elyor Khodzhiboboev; Andrejs Erglis; Dainus Gilis; Georgijs Nesterovics; Vita Saripo; Ruta Meiere; Arta Upena-RozeMicena; Elizabete Terauda; Selim Jambart; Petra E Khoury; Sandy Elbitar; Carine Ayoub; Youmna Ghaleb; Urte Aliosaitiene; Sandra Kutkiene; Noor AM Kasim; Noor SM Nor; Anis S Ramli; Suraya A Razak; Alyaa Al-Khateeb; Siti HSA Kadir; Suhaila A Muid; Thuhairah A Rahman; Sazzli S Kasim; Ahmad BM Radzi; Khairul S Ibrahim; Salmi Razali; Zaliha Ismail; Rohana A Ghani; Muhammad IA Hafidz; Ang L Chua; Marshima M Rosli; Muthukkaruppan Annamalai; Lay K Teh; Rafezah Razali; Yung A Chua; Azhari Rosman; Abdul R Sanusi; Nor AA Murad; A Rahman A Jamal; Sukma A Nazli; Aimi Z Razman; Norhidayah Rosman; Radzi Rahmat; Nur S Hamzan; C Azzopardi; Roopa Mehta; Alexandro J Martagon; Gabriela AG Ramirez; Neftali EA Villa; Arsenio V Vazquez; Daniel Elias-Lopez; Gustavo G Retana; Betsabel Rodriguez; Jose JC Macías; Alejandro R Zazueta; Rocio M Alvarado; Julieta DM Portano; Humberto A Lopez; Leobardo Sauque-Reyna; Laura GG Herrera; Luis ES Mendia; Humberto Garcia Aguilar; Elizabeth R Cooremans; Berenice P Aparicio; Victoria M Zubieta; Perla AC Gonzalez; Aldo Ferreira-Hermosillo; Nacu C Portilla; Guadalupe J Dominguez; Alinna YR Garcia; Hector EA Cazares; Jesus R Gonzalez; Carla VM Valencia; Francisco G Padilla; Ramon M Prado; Manuel O De los Rios Ibarra; Ruy DA Villicaña; Karina JA Rivera; Ricardo A Carrera; Jose A Alvarez; Jose CA Martinez; Manuel de los Reyes Barrera Bustillo; Gonzalo C Vargas; Roberto C Chacon; Mario HF Andrade; Ashanty F Ortega; Hector G Alcala; Laura EG de Leon; Berenice G Guzman; Jose JG Garcia; Juan CG Cuellar; Jose RG Cruz; Anell Hernandez Garcia; Jesus RH Almada; Ursulo J Herrera; Fabiola L Sobrevilla; Eduardo M Rodriguez; Cristina M Sibaja; Alma BM Rodriguez; Jose CM Oyervides; Daniel IP Vazquez; Eduardo AR Rodriguez; Ma LR Osorio; Juan R Saucedo; Margarita T Tamayo; Luis AV Talavera; Luis EV Arroyo; Eloy AZ Carrillo; Alphonsus Isara; Darlington E Obaseki; Khalid Al-Waili; Fahad Al-Zadjali; Ibrahim Al-Zakwani; Mohammed Al-Kindi; Suad Al-Mukhaini; Hamida Al-Barwani; Asim Rana; Lahore SU Shah; Ewa Starostecka; Agnieszka Konopka; Joanna Lewek; Marcin Bartłomiejczyk; Mariusz Gąsior; Krzysztof Dyrbuś; Jacek Jóźwiak; Marcin Gruchała; Marcin Pajkowski; Marzena Romanowska-Kocejko; Marta Żarczyńska-Buchowiecka; Magdalena Chmara; Bartosz Wasąg; Aleksandra Parczewska; Natasza Gilis-Malinowska; Justyna Borowiec-Wolna; Aneta Stróżyk; Marlena Woś; Aleksandra Michalska-Grzonkowska; Ana M Medeiros; Ana C Alves; Francisco Silva; Goreti Lobarinhas; Isabel Palma; Jose P de Moura; Miguel T Rico; Quitéria Rato; Patrícia Pais; Susana Correia; Oana Moldovan; Maria J Virtuoso; Jose M Salgado; Ines Colaço; Andreea Dumitrescu; Calin Lengher; Svetlana Mosteoru; Alexey Meshkov; Alexandra Ershova; Tatiana Rozkova; Victoria Korneva; Kuznetsova T Yu; Vitaliy Zafiraki; Mikhail Voevoda; Victor Gurevich; Dmitry Duplyakov; Yulia Ragino; Maya Safarova; Igor Shaposhnik; Fahmi Alkaf; Alia Khudari; Nawal Rwaili; Faisal Al-Allaf; Mohammad Alghamdi; Mohammed A Batais; Turky H Almigbal; Abdulhalim Kinsara; Ashraf HA AlQudaimi; Zuhier Awan; Omer A Elamin; Hani Altaradi; Natasa Rajkovic; Ljiljana Popovic; Sandra Singh; Ljubica Stosic; Iva Rasulic; Nebojsa M Lalic; Carolyn Lam; Tan J Le; Eric LT Siang; Sanjaya Dissanayake; Justin T I-Shing; Tai E Shyong; Terrance CS Jin; Karin Balinth; Ingrid Buganova; Lubomira Fabryova; Michaela Kadurova; Alexander Klabnik; Miriam Kozárová; Jana Sirotiakova; Tadej Battelino; Jernej Kovac; Matej Mlinaric; Ursa Sustar; Katarina T Podkrajsek; Zlatko Fras; Borut Jug; Matija Cevc; Gillian J Pilcher; D J Blom; K H Wolmarans; B C Brice; Ovidio Muñiz-Grijalvo; Jose L Díaz-Díaz; Leopoldo P de Isla; Francisco Fuentes; Lina Badimon; François Martin; Angela Lux; Nien-Tzu Chang; Poranee Ganokroj; Mehmet Akbulut; Gökhan Alici; Fahri Bayram; Levent H Can; Ahmet Celik; Ceyhun Ceyhan; Fatma Y Coskun; Mesut Demir; Sabri Demircan; Volkan Dogan; Emre Durakoglugil; Ibrahim E Dural; Omer Gedikli; Aysa Hacioglu; Muge Ildizli; Salih Kilic; Bahadir Kirilmaz; Merih Kutlu; Aytekin Oguz; Oner Ozdogan; Ersel Onrat; Savas Ozer; Tevfik Sabuncu; Tayfun Sahin; Fatih Sivri; Alper Sonmez; Ahmet Temizhan; Selim Topcu; Abdullah Tuncez; Mirac Vural; Mustafa Yenercag; Dilek Yesilbursa; Zerrin Yigit; Aytul B Yildirim; Aylin Yildirir; Mehmet B Yilmaz; Bassam Atallah; Mahmoud Traina; Hani Sabbour; Dana A Hay; Neama Luqman; Abubaker Elfatih; Arshad Abdulrasheed; See Kwok; Nicolas D Oca; Ximena Reyes; Rano B Alieva; Ravshanbek D Kurbanov; Shavkat U Hoshimov; Ulugbek I Nizamov; Adolat V Ziyaeva; Guzal J Abdullaeva; Doan L Do; Mai NT Nguyen; Ngoc T Kim; Thanh T Le; Hong A Le

doi:10.1016/s0140-6736(21)01122-3

Retour

Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Article de revue

Avec comité de lecture

Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

Antonio J Vallejo-Vaz, Christophe AT Stevens, Alexander RM Lyons, Kanika I Dharmayat, Tomas Freiberger, G Kees Hovingh, Pedro Mata, Frederick J Raal, Raul D Santos, Handrean Soran, …

The Lancet, Vol.398(10312), pp.1713-1725

06/11/2021

DOI: https://doi.org/10.1016/s0140-6736(21)01122-3

Résumé

11 Medical and Health Sciences

CLINICIAN

EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

General & Internal Medicine

GUIDANCE

INSIGHTS

Life Sciences & Biomedicine

Medicine, General & Internal

PREVALENCE

Science & Technology

Background The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally. Methods Using FHSC global registry data, we did a cross-sectional assessment of adults (aged 18 years or older) with a clinical or genetic diagnosis of probable or definite heterozygous familial hypercholesterolaemia at the time they were entered into the registries. Data were assessed overall and by WHO regions, sex, and index versus non-index cases. Findings Of the 61 612 individuals in the registry, 42 167 adults (21 999 [53·6%] women) from 56 countries were included in the study. Of these, 31 798 (75·4%) were diagnosed with the Dutch Lipid Clinic Network criteria, and 35 490 (84·2%) were from the WHO region of Europe. Median age of participants at entry in the registry was 46·2 years (IQR 34·3–58·0); median age at diagnosis of familial hypercholesterolaemia was 44·4 years (32·5–56·5), with 40·2% of participants younger than 40 years when diagnosed. Prevalence of cardiovascular risk factors increased progressively with age and varied by WHO region. Prevalence of coronary disease was 17·4% (2·1% for stroke and 5·2% for peripheral artery disease), increasing with concentrations of untreated LDL cholesterol, and was about two times lower in women than in men. Among patients receiving lipid-lowering medications, 16 803 (81·1%) were receiving statins and 3691 (21·2%) were on combination therapy, with greater use of more potent lipid-lowering medication in men than in women. Median LDL cholesterol was 5·43 mmol/L (IQR 4·32–6·72) among patients not taking lipid-lowering medications and 4·23 mmol/L (3·20–5·66) among those taking them. Among patients taking lipid-lowering medications, 2·7% had LDL cholesterol lower than 1·8 mmol/L; the use of combination therapy, particularly with three drugs and with proprotein convertase subtilisin–kexin type 9 inhibitors, was associated with a higher proportion and greater odds of having LDL cholesterol lower than 1·8 mmol/L. Compared with index cases, patients who were non-index cases were younger, with lower LDL cholesterol and lower prevalence of cardiovascular risk factors and cardiovascular diseases (all p<0·001). Interpretation Familial hypercholesterolaemia is diagnosed late. Guideline-recommended LDL cholesterol concentrations are infrequently achieved with single-drug therapy. Cardiovascular risk factors and presence of coronary disease were lower among non-index cases, who were diagnosed earlier. Earlier detection and greater use of combination therapies are required to reduce the global burden of familial hypercholesterolaemia. Funding Pfizer, Amgen, Merck Sharp & Dohme, Sanofi–Aventis, Daiichi Sankyo, and Regeneron.

Indicateurs

1 Consultations de la notice

See more details

Détails

Titre: Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
Créateurs - sans rôle: Antonio J Vallejo-Vaz
Christophe AT Stevens
Alexander RM Lyons
Kanika I Dharmayat
Tomas Freiberger
G Kees Hovingh
Pedro Mata
Frederick J Raal
Raul D Santos
Handrean Soran
Gerald F Watts
Marianne Abifadel
Carlos A Aguilar-Salinas
Khalid F Alhabib
Mutaz Alkhnifsawi
Wael Almahmeed
Fahad Alnouri
Rodrigo Alonso
Khalid Al-Rasadi
Ahmad Al-Sarraf
Nasreen Al-Sayed
Francisco Araujo
Tester F Ashavaid
Maciej Banach
Sophie Béliard
Marianne Benn
Christoph J Binder
Martin P Bogsrud
Mafalda Bourbon
Krzysztof Chlebus
Pablo Corral
Kairat Davletov
Olivier S Descamps
Ronen Durst
Marat Ezhov
Dan Gaita
Jacques Genest
Urh Groselj
Mariko Harada-Shiba
Kirsten B Holven
Meral Kayikcioglu
Weerapan Khovidhunkit
Katarina Lalic
Gustavs Latkovskis
Ulrich Laufs
Evangelos Liberopoulos
Marcos M Lima-Martinez
Jie Lin
Vincent Maher
A David Marais
Winfried März
Erkin Mirrakhimov
André R Miserez
Olena Mitchenko
Hapizah Nawawi
Børge G Nordestgaard
Andrie G Panayiotou
György Paragh
Zaneta Petrulioniene
Belma Pojskic
Arman Postadzhiyan
Katarina Raslova
Ashraf Reda
Željko Reiner
Fouzia Sadiq
Wilson Ehidiamen Sadoh
Heribert Schunkert
Aleksandr B Shek
Mario Stoll
Erik Stroes
Ta-Chen Su
Tavintharan Subramaniam
Andrey V Susekov
Myra Tilney
Brian Tomlinson
Thanh Huong Truong
Alexandros D Tselepis
Anne Tybjæg-Hansen
Alejandra Vázquez Cárdenas
Margus Viigimaa
Luya Wang
Shizuya Yamashita
Lale Tokgozoglu
Alberico L Catapano
Kausik K Ray
John JP Kastelein
Eric Bruckert
Branislav Vohnout
Laura Schreier
Jing Pang
Christoph Ebenbichler
Hans Dieplinger
Reinhold Innerhofer
Yvonne Winhofer-Stöckl
Susanne Greber-Platzer
Konstantin Krychtiuk
Walter Speidl
Hermann Toplak
Kurt Widhalm
Thomas Stulnig
Kurt Huber
Florian Höllerl
Gersina Rega-Kaun
Lucas Kleemann
Martin Mäser
Sabine Scholl-Bürgi
Christoph Säly
Florian J Mayer
Gaelle Sablon
Eric Tarantino
Charlotte Nzeyimana
Lamija Pojskic
Ibrahim Sisic
Azra D Nalbantic
Cinthia E Jannes
Alexandre C Pereira
Jose E Krieger
Ivo Petrov
Assen Goudev
Fedya Nikolov
Snejana Tisheva
Yoto Yotov
Ivajlo Tzvetkov
Alexis Baass
Jean Bergeron
Sophie Bernard
Diane Brisson
Liam R Brunham
Lubomira Cermakova
Patrick Couture
Gordon A Francis
Daniel Gaudet
Robert A Hegele
Etienne Khoury
GB John Mancini
Brian W McCrindle
Martine Paquette
Isabelle Ruel
Ada Cuevas
Sylvia Asenjo
Xumin Wang
Kang Meng
Xiantao Song
Qiang Yong
Tao Jiang
Ziyou Liu
Yanyu Duan
Jing Hong
Pucong Ye
Yan Chen
Jianguang Qi
Zesen Liu
Yuntao Li
Chaoyi Zhang
Jie Peng
Ya Yang
Wei Yu
Qian Wang
Hui Yuan
Shitong Cheng
Long Jiang
Mei Chong
Jian Jiao
Yue Wu
Wenhui Wen
Liyuan Xu
Ruiying Zhang
Yichen Qu
Jianxun He
Xuesong Fan
Zhenjia Wang
Elaine Chow
Ivan Pećin
Dražen Perica
Phivos Symeonides
Michal Vrablik
Richard Ceska
Vladimir Soska
Lukas Tichy
Vera Adamkova
Jana Franekova
Renata Cifkova
Pavel Kraml
Katerina Vonaskova
Jana Cepova
Magdalena Dusejovska
Lenka Pavlickova
Vladimir Blaha
Hana Rosolova
Barbora Nussbaumerova
Roman Cibulka
Helena Vaverkova
Lubica Cibickova
Zdenka Krejsova
Katerina Rehouskova
Pavel Malina
Milena Budikova
Vaclava Palanova
Lucie Solcova
Alena Lubasova
Helena Podzimkova
Juraj Bujdak
Jiri Vesely
Marta Jordanova
Tomas Salek
Robin Urbanek
Stanislav Zemek
Jan Lacko
Hana Halamkova
Sona Machacova
Sarka Mala
Eva Cubova
Katerina Valoskova
Lukas Burda
Ahmed Bendary
Ihab Daoud
Sameh Emil
Atef Elbahry
Samir Rafla
Osama Sanad
Ghada Kazamel
Mohamed Ashraf
Mohamed Sobhy
Amro El-Hadidy
Mohamed A Shafy
Saif Kamal
Mohamed Bendary
Grete Talviste
Denis Angoulvant
Franck Boccara
Bertrand Cariou
Valérie Carreau
Alain Carrie
Sybil Charrieres
Yves Cottin
Mathilde Di-Fillipo
Pierre H Ducluzeau
Sonia Dulong
Vincent Durlach
Michel Farnier
Emile Ferrari
Dorota Ferrieres
Jean Ferrieres
Antonio Gallo
Regis hankard
Jocelyne Inamo
Julie Lemale
Philippe Moulin
François Paillard
Noel Peretti
Agnès Perrin
Alain Pradignac
Jean P Rabes
Vincent Rigalleau
Ariane Sultan
François Schiele
Patrick Tounian
René Valero
Bruno Verges
Cécile Yelnik
Olivier Ziegler
Ira A Haack
Nina Schmidt
Alexander Dressel
Isabel Klein
Jutta Christmann
Antonia Sonntag
Christine Stumpp
Diana Boger
Dana Biedermann
Monica MN Usme
F Ulrich Beil
Gerald Klose
Christel König
Ioanna Gouni-Berthold
Britta Otte
Gereon Böll
Anja Kirschbaum
Jürgen Merke
Johannes Scholl
Thomas Segiet
Marco Gebauer
Florentina Predica
Manfred Mayer
Frank Leistikow
Sabine Füllgraf-Horst
Cornelius Müller
Melanie Schüler
Judith Wiener
Konrad Hein
Peter Baumgartner
Stefan Kopf
Reinhold Busch
Michael Schömig
Stephan Matthias
Nicole Allendorf-Ostwald
Bruno Fink
Dieter Böhm
Alexander Jäkel
Ann-Cathrin Koschker
Rüdiger Schweizer
Anja Vogt
Klaus Parhofer
Wolfgang König
Wibke Reinhard
Andrea Bäßler
Alexander Stadelmann
Volker Schrader
Julius Katzmann
Adrienne Tarr
Elisabeth Steinhagen-Thiessen
Ursula Kassner
Gerret Paulsen
Jürgen Homberger
Claudia Zemmrich
Wolfgang Seeger
Kathrin Biolik
Dorothee Deiss
Corinna Richter
Elina Pantchechnikova
Elena Dorn
Ulrike Schatz
Ulrich Julius
Antje Spens
Tobias Wiesner
Michael Scholl
Christos V Rizos
Nikolaos Sakkas
Moses Elisaf
Ioannis Skoumas
Konstantinos Tziomalos
Loukianos Rallidis
Vasileios Kotsis
Michalis Doumas
Vasileios Athyros
Emmanouil Skalidis
Genovefa Kolovou
Anastasia Garoufi
Eleni Bilianou
Iosif Koutagiar
Dimitrios Agapakis
Estela Kiouri
Christina Antza
Niki Katsiki
Evangelos Zacharis
Achilleas Attilakos
George Sfikas
Charalambos Koumaras
Panagiotis Anagnostis
Georgia Anastasiou
George Liamis
Amalia-Despoina Koutsogianni
Zsolt Karányi
Mariann Harangi
László Bajnok
Mária Audikovszky
László Márk
Béla Benczúr
István Reiber
Gergely Nagy
András Nagy
Lakshmi L Reddy
Swarup AV Shah
Chandrashekhar K Ponde
Jamshed J Dalal
Jitendra PS Sawhney
Ishwar C Verma
Mays Altaey
Khalid Al-Jumaily
Dilshad Rasul
Ali F Abdalsahib
Amer A Jabbar
Mohanad Al-ageedi
Ruth Agar
Hofit Cohen
Avishay Ellis
Dov Gavishv
Dror Harats
Yaacov Henkin
Hila Knobler
Leah Leavit
Eran Leitersdorf
Ardon Rubinstein
Daniel Schurr
Shoshi Shpitzen
Auryan Szalat
Manuela Casula
Veronica Zampoleri
Marta Gazzotti
Elena Olmastroni
Kota Matsuki
Mika Hori
Masatsune Ogura
Daisaku Masuda
Takuya Kobayashi
Kumiko Nagahama
Mohammed Al-Jarallah
Mirjana Radovic
Olga Lunegova
Erkayim Bektasheva
Elyor Khodzhiboboev
Andrejs Erglis
Dainus Gilis
Georgijs Nesterovics
Vita Saripo
Ruta Meiere
Arta Upena-RozeMicena
Elizabete Terauda
Selim Jambart
Petra E Khoury
Sandy Elbitar
Carine Ayoub
Youmna Ghaleb
Urte Aliosaitiene
Sandra Kutkiene
Noor AM Kasim
Noor SM Nor
Anis S Ramli
Suraya A Razak
Alyaa Al-Khateeb
Siti HSA Kadir
Suhaila A Muid
Thuhairah A Rahman
Sazzli S Kasim
Ahmad BM Radzi
Khairul S Ibrahim
Salmi Razali
Zaliha Ismail
Rohana A Ghani
Muhammad IA Hafidz
Ang L Chua
Marshima M Rosli
Muthukkaruppan Annamalai
Lay K Teh
Rafezah Razali
Yung A Chua
Azhari Rosman
Abdul R Sanusi
Nor AA Murad
A Rahman A Jamal
Sukma A Nazli
Aimi Z Razman
Norhidayah Rosman
Radzi Rahmat
Nur S Hamzan
C Azzopardi
Roopa Mehta
Alexandro J Martagon
Gabriela AG Ramirez
Neftali EA Villa
Arsenio V Vazquez
Daniel Elias-Lopez
Gustavo G Retana
Betsabel Rodriguez
Jose JC Macías
Alejandro R Zazueta
Rocio M Alvarado
Julieta DM Portano
Humberto A Lopez
Leobardo Sauque-Reyna
Laura GG Herrera
Luis ES Mendia
Humberto Garcia Aguilar
Elizabeth R Cooremans
Berenice P Aparicio
Victoria M Zubieta
Perla AC Gonzalez
Aldo Ferreira-Hermosillo
Nacu C Portilla
Guadalupe J Dominguez
Alinna YR Garcia
Hector EA Cazares
Jesus R Gonzalez
Carla VM Valencia
Francisco G Padilla
Ramon M Prado
Manuel O De los Rios Ibarra
Ruy DA Villicaña
Karina JA Rivera
Ricardo A Carrera
Jose A Alvarez
Jose CA Martinez
Manuel de los Reyes Barrera Bustillo
Gonzalo C Vargas
Roberto C Chacon
Mario HF Andrade
Ashanty F Ortega
Hector G Alcala
Laura EG de Leon
Berenice G Guzman
Jose JG Garcia
Juan CG Cuellar
Jose RG Cruz
Anell Hernandez Garcia
Jesus RH Almada
Ursulo J Herrera
Fabiola L Sobrevilla
Eduardo M Rodriguez
Cristina M Sibaja
Alma BM Rodriguez
Jose CM Oyervides
Daniel IP Vazquez
Eduardo AR Rodriguez
Ma LR Osorio
Juan R Saucedo
Margarita T Tamayo
Luis AV Talavera
Luis EV Arroyo
Eloy AZ Carrillo
Alphonsus Isara
Darlington E Obaseki
Khalid Al-Waili
Fahad Al-Zadjali
Ibrahim Al-Zakwani
Mohammed Al-Kindi
Suad Al-Mukhaini
Hamida Al-Barwani
Asim Rana
Lahore SU Shah
Ewa Starostecka
Agnieszka Konopka
Joanna Lewek
Marcin Bartłomiejczyk
Mariusz Gąsior
Krzysztof Dyrbuś
Jacek Jóźwiak
Marcin Gruchała
Marcin Pajkowski
Marzena Romanowska-Kocejko
Marta Żarczyńska-Buchowiecka
Magdalena Chmara
Bartosz Wasąg
Aleksandra Parczewska
Natasza Gilis-Malinowska
Justyna Borowiec-Wolna
Aneta Stróżyk
Marlena Woś
Aleksandra Michalska-Grzonkowska
Ana M Medeiros
Ana C Alves
Francisco Silva
Goreti Lobarinhas
Isabel Palma
Jose P de Moura
Miguel T Rico
Quitéria Rato
Patrícia Pais
Susana Correia
Oana Moldovan
Maria J Virtuoso
Jose M Salgado
Ines Colaço
Andreea Dumitrescu
Calin Lengher
Svetlana Mosteoru
Alexey Meshkov
Alexandra Ershova
Tatiana Rozkova
Victoria Korneva
Kuznetsova T Yu
Vitaliy Zafiraki
Mikhail Voevoda
Victor Gurevich
Dmitry Duplyakov
Yulia Ragino
Maya Safarova
Igor Shaposhnik
Fahmi Alkaf
Alia Khudari
Nawal Rwaili
Faisal Al-Allaf
Mohammad Alghamdi
Mohammed A Batais
Turky H Almigbal
Abdulhalim Kinsara
Ashraf HA AlQudaimi
Zuhier Awan
Omer A Elamin
Hani Altaradi
Natasa Rajkovic
Ljiljana Popovic
Sandra Singh
Ljubica Stosic
Iva Rasulic
Nebojsa M Lalic
Carolyn Lam
Tan J Le
Eric LT Siang
Sanjaya Dissanayake
Justin T I-Shing
Tai E Shyong
Terrance CS Jin
Karin Balinth
Ingrid Buganova
Lubomira Fabryova
Michaela Kadurova
Alexander Klabnik
Miriam Kozárová
Jana Sirotiakova
Tadej Battelino
Jernej Kovac
Matej Mlinaric
Ursa Sustar
Katarina T Podkrajsek
Zlatko Fras
Borut Jug
Matija Cevc
Gillian J Pilcher
D J Blom
K H Wolmarans
B C Brice
Ovidio Muñiz-Grijalvo
Jose L Díaz-Díaz
Leopoldo P de Isla
Francisco Fuentes
Lina Badimon
François Martin
Angela Lux
Nien-Tzu Chang
Poranee Ganokroj
Mehmet Akbulut
Gökhan Alici
Fahri Bayram
Levent H Can
Ahmet Celik
Ceyhun Ceyhan
Fatma Y Coskun
Mesut Demir
Sabri Demircan
Volkan Dogan
Emre Durakoglugil
Ibrahim E Dural
Omer Gedikli
Aysa Hacioglu
Muge Ildizli
Salih Kilic
Bahadir Kirilmaz
Merih Kutlu
Aytekin Oguz
Oner Ozdogan
Ersel Onrat
Savas Ozer
Tevfik Sabuncu
Tayfun Sahin
Fatih Sivri
Alper Sonmez
Ahmet Temizhan
Selim Topcu
Abdullah Tuncez
Mirac Vural
Mustafa Yenercag
Dilek Yesilbursa
Zerrin Yigit
Aytul B Yildirim
Aylin Yildirir
Mehmet B Yilmaz
Bassam Atallah
Mahmoud Traina
Hani Sabbour
Dana A Hay
Neama Luqman
Abubaker Elfatih
Arshad Abdulrasheed
See Kwok
Nicolas D Oca
Ximena Reyes
Rano B Alieva
Ravshanbek D Kurbanov
Shavkat U Hoshimov
Ulugbek I Nizamov
Adolat V Ziyaeva
Guzal J Abdullaeva
Doan L Do
Mai NT Nguyen
Ngoc T Kim
Thanh T Le
Hong A Le
Détails de publication: The Lancet, Vol.398(10312), pp.1713-1725
Éditeur: Elsevier BV
Identifiants: 99148699309311
Unité académique: Physiologie et Médecine Expérimentale du coeur et des muscles - PhyMedExp
Langue: English
Type de ressource: Journal article