Genomic history of the seventh pandemic of cholera in Africa

François-Xavier Weill; Daryl Domman; Elisabeth Njamkepo; Cheryl Tarr; Jean Rauzier; Nizar Fawal; Karen H Keddy; Henrik Salje; Sandra Moore; Asish K Mukhopadhyay; Raymond Bercion; Francisco J Luquero; Antoinette Ngandjio; Mireille Dosso; Elena Monakhova; Benoit Garin; Christiane Bouchier; Carlo Pazzani; Ankur Mutreja; Roland Grunow; Fati Sidikou; Laurence Bonte; Sébastien Breurec; Maria Damian; Berthe-Marie Njanpop-Lafourcade; Guillaume Sapriel; Anne-Laure Page; Monzer Hamze; Myriam Henkens; Goutam Chowdhury; Martin Mengel; Jean-Louis Koeck; Jean-Michel Fournier; Gordon Dougan; Patrick A D Grimont; Julian Parkhill; Kathryn E Holt; Renaud Piarroux; Thandavarayan Ramamurthy; Marie-Laure Quilici; Nicholas R Thomson

doi:10.1126/science.aad5901

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Genomic history of the seventh pandemic of cholera in Africa

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Genomic history of the seventh pandemic of cholera in Africa

François-Xavier Weill, Daryl Domman, Elisabeth Njamkepo, Cheryl Tarr, Jean Rauzier, Nizar Fawal, Karen H Keddy, Henrik Salje, Sandra Moore, Asish K Mukhopadhyay, …

Science (American Association for the Advancement of Science), Vol.358(6364), pp.785-789

10/11/2017

DOI: https://doi.org/10.1126/science.aad5901

PMID: 29123067

Résumé

Africa, Eastern - epidemiology

Africa, Southern - epidemiology

Africa, Western - epidemiology

Asia - epidemiology

Cholera - epidemiology

Cholera - microbiology

Genome, Bacterial

Genomics

Humans

Pandemics

Phylogeny

Vibrio cholerae O1 - classification

Vibrio cholerae O1 - genetics

Vibrio cholerae O1 - isolation & purification

The seventh cholera pandemic has heavily affected Africa, although the origin and continental spread of the disease remain undefined. We used genomic data from 1070 O1 isolates, across 45 African countries and over a 49-year period, to show that past epidemics were attributable to a single expanded lineage. This lineage was introduced at least 11 times since 1970, into two main regions, West Africa and East/Southern Africa, causing epidemics that lasted up to 28 years. The last five introductions into Africa, all from Asia, involved multidrug-resistant sublineages that replaced antibiotic-susceptible sublineages after 2000. This phylogenetic framework describes the periodicity of lineage introduction and the stable routes of cholera spread, which should inform the rational design of control measures for cholera in Africa.

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Titre: Genomic history of the seventh pandemic of cholera in Africa
Créateurs - sans rôle: François-Xavier Weill - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Daryl Domman - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Elisabeth Njamkepo - Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Paris, 75015, France
Cheryl Tarr - Centers for Disease Control and Prevention, Escherichia and Shigella Reference Unit, Atlanta, GA 30333, USA
Jean Rauzier - Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Paris, 75015, France
Nizar Fawal - Institut Pasteur, Unité des Bactéries Pathogènes Entériques, Paris, 75015, France
Karen H Keddy - Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa
Henrik Salje - Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Sandra Moore - Laboratoire de Parasitologie-Mycologie, CHU Timone, Université de la Méditerranée, Marseille, 13385, France
Asish K Mukhopadhyay - National Institute of Cholera and Enteric Diseases (NICED), Kolkata, West Bengal 700010, India
Raymond Bercion - Institut Pasteur de Dakar
Francisco J Luquero - Epicentre, Paris, 75011, France
Antoinette Ngandjio - Centre Pasteur du Cameroun, BP 1274, Yaoundé, Cameroon
Mireille Dosso - Bacteriology and Virology Department, Institut Pasteur, Abidjan, Côte d'Ivoire
Elena Monakhova - Rostov-on-Don Research Institute for Plague Control, Rostov-on-Don, 344022, Russia
Benoit Garin - Institut Pasteur de Dakar, BP 220, Dakar, Senegal
Christiane Bouchier - Institut Pasteur, Plate-forme Génomique (PF1), Paris, 75015, France
Carlo Pazzani - University of Bari "A. Moro", Department of Biology, Bari, 70126, Italy
Ankur Mutreja - Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana 121001, India
Roland Grunow - Robert Koch Institute, 13353 Berlin, Germany
Fati Sidikou - Centre de Recherche Medicale et Sanitaire (CERMES), BP 10887, Niamey, Niger
Laurence Bonte - Médecins Sans Frontières (MSF), Paris, 75011, France
Sébastien Breurec - Institut Pasteur de Bangui, BP 923, Bangui, Central African Republic
Maria Damian - Cantacuzino National Institute of Research-Development for Microbiology and Immunology, Bucharest, Romania
Berthe-Marie Njanpop-Lafourcade - Agence de Médecine Préventive (AMP), Paris, 75015, France
Guillaume Sapriel - Institut de Systématique, Évolution, Biodiversité
Anne-Laure Page - Epicentre, Paris, 75011, France
Monzer Hamze - Laboratoire Microbiologie Santé et Environnement (LMSE), EDST-FSP, Université Libanaise, Tripoli, Lebanon
Myriam Henkens - Médecins Sans Frontières, Brussels, B 1050, Belgium
Goutam Chowdhury - National Institute of Cholera and Enteric Diseases (NICED), Kolkata, West Bengal 700010, India
Martin Mengel - Agence de Médecine Préventive (AMP), Paris, 75015, France
Jean-Louis Koeck - Centre Hospitalier des Armées Bouffard, Djibouti, Republic of Djibouti
Jean-Michel Fournier - Institut Pasteur, Unité du Choléra et des Vibrions, Paris, 75015, France
Gordon Dougan - Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0SP, UK
Patrick A D Grimont - Institut Pasteur, Unité Biodiversité des Bactéries Pathogènes Emergentes, Paris, 75015, France
Julian Parkhill - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, UK
Kathryn E Holt - Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia
Renaud Piarroux - Laboratoire de Parasitologie-Mycologie, CHU Timone, Université de la Méditerranée, Marseille, 13385, France
Thandavarayan Ramamurthy - Translational Health Science and Technology Institute (THSTI), Faridabad, Haryana 121001, India
Marie-Laure Quilici - Institut Pasteur, Unité du Choléra et des Vibrions, Paris, 75015, France
Nicholas R Thomson - London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
Détails de publication: Science (American Association for the Advancement of Science), Vol.358(6364), pp.785-789
Note de subvention: Wellcome Trust
Identifiants: 99156962109311
Unité académique: Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Langue: English
Type de ressource: Journal article