Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

Thorsten Thye; Fredrik O Vannberg; Sunny H Wong; Ellis Owusu-Dabo; Ivy Osei; John Gyapong; Giorgio Sirugo; Fatou Sisay-Joof; Anthony Enimil; Margaret A Chinbuah; Sian Floyd; David K Warndorff; Lifted Sichali; Simon Malema; Amelia C Crampin; Bagrey Ngwira; Yik Y Teo; Kerrin Small; Kirk Rockett; Dominic Kwiatkowski; Paul E Fine; Philip C Hill; Melanie Newport; Christian Lienhardt; Richard A Adegbola; Tumani Corrah; Andreas Ziegler; Andrew P Morris; Christian G Meyer; Rolf D Horstmann; Adrian V S Hill; Wellcome Trust Case Control Consortium

doi:10.1038/ng.639

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Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

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Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

Thorsten Thye, Fredrik O Vannberg, Sunny H Wong, Ellis Owusu-Dabo, Ivy Osei, John Gyapong, Giorgio Sirugo, Fatou Sisay-Joof, Anthony Enimil, Margaret A Chinbuah, …

Nature genetics, Vol.42(9), pp.739-741

01/09/2010

DOI: https://doi.org/10.1038/ng.639

PMID: 20694014

Résumé

Case-Control Studies

Chromosomes, Human, Pair 18 - genetics

Gambia

Genetic Loci

Genetic Predisposition to Disease

Genetics, Population

Genome-Wide Association Study

Ghana

Humans

Linkage Disequilibrium

Odds Ratio

Polymorphism, Single Nucleotide

Tuberculosis - genetics

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 x 10(-9), odds ratio = 1.19, 95% CI = 1.13-1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

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Titre: Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2
Créateurs - sans rôle: Thorsten Thye - University Hospital Schleswig-Holstein
Fredrik O Vannberg - Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
Sunny H Wong - Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
Ellis Owusu-Dabo - Department of Community Health, College of Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Ivy Osei - Health Research Unit, Ghana Health Service, Accra, Ghana
John Gyapong - Ghana Health Service
Giorgio Sirugo - MRC Laboratories, Fajara, Banjul, The Gambia
Fatou Sisay-Joof - MRC Laboratories, Fajara, Banjul, The Gambia
Anthony Enimil - Komfo Anokye Teaching Hospital, Kumasi, Ghana
Margaret A Chinbuah - Health Research Unit, Ghana Health Service, Accra, Ghana
Sian Floyd - London School of Hygiene and Tropical Medicine, London, United Kingdom
David K Warndorff - Karonga Prevention Study, Chilumba, Karonga District, Malawi
Lifted Sichali - Karonga Prevention Study, Chilumba, Karonga District, Malawi
Simon Malema - Karonga Prevention Study, Chilumba, Karonga District, Malawi
Amelia C Crampin - London School of Hygiene and Tropical Medicine, London, United Kingdom
Bagrey Ngwira - Karonga Prevention Study, Chilumba, Karonga District, Malawi
Yik Y Teo - Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
Kerrin Small - Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
Kirk Rockett - Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
Dominic Kwiatkowski - University of Oxford
Paul E Fine - Karonga Prevention Study, Chilumba, Karonga District, Malawi
Philip C Hill - MRC Laboratories, Fajara, Banjul, The Gambia
Melanie Newport - MRC Laboratories, Fajara, Banjul, The Gambia
Christian Lienhardt - MRC Laboratories, Fajara, Banjul, The Gambia
Richard A Adegbola - MRC Laboratories, Fajara, Banjul, The Gambia
Tumani Corrah - MRC Laboratories, Fajara, Banjul, The Gambia
Andreas Ziegler - University Hospital Schleswig-Holstein
Andrew P Morris - Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
Christian G Meyer - Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Rolf D Horstmann - Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany
Adrian V S Hill - Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom
Wellcome Trust Case Control Consortium
Détails de publication: Nature genetics, Vol.42(9), pp.739-741
Note de subvention: 079828 / Wellcome Trust G19/9 / Medical Research Council 076438 / Wellcome Trust 084818 / Wellcome Trust MC_U190071468 / Medical Research Council
Identifiants: 99158566509311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article