Genome analysis of the platypus reveals unique signatures of evolution

Wesley C. Warren; LaDeana W. Hillier; Jennifer A. Marshall Graves; Ewan Birney; Chris P. Ponting; Frank Grutzner; Katherine Belov; Webb Miller; Laura Clarke; Asif T. Chinwalla; Shiaw-Pyng Yang; Andreas Heger; Devin P. Locke; Pat Miethke; Paul D. Waters; Frederic Veyrunes; Lucinda Fulton; Bob Fulton; Tina Graves; John Wallis; Xose S. Puente; Carlos Lopez-Otin; Gonzalo R. Ordonez; Evan E. Eichler; Lin Chen; Ze Cheng; Janine E. Deakin; Amber Alsop; Katherine Thompson; Patrick Kirby; Anthony T. Papenfuss; Matthew J. Wakefield; Tsviya Olender; Doron Lancet; Gavin A. Huttley; Arian F. A. Smit; Andrew Pask; Peter Temple-Smith; Mark A. Batzer; Jerilyn A. Walker; Miriam K. Konkel; Robert S. Harris; Camilla M. Whittington; Emily S. W. Wong; Neil J. Gemmell; Emmanuel Buschiazzo; Iris M. Vargas Jentzsch; Angelika Merkel; Juergen Schmitz; Anja Zemann; Gennady Churakov; Jan Ole Kriegs; Juergen Brosius; Elizabeth P. Murchison; Ravi Sachidanandam; Carly Smith; Gregory J. Hannon; Enkhjargal Tsend-Ayush; Daniel McMillan; Rosalind Attenborough; Willem Rens; Malcolm Ferguson-Smith; Christophe M. Lefevre; Julie A. Sharp; Kevin R. Nicholas; David A. Ray; Michael Kube; Richard Reinhardt; Thomas H. Pringle; James Taylor; Russell C. Jones; Brett Nixon; Jean-Louis Dacheux; Hitoshi Niwa; Yoko Sekita; Xiaoqiu Huang; Alexander Stark; Pouya Kheradpour; Manolis Kellis; Paul Flicek; Yuan Chen; Caleb Webber; Ross Hardison; Joanne Nelson; Kym Hallsworth-Pepin; Kim Delehaunty; Chris Markovic; Pat Minx; Yucheng Feng; Colin Kremitzki; Makedonka Mitreva; Jarret Glasscock; Todd Wylie; Patricia Wohldmann; Prathapan Thiru; Michael N. Nhan; Craig S. Pohl; Scott M. Smith; Shunfeng Hou; Marilyn B. Renfree; Elaine R. Mardis; Richard K. Wilson; A list of authors and their affiliations appears at the end of the paper

doi:10.1038/nature06936

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Genome analysis of the platypus reveals unique signatures of evolution

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Genome analysis of the platypus reveals unique signatures of evolution

Wesley C. Warren, LaDeana W. Hillier, Jennifer A. Marshall Graves, Ewan Birney, Chris P. Ponting, Frank Grutzner, Katherine Belov, Webb Miller, Laura Clarke, Asif T. Chinwalla, …

Nature (London), Vol.453(7192), pp.175-U1

08/05/2008

DOI: https://doi.org/10.1038/nature06936

PMID: 18464734

Résumé

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co- opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non- protein- coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.

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Titre: Genome analysis of the platypus reveals unique signatures of evolution
Créateurs - sans rôle: Wesley C. Warren - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
LaDeana W. Hillier - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Jennifer A. Marshall Graves - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Ewan Birney - EBI, EMBL, Cambridge CB10 1SD, England
Chris P. Ponting - Univ Oxford, Dept Human Physiol Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England
Frank Grutzner - The University of Adelaide
Katherine Belov - Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia
Webb Miller - Penn State Univ, Ctr Comparat Genom & Bioinformat, University Pk, PA 16802 USA
Laura Clarke - Wellcome Sanger Institute
Asif T. Chinwalla - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Shiaw-Pyng Yang - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Andreas Heger - Univ Oxford, Dept Human Physiol Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England
Devin P. Locke - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Pat Miethke - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Paul D. Waters - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Frederic Veyrunes - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Lucinda Fulton - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Bob Fulton - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Tina Graves - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
John Wallis - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Xose S. Puente - Univ Oviedo, Dept Bioquim & Biol Mol, Inst Univ Oncol, E-33006 Oviedo, Spain
Carlos Lopez-Otin - Univ Oviedo, Dept Bioquim & Biol Mol, Inst Univ Oncol, E-33006 Oviedo, Spain
Gonzalo R. Ordonez - Univ Oviedo, Dept Bioquim & Biol Mol, Inst Univ Oncol, E-33006 Oviedo, Spain
Evan E. Eichler - University of Washington
Lin Chen - Univ Washington, Howard Hughes Med Inst, Dept Genome Sci, Seattle, WA 98195 USA
Ze Cheng - Univ Washington, Howard Hughes Med Inst, Dept Genome Sci, Seattle, WA 98195 USA
Janine E. Deakin - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Amber Alsop - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Katherine Thompson - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Patrick Kirby - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Anthony T. Papenfuss - Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Matthew J. Wakefield - Royal Melbourne Hosp, Walter & Eliza Hall Inst Med Res, Parkville, Vic 3050, Australia
Tsviya Olender - Weizmann Inst Sci, Dept Mol Genet, Crown Human Genome Ctr, IL-76100 Rehovot, Israel
Doron Lancet - Weizmann Inst Sci, Dept Mol Genet, Crown Human Genome Ctr, IL-76100 Rehovot, Israel
Gavin A. Huttley - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Arian F. A. Smit - Inst Syst Biol, Seattle, WA 98103 USA
Andrew Pask - Univ Melbourne, Dept Zool, CRC Innovat Dairy Prod, Parkville, Vic 3010, Australia
Peter Temple-Smith - Univ Melbourne, Dept Zool, CRC Innovat Dairy Prod, Parkville, Vic 3010, Australia
Mark A. Batzer - Louisiana State Univ, Dept Biol Sci, Ctr Biomodular Multiscale Syst, Baton Rouge, LA 70803 USA
Jerilyn A. Walker - Louisiana State Univ, Dept Biol Sci, Ctr Biomodular Multiscale Syst, Baton Rouge, LA 70803 USA
Miriam K. Konkel - Louisiana State Univ, Dept Biol Sci, Ctr Biomodular Multiscale Syst, Baton Rouge, LA 70803 USA
Robert S. Harris - Penn State Univ, Ctr Comparat Genom & Bioinformat, University Pk, PA 16802 USA
Camilla M. Whittington - The University of Sydney
Emily S. W. Wong - Univ Sydney, Fac Vet Sci, Sydney, NSW 2006, Australia
Neil J. Gemmell - Univ Canterbury, Sch Biol Sci, Christchurch 8140, New Zealand
Emmanuel Buschiazzo - Univ Canterbury, Sch Biol Sci, Christchurch 8140, New Zealand
Iris M. Vargas Jentzsch - Univ Canterbury, Sch Biol Sci, Christchurch 8140, New Zealand
Angelika Merkel - Univ Canterbury, Sch Biol Sci, Christchurch 8140, New Zealand
Juergen Schmitz - Univ Munster, Inst Expt Pathol, D-48149 Munster, Germany
Anja Zemann - Univ Munster, Inst Expt Pathol, D-48149 Munster, Germany
Gennady Churakov - University of Münster
Jan Ole Kriegs - Univ Munster, Inst Expt Pathol, D-48149 Munster, Germany
Juergen Brosius - Univ Munster, Inst Expt Pathol, D-48149 Munster, Germany
Elizabeth P. Murchison - Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA
Ravi Sachidanandam - MED Institute
Carly Smith - Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA
Gregory J. Hannon - Cold Spring Harbor Lab, Howard Hughes Med Inst, Cold Spring Harbor, NY 11724 USA
Enkhjargal Tsend-Ayush - Univ Adelaide, Sch Mol & Biomed Sci, Discipline Genet, Adelaide, SA 5005, Australia
Daniel McMillan
Rosalind Attenborough - Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
Willem Rens - Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England
Malcolm Ferguson-Smith - University of Cambridge
Christophe M. Lefevre - Univ Melbourne, Dept Zool, CRC Innovat Dairy Prod, Parkville, Vic 3010, Australia
Julie A. Sharp - Univ Melbourne, Dept Zool, CRC Innovat Dairy Prod, Parkville, Vic 3010, Australia
Kevin R. Nicholas - Univ Melbourne, Dept Zool, CRC Innovat Dairy Prod, Parkville, Vic 3010, Australia
David A. Ray - W Virginia Univ, Dept Biol, Morgantown, WV 26505 USA
Michael Kube - Max Planck Inst Mol Genet, D-14195 Berlin, Germany
Richard Reinhardt - Max Planck Inst Mol Genet, D-14195 Berlin, Germany
Thomas H. Pringle - Sperling Fdn, Eugene, OR 97405 USA
James Taylor - NYU, Courant Inst, New York, NY 10012 USA
Russell C. Jones - Univ Newcastle, Sch Environm & Life Sci, Discipline Biol Sci, Newcastle, NSW 2308, Australia
Brett Nixon - Univ Newcastle, Sch Environm & Life Sci, Discipline Biol Sci, Newcastle, NSW 2308, Australia
Jean-Louis Dacheux - INRA, CNRS, UMR 6073, F-37380 Nouzilly, France
Hitoshi Niwa - RIKEN, CDB, Lab Pluripotent Cell Studies, Chuo Ku, Kobe, Hyogo 6500047, Japan
Yoko Sekita - RIKEN, CDB, Lab Pluripotent Cell Studies, Chuo Ku, Kobe, Hyogo 6500047, Japan
Xiaoqiu Huang - Iowa State Univ, Dept Comp Sci, Ames, IA 50011 USA
Alexander Stark - MIT, Broad Inst, Cambridge, MA 02139 USA
Pouya Kheradpour - Broad Institute
Manolis Kellis - Broad Institute
Paul Flicek - EBI, EMBL, Cambridge CB10 1SD, England
Yuan Chen - EBI, EMBL, Cambridge CB10 1SD, England
Caleb Webber - Univ Oxford, Dept Human Physiol Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England
Ross Hardison - Penn State Univ, Ctr Comparat Genom & Bioinformat, University Pk, PA 16802 USA
Joanne Nelson - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Kym Hallsworth-Pepin - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Kim Delehaunty - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Chris Markovic - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Pat Minx - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Yucheng Feng - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Colin Kremitzki - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Makedonka Mitreva - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Jarret Glasscock - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Todd Wylie - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Patricia Wohldmann - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Prathapan Thiru - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Michael N. Nhan - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Craig S. Pohl - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Scott M. Smith - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Shunfeng Hou - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Marilyn B. Renfree - The University of Melbourne
Elaine R. Mardis - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
Richard K. Wilson - Washington Univ, Sch Med, Genome Sequencing Ctr, St Louis, MO 63108 USA
A list of authors and their affiliations appears at the end of the paper
Détails de publication: Nature (London), Vol.453(7192), pp.175-U1
Éditeur: Springer Nature
Nombre de pages: 10
Note de subvention: P01CA013106 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) MC_U137761446 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission MC_U137761446 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) R01HG002385 / NATIONAL HUMAN GENOME RESEARCH INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) R01GM059290 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) R01 HG002385; R01 HG004037-02; R01HG02385; R01 HG004037; R01 HG002939; HG002238; R01 HG002238 / NHGRI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Human Genome Research Institute (NHGRI) R01 GM59290; R01 GM059290 / NIGMS NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) P01 CA013106-37; P01 CA013106 / NCI NIH HHS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 062023 / Wellcome Trust; European Commission
Identifiants: 99146465609311
Unité académique: Institut des Sciences de l'Evolution - Montpellier - ISEM
Langue: English
Type de ressource: Journal article