Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Fergus J. Couch; Xianshu Wang; Lesley McGuffog; Andrew Lee; Curtis Olswold; Karoline B. Kuchenbaecker; Penny Soucy; Zachary Fredericksen; Daniel Barrowdale; Joe Dennis; Mia M. Gaudet; Ed Dicks; Matthew Kosel; Sue Healey; Olga M. Sinilnikova; Adam Lee; Francois Bacot; Daniel Vincent; Frans B. L. Hogervorst; Susan Peock; Dominique Stoppa-Lyonnet; Anna Jakubowska; Paolo Radice; Rita Katharina Schmutzler; Susan M. Domchek; Marion Piedmonte; Christian F. Singer; Eitan Friedman; Mads Thomassen; Thomas V. O. Hansen; Susan L. Neuhausen; Csilla I. Szabo; Ignacio Blanco; Mark H. Greene; Beth Y. Karlan; Judy Garber; Catherine M. Phelan; Jeffrey N. Weitzel; Marco Montagna; Edith Olah; Irene L. Andrulis; Andrew K. Godwin; Drakoulis Yannoukakos; David E. Goldgar; Trinidad Caldes; Heli Nevanlinna; Ana Osorio; Mary Beth Terry; Mary B. Daly; Elizabeth J. van Rensburg; Ute Hamann; Susan J. Ramus; Amanda Ewart Toland; Maria A. Caligo; Olufunmilayo I. Olopade; Nadine Tung; Kathleen Claes; Mary S. Beattie; Melissa C. Southey; Evgeny N. Imyanitov; Marc Tischkowitz; Ramunas Janavicius; Esther M. John; Ava Kwong; Orland Diez; Judith Balmana; Rosa B. Barkardottir; Banu K. Arun; Gad Rennert; Soo-Hwang Teo; Patricia A. Ganz; Ian Campbell; Annemarie H. van der Hout; Carolien H. M. van Deurzen; Caroline Seynaeve; Encarna B. Gomez Garcia; Flora E. van Leeuwen; Hanne E. J. Meijers-Heijboer; Johannes J. P. Gille; Margreet G. E. M. Ausems; Marinus J. Blok; Marjolijn J. L. Ligtenberg; Matti A. Rookus; Peter Devilee; Senno Verhoef; Theo A. M. van Os; Juul T. Wijnen; Debra Frost; Steve Ellis; Elena Fineberg; Radka Platte; D. Gareth Evans; Louise Izatt; Rosalind A. Eeles; Julian Adlard; Diana M. Eccles; Jackie Cook; Carole Brewer; Fiona Douglas; Shirley Hodgson; Patrick J. Morrison; Lucy E. Side; Alan Donaldson; Catherine Houghton; Mark T. Rogers; Huw Dorkins; Jacqueline Eason; Helen Gregory; Emma McCann; Alex Murray; Alain Calender; Agnes Hardouin; Pascaline Berthet; Capucine Delnatte; Catherine Nogues; Christine Lasset; Claude Houdayer; Dominique Leroux; Etienne Rouleau; Fabienne Prieur; Francesca Damiola; Hagay Sobol; Isabelle Coupier; Laurence Venat-Bouvet; Laurent Castera; Marion Gauthier-Villars; Melanie Leone; Pascal Pujol; Sylvie Mazoyer; Yves-Jean Bignon; Elzbieta Zlowocka-Perlowska; Jacek Gronwald; Jan Lubinski; Katarzyna Durda; Katarzyna Jaworska; Tomasz Huzarski; Amanda B. Spurdle; Alessandra Viel; Bernard Peissel; Bernardo Bonanni; Giulia Melloni; Laura Ottini; Laura Papi; Liliana Varesco; Maria Grazia Tibiletti; Paolo Peterlongo; Sara Volorio; Siranoush Manoukian; Valeria Pensotti; Norbert Arnold; Christoph Engel; Helmut Deissler; Dorothea Gadzicki; Andrea Gehrig; Karin Kast; Kerstin Rhiem; Alfons Meindl; Dieter Niederacher; Nina Ditsch; Hansjoerg Plendl; Sabine Preisler-Adams; Stefanie Engert; Christian Sutter; Raymonda Varon-Mateeva; Barbara Wappenschmidt; Bernhard H. F. Weber; Brita Arver; Marie Stenmark-Askmalm; Niklas Loman; Richard Rosenquist; Zakaria Einbeigi; Katherine L. Nathanson; Timothy R. Rebbeck; Stephanie V. Blank; David E. Cohn; Gustavo C. Rodriguez; Laurie Small; Michael Friedlander; Victoria L. Bae-Jump; Anneliese Fink-Retter; Christine Rappaport; Daphne Gschwantler-Kaulich; Georg Pfeiler; Muy-Kheng Tea; Noralane M. Lindor; Bella Kaufman; Shani Shimon Paluch; Yael Laitman; Anne-Bine Skytte; Anne-Marie Gerdes; Inge Sokilde Pedersen; Sanne Traasdahl Moeller; Torben A. Kruse; Uffe Birk Jensen; Joseph Vijai; Kara Sarrel; Mark Robson; Noah Kauff; Anna Marie Mulligan; Gord Glendon; Hilmi Ozcelik; Bent Ejlertsen; Finn C. Nielsen; Lars Jonson; Mette K. Andersen; Yuan Chun Ding; Linda Steele; Lenka Foretova; Alex Teule; Conxi Lazaro; Joan Brunet; Miquel Angel Pujana; Phuong L. Mai; Jennifer T. Loud; Christine Walsh; Jenny Lester; Sandra Orsulic; Steven A. Narod; Josef Herzog; Sharon R. Sand; Silvia Tognazzo; Simona Agata; Tibor Vaszko; Joellen Weaver; Alexandra V. Stavropoulou; Saundra S. Buys; Atocha Romero; Miguel de la Hoya; Kristiina Aittomaki; Taru A. Muranen; Mercedes Duran; Wendy K. Chung; Adriana Lasa; Cecilia M. Dorfling; Alexander Miron; Javier Benitez; Leigha Senter; Dezheng Huo; Salina B. Chan; Anna P. Sokolenko; Jocelyne Chiquette; Laima Tihomirova; Tara M. Friebel; Bjarni A. Agnarsson; Karen H. Lu; Flavio Lejbkowicz; Paul A. James; Per Hall; Alison M. Dunning; Daniel Tessier; Julie Cunningham; Susan L. Slager; Chen Wang; Steven Hart; Kristen Stevens; Jacques Simard; Tomi Pastinen; Vernon S. Pankratz; Kenneth Offit; Douglas F. Easton; Georgia Chenevix-Trench; Antonis C. Antoniou; KConFab Investigators

doi:10.1371/journal.pgen.1003212

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Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Article de revue

Avec comité de lecture

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

Fergus J. Couch, Xianshu Wang, Lesley McGuffog, Andrew Lee, Curtis Olswold, Karoline B. Kuchenbaecker, Penny Soucy, Zachary Fredericksen, Daniel Barrowdale, Joe Dennis, …

PLoS genetics, Vol.9(3), p.e1003212

2013

DOI: https://doi.org/10.1371/journal.pgen.1003212

PMID: 23544013

Résumé

Genetics & Heredity

Life Sciences & Biomedicine

Science & Technology

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7 x 10(-8), HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4 x 10(-8), HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4 x 10(-8), HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific association. The 17q21.31 locus was also associated with ovarian cancer risk in 8,211 BRCA2 carriers (P = 2 x 10(-4)). These loci may lead to an improved understanding of the etiology of breast and ovarian tumors in BRCA1 carriers. Based on the joint distribution of the known BRCA1 breast cancer risk-modifying loci, we estimated that the breast cancer lifetime risks for the 5% of BRCA1 carriers at lowest risk are 28%-50% compared to 81%-100% for the 5% at highest risk. Similarly, based on the known ovarian cancer risk-modifying loci, the 5% of BRCA1 carriers at lowest risk have an estimated lifetime risk of developing ovarian cancer of 28% or lower, whereas the 5% at highest risk will have a risk of 63% or higher. Such differences in risk may have important implications for risk prediction and clinical management for BRCA1 carriers.

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Titre: Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk
Créateurs - sans rôle: Fergus J. Couch - Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
Xianshu Wang - Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
Lesley McGuffog - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Andrew Lee - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Curtis Olswold - Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Karoline B. Kuchenbaecker - University of Cambridge
Penny Soucy - Ctr Hosp Univ Quebec, Canc Genom Lab, Quebec City, PQ, Canada
Zachary Fredericksen - Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Daniel Barrowdale - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Joe Dennis - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Mia M. Gaudet - Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
Ed Dicks - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Matthew Kosel - Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Sue Healey - Queensland Inst Med Res, Dept Genet, Brisbane, Qld 4006, Australia
Olga M. Sinilnikova - Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Ctr Leon Berard, Lyon, France
Adam Lee - Mayo Clin, Dept Mol Pharmacol & Expt Therapeut MPET, Rochester, MN USA
Francois Bacot - Ctr Innovat Genome Quebec, Montreal, PQ, Canada
Daniel Vincent - Ctr Innovat Genome Quebec, Montreal, PQ, Canada
Frans B. L. Hogervorst - Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands
Susan Peock - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Dominique Stoppa-Lyonnet - Inst Curie, Dept Tumour Biol, Paris, France
Anna Jakubowska - University of Szczecin
Paolo Radice - Fdn IRCCS Ist Nazl Tumori INT, Unit Mol Bases Genet Risk & Genet Testing, Dept Prevent & Predict Med, Milan, Italy
Rita Katharina Schmutzler - Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany
Susan M. Domchek - Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
Marion Piedmonte - Roswell Pk Canc Inst, Gynecol Oncol Grp, Stat & Data Ctr, Buffalo, NY 14263 USA
Christian F. Singer - University of Vienna
Eitan Friedman - Chaim Sheba Med Ctr, Tel Aviv, Israel
Mads Thomassen - Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Thomas V. O. Hansen - Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Copenhagen, Denmark
Susan L. Neuhausen - Beckman Research Institute
Csilla I. Szabo - University of Delaware
Ignacio Blanco - IDIBELL Catalan Inst Oncol, Genet Counseling Unit, Hereditary Canc Program, Barcelona, Spain
Mark H. Greene - NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA
Beth Y. Karlan - College Station Medical Center
Judy Garber - Dana Farber Canc Inst, Boston, MA 02115 USA
Catherine M. Phelan - Univ S Florida, H Lee Moffitt Canc Ctr, Dept Canc Epidemiol, Tampa, FL 33682 USA
Jeffrey N. Weitzel - City of Hope
Marco Montagna - Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Edith Olah - Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary
Irene L. Andrulis - Lunenfeld-Tanenbaum Research Institute
Andrew K. Godwin - University of Kansas
Drakoulis Yannoukakos - National Centre of Scientific Research "Demokritos"
David E. Goldgar - University of Utah
Trinidad Caldes - Hosp Clin San Carlos, IdISSC, Mol Oncol Lab, Madrid, Spain
Heli Nevanlinna - Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Ana Osorio - Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain
Mary Beth Terry - Columbia University
Mary B. Daly - Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Elizabeth J. van Rensburg
Ute Hamann - Deutsch Krebsforschungszentrum DKFZ, Heidelberg, Germany
Susan J. Ramus - Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
Amanda Ewart Toland - The Ohio State University
Maria A. Caligo - University of Pisa
Olufunmilayo I. Olopade - University of Chicago
Nadine Tung - College Station Medical Center
Kathleen Claes - Ghent Univ Hosp, Ctr Med Genet, Ghent, Belgium
Mary S. Beattie - Univ Calif San Francisco, Dept Med, San Francisco, CA USA
Melissa C. Southey - Univ Melbourne, Dept Pathol, Genet Epidemiol Lab, Parkville, Vic 3052, Australia
Evgeny N. Imyanitov - NN Petrov Oncol Res Inst, St Petersburg, Russia
Marc Tischkowitz - McGill University
Ramunas Janavicius - Vilnius University
Esther M. John - Canc Prevent Inst Calif, Dept Epidemiol, Fremont, CA USA
Ava Kwong - Hong Kong Sanat & Hosp, Hong Kong Hereditary Breast Canc Family Registry, Canc Genet Ctr, Hong Kong, Hong Kong, Peoples R China
Orland Diez - Univ Hosp Vall dHebron, Oncogenet Lab, Barcelona, Spain
Judith Balmana - Univ Hosp, Dept Med Oncol, Barcelona, Spain
Rosa B. Barkardottir - Landspitali Univ Hosp, Dept Pathol, Reykjavik, Iceland
Banu K. Arun - Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol & Clin Canc Genet, Houston, TX 77030 USA
Gad Rennert - Clalit Natl Israeli Canc Control Ctr, Haifa, Israel
Soo-Hwang Teo - Univ Malaya, Canc Res Initiat Fdn, Sime Darby Med Ctr, Kuala Lumpur, Malaysia
Patricia A. Ganz - Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Sch Med, Div Canc Prevent & Control Res, Los Angeles, CA 90024 USA
Ian Campbell - Peter MacCallum Canc Ctr, VBCRC Canc Genet Lab, Melbourne, Vic, Australia
Annemarie H. van der Hout - University of Groningen
Carolien H. M. van Deurzen - Erasmus Univ, Dept Pathol, Family Canc Clin, Med Ctr, NL-3000 DR Rotterdam, Netherlands
Caroline Seynaeve - Erasmus Univ, Dept Med Oncol, Family Canc Clin, Med Ctr, Rotterdam, Netherlands
Encarna B. Gomez Garcia - MUMC, Dept Clin Genet, Sch Oncol & Dev Biol, Maastricht, Netherlands
Flora E. van Leeuwen - Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Hanne E. J. Meijers-Heijboer - Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
Johannes J. P. Gille - Vrije Univ Amsterdam Med Ctr, Dept Clin Genet, Amsterdam, Netherlands
Margreet G. E. M. Ausems - Univ Med Ctr Utrecht, Dept Med Genet, Utrecht, Netherlands
Marinus J. Blok - Maastricht University
Marjolijn J. L. Ligtenberg - Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, NL-6525 ED Nijmegen, Netherlands
Matti A. Rookus - Netherlands Canc Inst, Dept Epidemiol, Amsterdam, Netherlands
Peter Devilee - Leiden Univ, Dept Human Genet, Med Ctr, NL-2300 RA Leiden, Netherlands
Senno Verhoef - Netherlands Canc Inst, Family Canc Clin, Amsterdam, Netherlands
Theo A. M. van Os - University of Amsterdam
Juul T. Wijnen - Leiden University
Debra Frost - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Steve Ellis
Elena Fineberg - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Radka Platte - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
D. Gareth Evans - Cent Manchester Univ Hosp NHS Fdn Trust, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England
Louise Izatt - Guys & St Thomas NHS Fdn Trust, London, England
Rosalind A. Eeles - Inst Canc Res, Oncogenet Team, London SW3 6JB, England
Julian Adlard - Yorkshire Reg Genet Serv, Leeds, W Yorkshire, England
Diana M. Eccles - University of Southampton
Jackie Cook - Sheffield Childrens Hosp, Sheffield Clin Genet Serv, Sheffield, S Yorkshire, England
Carole Brewer - Royal Devon University Healthcare NHS Foundation Trust
Fiona Douglas - Newcastle Upon Tyne Hosp NHS Trust, Inst Med Genet, Ctr Life, Newcastle Upon Tyne, Tyne & Wear, England
Shirley Hodgson - University of London
Patrick J. Morrison - Belfast Hlth & Social Care Trust, Northern Ireland Reg Genet Ctr, Belfast, Antrim, North Ireland
Lucy E. Side - Great Ormond St Hosp Sick Children, North East Thames Reg Genet Serv, London WC1N 3JH, England
Alan Donaldson - St Michaels Hosp, Dept Clin Genet, Bristol, Avon, England
Catherine Houghton - Liverpool Womens NHS Fdn Trust, Cheshire & Merseyside Clin Genet Serv, Liverpool, Merseyside, England
Mark T. Rogers - University of Wales
Huw Dorkins - Kennedy Galton Ctr, North West Thames Reg Genet Serv, Harrow, Middx, England
Jacqueline Eason - Nottingham Univ Hosp NHS Trust, Nottingham Clin Genet Serv, Nottingham, England
Helen Gregory - NHS Grampian
Emma McCann
Alex Murray - Singleton Hosp, All Wales Med Genet Serv, Swansea SA2 8QA, W Glam, Wales
Alain Calender - Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Ctr Leon Berard, Lyon, France
Agnes Hardouin - Ctr Francois Baclesse, F-14021 Caen, France
Pascaline Berthet - Ctr Francois Baclesse, F-14021 Caen, France
Capucine Delnatte - Université de Nantes
Catherine Nogues - Hop Rene Huguenin, Oncogenet Clin, Inst Curie, St Cloud, France
Christine Lasset - Ctr Leon Berard, Unite Prevent & Epidemiol Genet, F-69373 Lyon, France
Claude Houdayer - Inst Curie, Dept Tumour Biol, Paris, France
Dominique Leroux - CHU Grenoble, Dept Genet, F-38043 Grenoble, France
Etienne Rouleau - Hop Rene Huguenin, Lab Oncogenet, Inst Curie, St Cloud, France
Fabienne Prieur - Ctr Hosp Univ St Etienne, Serv Genet Clin Chromosom & Mol, St Etienne, France
Francesca Damiola - Inserm
Hagay Sobol - Inserm
Isabelle Coupier - CHU Arnaud de Villeneuve, Unite Oncogenet, Montpellier, France
Laurence Venat-Bouvet - Ctr Hosp Univ Dupuytren, Dept Med Oncol, Limoges, France
Laurent Castera - Inst Curie, Dept Tumour Biol, Paris, France
Marion Gauthier-Villars - Inst Curie, Dept Tumour Biol, Paris, France
Melanie Leone - Hosp Civils Lyon, Unite Mixte Genet Constitut Canc Frequents, Ctr Leon Berard, Lyon, France
Pascal Pujol - CHU Arnaud de Villeneuve, Unite Oncogenet, Montpellier, France
Sylvie Mazoyer - Univ Lyon 1, INSERM U1052, CNRS UMR5286, Ctr Rech Cancerol Lyon, F-69365 Lyon, France
Yves-Jean Bignon - Univ Clermont Ferrand 2, Dept Oncogenet, Ctr Jean Perrin, Clermont Ferrand, France
Elzbieta Zlowocka-Perlowska - Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Jacek Gronwald - University of Szczecin
Jan Lubinski - University of Szczecin
Katarzyna Durda - University of Szczecin
Katarzyna Jaworska - Pomeranian Med Univ, Dept Genet & Pathol, Szczecin, Poland
Tomasz Huzarski - University of Szczecin
Amanda B. Spurdle - Queensland Inst Med Res, Dept Genet, Brisbane, Qld 4006, Australia
Alessandra Viel - IRCCS, Div Expt Oncol 1, Ctr Riferimento Oncologico, Aviano, Italy
Bernard Peissel - Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predict Med, Milan, Italy
Bernardo Bonanni - Ist Europeo Oncol, Div Canc Prevent & Genet, Milan, Italy
Giulia Melloni - Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predict Med, Milan, Italy
Laura Ottini - Univ Roma La Sapienza, Dept Mol Med, Rome, Italy
Laura Papi - University of Florence
Liliana Varesco - Ospedale Policlinico San Martino
Maria Grazia Tibiletti - University of Insubria
Paolo Peterlongo - Fdn IRCCS Ist Nazl Tumori INT, Unit Mol Bases Genet Risk & Genet Testing, Dept Prevent & Predict Med, Milan, Italy
Sara Volorio - Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Siranoush Manoukian - Fdn IRCCS Ist Nazl Tumori INT, Unit Med Genet, Dept Prevent & Predict Med, Milan, Italy
Valeria Pensotti - Fdn Ist FIRC Oncol Mol, IFOM, Milan, Italy
Norbert Arnold - Univ Kiel, Univ Hosp Schleswig Holstein, Kiel, Germany
Christoph Engel - Univ Leipzig, Inst Med Informat Stat & Epidemiol, D-04109 Leipzig, Germany
Helmut Deissler - Univ Hosp Ulm, Ulm, Germany
Dorothea Gadzicki - Hannover Med Sch, Hannover, Germany
Andrea Gehrig - University of Würzburg
Karin Kast - Tech Univ Dresden, Dept Obstet & Gynaecol, Univ Hosp Carl Gustav Carus, D-01062 Dresden, Germany
Kerstin Rhiem - Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany
Alfons Meindl - Ludwig-Maximilians-Universität München
Dieter Niederacher - Univ Dusseldorf, Dept Obstet & Gynaecol, Univ Med Ctr Dusseldorf, D-40225 Dusseldorf, Germany
Nina Ditsch - Ludwig-Maximilians-Universität München
Hansjoerg Plendl - Univ Kiel, Univ Hosp Schleswig Holstein, Inst Human Genet, Kiel, Germany
Sabine Preisler-Adams - Univ Munster, Inst Human Genet, D-48149 Munster, Germany
Stefanie Engert - Ludwig-Maximilians-Universität München
Christian Sutter - Heidelberg Univ, Inst Human Genet, Heidelberg, Germany
Raymonda Varon-Mateeva - Inst Med & Human Genet, Berlin, Germany
Barbara Wappenschmidt - Univ Hosp Cologne, Ctr Familial Breast & Ovarian Canc, Dept Obstet & Gynaecol, Cologne, Germany
Bernhard H. F. Weber - University of Regensburg
Brita Arver - Karolinska Univ Hosp, Dept Pathol & Oncol, Stockholm, Sweden
Marie Stenmark-Askmalm - Linkoping Univ, Div Clin Genet, Dept Clin & Expt Med, Linkoping, Sweden
Niklas Loman - Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden
Richard Rosenquist - Uppsala University
Zakaria Einbeigi - Sahlgrens Univ Hosp, Dept Oncol, Gothenburg, Sweden
Katherine L. Nathanson - Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA
Timothy R. Rebbeck - Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA
Stephanie V. Blank - NYU, Sch Med, NYU Womens Canc Program, New York, NY USA
David E. Cohn - Ohio State Univ, Columbus Canc Council, Columbus, OH 43210 USA
Gustavo C. Rodriguez - University of Chicago
Laurie Small - College Station Medical Center
Michael Friedlander - Australia New Zealand GOG, ANZ GOTG Coordinating Ctr, Camperdown, NSW, Australia
Victoria L. Bae-Jump - Univ N Carolina, Chapel Hill, NC USA
Anneliese Fink-Retter - Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Christine Rappaport - University of Vienna
Daphne Gschwantler-Kaulich - Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Georg Pfeiler - University of Vienna
Muy-Kheng Tea - Med Univ Vienna, Dept Obstet & Gynecol, Vienna, Austria
Noralane M. Lindor - Mayo Clin Arizona, Dept Hlth Sci Res, Scottsdale, AZ USA
Bella Kaufman - Chaim Sheba Med Ctr, Tel Aviv, Israel
Shani Shimon Paluch - Chaim Sheba Med Ctr, Tel Aviv, Israel
Yael Laitman - Chaim Sheba Med Ctr, Tel Aviv, Israel
Anne-Bine Skytte - Vejle Hosp, Dept Clin Genet, Vejle, Denmark
Anne-Marie Gerdes - Rigshosp, Dept Clincial Genet, Copenhagen, Denmark
Inge Sokilde Pedersen - Aalborg Univ Hosp, Sect Mol Diagnost, Dept Clin Biochem, Aalborg, Denmark
Sanne Traasdahl Moeller - Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Torben A. Kruse - Odense Univ Hosp, Dept Clin Genet, DK-5000 Odense, Denmark
Uffe Birk Jensen - Aarhus Univ Hosp, Dept Clin Genet, DK-8000 Aarhus, Denmark
Joseph Vijai - Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Kara Sarrel - Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Mark Robson - Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Noah Kauff - Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Anna Marie Mulligan - University of Toronto
Gord Glendon - Lunenfeld-Tanenbaum Research Institute
Hilmi Ozcelik - Lunenfeld-Tanenbaum Research Institute
Bent Ejlertsen - Copenhagen Univ Hosp, Dept Oncol, Rigshosp, Copenhagen, Denmark
Finn C. Nielsen - Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Copenhagen, Denmark
Lars Jonson - Copenhagen Univ Hosp, Ctr Genom Med, Rigshosp, Copenhagen, Denmark
Mette K. Andersen - Copenhagen Univ Hosp, Dept Clin Genet, Rigshosp, Copenhagen, Denmark
Yuan Chun Ding - Beckman Research Institute
Linda Steele - Beckman Research Institute
Lenka Foretova - Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic
Alex Teule - IDIBELL Catalan Inst Oncol, Genet Counseling Unit, Hereditary Canc Program, Barcelona, Spain
Conxi Lazaro - IDIBELL Catalan Inst Oncol, Mol Diagnost Unit, Hereditary Canc Program, Barcelona, Spain
Joan Brunet - IDIBGI Catalan Inst Oncol, Genet Counseling Unit, Hereditary Canc Program, Girona, Spain
Miquel Angel Pujana - IDIBELL Catalan Inst Oncol, Translat Res Lab, Breast Canc & Syst Biol Unit, Barcelona, Spain
Phuong L. Mai - NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA
Jennifer T. Loud - NCI, Clin Genet Branch, Div Canc Epidemiol & Genet, NIH, Rockville, MD USA
Christine Walsh - College Station Medical Center
Jenny Lester - College Station Medical Center
Sandra Orsulic - College Station Medical Center
Steven A. Narod - University of Toronto
Josef Herzog - City Hope Natl Med Ctr, Clin Canc Genet, City Hope Clin Canc Genet Community Res Network, Duarte, CA USA
Sharon R. Sand - City Hope Natl Med Ctr, Clin Canc Genet, City Hope Clin Canc Genet Community Res Network, Duarte, CA USA
Silvia Tognazzo - Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Simona Agata - Ist Oncol Veneto IOV IRCCS, Immunol & Mol Oncol Unit, Padua, Italy
Tibor Vaszko - Natl Inst Oncol, Dept Mol Genet, Budapest, Hungary
Joellen Weaver - Fox Chase Canc Ctr, Philadelphia, PA 19111 USA
Alexandra V. Stavropoulou - Natl Ctr Sci Res Demokritos, Mol Diagnost Lab, IRRP, Athens, Greece
Saundra S. Buys - University of Utah
Atocha Romero - Hosp Clin San Carlos, IdISSC, Mol Oncol Lab, Madrid, Spain
Miguel de la Hoya - Instituto de Investigación Sanitaria del Hospital Clínico San Carlos
Kristiina Aittomaki - University of Helsinki
Taru A. Muranen - Univ Helsinki, Dept Obstet & Gynecol, Helsinki, Finland
Mercedes Duran - Univ Valladolid IBGM UVA, Inst Biol & Mol Genet, Valladolid, Spain
Wendy K. Chung - Columbia Univ, Dept Pediat, New York, NY 10027 USA
Adriana Lasa - Hosp Santa Creu & Sant Pau, Genet Serv, Barcelona, Spain
Cecilia M. Dorfling - University of Pretoria
Alexander Miron - Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
Javier Benitez - Spanish Natl Canc Ctr CNIO, Human Genet Grp, Madrid, Spain
Leigha Senter - The Ohio State University
Dezheng Huo - University of Chicago
Salina B. Chan - Univ Calif San Francisco, Canc Risk Program, Helen Diller Family Canc Ctr, San Francisco, CA 94143 USA
Anna P. Sokolenko - NN Petrov Oncol Res Inst, St Petersburg, Russia
Jocelyne Chiquette - Univ Quebec, Unite Rech Sante Populat, Ctr Malad Sein Deschenes Fabia, Ctr Rech FRSQ,Ctr Hosp, Quebec City, PQ, Canada
Laima Tihomirova - Latvian Biomed Res & Study Ctr, Riga, Latvia
Tara M. Friebel - Univ Penn, Philadelphia, PA 19104 USA
Bjarni A. Agnarsson - Landspitali Univ Hosp, Reykjavik, Iceland
Karen H. Lu - Univ Texas MD Anderson Canc Ctr, Dept Breast Med Oncol & Clin Canc Genet, Houston, TX 77030 USA
Flavio Lejbkowicz - Clalit Natl Israeli Canc Control Ctr, Haifa, Israel
Paul A. James - Peter MacCallum Canc Ctr, Familial Canc Ctr, Melbourne, Vic, Australia
Per Hall - Karolinska Institutet
Alison M. Dunning - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England
Daniel Tessier - Ctr Innovat Genome Quebec, Montreal, PQ, Canada
Julie Cunningham - Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
Susan L. Slager - Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Chen Wang - Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Steven Hart - Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Kristen Stevens - Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
Jacques Simard - Ctr Hosp Univ Quebec, Canc Genom Lab, Quebec City, PQ, Canada
Tomi Pastinen - McGill Univ, Dept Human Genet, Montreal, PQ, Canada
Vernon S. Pankratz - Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Kenneth Offit - Mem Sloan Kettering Canc Ctr, Clin Genet Serv, New York, NY 10021 USA
Douglas F. Easton - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
Georgia Chenevix-Trench - Queensland Inst Med Res, Dept Genet, Brisbane, Qld 4006, Australia
Antonis C. Antoniou - Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England
KConFab Investigators
Détails de publication: PLoS genetics, Vol.9(3), p.e1003212
Éditeur: Public Library Science
Nombre de pages: 21
Note de subvention: 132473 / Academy of Finland; Research Council of Finland Israel Cancer Association LIG-19/2010 / Research Council of Lithuania; Research Council of Lithuania (LMTLT) Hereditary Cancer Association (Paveldimo vezio asociacija) IG 8713 / Italian Association for Cancer Research (AIRC); Fondazione AIRC per la ricerca sul cancro NHMRC; National Health & Medical Research Council (NHMRC) of Australia University of Kansas Cancer Center Association "Le cancer du sein, parlons-en!" Catalan Health Institute National Health and Medical Research Council (NHMRC); National Health & Medical Research Council (NHMRC) of Australia
Identifiants: 99158948609311
Unité académique: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Langue: English
Type de ressource: Journal article