Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis

Junichi Watanabe; Masahira Hattori; Matthew Berriman; Michael J. Lehane; Neil Hall; Philippe Solano; Winston Hide; Yeya Toure; Geoffrey M. Attardo; Alistair C. Darby; Atsushi Toyoda; Christiane Hertz-Fowler; Denis M. Larkin; James A. Cotton; Mandy J. Sanders; Martin T. Swain; Michael A. Quail; Noboru Inoue; Sophie Ravel; Todd D. Taylor; Tulika P. Srivastava; Vineet Sharma; Wesley Warren; Richard K. Wilson; Yutaka Suzuki; Daniel Lawson; Daniel S. T. Hughes; Karyn Megy; Daniel K. Masiga; Paul O. Mireji; Imma A. Hansen; Jan Van den Abbeele; Joshua B. Benoit; Kostas Bourtzis; George F. O. Obiero; Hugh M. Robertson; Jeffery W. Jones; Jing-Jiang Zhou; Linda M. Field; Markus Friedrich; Steven R. G. Nyanjom; Erich L. Telleria; Guy Caljon; Jose M. C. Ribeiro; Alvaro Acosta-Serrano; Cher-Pheng Ooi; Clair Rose; David P. Price; Lee R. Haines; Alan Christoffels; Cheolho Sim; Daphne Q. D. Pham; David L. Denlinger; Dawn L. Geiser; Irene A. Omedo; Joy J. Winzerling; Justin T. Peyton; Kevin K. Marucha; Mario Jonas; Megan E. Meuti; Neil D. Rawlings; Qirui Zhang; Rosaline W. Macharia; Veronika Michalkova; Zahra Jalali Sefid Dashti; Aaron A. Baumann; Gerd Gaede; Heather G. Marco; Immo A. Hansen; Jelle Caers; Liliane Schoofs; Michael A. Riehle; Wanqi Hu; Zhijian Tu; Aaron M. Tarone; Anna R. Malacrida; Caleb K. Kibet; Francesca Scolari; Jacobus J. O. Koekemoer; Judith Willis; Ludvik M. Gomulski; Marco Falchetto; Maxwell J. Scott; Shuhua Fu; Sing-Hoi Sze; Thiago Luiz; Brian Weiss; Deirdre P. Walshe; Jingwen Wang; Mark Wamalwa; Sarah Mwangi; Urvashi N. Ramphul; Anna K. Snyder; Corey L. Brelsfoard; Gavin H. Thomas; George Tsiamis; Peter Arensburger; Rita V. M. Rio; Sandy J. Macdonald; Sumir Panji; Adele Kruger; Alia Benkahla; Apollo S. P. Balyeidhusa; Atway Msangi; Chinyere K. Okoro; Dawn Stephens; Eleanor J. Stanley; Feziwe Mpondo; Florence Wamwiri; Furaha Mramba; Geoffrey Siwo; George Githinji; Gordon Harkins; Grace Murilla; Heikki Lehvaeslaiho; Imna Malele; Joanna E. Auma; Johnson K. Kinyua; Johnson Ouma; Loyce Okedi; Lucien Manga; Martin Aslett; Mathurin Koffi; Michael W. Gaunt; Mmule Makgamathe; Nicola Mulder; Oliver Manangwa; Patrick P. Abila; Patrick Wincker; Richard Gregory; Rosemary Bateta; Ryuichi Sakate; Serap Aksoy; Sheila Ommeh; Stella Lehane; Tadashi Imanishi; Victor C. Osamor; Yoshihiro Kawahara; IGGI

doi:10.1126/science.1249656

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Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis

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Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis

Junichi Watanabe, Masahira Hattori, Matthew Berriman, Michael J. Lehane, Neil Hall, Philippe Solano, Winston Hide, Yeya Toure, Geoffrey M. Attardo, Alistair C. Darby, …

Science (American Association for the Advancement of Science), Vol.344(6182), pp.380-386

25/04/2014

DOI: https://doi.org/10.1126/science.1249656

PMID: 24763584

Résumé

Multidisciplinary Sciences

Science & Technology

Science & Technology - Other Topics

Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/ chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.

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Titre: Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis
Créateurs - sans rôle: Junichi Watanabe - Univ Tokyo, Inst Med Sci, Minato Ku, Tokyo 1088639, Japan
Masahira Hattori
Matthew Berriman
Michael J. Lehane
Neil Hall
Philippe Solano - CIRDES Bobo Dioulasso, UMR IRD CIRAD INTERTRYP 177, IRD, Bobo Dioulasso, Burkina Faso
Winston Hide
Yeya Toure - WHO, Special Programme Res & Training Trop Dis TDR, CH-1211 Geneva 27, Switzerland
Geoffrey M. Attardo
Alistair C. Darby - Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England
Atsushi Toyoda - Natl Inst Genet, Comparat Genom Lab, Mishima, Shizuoka 4118540, Japan
Christiane Hertz-Fowler - Wellcome Trust Sanger Inst, Parasite Genom Grp, Cambridge CB10 1SA, Cambs, England
Denis M. Larkin - Aberystwyth Univ, Inst Biol Environm & Rural Sci, Aberystwyth SY23 3FG, Ceredigion, Wales
James A. Cotton - Wellcome Sanger Institute
Junichi Watanabe
Mandy J. Sanders - Wellcome Sanger Institute
Martin T. Swain - Aberystwyth Univ, Inst Biol Environm & Rural Sci, Aberystwyth SY23 3FG, Ceredigion, Wales
Masahira Hattori
Matthew Berriman
Michael A. Quail - Wellcome Trust Sanger Inst, Parasite Genom Grp, Cambridge CB10 1SA, Cambs, England
Noboru Inoue - Obihiro Univ Agr & Vet Med, Natl Res Ctr Protozoan Dis, Obihiro, Hokkaido 0808555, Japan
Sophie Ravel - LRCT Campus Int Baillarguet, UMR IRD CIRAD INTERTRYP 177, IRD, Montpellier, France
Todd D. Taylor
Tulika P. Srivastava - RIKEN Ctr Integrat Med Sci, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
Vineet Sharma - RIKEN Ctr Integrat Med Sci, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
Wesley Warren - Washington Univ, Sch Med, Genome Inst, St Louis, MO 63110 USA
Richard K. Wilson - Washington Univ, Sch Med, Genome Inst, St Louis, MO 63110 USA
Yutaka Suzuki - Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol, Ctr Om & Bioinformat, Kashiwa, Chiba 2778561, Japan
Daniel Lawson - European Bioinformat Inst EMBL EBI, European Mol Biol Labs, Cambridge CB10 1SA, Cambs, England
Daniel S. T. Hughes - European Bioinformat Inst EMBL EBI, European Mol Biol Labs, Cambridge CB10 1SA, Cambs, England
Karyn Megy
Daniel K. Masiga
Paul O. Mireji
Geoffrey M. Attardo
Imma A. Hansen - New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA
Jan Van den Abbeele - Inst Trop Med Antwerp, Dept Biomed Sci, B-2000 Antwerp, Belgium
Joshua B. Benoit - Univ Cincinnati, McMicken Coll Arts & Sci, Dept Biol Sci, Cincinnati, OH 45221 USA
Kostas Bourtzis - Alexander Fleming Biomed Sci Res Ctr, Biomed Sci Res Ctr, Vari 16672, Greece
Michael J. Lehane
Daniel K. Masiga
George F. O. Obiero - Int Ctr Insect Physiol & Ecol, Mol Biol & Bioinformat Unit, Nairobi, Kenya
Hugh M. Robertson - University of Illinois Urbana-Champaign
Jeffery W. Jones - Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA
Jing-Jiang Zhou - Rothamsted Res, Dept Biol Chem & Crop Protect, Harpenden AL5 2JQ, Herts, England
Linda M. Field - Rothamsted Research
Markus Friedrich - Wayne State Univ, Dept Biol Sci, Detroit, MI 48202 USA
Paul O. Mireji
Steven R. G. Nyanjom
Erich L. Telleria - Yale Univ, Sch Publ Hlth, Dept Epidemiol Microbial Dis, 60 Coll St, New Haven, CT 06520 USA
Guy Caljon - Inst Trop Med Antwerp, Dept Biomed Sci, B-2000 Antwerp, Belgium
Jan Van den Abbeele
Jose M. C. Ribeiro - NIAID, Lab Malaria & Vector Res, Rockville, MD 20852 USA
Alvaro Acosta-Serrano - Univ Liverpool, Liverpool Sch Trop Med, Dept Parasitol, Liverpool L3 5QA, Merseyside, England
Joshua B. Benoit
Cher-Pheng Ooi
Clair Rose - Univ Liverpool, Liverpool Sch Trop Med, Dept Parasitol, Liverpool L3 5QA, Merseyside, England
David P. Price - New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA
Lee R. Haines - Univ Liverpool, Liverpool Sch Trop Med, Dept Vector Biol, Liverpool L3 5QA, Merseyside, England
Michael J. Lehane
Alan Christoffels - Univ Western Cape, South African MRC Bioinformat Unit, South African Natl Bioinformat Inst, ZA-7530 Bellville, South Africa
Cheolho Sim - Baylor Univ, Dept Biol, Waco, TX 76798 USA
Daphne Q. D. Pham - Univ Wisconsin Parkside, Dept Biol Sci, Kenosha, WI 53144 USA
David L. Denlinger - Ohio State Univ, Dept Entomol, Aronoff Lab 400, Columbus, OH 43210 USA
Dawn L. Geiser - Univ Arizona, Dept Nutr Sci, Tucson, AZ 85721 USA
Irene A. Omedo - CGMRC, KEMRI Wellcome Trust Programme, Dept Clin Res, Kilifi, Kenya
Joshua B. Benoit
Joy J. Winzerling - Univ Arizona, Coll Agr & Life Sci, Dept Nutr Sci, Career Serv, Tucson, AZ 85721 USA
Justin T. Peyton - Ohio State Univ, Dept Ecol Evolut & Organismal Biol, Aronoff Lab 300, Columbus, OH 43210 USA
Kevin K. Marucha - Egerton Univ, Dept Biochem & Mol Biol, Njoro, Kenya
Mario Jonas
Megan E. Meuti
Neil D. Rawlings - EMBL European Bioinformat Inst, Wellcome Trust Sanger Inst, Bateman Grp, Cambridge CB10 1SA, Cambs, England
Paul O. Mireji
Qirui Zhang - Ohio State Univ, Dept Entomol, Aronoff Lab 400, Columbus, OH 43210 USA
Rosaline W. Macharia - Univ Nairobi, Ctr Biotechnol & Bioinformat, Nairobi 00100, Kenya
Veronika Michalkova - Yale Univ, Sch Publ Hlth, Dept Epidemiol Microbial Dis, 60 Coll St, New Haven, CT 06520 USA
Zahra Jalali Sefid Dashti - Univ Western Cape, South African MRC Bioinformat Unit, South African Natl Bioinformat Inst, ZA-7530 Bellville, South Africa
Aaron A. Baumann - Howard Hughes Med Inst, Riddiford Lab, Ashburn, VA 20147 USA
Gerd Gaede - Univ Cape Town, Dept Biol Sci, ZA-7700 Rondebosch, South Africa
Heather G. Marco - Univ Cape Town, Dept Biol Sci, ZA-7700 Rondebosch, South Africa
Immo A. Hansen - New Mexico State Univ, Dept Biol, Las Cruces, NM 88003 USA
Jelle Caers - Katholieke Univ Leuven, Dept Biol, B-3000 Louvain, Belgium
Liliane Schoofs - Katholieke Univ Leuven, Dept Biol, B-3000 Louvain, Belgium
Michael A. Riehle - Univ Arizona, Dept Entomol, Tucson, AZ 85721 USA
Wanqi Hu - Virginia Polytech Inst & State Univ, Dept Biochem, Blacksburg, VA 24061 USA
Zhijian Tu - Virginia Polytech Inst & State Univ, Dept Biochem, Blacksburg, VA 24061 USA
Aaron M. Tarone - Texas A&M Univ, Dept Entomol, College Stn, TX 77843 USA
Anna R. Malacrida - Univ Pavia, Dept Biol & Biotechnol, I-27100 Pavia, Italy
Caleb K. Kibet - Int Ctr Insect Physiol & Ecol, Mol Biol & Bioinformat Unit, Nairobi, Kenya
Joshua B. Benoit
Francesca Scolari - Univ Pavia, Dept Biol & Biotechnol, I-27100 Pavia, Italy
Geoffrey M. Attardo
Jacobus J. O. Koekemoer - Onderstepoort Vet Inst, Entomol Sect, ZA-110 Onderstepoort, South Africa
Judith Willis - Univ Georgia, Dept Cellular Biol, Athens, GA 30602 USA
Ludvik M. Gomulski - Univ Pavia, Dept Biol & Biotechnol, I-27100 Pavia, Italy
Marco Falchetto - Univ Pavia, Dept Biol & Biotechnol, I-27100 Pavia, Italy
Maxwell J. Scott - N Carolina State Univ, Dept Entomol, Raleigh, NC 27695 USA
Shuhua Fu - Texas A&M Univ, Dept Biochem & Biophys, College Stn, TX 77843 USA
Sing-Hoi Sze - Texas A&M Univ, Dept Biochem & Biophys, Dept Comp Sci & Engn, College Stn, TX 77843 USA
Thiago Luiz - Yale Univ, Sch Publ Hlth, Dept Epidemiol Microbial Dis, 60 Coll St, New Haven, CT 06520 USA
Brian Weiss - Yale Univ, Sch Publ Hlth, Dept Epidemiol Microbial Dis, 60 Coll St, New Haven, CT 06520 USA
Deirdre P. Walshe - Univ Liverpool, Liverpool Sch Trop Med, Dept Vector Biol, Liverpool L3 5QA, Merseyside, England
Jingwen Wang - Yale Univ, Sch Publ Hlth, Dept Epidemiol Microbial Dis, 60 Coll St, New Haven, CT 06520 USA
Joshua B. Benoit
Geoffrey M. Attardo
Mark Wamalwa - Univ Western Cape, South African MRC Bioinformat Unit, South African Natl Bioinformat Inst, ZA-7530 Bellville, South Africa
Sarah Mwangi - Univ Western Cape, South African MRC Bioinformat Unit, South African Natl Bioinformat Inst, ZA-7530 Bellville, South Africa
Urvashi N. Ramphul - Univ Liverpool, Liverpool Sch Trop Med, Dept Vector Biol, Liverpool L3 5QA, Merseyside, England
Anna K. Snyder - W Virginia Univ, Dept Biol, Morgantown, WV 26506 USA
Corey L. Brelsfoard - St Catharine Coll, Dept Nat Sci, St Catharine, KY 40061 USA
Gavin H. Thomas - Univ York, Dept Biol, York Y010 5DD, N Yorkshire, England
George Tsiamis - Univ Patras, Dept Environm & Nat Resources Management, Agrinion 30100, Greece
Kostas Bourtzis
Peter Arensburger - Calif State Polytech Univ Pomona, Dept Biol Sci, Pomona, CA 91768 USA
Rita V. M. Rio - W Virginia Univ, Dept Biol, Morgantown, WV 26506 USA
Sandy J. Macdonald - Univ York, Dept Biol, York Y010 5DD, N Yorkshire, England
Sumir Panji - University of Cape Town
Adele Kruger - Univ Western Cape, South African MRC Bioinformat Unit, South African Natl Bioinformat Inst, ZA-7530 Bellville, South Africa
Alan Christoffels
Alia Benkahla - Inst Pasteur Tunis, Lab Med Parasitol Biotechnol & Biomol, Grp Bioinformat & Modeling, Tunis 1002, Tunisia
Apollo S. P. Balyeidhusa - Makerere Univ, Dept Biochem & Sports Sci, Kampala, Uganda
Atway Msangi - TTRI, Tanga, Tanzania
Cher-Pheng Ooi
Chinyere K. Okoro - Wellcome Trust Sanger Inst, Cambridge CB10 1SA, Cambs, England
Daniel K. Masiga
Dawn Stephens - Technol Innovat Agcy, Natl Genom Platform, ZA-4058 Durban, South Africa
Deirdre P. Walshe
Eleanor J. Stanley - European Bioinformat Inst EMBL EBI, European Mol Biol Labs, Cambridge CB10 1SA, Cambs, England
Feziwe Mpondo - Univ Western Cape, South African MRC Bioinformat Unit, South African Natl Bioinformat Inst, ZA-7530 Bellville, South Africa
Florence Wamwiri - Kenya Agr Res Inst, Trypanosomiasis Res Ctr, Kikuyu 902, Kenya
Furaha Mramba - TTRI, Tanga, Tanzania
Geoffrey M. Attardo
Geoffrey Siwo - Univ Notre Dame, Dept Biol Sci, Eck Inst Global Hlth, Notre Dame, IN 46556 USA
George F. O. Obiero
George Githinji - CGMRC, KEMRI Wellcome Trust Programme, Dept Parasite Vector & Human Biol, Kilifi, Kenya
Gordon Harkins - University of the Western Cape
Grace Murilla - Kenya Agr Res Inst, Trypanosomiasis Res Ctr, Kikuyu 902, Kenya
Heikki Lehvaeslaiho - KAUST, Thuwal 239556900, Saudi Arabia
Imna Malele - TTRI, Tanga, Tanzania
Jacobus J. O. Koekemoer
Joanna E. Auma - Kenya Agr Res Inst, Trypanosomiasis Res Ctr, Kikuyu 902, Kenya
Johnson K. Kinyua - JKUAT, Dept Biochem, Nairobi, Kenya
Johnson Ouma - Kenya Agr Res Inst, Trypanosomiasis Res Ctr, Kikuyu 902, Kenya
Junichi Watanabe
Karyn Megy
Loyce Okedi - Natl Livestock Resources Res Inst NaLIRRI, Tororo, Uganda
Lucien Manga - WHO, WHO Reg Off Africa, Brazzaville, Rep Congo
Mario Jonas
Mark Wamalwa
Martin Aslett - Wellcome Trust Sanger Inst, Parasite Genom Grp, Cambridge CB10 1SA, Cambs, England
Mathurin Koffi - CIRDES Bobo Dioulasso, UMR IRD CIRAD INTERTRYP 177, IRD, Bobo Dioulasso, Burkina Faso
Matthew Berriman
Michael J. Lehane
Michael W. Gaunt - Univ London London Sch Hyg & Trop Med, Dept Pathogen Mol Biol, London WC1E 7HT, England
Mmule Makgamathe - Technol Innovat Agcy, Natl Genom Platform, ZA-4058 Durban, South Africa
Neil Hall
Nicola Mulder - Univ Cape Town, Fac Hlth Sci, IIDMM, Computat Biol Grp, ZA-7925 Cape Town, South Africa
Oliver Manangwa - TTRI, Tanga, Tanzania
Patrick P. Abila - Natl Livestock Resources Res Inst NaLIRRI, Tororo, Uganda
Patrick Wincker - CEA, F-91507 Evry, France
Paul O. Mireji
Richard Gregory - Univ Liverpool, Inst Integrat Biol, Liverpool L69 7ZB, Merseyside, England
Rita V. M. Rio
Rosemary Bateta - Egerton Univ, Dept Biochem & Mol Biol, Njoro, Kenya
Ryuichi Sakate - Natl Inst Adv Ind Sci & Technol, Biol Informat Res Ctr, Integrated Database Team, Koto Ku, Tokyo 1350064, Japan
Serap Aksoy - Yale University
Sheila Ommeh - JKUAT, Biotechnol Res Inst, Nairobi, Kenya
Stella Lehane - Univ Liverpool, Liverpool Sch Trop Med, Dept Vector Biol, Liverpool L3 5QA, Merseyside, England
Steven R. G. Nyanjom
Tadashi Imanishi - Natl Inst Adv Ind Sci & Technol, Biol Informat Res Ctr, Integrated Database Team, Koto Ku, Tokyo 1350064, Japan
Todd D. Taylor
Victor C. Osamor - Covenant Univ, Coll Sci & Technol, Dept Comp & Informat Sci, Ota, Ogun State, Nigeria
Vineet Sharma - RIKEN Ctr Integrat Med Sci, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan
Winston Hide
Yoshihiro Kawahara - Natl Inst Adv Ind Sci & Technol, Biol Informat Res Ctr, Integrated Database Team, Koto Ku, Tokyo 1350064, Japan
Joshua B. Benoit
IGGI
Détails de publication: Science (American Association for the Advancement of Science), Vol.344(6182), pp.380-386
Éditeur: Amer Assoc Advancement Science
Nombre de pages: 7
Note de subvention: FA0701 / European Union Cooperation in Science and Technology (COST) Action Ministry of Education, Culture, Sports, Science, and Technology of Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) Ambrose Monell Foundation A90088 / World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR); World Health Organization MR/K002279/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) 0951886 / Direct For Biological Sciences; Division Of Integrative Organismal Systems; National Science Foundation (NSF); NSF - Directorate for Biological Sciences (BIO); NSF - Division of Integrative Organismal Systems (IOS) 085775/Z/08/Z; 098051 / Wellcome Trust Food and Agriculture Organization/International Atomic Energy Agency Coordinated Research Program "Improving SIT for Tsetse Flies through Research on their Symbionts" BB/J017698/1; BBS/E/C/00005193; BBS/E/C/00005194 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC)
Identifiants: 99154995809311
Unité académique: Intéractions hôtes-vecteurs-parasites-environnement maladies tropicales - INTERTRYP
Langue: English
Type de ressource: Journal article