Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Magnus Johannesson; David I. Laibson; Sarah E. Medland; Michelle N. Meyer; Joseph K. Pickrell; Tõnu Esko; Robert F. Krueger; Jonathan P. Beauchamp; Philipp D. Koellinger; Daniel J. Benjamin; Meike Bartels; David Cesarini; Aysu Okbay; Bart M. L. Baselmans; Jan-Emmanuel de Neve; Patrick Turley; Michel G. Nivard; Mark Alan Fontana; S. Fleur W. Meddens; Richard Karlsson Linnér; Cornelius A. Rietveld; Jaime Derringer; Jacob Gratten; James J. Lee; Jimmy Z. Liu; Ronald De Vlaming; Tarunveer S. Ahluwalia; Jadwiga Buchwald; Alana Cavadino; Alexis C. Frazier-Wood; Nicholas A. Furlotte; Victoria Garfield; Marie Henrike Geisel; Juan R. Gonzalez; Saskia Haitjema; Robert Karlsson; Sander W. van Der Laan; Karl-Heinz Ladwig; Jari Lahti; Sven J. van Der Lee; Penelope A. Lind; Tian Liu; Lindsay Matteson; Evelin Mihailov; Michael B. Miller; Camelia C. Minica; Ilja M. Nolte; Dennis Mook-Kanamori; Peter J. van Der Most; Christopher Oldmeadow; Yong Qian; Olli Raitakari; Rajesh Rawal; Anu Realo; Rico Rueedi; Börge Schmidt; Albert V. Smith; Evie Stergiakouli; Toshiko Tanaka; Kent Taylor; Gudmar Thorleifsson; Juho Wedenoja; Juergen Wellmann; Harm-Jan Westra; Sara M. Willems; Wei Zhao; Lifelines Cohort Study; Najaf Amin; Andrew Bakshi; Sven Bergmann; Gyda Bjornsdottir; Patricia A. Boyle; Samantha Cherney; Simon R. Cox; Gail Davies; Oliver S. P. Davis; Jun Ding; Nese Direk; Peter Eibich; Rebecca T. Emeny; Ghazaleh Fatemifar; Jessica D. Faul; Luigi Ferrucci; Andreas J. Forstner; Christian Gieger; Richa Gupta; Tamara B. Harris; Juliette M. Harris; Elizabeth G. Holliday; Jouke-Jan Hottenga; Philip L. de Jager; Marika A. Kaakinen; Eero Kajantie; Ville Karhunen; Ivana Kolcic; Meena Kumari; Lenore J. Launer; Lude Franke; Ruifang Li-Gao; David C. Liewald; Marisa Koini; Anu Loukola; Pedro Marques-Vidal; Grant W. Montgomery; Miriam A. Mosing; Lavinia Paternoster; Alison Pattie; Katja E. Petrovic; Laura Pulkki-R Aback; Lydia Quaye; Katri Räikkönen; Igor Rudan; Rodney J. Scott; Jennifer A. Smith; Angelina R. Sutin; Maciej Trzaskowski; Anna E. Vinkhuyzen; Lei Yu; Delilah Zabaneh; John R. Attia; David A. Bennett; Klaus Berger; Lars Bertram; Dorret I. Boomsma; Harold Snieder; Shun-Chiao Chang; Francesco Cucca; Ian J. Deary; Cornelia M. Van Duijn; Johan G. Eriksson; Ute Bültmann; Eco J. C. De Geus; Patrick J. F. Groenen; Vilmundur Gudnason; Torben Hansen; Catharine A. Hartman; Claire M. A. Haworth; Caroline Hayward; Andrew C. Heath; David A. Hinds; Elina Hyppönen; William G. Iacono; Marjo-Riitta Järvelin; Karl-Heinz Jöckel; Jaakko Kaprio; Sharon L. R. Kardia; Liisa Keltikangas-Järvinen; Peter Kraft; Laura D. Kubzansky; Terho Lehtimäki; Patrik K. E. Magnusson; Nicholas G. Martin; Matt Mcgue; Andres Metspalu; Melinda Mills; Renée De Mutsert; Albertine J. Oldehinkel; Gerard Pasterkamp; Nancy L. Pedersen; Robert Plomin; Ozren Polasek; Christine Power; Stephen S. Rich; Frits R. Rosendaal; Hester M. Den Ruijter; David Schlessinger; Helena Schmidt; Rauli Svento; Reinhold Schmidt; Behrooz Z. Alizadeh; Thorkild I. A. Sørensen; Tim D. Spector; John M. Starr; Kari Stefansson; Andrew Steptoe; Antonio Terracciano; Unnur Thorsteinsdottir; A. Roy Thurik; Nicholas J. Timpson; Henning Tiemeier; André G. Uitterlinden; Peter Vollenweider; Gert G. Wagner; David R. Weir; Jian Yang; Dalton C. Conley; George Davey Smith; Albert Hofman

doi:10.1038/ng.3552

Back

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Journal article

Peer reviewed

Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses

Magnus Johannesson, David I. Laibson, Sarah E. Medland, Michelle N. Meyer, Joseph K. Pickrell, Tõnu Esko, Robert F. Krueger, Jonathan P. Beauchamp, Philipp D. Koellinger, Daniel J. Benjamin, …

Nature Genetics, Vol.48(6), pp.624-633

2016

DOI: https://doi.org/10.1038/ng.3552

PMCID: PMC4884152

Abstract

Behavioural genetics

Genome-wide association studies

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (\textbarρ^\textbar ? 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.

Files and links (1)

url

Find in HALView

Metrics

1 Record Views

See more details

Details

Title: Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Creators - without role: Magnus Johannesson - Stockholm School of Economics
David I. Laibson - Harvard University
Sarah E. Medland - QIMR Berghofer Medical Research Institute
Michelle N. Meyer - Clarkson University
Joseph K. Pickrell - Columbia University
Tõnu Esko - University of Tartu
Robert F. Krueger - Twin Cities Orthopedics
Jonathan P. Beauchamp - Harvard University
Philipp D. Koellinger - University of Amsterdam
Daniel J. Benjamin - University of Southern California
Meike Bartels - Amsterdam Neuroscience
David Cesarini - New York University
Aysu Okbay - Erasmus University Rotterdam
Bart M. L. Baselmans - Vrije Universiteit Amsterdam
Jan-Emmanuel de Neve - University of Oxford
Patrick Turley - Harvard University
Michel G. Nivard - Vrije Universiteit Amsterdam
Mark Alan Fontana - University of Southern California
S. Fleur W. Meddens - Erasmus University Rotterdam
Richard Karlsson Linnér - Erasmus University Rotterdam
Cornelius A. Rietveld - Erasmus MC
Jaime Derringer - University of Illinois Urbana-Champaign
Jacob Gratten - University of Queensland
James J. Lee - Twin Cities Orthopedics
Jimmy Z. Liu - New York Genome Center
Ronald De Vlaming
Tarunveer S. Ahluwalia - University of Copenhagen
Jadwiga Buchwald - University of Helsinki
Alana Cavadino - Queen Mary University of London
Alexis C. Frazier-Wood
Nicholas A. Furlotte - 23andMe
Victoria Garfield - University College London
Marie Henrike Geisel - Institut für Medizinische Informatik, Biometrie und Epidemiologie
Juan R. Gonzalez - Center for Research in Environmental Epidemiology
Saskia Haitjema - University Medical Center Utrecht
Robert Karlsson - Karolinska Institutet
Sander W. van Der Laan
Karl-Heinz Ladwig - Helmholtz Zentrum München
Jari Lahti - University of Helsinki
Sven J. van Der Lee
Penelope A. Lind - QIMR Berghofer Medical Research Institute
Tian Liu - Max Planck Institute for Human Development
Lindsay Matteson - Twin Cities Orthopedics
Evelin Mihailov - University of Tartu
Michael B. Miller - Twin Cities Orthopedics
Camelia C. Minica - Vrije Universiteit Amsterdam
Ilja M. Nolte - University of Groningen
Dennis Mook-Kanamori - Leiden University Medical Center
Peter J. van Der Most
Christopher Oldmeadow - Hunter Medical Research Institute
Yong Qian - National Institute on Aging
Olli Raitakari - University of Turku
Rajesh Rawal - Helmholtz Zentrum München
Anu Realo - University of Tartu
Rico Rueedi - University of Lausanne
Börge Schmidt - Institut für Medizinische Informatik, Biometrie und Epidemiologie
Albert V. Smith - Icelandic Heart Association
Evie Stergiakouli - MRC Epidemiology Unit
Toshiko Tanaka - National Institute on Aging
Kent Taylor - The Lundquist Institute
Gudmar Thorleifsson - deCODE Genetics
Juho Wedenoja - University of Helsinki
Juergen Wellmann - University of Münster
Harm-Jan Westra - Brigham and Women's Hospital
Sara M. Willems - Erasmus MC
Wei Zhao - University of Michigan–Ann Arbor
Lifelines Cohort Study
Najaf Amin - Erasmus MC
Andrew Bakshi - University of Queensland
Sven Bergmann - University of Lausanne
Gyda Bjornsdottir
Patricia A. Boyle - Rush University Medical Center
Samantha Cherney - RAND Corporation
Simon R. Cox - University of Edinburgh
Gail Davies - University of Edinburgh
Oliver S. P. Davis - MRC Epidemiology Unit
Jun Ding - National Institute on Aging
Nese Direk - Erasmus MC
Peter Eibich - German Institute for Economic Research
Rebecca T. Emeny - Helmholtz Zentrum München
Ghazaleh Fatemifar - University College London
Jessica D. Faul - University of Michigan–Ann Arbor
Luigi Ferrucci - National Institute on Aging
Andreas J. Forstner - University of Bonn
Christian Gieger - Helmholtz Zentrum München
Richa Gupta - University of Helsinki
Tamara B. Harris - National Institutes of Health
Juliette M. Harris - King's College London
Elizabeth G. Holliday - Hunter Medical Research Institute
Jouke-Jan Hottenga - EMGO Institute for Health and Care Research
Philip L. de Jager - Brigham and Women's Hospital
Marika A. Kaakinen - Genomics England
Eero Kajantie - University of Helsinki
Ville Karhunen - University of Oulu
Ivana Kolcic - University of Split
Meena Kumari - University of Essex
Lenore J. Launer - National Institute on Aging
Lude Franke - University Medical Center Groningen
Ruifang Li-Gao - Leiden University Medical Center
David C. Liewald - University of Edinburgh
Marisa Koini - Medical University of Graz
Anu Loukola - University of Helsinki
Pedro Marques-Vidal - University of Lausanne
Grant W. Montgomery - QIMR Berghofer Medical Research Institute
Miriam A. Mosing - Karolinska Institutet
Lavinia Paternoster - University of Bristol
Alison Pattie - University of Edinburgh
Katja E. Petrovic - Medical University of Graz
Laura Pulkki-R Aback
Lydia Quaye - King's College London
Katri Räikkönen - University of Helsinki
Igor Rudan - University of Edinburgh
Rodney J. Scott - University of Newcastle Australia
Jennifer A. Smith - University of Michigan–Ann Arbor
Angelina R. Sutin - National Institutes of Health
Maciej Trzaskowski - University of Queensland
Anna E. Vinkhuyzen - University of Queensland
Lei Yu - Rush University Medical Center
Delilah Zabaneh - University of Split
John R. Attia - Hunter Medical Research Institute
David A. Bennett - Rush University Medical Center
Klaus Berger - University of Münster
Lars Bertram - Institute for Integrative and Experimental Genomics
Dorret I. Boomsma - EMGO Institute for Health and Care Research
Harold Snieder - University Medical Center Groningen
Shun-Chiao Chang - Brigham and Women's Hospital
Francesco Cucca - Institute of Genetic and Biomedical Research
Ian J. Deary - University of Edinburgh
Cornelia M. Van Duijn - Department of Epidemiology [Rotterdam]
Johan G. Eriksson - University of Helsinki
Ute Bültmann - University of Groningen
Eco J. C. De Geus
Patrick J. F. Groenen - Erasmus University Rotterdam
Vilmundur Gudnason
Torben Hansen - University of Copenhagen
Catharine A. Hartman - University of Groningen
Claire M. A. Haworth - University of Bristol
Caroline Hayward - MRC Institute of Genetics and Molecular Medicine
Andrew C. Heath - Washington University in St. Louis
David A. Hinds - 23andMe
Elina Hyppönen - South Australian Health and Medical Research Institute
William G. Iacono - Twin Cities Orthopedics
Marjo-Riitta Järvelin - Imperial College London
Karl-Heinz Jöckel - Institut für Medizinische Informatik, Biometrie und Epidemiologie
Jaakko Kaprio - University of Helsinki
Sharon L. R. Kardia - University of Michigan–Ann Arbor
Liisa Keltikangas-Järvinen
Peter Kraft - Harvard University
Laura D. Kubzansky - Harvard University
Terho Lehtimäki - Fimlab
Patrik K. E. Magnusson - Karolinska Institutet
Nicholas G. Martin - QIMR Berghofer Medical Research Institute
Matt Mcgue - Twin Cities Orthopedics
Andres Metspalu - University of Tartu
Melinda Mills - University of Oxford
Renée De Mutsert
Albertine J. Oldehinkel - Erasmus University Rotterdam
Gerard Pasterkamp - University Medical Center Utrecht
Nancy L. Pedersen - Karolinska Institutet
Robert Plomin - King's College London
Ozren Polasek - University of Split
Christine Power
Stephen S. Rich - University of Virginia
Frits R. Rosendaal - Leiden University Medical Center
Hester M. Den Ruijter - University Medical Center Utrecht
David Schlessinger - National Institute on Aging
Helena Schmidt - Medical University of Graz
Rauli Svento - Oulu University of Applied Sciences
Reinhold Schmidt - Medical University of Graz
Behrooz Z. Alizadeh - University Medical Center Groningen
Thorkild I. A. Sørensen - MRC Epidemiology Unit
Tim D. Spector - King's College London
John M. Starr - University of Edinburgh
Kari Stefansson - deCODE Genetics
Andrew Steptoe - University College London
Antonio Terracciano - National Institute on Aging
Unnur Thorsteinsdottir
A. Roy Thurik - Erasmus University Rotterdam
Nicholas J. Timpson - University of Bristol
Henning Tiemeier - Erasmus MC
André G. Uitterlinden - Erasmus MC
Peter Vollenweider - University of Lausanne
Gert G. Wagner - German Institute for Economic Research
David R. Weir - University of Michigan–Ann Arbor
Jian Yang - Translational Research Institute
Dalton C. Conley - Princeton University
George Davey Smith - University of Bristol
Albert Hofman - Harvard University
Publication Details: Nature Genetics, Vol.48(6), pp.624-633
Identifiers: 9935253409311
Academic Unit: Montpellier Recherche en Management - MRM
Language: English
Resource Type: Journal article
Local Fields: hal-02017373