Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population

Oumou Niaré; Kyriacos Markianos; Jennifer Volz; Frederick Oduol; Abdoulaye Touré; Magaran Bagayoko; Djibril Sangaré; Sekou F. Traoré; Rui Wang; Claudia Blass; Guimogo Dolo; Madama Bouaré; Fotis C. Kafatos; Leonid Kruglyak; Yeya T. Touré; Kenneth D. Vernick

doi:10.1126/science.1073420

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Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population

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Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population

Oumou Niaré, Kyriacos Markianos, Jennifer Volz, Frederick Oduol, Abdoulaye Touré, Magaran Bagayoko, Djibril Sangaré, Sekou F. Traoré, Rui Wang, Claudia Blass, …

Science (American Association for the Advancement of Science), Vol.298(5591), pp.213-216

04/10/2002

DOI: https://doi.org/10.1126/science.1073420

PMID: 12364806

Résumé

Successful propagation of the malaria parasite Plasmodium falciparum within a susceptible mosquito vector is a prerequisite for the transmission of malaria. A field-based genetic analysis of the major human malaria vector, Anopheles gambiae , has revealed natural factors that reduce the transmission of P. falciparum . Differences in P. falciparum oocyst numbers between mosquito isofemale families fed on the same infected blood indicated a large genetic component affecting resistance to the parasite, and genome-wide scanning in pedigrees of wild mosquitoes detected segregating resistance alleles. The apparently high natural frequency of resistance alleles suggests that malaria parasites (or a similar pathogen) exert a significant selective pressure on vector populations.

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Titre: Genetic Loci Affecting Resistance to Human Malaria Parasites in a West African Mosquito Vector Population
Créateurs - sans rôle: Oumou Niaré - Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA., Département d'Epidémiologie des Affectations Parasitaires, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale 1805, Bamako, Mali
Kyriacos Markianos - Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Jennifer Volz - European Molecular Biology Laboratories, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Frederick Oduol - Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
Abdoulaye Touré - Département d'Epidémiologie des Affectations Parasitaires, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale 1805, Bamako, Mali
Magaran Bagayoko - Département d'Epidémiologie des Affectations Parasitaires, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale 1805, Bamako, Mali
Djibril Sangaré - Département d'Epidémiologie des Affectations Parasitaires, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale 1805, Bamako, Mali
Sekou F. Traoré - Département d'Epidémiologie des Affectations Parasitaires, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale 1805, Bamako, Mali
Rui Wang - European Molecular Biology Laboratories, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Claudia Blass - European Molecular Biology Laboratories, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Guimogo Dolo - Département d'Epidémiologie des Affectations Parasitaires, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale 1805, Bamako, Mali
Madama Bouaré - Département d'Epidémiologie des Affectations Parasitaires, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale 1805, Bamako, Mali
Fotis C. Kafatos - European Molecular Biology Laboratories, Meyerhofstrasse 1, 69117 Heidelberg, Germany
Leonid Kruglyak - Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA., Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815, USA
Yeya T. Touré - Département d'Epidémiologie des Affectations Parasitaires, Faculté de Médecine, de Pharmacie et d'Odonto-Stomatologie, Boite Postale 1805, Bamako, Mali
Kenneth D. Vernick - Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA
Détails de publication: Science (American Association for the Advancement of Science), Vol.298(5591), pp.213-216
Nombre de pages: 4
Identifiants: 99158658609311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article