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Generation of induced pluripotent stem cell lines IRMBi003-A and IRMBi003-B from a healthy donor to model Alzheimer’s disease
Journal article   Open access   Peer reviewed

Generation of induced pluripotent stem cell lines IRMBi003-A and IRMBi003-B from a healthy donor to model Alzheimer’s disease

C. Clua Provost, L. Auboyer, Anne Rovelet-Lecrux, C. Monzo, E. Schob, F. Andreux, C. Quittet, S. Lehmann, D. Wallon and C. Crozet
Stem Cell Research, Vol.73
12/2023
PMID: 37979430

Abstract

Humans Middle Aged Induced Pluripotent Stem Cells Alzheimer Disease Fibroblasts Germ Layers Cell Differentiation Cellular Reprogramming
Induced Pluripotent Stem Cell (iPSC) lines derived from healthy individuals are helpful and essential tools for disease modelling. Here, we described the reprogramming of skin fibroblasts obtained from a healthy 59-year-old individual without Alzheimer's disease. The generated iPSC lines have a normal karyotype, expressed pluripotency markers, and demonstrated the ability to differentiate into the three germ layers. The iPSC lines will be used as controls to study Alzheimer's disease mechanisms.
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https://doi.org/10.1016/j.scr.2023.103250View
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