Generation of a human iPSC line, INMi002-A, carrying the most prevalent USH2A variant associated with Usher syndrome type 2

Carla Sanjurjo-Soriano; Nejla Erkilic; Gael Manes; Grégor Dubois; Christian Hamel; Isabelle Meunier; Vasiliki Kalatzis

doi:10.1016/j.scr.2018.11.007

Retour

Generation of a human iPSC line, INMi002-A, carrying the most prevalent USH2A variant associated with Usher syndrome type 2

Article de revue

Open Access

Avec comité de lecture

Generation of a human iPSC line, INMi002-A, carrying the most prevalent USH2A variant associated with Usher syndrome type 2

Carla Sanjurjo-Soriano, Nejla Erkilic, Gael Manes, Grégor Dubois, Christian Hamel, Isabelle Meunier et Vasiliki Kalatzis

Stem Cell Research, Vol.33, pp.247-250

12/2018

DOI: https://doi.org/10.1016/j.scr.2018.11.007

PMID: 30468996

Résumé

We generated an induced pluripotent stem cell (iPSC) line using dermal fibroblasts from a patient with Usher syndrome type 2 (USH2). This individual was homozygous for the most prevalent variant reported in the USH2A gene, c.2299delG localized in exon 13. Reprogramming was performed using the non-integrative Sendai virus reprogramming method and the human OSKM transcription factor cocktail under feeder-free culture conditions. This iPSC line will be an invaluable tool for studying the pathophysiology of USH2 and for testing the efficacy of novel treatments.

Fichiers et liens (2)

url

Find in HALAfficher

url

https://doi.org/10.1016/j.scr.2018.11.007Afficher

Published (Version of record) Ouvrir

Indicateurs

1 Consultations de la notice

See more details

Détails

Titre: Generation of a human iPSC line, INMi002-A, carrying the most prevalent USH2A variant associated with Usher syndrome type 2
Créateurs - sans rôle: Carla Sanjurjo-Soriano - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Nejla Erkilic - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Gael Manes - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Grégor Dubois - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Christian Hamel - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Isabelle Meunier - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Vasiliki Kalatzis - Université de Montpellier, Institut des Neurosciences de Montpellier - INM
Détails de publication: Stem Cell Research, Vol.33, pp.247-250
Identifiants: 99150565309311
Unité académique: Institut des Neurosciences de Montpellier - INM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-02307062