Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

Salim Abdulla; Jane Achan; Ishag Adam; Bereket H. Alemayehu; Richard Allan; Elizabeth N. Allen; Anupkumar R. Anvikar; Emmanuel Arinaitwe; Elizabeth A. Ashley; Puji Budi Setia Asih; Ghulam Rahim Awab; Karen I. Barnes; Quique Bassat; Elisabeth Baudin; Anders Bjorkman; Francois Bompart; Maryline Bonnet; Steffen Borrmann; Teun Bousema; Verena I. Carrara; Fabio Cenci; Francesco Checchi; Michel Cot; Prabin Dahal; Umberto D'Alessandro; Philippe Deloron; Abdoulaye Djimde; Arjen Dondorp; Grant Dorsey; Ogobara K. Doumbo; Chris J. Drakeley; Stephan Duparc; Emmanuelle Espie; Abul Faiz; Catherine O. Falade; Caterina Fanello; Jean-Francois Faucher; Babacar Faye; Scott Filler; Bakary Fofana; Carole Fogg; Adama Gansane; Oumar Gaye; Blaise Genton; Peter W. Gething; Raquel Gonzalez; Francesco Grandesso; Brian Greenwood; Anastasia Grivoyannis; Philippe J. Guerin; Kamal Hamed; Christoph Hatz; Simon I. Hay; Eva Maria Hodel; Georgina S. Humphreys; Jimee Hwang; Bart Janssens; Daddi Jima; Elizabeth Juma; S. Patrick Kachur; Piet Kager; Moses R. Kamya; Melissa Kapulu; Corine Karema; Kassoum Kayentao; Jean R. Kiechel; Poul-Erik Kofoed; Valerie Lameyre; Sue J. Lee; Bertrand Lell; Nines Lima; Kevin Marsh; Andreas Martensson; Achille Massougbodji; Mayfong Mayxay; Rose McGready; Herve Menan; Clara Menendez; Petra Mens; Martin Meremikwu; Frank P. Mockenhaupt; Clarissa Moreira; Carolyn Nabasumba; Michael Nambozi; Jean-Louis Ndiaye; Paul N. Newton; Billy E. Ngasala; Francois Nosten; Christian Nsanzabana; Andre Toure Offianan; Mary Oguike; Bernhards R. Ogutu; Piero Olliaro; Sabah A. Omar; Lyda Osorio; Seth Owusu-Agyei; Louis K. Penali; Mbaye Pene; Judy Peshu; Patrice Piola; Zul Premji; Ric N. Price; Michael Ramharter; Lars Rombo; Cally Roper; Philip J. Rosenthal; Issaka Sagara; Patrick Sawa; Henk D. F. H. Schallig; Birgit Schramm; Seif A. Shekalaghe; Carol H. Sibley; Sodiomon Sirima; Frank Smithuis; Doudou Sow; Sarah G. Staedke; Kasia Stepniewska; Inge Sutanto; Colin J. Sutherland; Todd D. Swarthout; Din Syafruddin; Khadime Sylla; Ambrose O. Talisuna; Walter R. Taylor; Emmanuel A. Temu; Feiko Ter Kuile; Halidou Tinto; Emiliana Tjitra; Johan Ursing; Neena Valecha; Ingrid van den Broek; Michel van Herp; Michele van Vugt; Stephen A. Ward; Nicholas J. White; Peter A. Winstanley; Charles J. Woodrow; Adoke Yeka; Julien Zwang; WWARN Gametocyte Study Grp

doi:10.1186/s12916-016-0621-7

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Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

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Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data

Salim Abdulla, Jane Achan, Ishag Adam, Bereket H. Alemayehu, Richard Allan, Elizabeth N. Allen, Anupkumar R. Anvikar, Emmanuel Arinaitwe, Elizabeth A. Ashley, Puji Budi Setia Asih, …

BMC medicine, Vol.14(1), pp.79-79

24/05/2016

DOI: https://doi.org/10.1186/s12916-016-0621-7

PMID: 27221542

Résumé

General & Internal Medicine

Life Sciences & Biomedicine

Medicine, General & Internal

Science & Technology

Background: Gametocytes are responsible for transmission of malaria from human to mosquito. Artemisinin combination therapy (ACT) reduces post-treatment gametocyte carriage, dependent upon host, parasite and pharmacodynamic factors. The gametocytocidal properties of antimalarial drugs are important for malaria elimination efforts. An individual patient clinical data meta-analysis was undertaken to identify the determinants of gametocyte carriage and the comparative effects of four ACTs: artemether-lumefantrine (AL), artesunate/amodiaquine (AS-AQ), artesunate/mefloquine (AS-MQ), and dihydroartemisinin-piperaquine (DP). Methods: Factors associated with gametocytaemia prior to, and following, ACT treatment were identified in multivariable logistic or Cox regression analysis with random effects. All relevant studies were identified through a systematic review of PubMed. Risk of bias was evaluated based on study design, methodology, and missing data. Results: The systematic review identified 169 published and 9 unpublished studies, 126 of which were shared with the WorldWide Antimalarial Resistance Network (WWARN) and 121 trials including 48,840 patients were included in the analysis. Prevalence of gametocytaemia by microscopy at enrolment was 12.1 % (5887/48,589), and increased with decreasing age, decreasing asexual parasite density and decreasing haemoglobin concentration, and was higher in patients without fever at presentation. After ACT treatment, gametocytaemia appeared in 1.9 % (95 % CI, 1.7-2.1) of patients. The appearance of gametocytaemia was lowest after AS-MQ and AL and significantly higher after DP (adjusted hazard ratio (AHR), 2.03; 95 % CI, 1.24-3.12; P = 0.005 compared to AL) and AS-AQ fixed dose combination (FDC) (AHR, 4.01; 95 % CI, 2.40-6.72; P < 0.001 compared to AL). Among individuals who had gametocytaemia before treatment, gametocytaemia clearance was significantly faster with AS-MQ (AHR, 1.26; 95 % CI, 1.00-1.60; P = 0.054) and slower with DP (AHR, 0.74; 95 % CI, 0.63-0.88; P = 0.001) compared to AL. Both recrudescent (adjusted odds ratio (AOR), 9.05; 95 % CI, 3.74-21.90; P < 0.001) and new (AOR, 3.03; 95 % CI, 1.66-5.54; P < 0.001) infections with asexual-stage parasites were strongly associated with development of gametocytaemia after day 7. Conclusions: AS-MQ and AL are more effective than DP and AS-AQ FDC in preventing gametocytaemia shortly after treatment, suggesting that then on-artemisinin partner drug or the timing of artemisinin dosing are important determinants of post-treatment gametocyte dynamics.

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Titre: Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data
Créateurs - sans rôle: Salim Abdulla - Ifakara Hlth Inst, Dar Es Salaam, Tanzania
Jane Achan - Uganda Malaria Surveillance Project, Kampala, Uganda
Ishag Adam - Univ Khartoum, Fac Med, Khartoum, Sudan
Bereket H. Alemayehu - Columbia Univ, Mailman Sch Publ Hlth, ICAP, New York, NY USA
Richard Allan - Mentor
Elizabeth N. Allen - Univ Cape Town, Dept Med, Div Clin Pharmacol, ZA-7925 Cape Town, South Africa
Anupkumar R. Anvikar - Natl Inst Malaria Res, New Delhi, India
Emmanuel Arinaitwe - Infect Dis Res Collaborat, Kampala, Uganda
Elizabeth A. Ashley - Mahidol University
Puji Budi Setia Asih - Eijkman Inst Mol Biol, Jakarta, Indonesia
Ghulam Rahim Awab - Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand
Karen I. Barnes - WWARN, Oxford, England
Quique Bassat - Ctr Invest Saude Manhica, Manhica, Mozambique
Elisabeth Baudin - Epictr, Paris, France
Anders Bjorkman - Karolinska Institutet
Francois Bompart - Sanofi, Paris, France
Maryline Bonnet - Epictr, Mbarara, Uganda
Steffen Borrmann - Wellcome Trust
Teun Bousema - London Sch Hyg & Trop Med, Dept Infect & Immunity, London WC1, England
Verena I. Carrara - Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Shoklo Malaria Res Unit, Mae Sot, Thailand
Fabio Cenci - Sigma Tau Pharmaceut Co, Rome, Italy
Francesco Checchi - Epictr, Paris, France
Michel Cot - Univ Paris 05, Mother & Child Hlth Trop Res Unit, IRD, Paris, France
Prabin Dahal - WWARN, Oxford, England
Umberto D'Alessandro - MRC Unit, Fajara, Gambia
Philippe Deloron - Mother & Child Faced Trop Infect Res Unit, Inst Rech Dev, Paris, France
Abdoulaye Djimde - University of Bamako
Arjen Dondorp - Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand
Grant Dorsey - Univ Calif San Francisco, Dept Med, San Francisco, CA USA
Ogobara K. Doumbo - University of Bamako
Chris J. Drakeley - LSHTM, Dept Infect & Immunity, London, England
Stephan Duparc - Med Malaria Venture, Geneva, Switzerland
Emmanuelle Espie - Epictr, Paris, France
Abul Faiz - Dev Care Fdn, Dhaka, Bangladesh
Catherine O. Falade - Univ Ibadan, Coll Med, Dept Pharmacol & Therapeut, Ibadan, Nigeria
Caterina Fanello - Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand
Jean-Francois Faucher - Mother & Child Faced Trop Infect Res Unit, Inst Rech Dev, Paris, France
Babacar Faye - Univ Cheikh Anta Diop, Dept Med Parasitol, Fac Med, Dakar, Senegal
Scott Filler - Global Fund Fight AIDS TB & Malaria, Geneva, Switzerland
Bakary Fofana - University of Bamako
Carole Fogg - Univ Portsmouth, Portsmouth, Hants, England
Adama Gansane - Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso
Oumar Gaye - Univ Cheikh Anta Diop, Fac Med, Dept Med Parasitol, Dakar, Senegal
Blaise Genton - Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, Basel, Switzerland
Peter W. Gething - University of Oxford
Raquel Gonzalez - Univ Barcelona, Hosp Clin, Ctr Invest Saude Manhica Manhica Mozamb & ISGloba, Barcelona Ctr Int Hlth Res CRESIB, E-08007 Barcelona, Spain
Francesco Grandesso - Epictr, Paris, France
Brian Greenwood - LSHTM, Dept Dis Control, London, England
Anastasia Grivoyannis - Univ Washington, Seattle, WA 98195 USA
Philippe J. Guerin - WWARN, Oxford, England
Kamal Hamed - Novartis Pharmaceut, E Hanover, NJ USA
Christoph Hatz - Swiss Trop Inst, Dept Med, CH-4002 Basel, Switzerland
Simon I. Hay - Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England
Eva Maria Hodel - Swiss Trop Inst & Publ Hlth Inst, Basel, Switzerland
Georgina S. Humphreys - WWARN, Oxford, England
Jimee Hwang - US Ctr Dis Control & Prevent, Atlanta, GA USA
Bart Janssens - Med Sans Frontieres Operat Ctr, Brussels, Belgium
Daddi Jima - Fed Minist Hlth, Addis Ababa, Ethiopia
Elizabeth Juma - Kenya Govt Med Res Ctr, Nairobi, Kenya
S. Patrick Kachur - US Ctr Dis Control & Prevent, Atlanta, GA USA
Piet Kager - Univ Amsterdam, Acad Med Ctr, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands
Moses R. Kamya - Makerere Univ, Coll Hlth Sci, Kampala, Uganda
Melissa Kapulu - Wellcome Trust
Corine Karema - Minist Hlth, RBC, Malaria & Other Parasit Dis Div, Kigali, Rwanda
Kassoum Kayentao - Univ Bamako, Fac Med Pharm & Odontostomatol, Dept Epidemiol Parasit Dis, Malaria Res & Training Ctr, Bamako, Mali
Jean R. Kiechel - Drugs Neglected Dis Initiat DNDi, Geneva, Switzerland
Poul-Erik Kofoed - Projecto Saude Bandim, Bissau, Guinea Bissau
Valerie Lameyre - Sanofi, Paris, France
Sue J. Lee - Mahidol University
Bertrand Lell - Univ Tubingen, Inst Trop Med, Tubingen, Germany
Nines Lima - Med Sans Frontieres Operat Ctr Barcelona Athens, Barcelona, Spain
Kevin Marsh - Wellcome Trust
Andreas Martensson - Karolinska Inst, Dept Microbiol Tumor & Cell Biol, Stockholm, Sweden
Achille Massougbodji - Univ Abomey Calavi, Fac Sci Sante, Ctr Etud & Rech Paludisme Associe Grossesse & Enf, Cotonou, Benin
Mayfong Mayxay - Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England
Rose McGready - Mahidol Univ, Fac Trop Med, Mahidol Oxford Trop Med Res Unit, Shoklo Malaria Res Unit, Mae Sot, Thailand
Herve Menan - Univ Cocody, Fac Pharm, Dept Parasitol, Abidjan, Cote Ivoire
Clara Menendez - Univ Barcelona, Barcelona Inst Global Hlth ISGlobal, Hosp Clin, E-08007 Barcelona, Spain
Petra Mens - KIT Biomed Res, Royal Trop Inst, Amsterdam, Netherlands
Martin Meremikwu - Univ Calabar, Dept Paediat, Calabar, Nigeria
Frank P. Mockenhaupt - Charite, Inst Trop Med & Int Hlth, D-13353 Berlin, Germany
Clarissa Moreira - WWARN, Oxford, England
Carolyn Nabasumba - Epictr, Paris, France
Michael Nambozi - Trop Dis Res Ctr, Ndola, Zambia
Jean-Louis Ndiaye - Univ Cheikh Anta Diop, Fac Med, Parasitol & Mycol Lab, Dakar, Senegal
Paul N. Newton - University of Oxford
Billy E. Ngasala - Muhimbili Univ Hlth & Allied Sci, Dept Parasitol, Dar Es Salaam, Tanzania
Francois Nosten - Mahidol University
Christian Nsanzabana - WWARN, Oxford, England
Andre Toure Offianan - Inst Pasteur, Malariol Dept, Abidjan, Cote Ivoire
Mary Oguike - LSHTM, Dept Immunol & Infect, London, England
Bernhards R. Ogutu - Univ Oxford, Nuffield Dept Clin Med, Ctr Trop Med & Global Hlth, Oxford, England
Piero Olliaro - UNICEF UNDP World Bank WHO Special Programme Res, Geneva, Switzerland
Sabah A. Omar - Int Ctr Insect Physiol & Ecol, Mbita Point, Kenya
Lyda Osorio - Univ Valle, Fac Salud, Cali, Colombia
Seth Owusu-Agyei - Kintampo Hlth Res Ctr, Kintampo, Ghana
Louis K. Penali - WWARN, Dakar, Senegal
Mbaye Pene - Univ Cheikh Anta Diop, Dept Med Parasitol, Fac Med, Dakar, Senegal
Judy Peshu - Wellcome Trust Res Programme, Kenya Med Res Inst, Kilifi, Kenya
Patrice Piola - Inst Pasteur Madagascar, Antananarivo, Madagascar
Zul Premji - Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania
Ric N. Price - WWARN, Oxford, England
Michael Ramharter - Ctr Rech Medicales Lambarene, Lambarene, Gabon
Lars Rombo - Karolinska Inst, Karolinska Univ Hosp, Dept Med Solna, Infect Dis Unit, Stockholm, Sweden
Cally Roper - LSHTM, London, England
Philip J. Rosenthal - Univ Calif San Francisco, Dept Med, San Francisco, CA USA
Issaka Sagara - Univ Bamako, Fac Med Pharm & Odontostomatol, Dept Epidemiol Parasit Dis, Malaria Res & Training Ctr, Bamako, Mali
Patrick Sawa - Int Ctr Insect Physiol & Ecol, Human Hlth Div, Mbita, Kenya
Henk D. F. H. Schallig - KIT Biomed Res, Royal Trop Inst, Amsterdam, Netherlands
Birgit Schramm - Epictr, Paris, France
Seif A. Shekalaghe
Carol H. Sibley - WWARN, Oxford, England
Sodiomon Sirima - Ctr Natl Rech & Format Paludisme, Ouagadougou, Burkina Faso
Frank Smithuis - Myanmar Oxford Clin Res Unit, Yangon, Myanmar
Doudou Sow - Univ Cheikh Anta Diop, Fac Med, Serv Parasitol, Dakar, Senegal
Sarah G. Staedke - LSHTM, Dept Clin Res, London, England
Kasia Stepniewska - WWARN, Oxford, England
Inge Sutanto - Univ Indonesia, Fac Med, Dept Parasitol, Jakarta, Indonesia
Colin J. Sutherland - LSHTM, Dept Immunol & Infect, London, England
Todd D. Swarthout - Med Sans Frontieres, London, England
Din Syafruddin - Eijkman Institute for Molecular Biology
Khadime Sylla - Univ Cheikh Anta Diop, Serv Parasitol Mycol Medicale, Dakar, Senegal
Ambrose O. Talisuna - Univ Oxford, KEMRI, Wellcome Trust Res Programme, Nairobi, Kenya
Walter R. Taylor - ETH, Dept Hlth Sci & Technol, Inst Biomech, Zurich, Switzerland
Emmanuel A. Temu - MENTOR Initiat, Crawley, England
Feiko Ter Kuile - Univ Liverpool, Liverpool Sch Trop Med, Liverpool L3 5QA, Merseyside, England
Halidou Tinto - Burkina Faso & Ctr Muraz, Inst Rech Sci Sante, Bobo Dioulasso, Burkina Faso
Emiliana Tjitra - Minist Hlth, Natl Inst Hlth Res & Dev, Jakarta, Indonesia
Johan Ursing - Indepth Network, Projecto Saude Bandim, Bissau, Guinea Bissau
Neena Valecha - Natl Inst Malaria Res, New Delhi, India
Ingrid van den Broek - Med Sans Frontieres, London, England
Michel van Herp - Operat Ctr Brussels, Med Sans Frontieres, Brussels, Belgium
Michele van Vugt - Univ Amsterdam, Acad Med Ctr, Ctr Trop Med & Travel Med, Div Infect Dis, NL-1012 WX Amsterdam, Netherlands
Stephen A. Ward - Univ Liverpool, Liverpool Sch Trop Med, Dept Parasitol, Liverpool L3 5QA, Merseyside, England
Nicholas J. White - Mahidol Univ, Fac Trop Med, Bangkok, Thailand
Peter A. Winstanley - Univ Liverpool, Sch Clin Sci, Liverpool L69 3BX, Merseyside, England
Charles J. Woodrow - Mahidol Oxford Trop Med Res Unit MORU, Bangkok, Thailand
Adoke Yeka - Uganda Malaria Surveillance Project, Kampala, Uganda
Julien Zwang - Drugs Neglected Dis Initiat DNDi, Geneva, Switzerland
WWARN Gametocyte Study Grp
Détails de publication: BMC medicine, Vol.14(1), pp.79-79
Éditeur: Springer Nature
Nombre de pages: 18
Note de subvention: MR/K00669X/1; MC_UP_A900_1119 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) ERC-2014-StG 639776 / European Research Council; European Research Council (ERC); European Commission Bill and Melinda Gates Foundation grant; Bill & Melinda Gates Foundation
Identifiants: 99158570009311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article