GENESIS: a French national resource to study the missing heritability of breast cancer

Olga M Sinilnikova; Marie-Gabrielle Dondon; Séverine Eon-Marchais; Francesca Damiola; Laure Barjhoux; Morgane Marcou; Carole Verny-Pierre; Valérie Sornin; Lucie Toulemonde; Juana Beauvallet; Dorothée Le Gal; Noura Mebirouk; Muriel Belotti; Olivier Caron; Marion Gauthier-Villars; Isabelle Coupier; Bruno Buecher; Alain Lortholary; Catherine Dugast; Paul Gesta; Jean-Pierre Fricker; Catherine Noguès; Laurence Faivre; Elisabeth Luporsi; Pascaline Berthet; Capucine Delnatte; Valérie Bonadona; Christine Maugard; Pascal Pujol; Christine Lasset; Michel Longy; Yves-Jean Bignon; Claude Adenis; Laurence Venat-Bouvet; Liliane Demange; Hélène Dreyfus; Marc Frenay; Laurence Gladieff; Isabelle Mortemousque; Séverine Audebert-Bellanger; Florent Soubrier; Sophie Giraud; Sophie S. Lejeune-Dumoulin; Annie Chevrier; Jean-Marc Limacher; Jean Chiesa; Anne Fajac; Anne Floquet; Francois Eisinger; Julie Tinat; Chrystelle Colas; Sandra Fert Ferrer; Clotilde Penet; Thierry Frebourg; Marie-Agnès Collonge-Rame; Emmanuelle Barouk-Simonet; Valerie Layet; Dominique Leroux; Odile Cohen-Haguenauer; Fabienne Prieur; Emmanuelle Mouret-Fourme; François Cornelis; Philippe Jonveaux; Odile Bera; Eve Cavaciuti; Anne Tardivon; Fabienne Lesueur; Sylvie Mazoyer; Dominique Stoppa-Lyonnet; Nadine Andrieu

doi:10.1186/s12885-015-2028-9

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GENESIS: a French national resource to study the missing heritability of breast cancer

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GENESIS: a French national resource to study the missing heritability of breast cancer

Olga M Sinilnikova, Marie-Gabrielle Dondon, Séverine Eon-Marchais, Francesca Damiola, Laure Barjhoux, Morgane Marcou, Carole Verny-Pierre, Valérie Sornin, Lucie Toulemonde, Juana Beauvallet, …

BMC Cancer, Vol.16(1), pp.606 - 606

12/2016

DOI: https://doi.org/10.1186/s12885-015-2028-9

Abstract

Confer Susceptibility

Genome-Wide Association

Common Variants

Identifies 2

Risk

Alleles

Susceptibility Loci

Background: Less than 20 % of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify new breast cancer susceptibility genes in women attending cancer genetics clinics and with no BRCA1/2 mutation. Methods: The study involved the French national network of family cancer clinics. It was based on enrichment in genetic factors of the recruited population through case selection relying on familial criteria, but also on the consideration of environmental factors and endophenotypes like mammary density or tumor characteristics to assess potential genetic heterogeneity. One of the initial aims of GENESIS was to recruit affected sibpairs. Siblings were eligible when index cases and at least one affected sister were diagnosed with infiltrating mammary or ductal adenocarcinoma, with no BRCA1/2 mutation. In addition, unrelated controls and unaffected sisters were recruited. The enrolment of patients, their relatives and their controls, the collection of the clinical, epidemiological, familial and biological data were centralized by a coordinating center.

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Title: GENESIS: a French national resource to study the missing heritability of breast cancer
Creators - without role: Olga M Sinilnikova - Université Claude Bernard Lyon 1
Marie-Gabrielle Dondon - Université Paris Sciences et Lettres
Séverine Eon-Marchais - Inserm
Francesca Damiola - Université Claude Bernard Lyon 1
Laure Barjhoux - Université Claude Bernard Lyon 1
Morgane Marcou - Inserm
Carole Verny-Pierre - Centre de Recherche en Cancérologie de Lyon
Valérie Sornin - Université Claude Bernard Lyon 1
Lucie Toulemonde - Inserm
Juana Beauvallet - Inserm
Dorothée Le Gal - Inserm
Noura Mebirouk - Inserm
Muriel Belotti - Institut Curie
Olivier Caron - Institut Gustave Roussy
Marion Gauthier-Villars - Institut Curie
Isabelle Coupier - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Bruno Buecher - Institut Curie
Alain Lortholary - Centre Catherine-de-Sienne [Nantes]
Catherine Dugast - Centre Eugène Marquis
Paul Gesta - Groupe d’Etude des Cétacés du Cotentin
Jean-Pierre Fricker - Centre Paul Strauss
Catherine Noguès - Hôpital René Huguenin
Laurence Faivre - Hôpital d'Enfants
Elisabeth Luporsi - Institut de Cancérologie de Lorraine
Pascaline Berthet - Centre François Baclesse
Capucine Delnatte - Institut Génétique Nantes Atlantique
Valérie Bonadona - Université Claude Bernard Lyon 1
Christine Maugard - Hôpitaux Universitaires de Strasbourg
Pascal Pujol - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Christine Lasset - Université Claude Bernard Lyon 1
Michel Longy - Institut Bergonié
Yves-Jean Bignon - Centre Jean Perrin
Claude Adenis - Centre Oscar Lambret
Laurence Venat-Bouvet - Hôpital Universitaire Dupuytren
Liliane Demange - L’Institut du Cancer Courlancy Reims
Hélène Dreyfus - Institut Sainte Catherine
Marc Frenay - Centre Antoine Lacassagne
Laurence Gladieff - Institut Claudius Regaud
Isabelle Mortemousque - Centre Hospitalier Universitaire de Tours
Séverine Audebert-Bellanger - Centre Hospitalier Régional Universitaire de Brest
Florent Soubrier - Sorbonne Université
Sophie Giraud - Hôpital Edouard Herriot
Sophie S. Lejeune-Dumoulin - Hôpital Jeanne de Flandre
Annie Chevrier - Centre Hospitalier Universitaire de Rouen
Jean-Marc Limacher - Hôpital Pasteur
Jean Chiesa - Centre Hospitalier Universitaire de Nîmes
Anne Fajac - Hôpital Tenon
Anne Floquet - Institut Bergonié
Francois Eisinger - Centre de Recherche en Cancérologie de Marseille
Julie Tinat - Centre Hospitalier Universitaire de Rouen
Chrystelle Colas - Sorbonne Université
Sandra Fert Ferrer - Centre Hospitalier Métropole Savoie
Clotilde Penet - Institut Jean Godinot
Thierry Frebourg - Centre Hospitalier Universitaire de Rouen
Marie-Agnès Collonge-Rame - Centre Hospitalier Régional Universitaire de Besançon
Emmanuelle Barouk-Simonet - Institut Bergonié
Valerie Layet - Groupe Hospitalier du Havre
Dominique Leroux - Hôpital Couple Enfant
Odile Cohen-Haguenauer - Hôpital Saint-Louis
Fabienne Prieur - Hôpital Nord
Emmanuelle Mouret-Fourme - Institut Curie
François Cornelis - Hôpital Lariboisière
Philippe Jonveaux - Nutrition-Génétique et Exposition aux Risques Environnementaux
Odile Bera - Centre Hospitalier Universitaire de Martinique
Eve Cavaciuti - École Nationale Supérieure des Mines de Paris
Anne Tardivon - Institut Curie
Fabienne Lesueur - École Nationale Supérieure des Mines de Paris
Sylvie Mazoyer - Université Claude Bernard Lyon 1
Dominique Stoppa-Lyonnet - Institut Curie
Nadine Andrieu - École Nationale Supérieure des Mines de Paris
Publication Details: BMC Cancer, Vol.16(1), pp.606 - 606
Identifiers: 9939532209311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM; Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC; Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-01662200