Full-length genome sequence of a simian immunodeficiency virus (SIV) infecting a captive agile mangabey (Cercocebus agilis) is closely related to SIVrcm infecting wild red-capped mangabeys (Cercocebus torquatus) in Cameroon

Steve Ahuka-Mundeke; Florian Liegeois; Ahidjo Ayouba; Yacouba Foupouapouognini; Eric Nerrienet; Eric Delaporte; Martine Peeters

doi:10.1099/vir.0.025767-0

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Full-length genome sequence of a simian immunodeficiency virus (SIV) infecting a captive agile mangabey (Cercocebus agilis) is closely related to SIVrcm infecting wild red-capped mangabeys (Cercocebus torquatus) in Cameroon

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Full-length genome sequence of a simian immunodeficiency virus (SIV) infecting a captive agile mangabey (Cercocebus agilis) is closely related to SIVrcm infecting wild red-capped mangabeys (Cercocebus torquatus) in Cameroon

Steve Ahuka-Mundeke, Florian Liegeois, Ahidjo Ayouba, Yacouba Foupouapouognini, Eric Nerrienet, Eric Delaporte et Martine Peeters

Journal of general virology, Vol.91(Pt 12), pp.2959-2964

01/12/2010

DOI: https://doi.org/10.1099/vir.0.025767-0

PMID: 20797968

Résumé

Animal

Simian immunodeficiency viruses (SIVs) are lentiviruses that infect an extensive number of wild African primate species. Here we describe for the first time SIV infection in a captive agile mangabey (Cercocebus agilis) from Cameroon. Phylogenetic analysis of the full-length genome sequence of SIVagi-00CM312 showed that this novel virus fell into the SIVrcm lineage and was most closely related to a newly characterized SIVrcm strain (SIVrcm-02CM8081) from a wild-caught red-capped mangabey (Cercocebus torquatus) from Cameroon. In contrast to red-capped mangabeys, no 24 bp deletion in CCR5 has been observed in the agile mangabey. Further studies on wild agile mangabeys are needed to determine whether agile and red-capped mangabeys are naturally infected with the same SIV lineage, or whether this agile mangabey became infected with an SIVrcm strain in captivity. However, our study shows that agile mangabeys are susceptible to SIV infection.

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Titre: Full-length genome sequence of a simian immunodeficiency virus (SIV) infecting a captive agile mangabey (Cercocebus agilis) is closely related to SIVrcm infecting wild red-capped mangabeys (Cercocebus torquatus) in Cameroon
Créateurs - sans rôle: Steve Ahuka-Mundeke - UMR145, Institut de Recherche pour le Developpement (IRD) and University of Montpellier 1, Montpellier, France Centre Pasteur du Cameroun, Laboratoire de Virologie, BP1274, Yaoundé, Cameroon Institut Pasteur Cambodge, Laboratoire VIH/Hépatites, Phnom Penh, Cambodia
Florian Liegeois - UMR145, Institut de Recherche pour le Developpement (IRD) and University of Montpellier 1, Montpellier, France Centre Pasteur du Cameroun, Laboratoire de Virologie, BP1274, Yaoundé, Cameroon Institut Pasteur Cambodge, Laboratoire VIH/Hépatites, Phnom Penh, Cambodia
Ahidjo Ayouba - UMR145, Institut de Recherche pour le Developpement (IRD) and University of Montpellier 1, Montpellier, France Centre Pasteur du Cameroun, Laboratoire de Virologie, BP1274, Yaoundé, Cameroon Institut Pasteur Cambodge, Laboratoire VIH/Hépatites, Phnom Penh, Cambodia
Yacouba Foupouapouognini - UMR145, Institut de Recherche pour le Developpement (IRD) and University of Montpellier 1, Montpellier, France Centre Pasteur du Cameroun, Laboratoire de Virologie, BP1274, Yaoundé, Cameroon Institut Pasteur Cambodge, Laboratoire VIH/Hépatites, Phnom Penh, Cambodia
Eric Nerrienet - UMR145, Institut de Recherche pour le Developpement (IRD) and University of Montpellier 1, Montpellier, France Centre Pasteur du Cameroun, Laboratoire de Virologie, BP1274, Yaoundé, Cameroon Institut Pasteur Cambodge, Laboratoire VIH/Hépatites, Phnom Penh, Cambodia
Eric Delaporte - UMR145, Institut de Recherche pour le Developpement (IRD) and University of Montpellier 1, Montpellier, France Centre Pasteur du Cameroun, Laboratoire de Virologie, BP1274, Yaoundé, Cameroon Institut Pasteur Cambodge, Laboratoire VIH/Hépatites, Phnom Penh, Cambodia
Martine Peeters - UMR145, Institut de Recherche pour le Developpement (IRD) and University of Montpellier 1, Montpellier, France Centre Pasteur du Cameroun, Laboratoire de Virologie, BP1274, Yaoundé, Cameroon Institut Pasteur Cambodge, Laboratoire VIH/Hépatites, Phnom Penh, Cambodia
Détails de publication: Journal of general virology, Vol.91(Pt 12), pp.2959-2964
Éditeur: Society for General Microbiology
Nombre de pages: 6
Identifiants: 99147792409311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article