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From cochlear cell death pathways to new pharmacological therapies.
Article de revue

From cochlear cell death pathways to new pharmacological therapies.

Jing Wang et Jean-Luc Puel
Mini Reviews in Medicinal Chemistry / Mini-Reviews in Medicinal Chemistry, Vol.8(10), pp.1006-19
09/2008
PMID: 18782053

Résumé

Age Factors Animals Antioxidants Apoptosis Cochlea Drug Design Hearing Loss, Sensorineural Humans Signal Transduction
Ototoxic drugs, intense sound or age-related hearing loss recruit most of the apoptotic pathways, but also several additional enzymatic pathways which eventually result in cell death. Here, we discuss therapeutic strategies based on the inhibition of regulators or executors of apoptotic cell death pathways and on the use of antioxidants.

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