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Fluorinated and hemifluorinated surfactants derived from maltose: Synthesis and application to handling membrane proteins in aqueous solution
Journal article   Peer reviewed

Fluorinated and hemifluorinated surfactants derived from maltose: Synthesis and application to handling membrane proteins in aqueous solution

Ange Polidori, Marc Presset, Florence Lebaupain, Bruno Ameduri, Jean-Luc Popot, Cécile Breyton and Bernard Pucci
Bioorganic and Medicinal Chemistry Letters, Vol.16, pp.5827-5831
2006

Abstract

Aggregates Fluorinated surfactants Maltoside Membrane proteins Solubilization Aggregates.
Two novel fluorinated surfactants have been obtained by grafting by radical reaction either a fluorocarbon or an ethyl end-capped fluorocarbon chain onto the double bond of b-D-allyl maltose. The two compounds thus obtained form polydisperse aggregates in water. They can keep membrane proteins water-soluble, but the protein/surfactant complexes are polydisperse, which affects neither the native state nor the stability of the proteins.
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