Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis

Andries Gous; Jeffrey Lipman; Juan Scribante; Shephelia Tshukutsoane; Hubert Hon; Mary Pinder; Rudo Mathivha; Lia Verhoef; Heino Stass

doi:10.1016/j.ijantimicag.2005.04.005

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Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis

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Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis

Andries Gous, Jeffrey Lipman, Juan Scribante, Shephelia Tshukutsoane, Hubert Hon, Mary Pinder, Rudo Mathivha, Lia Verhoef et Heino Stass

International journal of antimicrobial agents, Vol.26(1), pp.50-55

07/2005

DOI: https://doi.org/10.1016/j.ijantimicag.2005.04.005

PMID: 15955670

Résumé

Antibiotics

Fluoroquinolone

Intensive Care Unit

Pharmacokinetics

Volume of distribution

This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients ≥18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intra-abdominal infections. Group B (18 patients) included patients with severe sepsis from other causes. All patients received intravenous ciprofloxacin 400 mg every 8 h infused over 60 min. Eight timed blood specimens were taken on days 0, 2 and 7. Ciprofloxacin plasma concentrations were determined using high performance liquid chromatography. There were no significant differences between the pharmacokinetics of the two groups or over time. Ciprofloxacin pharmacokinetics in critically ill patients do not change over time, and intra-abdominal sepsis does not alter ciprofloxacin pharmacokinetic parameters to a greater degree than sepsis from other causes in critically ill patients.

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Titre: Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis
Créateurs - sans rôle: Andries Gous - School of Pharmacy, University of Limpopo, P.O. Box 218, Medunsa 0204, South Africa
Jeffrey Lipman - Burns, Trauma and Critical Care Research Centre, University of Queensland, Royal Brisbane and Women's Hospital, Brisbane, Qld, Australia
Juan Scribante - Intensive Care Unit, Chris Hani Baragwanath Hospital, Department of Medicine, Witwatersrand University, Johannesburg, South Africa
Shephelia Tshukutsoane - Intensive Care Unit, Chris Hani Baragwanath Hospital, Department of Medicine, Witwatersrand University, Johannesburg, South Africa
Hubert Hon - Intensive Care Unit, Chris Hani Baragwanath Hospital, Department of Medicine, Witwatersrand University, Johannesburg, South Africa
Mary Pinder - Intensive Care Unit, Chris Hani Baragwanath Hospital, Department of Medicine, Witwatersrand University, Johannesburg, South Africa
Rudo Mathivha - Intensive Care Unit, Chris Hani Baragwanath Hospital, Department of Medicine, Witwatersrand University, Johannesburg, South Africa
Lia Verhoef - Bayer (PTY and AG Germany), 27 Wrench Road, Isando 1600, South Africa
Heino Stass - Bayer (PTY and AG Germany), 27 Wrench Road, Isando 1600, South Africa
Détails de publication: International journal of antimicrobial agents, Vol.26(1), pp.50-55
Éditeur: Elsevier B.V
Nombre de pages: 6
Identifiants: 99153974509311
Unité académique: Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE
Langue: English
Type de ressource: Journal article